{"id":"https://openalex.org/W1963549388","doi":"https://doi.org/10.1016/s1672-0229(10)60019-8","title":"Regulation of U6 Promoter Activity by Transcriptional Interference in Viral Vector-Based RNAi","display_name":"Regulation of U6 Promoter Activity by Transcriptional Interference in Viral Vector-Based RNAi","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W1963549388","doi":"https://doi.org/10.1016/s1672-0229(10)60019-8","mag":"1963549388","pmid":"https://pubmed.ncbi.nlm.nih.gov/20970745"},"language":"en","primary_location":{"id":"doi:10.1016/s1672-0229(10)60019-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1672-0229(10)60019-8","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/s1672-0229(10)60019-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086194361","display_name":"Linghu Nie","orcid":null},"institutions":[{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linghu Nie","raw_affiliation_strings":["Key Laboratory of Genome Sciences and Information, Cancer Biology and Genetics Group, Beijing Institute of Genomics, Chinese Acadamy of Sciences , Beijing, 100029 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Genome Sciences and Information, Cancer Biology and Genetics Group, Beijing Institute of Genomics, Chinese Acadamy of Sciences , Beijing, 100029 , China","institution_ids":["https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061132840","display_name":"Meghna Das Thakur","orcid":"https://orcid.org/0000-0003-2177-7401"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meghna Das Thakur","raw_affiliation_strings":["Departments of Medicine and Cell Biology, Washington University , St. Louis, MO, 63110 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Cell Biology, Washington University , St. Louis, MO, 63110 , USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100703520","display_name":"Yumei Wang","orcid":"https://orcid.org/0000-0001-5869-9203"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yumei Wang","raw_affiliation_strings":["Departments of Medicine and Cell Biology, Washington University , St. Louis, MO, 63110 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Cell Biology, Washington University , St. Louis, MO, 63110 , USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036576811","display_name":"Qin Su","orcid":"https://orcid.org/0000-0001-9437-6292"},"institutions":[{"id":"https://openalex.org/I4210104024","display_name":"Immunocore (United Kingdom)","ror":"https://ror.org/014xzez86","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210104024"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Qin Su","raw_affiliation_strings":["Immunocore Limited , Abingdon, Oxon, OX14 4RX , UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunocore Limited , Abingdon, Oxon, OX14 4RX , UK","institution_ids":["https://openalex.org/I4210104024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080562594","display_name":"Yongliang Zhao","orcid":"https://orcid.org/0000-0003-0121-1312"},"institutions":[{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongliang Zhao","raw_affiliation_strings":["Key Laboratory of Genome Sciences and Information, Cancer Biology and Genetics Group, Beijing Institute of Genomics, Chinese Acadamy of Sciences , Beijing, 100029 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Genome Sciences and Information, Cancer Biology and Genetics Group, Beijing Institute of Genomics, Chinese Acadamy of Sciences , Beijing, 100029 , China","institution_ids":["https://openalex.org/I2801577699"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019252223","display_name":"Yunfeng Feng","orcid":"https://orcid.org/0000-0001-9150-7795"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yunfeng Feng","raw_affiliation_strings":["Departments of Medicine and Cell Biology, Washington University , St. Louis, MO, 63110 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Cell Biology, Washington University , St. Louis, MO, 63110 , USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019252223"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":{"value":3650,"currency":"USD","value_usd":3650},"fwci":0.3734,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.58363341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"3","first_page":"170","last_page":"179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-hairpin-rna","display_name":"Small hairpin RNA","score":0.8111458420753479},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.7611145973205566},{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.6521137952804565},{"id":"https://openalex.org/keywords/transcription","display_name":"Transcription (linguistics)","score":0.5725841522216797},{"id":"https://openalex.org/keywords/enhancer","display_name":"Enhancer","score":0.5655176043510437},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5536646246910095},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.4990353584289551},{"id":"https://openalex.org/keywords/rna-polymerase-iii","display_name":"RNA polymerase III","score":0.473873108625412},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4449915289878845},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3987470865249634},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.38611358404159546},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2118997871875763},{"id":"https://openalex.org/keywords/rna-polymerase","display_name":"RNA polymerase","score":0.19570571184158325}],"concepts":[{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.8111458420753479},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.7611145973205566},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.6521137952804565},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5725841522216797},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.5655176043510437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5536646246910095},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4990353584289551},{"id":"https://openalex.org/C70916841","wikidata":"https://www.wikidata.org/wiki/Q3501658","display_name":"RNA