{"id":"https://openalex.org/W2007416079","doi":"https://doi.org/10.1016/s1672-0229(08)60018-2","title":"Transcriptional Analysis of Normal Human Fibroblast Responses to Microgravity Stress","display_name":"Transcriptional Analysis of Normal Human Fibroblast Responses to Microgravity Stress","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2007416079","doi":"https://doi.org/10.1016/s1672-0229(08)60018-2","mag":"2007416079","pmid":"https://pubmed.ncbi.nlm.nih.gov/18558383"},"language":"en","primary_location":{"id":"doi:10.1016/s1672-0229(08)60018-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1672-0229(08)60018-2","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/s1672-0229(08)60018-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101724710","display_name":"Yongqing Liu","orcid":"https://orcid.org/0000-0003-1090-0865"},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]},{"id":"https://openalex.org/I4210146772","display_name":"James Graham Brown Foundation","ror":"https://ror.org/04rsgp216","country_code":"US","type":"other","lineage":["https://openalex.org/I4210146772"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yongqing Liu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine , Louisville, KY, 40202 , USA","James Graham Brown Cancer Center, Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine , Louisville, KY, 40202 , USA","Current address: James Graham Brown Cancer Center, Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine , Louisville, KY, 40202 , USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"James Graham Brown Cancer Center, Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine , Louisville, KY, 40202 , USA","institution_ids":["https://openalex.org/I142740786","https://openalex.org/I4210146772"]},{"raw_affiliation_string":"Current address: James Graham Brown Cancer Center, Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030025920","display_name":"Eugenia Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eugenia Wang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine , Louisville, KY, 40202 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine , Louisville, KY, 40202 , USA","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030025920"],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.777,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.83675974,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"6","issue":"1","first_page":"29","last_page":"41"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9905999898910522,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9660999774932861,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6937054395675659},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.679206132888794},{"id":"https://openalex.org/keywords/suppression-subtractive-hybridization","display_name":"Suppression subtractive hybridization","score":0.6717679500579834},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5325849056243896},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4965706467628479},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.48892131447792053},{"id":"https://openalex.org/keywords/spaceflight","display_name":"Spaceflight","score":0.4797612130641937},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.43536576628685},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30910658836364746},{"id":"https://openalex.org/keywords/cdna-library","display_name":"cDNA library","score":0.20204311609268188}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6937054395675659},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.679206132888794},{"id":"https://openalex.org/C196436469","wikidata":"https://www.wikidata.org/wiki/Q6587700","display_name":"Suppression subtractive hybridization","level":5,"score":0.6717679500579834},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5325849056243896},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4965706467628479},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48892131447792053},{"id":"https://openalex.org/C103888896","wikidata":"https://www.wikidata.org/wiki/Q5916","display_name":"Spaceflight","level":2,"score":0.4797612130641937},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.43536576628685},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30910658836364746},{"id":"https://openalex.org/C189482833","wikidata":"https://www.wikidata.org/wiki/Q869146","display_name":"cDNA library","level":4,"score":0.20204311609268188},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013026","descriptor_name":"Space Flight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013026","descriptor_name":"Space Flight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013026","descriptor_name":"Space Flight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014893","descriptor_name":"Weightlessness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014893","descriptor_name":"Weightlessness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014893","descriptor_name":"Weightlessness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015723","descriptor_name":"Gene Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042002","descriptor_name":"Chromatin Assembly and