{"id":"https://openalex.org/W1968225928","doi":"https://doi.org/10.1016/s1672-0229(07)60003-5","title":"Comparative Analysis of Splice Site Regions by Information Content","display_name":"Comparative Analysis of Splice Site Regions by Information Content","publication_year":2006,"publication_date":"2006-12-01","ids":{"openalex":"https://openalex.org/W1968225928","doi":"https://doi.org/10.1016/s1672-0229(07)60003-5","mag":"1968225928","pmid":"https://pubmed.ncbi.nlm.nih.gov/17531798"},"language":"en","primary_location":{"id":"doi:10.1016/s1672-0229(07)60003-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1672-0229(07)60003-5","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/s1672-0229(07)60003-5","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020910751","display_name":"T. Shashi Rekha","orcid":null},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"T. Shashi Rekha","raw_affiliation_strings":["Department of Biochemistry, University of Hyderabad , Hyderabad, 500046 , India"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Hyderabad , Hyderabad, 500046 , India","institution_ids":["https://openalex.org/I36893310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041750997","display_name":"Chanchal K. Mitra","orcid":"https://orcid.org/0009-0008-1144-3188"},"institutions":[{"id":"https://openalex.org/I36893310","display_name":"University of Hyderabad","ror":"https://ror.org/04a7rxb17","country_code":"IN","type":"education","lineage":["https://openalex.org/I36893310"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Chanchal K. Mitra","raw_affiliation_strings":["Department of Biochemistry, University of Hyderabad , Hyderabad, 500046 , India"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Hyderabad , Hyderabad, 500046 , India","institution_ids":["https://openalex.org/I36893310"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041750997"],"corresponding_institution_ids":["https://openalex.org/I36893310"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":0.2725,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.56137643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"4","issue":"4","first_page":"230","last_page":"237"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/splice","display_name":"splice","score":0.909275472164154},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.682796835899353},{"id":"https://openalex.org/keywords/mutual-information","display_name":"Mutual information","score":0.5312898755073547},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4631912410259247},{"id":"https://openalex.org/keywords/block","display_name":"Block (permutation group theory)","score":0.45758572220802307},{"id":"https://openalex.org/keywords/entropy","display_name":"Entropy (arrow of time)","score":0.4565243124961853},{"id":"https://openalex.org/keywords/content","display_name":"Content (measure theory)","score":0.4554171562194824},{"id":"https://openalex.org/keywords/pairing","display_name":"Pairing","score":0.4516236186027527},{"id":"https://openalex.org/keywords/nucleotide","display_name":"Nucleotide","score":0.4506143629550934},{"id":"https://openalex.org/keywords/gc-content","display_name":"GC-content","score":0.44405877590179443},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.43090981245040894},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.40810099244117737},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.34890681505203247},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.28657835721969604},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2805074453353882},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.228681743144989},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.19898691773414612},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.17392194271087646},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.06651222705841064}],"concepts":[{"id":"https://openalex.org/C2780989783","wikidata":"https://www.wikidata.org/wiki/Q7578557","display_name":"splice","level":3,"score":0.909275472164154},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.682796835899353},{"id":"https://openalex.org/C152139883","wikidata":"https://www.wikidata.org/wiki/Q252973","display_name":"Mutual information","level":2,"score":0.5312898755073547},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4631912410259247},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.45758572220802307},{"id":"https://openalex.org/C106301342","wikidata":"https://www.wikidata.org/wiki/Q4117933","display_name":"Entropy (arrow of time)","level":2,"score":0.4565243124961853},{"id":"https://openalex.org/C2778152352","wikidata":"https://www.wikidata.org/wiki/Q5165061","display_name":"Content (measure