polymerase III","level":5,"score":0.473873108625412},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4449915289878845},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3987470865249634},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.38611358404159546},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2118997871875763},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.19570571184158325},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005821","descriptor_name":"Genetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005821","descriptor_name":"Genetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005821","descriptor_name":"Genetic Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007652","descriptor_name":"Oxo-Acid-Lyases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007652","descriptor_name":"Oxo-Acid-Lyases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007652","descriptor_name":"Oxo-Acid-Lyases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012342","descriptor_name":"RNA, Small Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012342","descriptor_name":"RNA, Small Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012342","descriptor_name":"RNA, Small Nuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s1672-0229(10)60019-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1672-0229(10)60019-8","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20970745","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20970745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, proteomics & bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:4016509","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5054135","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/s1672-0229(10)60019-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1672-0229(10)60019-8","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1611419331","https://openalex.org/W1647075334","https://openalex.org/W1965306643","https://openalex.org/W1966359331","https://openalex.org/W1967517087","https://openalex.org/W1973924029","https://openalex.org/W1974861468","https://openalex.org/W1988183618","https://openalex.org/W1988967884","https://openalex.org/W1992941735","https://openalex.org/W1995149647","https://openalex.org/W2000241413","https://openalex.org/W2005506831","https://openalex.org/W2015243129","https://openalex.org/W2015800866","https://openalex.org/W2016999029","https://openalex.org/W2037174767","https://openalex.org/W2046440901","https://openalex.org/W2071779610","https://openalex.org/W2083759860","https://openalex.org/W2123352893","https://openalex.org/W2129016093","https://openalex.org/W2139791626","https://openalex.org/W2145540744","https://openalex.org/W2146900615","https://openalex.org/W2151922790","https://openalex.org/W2153478121","https://openalex.org/W2153747430","https://openalex.org/W2158043342","https://openalex.org/W2159532582","https://openalex.org/W2166903671","https://openalex.org/W2167557255","https://openalex.org/W2171109371"],"related_works":["https://openalex.org/W3156071777","https://openalex.org/W2289304380","https://openalex.org/W2139684752","https://openalex.org/W4283214369","https://openalex.org/W4296940635","https://openalex.org/W3208446472","https://openalex.org/W2791084809","https://openalex.org/W2119212619","https://openalex.org/W4281254649","https://openalex.org/W2914108095"],"abstract_inverted_index":{"The":[0],"direct":[1],"negative":[2,157,169],"impact":[3,170],"of":[4,8,50,81,160,178],"the":[5,12,46,79,143,176],"transcriptional":[6,21,112],"activity":[7,70,135,174,187],"one":[9,14],"component":[10],"on":[11,171],"second":[13],"in":[15,42,59,62,84,124,142,148,175,193],"cis":[16],"is":[17,25,76],"referred":[18],"to":[19],"as":[20],"interference":[22],"(TI).":[23],"U6":[24,68,116,133,162,172,185],"a":[26,63,97,194],"type":[27],"III":[28,31],"RNA":[29,39],"polymerase":[30],"promoter":[32,69,117,123,126,134,140,153,163,173,186],"commonly":[33],"used":[34],"for":[35,78],"driving":[36,118],"small":[37],"hairpin":[38],"(shRNA)":[40],"expression":[41,80,120],"vector-based":[43],"RNAi.":[44],"In":[45,90,128,150],"design":[47],"and":[48,95,103,121,197],"construction":[49],"viral":[51],"vectors,":[52],"multiple":[53],"transcription":[54],"units":[55],"may":[56],"be":[57,72,189],"arranged":[58,115],"close":[60],"proximity":[61],"space-limited":[64],"vector.":[65],"Determining":[66],"if":[67],"can":[71,188],"affected":[73,190],"by":[74,109,138,191],"TI":[75,192],"critical":[77],"target":[82],"shRNA":[83,102,119],"gene":[85,105],"therapy":[86],"or":[87],"loss-of-function":[88],"studies.":[89],"this":[91],"research,":[92],"we":[93,131],"designed":[94],"implemented":[96],"modified":[98],"retroviral":[99],"system":[100],"where":[101],"exogenous":[104],"expressions":[106],"were":[107],"driven":[108],"two":[110,125],"independent":[111],"units.":[113],"We":[114],"UbiC":[122,139,179],"arrangements.":[127],"primary":[129],"macrophages,":[130],"found":[132],"was":[136],"inhibited":[137],"when":[141],"divergent":[144],"arrangement":[145],"but":[146],"not":[147],"tandem.":[149],"contrast,":[151],"PKG":[152],"had":[154,167],"no":[155],"such":[156],"impact.":[158],"Instead":[159],"enhancing":[161],"activity,":[164],"CMV":[165],"enhancer":[166],"significant":[168],"presence":[177],"promoter.":[180],"Our":[181],"results":[182],"indicate":[183],"that":[184],"proximal":[195],"promoter-specific":[196],"arrangement-dependent":[198],"manner.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}