{"id":"https://openalex.org/W2001168187","doi":"https://doi.org/10.1016/s1672-0229(07)60002-3","title":"High-Sensitivity Transcriptome Data Structure and Implications for Analysis and Biologic Interpretation","display_name":"High-Sensitivity Transcriptome Data Structure and Implications for Analysis and Biologic Interpretation","publication_year":2006,"publication_date":"2006-12-01","ids":{"openalex":"https://openalex.org/W2001168187","doi":"https://doi.org/10.1016/s1672-0229(07)60002-3","mag":"2001168187","pmid":"https://pubmed.ncbi.nlm.nih.gov/17531797"},"language":"en","primary_location":{"id":"doi:10.1016/s1672-0229(07)60002-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1672-0229(07)60002-3","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics &amp; Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/s1672-0229(07)60002-3","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058675660","display_name":"Sebastian Noth","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I84909340","display_name":"Institut des Hautes \u00c9tudes Scientifiques","ror":"https://ror.org/05d5m2r55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I84909340"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sebastian Noth","raw_affiliation_strings":["Systems Epigenomics Group, Institut des Hautes Etudes Scientifiques, Institut de Recherches Interdisciplinaires, CNRS, INSERM , Bures sur Yvette, 91440 , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Epigenomics Group, Institut des Hautes Etudes Scientifiques, Institut de Recherches Interdisciplinaires, CNRS, INSERM , Bures sur Yvette, 91440 , France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I84909340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074121731","display_name":"Guillaume Brysbaert","orcid":"https://orcid.org/0000-0002-6807-6621"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I84909340","display_name":"Institut des Hautes \u00c9tudes Scientifiques","ror":"https://ror.org/05d5m2r55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I84909340"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guillaume Brysbaert","raw_affiliation_strings":["Systems Epigenomics Group, Institut des Hautes Etudes Scientifiques, Institut de Recherches Interdisciplinaires, CNRS, INSERM , Bures sur Yvette, 91440 , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Epigenomics Group, Institut des Hautes Etudes Scientifiques, Institut de Recherches Interdisciplinaires, CNRS, INSERM , Bures sur Yvette, 91440 , France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I84909340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006591078","display_name":"Fran\u00e7ois\u2010Xavier Pellay","orcid":"https://orcid.org/0000-0001-8921-7553"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I84909340","display_name":"Institut des Hautes \u00c9tudes Scientifiques","ror":"https://ror.org/05d5m2r55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I84909340"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois-Xavier Pellay","raw_affiliation_strings":["Systems Epigenomics Group, Institut des Hautes Etudes Scientifiques, Institut de Recherches Interdisciplinaires, CNRS, INSERM , Bures sur Yvette, 91440 , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Epigenomics Group, Institut des Hautes Etudes Scientifiques, Institut de Recherches Interdisciplinaires, CNRS, INSERM , Bures sur Yvette, 91440 , France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I84909340"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054769886","display_name":"Arndt Benecke","orcid":"https://orcid.org/0000-0002-7121-823X"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I84909340","display_name":"Institut des Hautes \u00c9tudes Scientifiques","ror":"https://ror.org/05d5m2r55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I84909340"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Arndt Benecke","raw_affiliation_strings":["Systems Epigenomics Group, Institut des Hautes Etudes Scientifiques, Institut de Recherches Interdisciplinaires, CNRS, INSERM , Bures sur Yvette, 91440 , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Epigenomics Group, Institut des Hautes Etudes Scientifiques, Institut de Recherches Interdisciplinaires, CNRS, INSERM , Bures sur Yvette, 91440 , France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I84909340"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054769886"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I84909340"],"apc_list":{"value":3650,"currency":"USD","value_usd":3650},"apc_paid":{"value":3650,"currency":"USD","value_usd":3650},"fwci":0.8896,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.70247989,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"4","issue":"4","first_page":"212","last_page":"229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.5051353573799133},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4677904546260834},{"id":"https://openalex.org/keywords/log-normal-distribution","display_name":"Log-normal distribution","score":0.4595656991004944},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.37582188844680786},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.35161909461021423},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2982308566570282},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.0806526243686676}],"concepts":[{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.5051353573799133},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4677904546260834},{"id":"https://openalex.org/C151620405","wikidata":"https://www.wikidata.org/wiki/Q826116","display_name":"Log-normal