theory)","level":2,"score":0.4554171562194824},{"id":"https://openalex.org/C14103023","wikidata":"https://www.wikidata.org/wiki/Q11681459","display_name":"Pairing","level":3,"score":0.4516236186027527},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.4506143629550934},{"id":"https://openalex.org/C42251679","wikidata":"https://www.wikidata.org/wiki/Q933491","display_name":"GC-content","level":4,"score":0.44405877590179443},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43090981245040894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40810099244117737},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34890681505203247},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.28657835721969604},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2805074453353882},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.228681743144989},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.19898691773414612},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.17392194271087646},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.06651222705841064},{"id":"https://openalex.org/C54101563","wikidata":"https://www.wikidata.org/wiki/Q124131","display_name":"Superconductivity","level":2,"score":0.0},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s1672-0229(07)60003-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1672-0229(07)60003-5","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17531798","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17531798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, proteomics & bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:4016447","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5054069","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/s1672-0229(07)60003-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1672-0229(07)60003-5","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6800000071525574,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W188500179","https://openalex.org/W1973578915","https://openalex.org/W1993608017","https://openalex.org/W1995875735","https://openalex.org/W2001730018","https://openalex.org/W2009570821","https://openalex.org/W2014181394","https://openalex.org/W2030300649","https://openalex.org/W2035564383","https://openalex.org/W2044442377","https://openalex.org/W2051490611","https://openalex.org/W2067096868","https://openalex.org/W2074703985","https://openalex.org/W2081411150","https://openalex.org/W2099111195","https://openalex.org/W2104120573","https://openalex.org/W2110400205","https://openalex.org/W2119309676","https://openalex.org/W2141803313","https://openalex.org/W2143210482","https://openalex.org/W2145992497","https://openalex.org/W2169669582","https://openalex.org/W2600349519","https://openalex.org/W2601913882","https://openalex.org/W4245668478","https://openalex.org/W6607710048","https://openalex.org/W6674851815"],"related_works":["https://openalex.org/W3015473028","https://openalex.org/W3201176751","https://openalex.org/W1943031701","https://openalex.org/W2095502359","https://openalex.org/W2023018590","https://openalex.org/W2887346131","https://openalex.org/W2001318760","https://openalex.org/W2014791263","https://openalex.org/W4213165146","https://openalex.org/W1992436314"],"abstract_inverted_index":{"We":[0,86,136],"have":[1],"applied":[2],"concepts":[3],"from":[4,88],"information":[5,31,46,69],"theory":[6],"for":[7,56,71],"a":[8,36],"comparative":[9],"analysis":[10],"of":[11,23,39,79,100,106,112,129],"donor":[12],"(gt)":[13],"and":[14],"acceptor":[15],"(ag)":[16],"splice":[17,108,148],"site":[18],"regions":[19,58,105],"in":[20,59,76,102],"the":[21,45,50,61,68,77,94,103,107,119,127],"genes":[22],"five":[24],"different":[25,147,151],"organisms":[26,62],"by":[27,145],"calculating":[28],"their":[29],"mutual":[30],"content":[32,47],"(relative":[33],"entropy)":[34],"over":[35],"selected":[37],"block":[38,51],"nucleotides.":[40],"A":[41],"similar":[42],"pattern":[43],"that":[44,67,91,139],"decreases":[48],"as":[49],"size":[52],"increases":[53],"was":[54],"observed":[55],"both":[57,84],"all":[60],"studied.":[63],"This":[64],"result":[65],"suggests":[66],"required":[70],"splicing":[72,120],"might":[73],"be":[74,143],"contained":[75],"consensus":[78],"approximately":[80],"6-8":[81],"nt":[82],"at":[83],"regions.":[85],"assume":[87],"our":[89],"study":[90],"even":[92,125],"though":[93],"nucleotides":[95],"are":[96],"showing":[97],"some":[98],"degrees":[99],"conservation":[101],"flanking":[104],"sites,":[109],"certain":[110],"level":[111],"variability":[113,141],"is":[114,132],"still":[115],"tolerated,":[116],"which":[117],"leads":[118],"process":[121],"to":[122],"occur":[123],"normally":[124],"if":[126],"extent":[128],"base":[130],"pairing":[131],"not":[133],"fully":[134],"satisfied.":[135],"also":[137],"suggest":[138],"this":[140],"can":[142],"compensated":[144],"recognizing":[146],"sites":[149],"with":[150],"spliceosomal":[152],"factors.":[153]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}