{"id":"https://openalex.org/W4412055481","doi":"https://doi.org/10.1016/j.biosystems.2025.105528","title":"The origins of ATP synthases, the identity of LUCA, and the progenote","display_name":"The origins of ATP synthases, the identity of LUCA, and the progenote","publication_year":2025,"publication_date":"2025-07-05","ids":{"openalex":"https://openalex.org/W4412055481","doi":"https://doi.org/10.1016/j.biosystems.2025.105528","pmid":"https://pubmed.ncbi.nlm.nih.gov/40623518"},"language":"en","primary_location":{"id":"doi:10.1016/j.biosystems.2025.105528","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2025.105528","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioSystems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016903088","display_name":"Massimo Di Giulio","orcid":"https://orcid.org/0000-0003-2660-2571"},"institutions":[{"id":"https://openalex.org/I26415053","display_name":"University of L'Aquila","ror":"https://ror.org/01j9p1r26","country_code":"IT","type":"education","lineage":["https://openalex.org/I26415053"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Massimo Di Giulio","raw_affiliation_strings":["The Ionian School, Early Evolution of Life Department, Genetic Code and tRNA Origin Laboratory, Via Roma 19, 67030, Alfedena, L'Aquila, Italy. Electronic address: massimodigiulio1952@gmail.com","The Ionian School, Early Evolution of Life Department, Genetic Code and tRNA Origin Laboratory, Via Roma 19, 67030 Alfedena, L'Aquila, Italy. Electronic address: massimodigiulio1952@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Ionian School, Early Evolution of Life Department, Genetic Code and tRNA Origin Laboratory, Via Roma 19, 67030, Alfedena, L'Aquila, Italy. Electronic address: massimodigiulio1952@gmail.com","institution_ids":["https://openalex.org/I26415053"]},{"raw_affiliation_string":"The Ionian School, Early Evolution of Life Department, Genetic Code and tRNA Origin Laboratory, Via Roma 19, 67030 Alfedena, L'Aquila, Italy. Electronic address: massimodigiulio1952@gmail.com","institution_ids":["https://openalex.org/I26415053"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016903088"],"corresponding_institution_ids":["https://openalex.org/I26415053"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":null,"fwci":0.9736,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.75134641,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"254","issue":null,"first_page":"105528","last_page":"105528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9697999954223633,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identity","display_name":"Identity (music)","score":0.589555025100708},{"id":"https://openalex.org/keywords/atp-synthase","display_name":"ATP synthase","score":0.4771370589733124},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.45271289348602295},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3313489556312561},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2541501522064209},{"id":"https://openalex.org/keywords/philosophy","display_name":"Philosophy","score":0.2265613079071045},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.14581871032714844}],"concepts":[{"id":"https://openalex.org/C2778355321","wikidata":"https://www.wikidata.org/wiki/Q17079427","display_name":"Identity (music)","level":2,"score":0.589555025100708},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.4771370589733124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45271289348602295},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3313489556312561},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2541501522064209},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.2265613079071045},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14581871032714844},{"id":"https://openalex.org/C107038049","wikidata":"https://www.wikidata.org/wiki/Q35986","display_name":"Aesthetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001105","descriptor_name":"Archaea","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001105","descriptor_name":"Archaea","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001105","descriptor_name":"Archaea","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001105","descriptor_name":"Archaea","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005815","descriptor_name":"Genetic Code","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005815","descriptor_name":"Genetic Code","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biosystems.2025.105528","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biosystems.2025.105528","pdf_url":null,"source":{"id":"https://openalex.org/S99347777","display_name":"Biosystems","issn_l":"0303-2647","issn":["0303-2647","1872-8324"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioSystems","raw_type":"journal-article"},{"id":"pmid:40623518","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40623518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bio Systems","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.41999998688697815,"id":"https://metadata.un.org/sdg/2"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W1573058105","https://openalex.org/W1973481154","https://openalex.org/W1974151463","https://openalex.org/W1974443096","https://openalex.org/W1991207390","https://openalex.org/W2001138638","https://openalex.org/W2001783814","https://openalex.org/W2006525704","https://openalex.org/W2011537739","https://openalex.org/W2013414898","https://openalex.org/W2014772066","https://openalex.org/W2017754509","https://openalex.org/W2018695959","https://openalex.org/W2019978827","https://openalex.org/W2021806117","https://openalex.org/W2032247127","https://openalex.org/W2032505000","https://openalex.org/W2033609269","https://openalex.org/W2033634049","https://openalex.org/W2035772300","https://openalex.org/W2036370308","https://openalex.org/W2040461302","https://openalex.org/W2043281233","https://openalex.org/W2044214664","https://openalex.org/W2045007774","https://openalex.org/W2053096433","https://openalex.org/W2058299864","https://openalex.org/W2059599979","https://openalex.org/W2059730211","https://openalex.org/W2060320059","https://openalex.org/W2062562477","https://openalex.org/W2066258259","https://openalex.org/W2067599317","https://openalex.org/W2068419696","https://openalex.org/W2070889260","https://openalex.org/W2071437577","https://openalex.org/W2072348389","https://openalex.org/W2081596649","https://openalex.org/W2084170559","https://openalex.org/W2093210315","https://openalex.org/W2098015235","https://openalex.org/W2099860179","https://openalex.org/W2100572467","https://openalex.org/W2101540894","https://openalex.org/W2117729494","https://openalex.org/W2128892592","https://openalex.org/W2136495792","https://openalex.org/W2138220095","https://openalex.org/W2146448539","https://openalex.org/W2152177254","https://openalex.org/W2153151155","https://openalex.org/W2181418669","https://openalex.org/W2660755699","https://openalex.org/W2730318084","https://openalex.org/W2790613820","https://openalex.org/W2896531101","https://openalex.org/W2900539794","https://openalex.org/W2907436695","https://openalex.org/W2909190155","https://openalex.org/W2972943898","https://openalex.org/W2984000771","https://openalex.org/W3007830711","https://openalex.org/W3022704487","https://openalex.org/W3072710055","https://openalex.org/W3084049955","https://openalex.org/W3118123444","https://openalex.org/W3126166777","https://openalex.org/W3134445490","https://openalex.org/W3159258396","https://openalex.org/W3206450084","https://openalex.org/W4206541423","https://openalex.org/W4221125846","https://openalex.org/W4244216208","https://openalex.org/W4288039801","https://openalex.org/W4296105095","https://openalex.org/W4307905672","https://openalex.org/W4386258514","https://openalex.org/W4388759190","https://openalex.org/W4389037197","https://openalex.org/W4395117633","https://openalex.org/W4400589084","https://openalex.org/W4400764142","https://openalex.org/W4401453410","https://openalex.org/W4401474480","https://openalex.org/W4401618239","https://openalex.org/W4401694552","https://openalex.org/W4402443888","https://openalex.org/W4402847818","https://openalex.org/W4403053266","https://openalex.org/W4404571964","https://openalex.org/W4405509050","https://openalex.org/W4406044296","https://openalex.org/W6634426563","https://openalex.org/W6643589087","https://openalex.org/W6808352255","https://openalex.org/W6872457217","https://openalex.org/W6872740715"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}