distribution","level":2,"score":0.4595656991004944},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37582188844680786},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.35161909461021423},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2982308566570282},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0806526243686676},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s1672-0229(07)60002-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1672-0229(07)60002-3","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics &amp; Bioinformatics","raw_type":"journal-article"},{"id":"pmid:17531797","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17531797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, proteomics & bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:4016458","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5054080","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/s1672-0229(07)60002-3","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1672-0229(07)60002-3","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics &amp; Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Responsible consumption and production","score":0.4300000071525574,"id":"https://metadata.un.org/sdg/12"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320337227","display_name":"Institut des Hautes \u00c9tudes Scientifiques, Universit\u00e9 Paris-Saclay","ror":"https://ror.org/05d5m2r55"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1485108553","https://openalex.org/W1486632395","https://openalex.org/W1502936039","https://openalex.org/W1549698322","https://openalex.org/W1583301427","https://openalex.org/W1599849035","https://openalex.org/W1727290854","https://openalex.org/W1955660753","https://openalex.org/W1993333483","https://openalex.org/W1993927835","https://openalex.org/W2008083733","https://openalex.org/W2008821724","https://openalex.org/W2009305315","https://openalex.org/W2017977879","https://openalex.org/W2021537896","https://openalex.org/W2024081693","https://openalex.org/W2029441111","https://openalex.org/W2043124217","https://openalex.org/W2077046573","https://openalex.org/W2083550293","https://openalex.org/W2091198609","https://openalex.org/W2093017030","https://openalex.org/W2098841537","https://openalex.org/W2099688399","https://openalex.org/W2103994569","https://openalex.org/W2116811581","https://openalex.org/W2126226510","https://openalex.org/W2130010891","https://openalex.org/W2130722778","https://openalex.org/W2135079658","https://openalex.org/W2141009231","https://openalex.org/W2146997097","https://openalex.org/W2157132621","https://openalex.org/W2164683872","https://openalex.org/W2167980479","https://openalex.org/W2171280873","https://openalex.org/W2171327609","https://openalex.org/W2223389682","https://openalex.org/W4300507896","https://openalex.org/W6640934501","https://openalex.org/W6674632333","https://openalex.org/W6688890919"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2493033802","https://openalex.org/W3098004296","https://openalex.org/W2083114504","https://openalex.org/W2011669161","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W3149585742","https://openalex.org/W3125645241","https://openalex.org/W2122901290"],"abstract_inverted_index":{"Novel":[0],"microarray":[1,131],"technologies":[2],"such":[3,154],"as":[4],"the":[5,15,47,53,91,99,129,136,157,163],"AB1700":[6,34,44,100,148,164],"platform":[7],"from":[8],"Applied":[9],"Biosystems":[10],"promise":[11],"significant":[12],"increases":[13],"in":[14,98,162],"signal":[16,48,63,107,143],"dynamic":[17,49],"range":[18,51],"and":[19],"a":[20,30,37,103,111,142],"higher":[21],"sensitivity":[22],"for":[23,147,153],"weakly":[24],"expressed":[25],"transcripts.":[26],"We":[27],"have":[28,87,140],"compared":[29],"representative":[31,39],"set":[32],"of":[33,59,66,106,118,128,172],"data":[35,69,101,149,165],"with":[36],"similarly":[38],"Affymetrix":[40,92],"HG-U133A":[41],"dataset.":[42],"The":[43,61,78,94,114],"design":[45],"extends":[46],"detection":[50],"at":[52],"lower":[54],"bound":[55],"by":[56,74],"one":[57],"order":[58],"magnitude.":[60],"lognormal":[62,159],"distribution":[64,81,97,145,160],"profiles":[65,122],"these":[67,119],"high-sensitivity":[68,120],"need":[70],"to":[71],"be":[72],"represented":[73],"two":[75,167],"independent":[76],"distributions.":[77],"additional":[79],"second":[80],"covers":[82],"those":[83],"transcripts":[84],"that":[85,150],"would":[86],"gone":[88],"undetected":[89],"using":[90,110],"technology.":[93],"signal-dependent":[95],"variance":[96,144],"is":[102,151],"non-trivial":[104],"function":[105],"intensity,":[108],"describable":[109],"composite":[112],"function.":[113],"drastically":[115],"different":[116,169],"structure":[117],"transcriptome":[121],"requires":[123],"adaptation":[124],"or":[125],"even":[126],"redevelopment":[127],"standard":[130],"analysis":[132],"methods.":[133],"Based":[134],"on":[135],"statistical":[137],"properties,":[138],"we":[139],"derived":[141],"model":[146],"necessary":[152],"development.":[155],"Interestingly,":[156],"dual":[158],"observed":[161],"reflects":[166],"fundamentally":[168],"biologic":[170],"mechanisms":[171],"transcription":[173],"initiation.":[174]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