Disassembly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s1672-0229(08)60018-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1672-0229(08)60018-2","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},{"id":"pmid:18558383","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18558383","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, proteomics & bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:4016467","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5054092","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/s1672-0229(08)60018-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1672-0229(08)60018-2","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"},{"id":"https://openalex.org/F4320332377","display_name":"Goddard Space Flight Center","ror":"https://ror.org/0171mag52"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W40385902","https://openalex.org/W115790926","https://openalex.org/W125106425","https://openalex.org/W173079764","https://openalex.org/W1607679412","https://openalex.org/W1677608250","https://openalex.org/W1877825263","https://openalex.org/W1964440144","https://openalex.org/W1966453709","https://openalex.org/W1970497539","https://openalex.org/W1979216378","https://openalex.org/W1993103455","https://openalex.org/W1994720818","https://openalex.org/W2001443196","https://openalex.org/W2017955991","https://openalex.org/W2027974713","https://openalex.org/W2036741123","https://openalex.org/W2043449536","https://openalex.org/W2047065962","https://openalex.org/W2049262086","https://openalex.org/W2057951424","https://openalex.org/W2071197656","https://openalex.org/W2071813691","https://openalex.org/W2078601089","https://openalex.org/W2079437966","https://openalex.org/W2080668289","https://openalex.org/W2084308247","https://openalex.org/W2087404852","https://openalex.org/W2091901317","https://openalex.org/W2095857644","https://openalex.org/W2101179323","https://openalex.org/W2105112194","https://openalex.org/W2113597032","https://openalex.org/W2113766700","https://openalex.org/W2122584509","https://openalex.org/W2126214612","https://openalex.org/W2126669509","https://openalex.org/W2139834662","https://openalex.org/W2155429403","https://openalex.org/W2157575236","https://openalex.org/W2165617921","https://openalex.org/W2168607364","https://openalex.org/W2171016021","https://openalex.org/W2240983374","https://openalex.org/W2300332822","https://openalex.org/W2404701309","https://openalex.org/W2415905755","https://openalex.org/W4240479615","https://openalex.org/W4313333877","https://openalex.org/W4320300864","https://openalex.org/W6604714277","https://openalex.org/W6637383242","https://openalex.org/W6639386767"],"related_works":["https://openalex.org/W2996915774","https://openalex.org/W2390042361","https://openalex.org/W4390657743","https://openalex.org/W2068030098","https://openalex.org/W3032163900","https://openalex.org/W3122934740","https://openalex.org/W2383612457","https://openalex.org/W3166842500","https://openalex.org/W2396334765","https://openalex.org/W1567096057"],"abstract_inverted_index":{"To":[0],"understand":[1],"the":[2,20,29,77,88,94,107,152],"molecular":[3],"mechanism(s)":[4],"of":[5,79,90,129,144],"how":[6],"spaceflight":[7,105],"affects":[8],"cellular":[9,80,176],"signaling":[10,114],"pathways,":[11,115],"quiescent":[12],"normal":[13],"human":[14],"WI-38":[15],"fibroblasts":[16],"were":[17,34,42],"flown":[18],"on":[19],"STS-93":[21],"space":[22],"shuttle":[23],"mission.":[24],"Subsequently,":[25],"RNA":[26],"samples":[27],"from":[28],"space-flown":[30],"and":[31,68,93,111,136],"ground-control":[32],"cells":[33,180],"used":[35],"to":[36,50,63,181],"construct":[37],"two":[38],"cDNA":[39],"libraries,":[40],"which":[41],"then":[43],"processed":[44],"for":[45,154],"suppression":[46],"subtractive":[47],"hybridization":[48],"(SSH)":[49],"identify":[51],"spaceflight-specific":[52],"gene":[53,171],"expression.":[54],"The":[55],"SSH":[56],"data":[57],"show":[58],"that":[59,104,149,164],"key":[60],"genes":[61,126,147,156],"related":[62,146],"oxidative":[64,81],"stress,":[65],"DNA":[66],"repair,":[67],"fatty":[69],"acid":[70],"oxidation":[71],"are":[72,131],"activated":[73],"by":[74,87],"spaceflight,":[75],"suggesting":[76],"induction":[78],"stress.":[82],"This":[83],"is":[84,103,151],"further":[85],"substantiated":[86],"up-regulation":[89,128],"neuregulin":[91],"1":[92],"calcium-binding":[95],"protein":[96,109,134],"calmodulin":[97],"2.":[98],"Another":[99],"obvious":[100],"stress":[101,177],"sign":[102],"evokes":[106],"Ras/mitogen-activated":[108],"kinase":[110,113],"phosphatidylinositol-3":[112],"along":[116],"with":[117,175],"up-regulating":[118],"several":[119],"G1-phase":[120],"cell":[121],"cycle":[122],"traverse":[123],"genes.":[124],"Other":[125],"showing":[127,157],"expression":[130,172],"involved":[132],"in":[133,170],"synthesis":[135],"pro-apoptosis,":[137],"as":[138,140],"well":[139],"pro-survival.":[141],"Interactome":[142],"analysis":[143],"functionally":[145],"shows":[148],"c-Myc":[150],"\"hub\"":[153],"those":[155],"significant":[158],"changes.":[159],"Hence,":[160],"our":[161],"results":[162],"suggest":[163],"microgravity":[165],"travel":[166],"may":[167],"impact":[168],"changes":[169],"mostly":[173],"associated":[174],"signaling,":[178],"directing":[179],"either":[182],"apoptotic":[183],"death":[184],"or":[185],"premature":[186],"senescence.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}