{"id":"https://openalex.org/W2023000512","doi":"https://doi.org/10.1016/s0933-3657(00)00113-5","title":"A formal framework of knowledge to support rational psychoactive drug selection","display_name":"A formal framework of knowledge to support rational psychoactive drug selection","publication_year":2001,"publication_date":"2001-06-01","ids":{"openalex":"https://openalex.org/W2023000512","doi":"https://doi.org/10.1016/s0933-3657(00)00113-5","mag":"2023000512","pmid":"https://pubmed.ncbi.nlm.nih.gov/11377151"},"language":"en","primary_location":{"id":"doi:10.1016/s0933-3657(00)00113-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0933-3657(00)00113-5","pdf_url":null,"source":{"id":"https://openalex.org/S42468263","display_name":"Artificial Intelligence in Medicine","issn_l":"0933-3657","issn":["0933-3657","1873-2860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial Intelligence in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037749731","display_name":"Dirk Van Hyfte","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dirk Van Hyfte","raw_affiliation_strings":["Biological Psychiatry, K.U., Nijmegen, The Netherlands. dirk.van.hyfte@skynet.be","Biological Psychiatry, K.U. Nijmegen, The Netherlands#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Psychiatry, K.U., Nijmegen, The Netherlands. dirk.van.hyfte@skynet.be","institution_ids":[]},{"raw_affiliation_string":"Biological Psychiatry, K.U. Nijmegen, The Netherlands#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012882521","display_name":"Arnoud Van Der Maas","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arnoud Van Der Maas","raw_affiliation_strings":["Medical Informatics, K.U. Nijmegen, The Netherlands","Medical Informatics, K.U. Nijmegen, The Netherlands#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Informatics, K.U. Nijmegen, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Medical Informatics, K.U. Nijmegen, The Netherlands#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076332182","display_name":"Tikma Tjandra-Maga","orcid":null},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Tikma Tjandra-Maga","raw_affiliation_strings":["Clinical Pharmacology, K.U. Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology, K.U. Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083584819","display_name":"Pieter de Vries Robb\u00e9","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pieter De Vries Robb\u00e9","raw_affiliation_strings":["Medical Informatics, K.U. Nijmegen, The Netherlands","Medical Informatics, K.U. Nijmegen, The Netherlands#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Informatics, K.U. Nijmegen, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Medical Informatics, K.U. Nijmegen, The Netherlands#TAB#","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037749731"],"corresponding_institution_ids":[],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":null,"fwci":0.1118,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.44515163,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"22","issue":"3","first_page":"261","last_page":"275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10215","display_name":"Semantic Web and Ontologies","score":0.9909999966621399,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10317","display_name":"Advanced Database Systems and Queries","score":0.9344000220298767,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7421404123306274},{"id":"https://openalex.org/keywords/terminology","display_name":"Terminology","score":0.6492874622344971},{"id":"https://openalex.org/keywords/ambiguity","display_name":"Ambiguity","score":0.6252868175506592},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.6244134306907654},{"id":"https://openalex.org/keywords/knowledge-base","display_name":"Knowledge base","score":0.49129384756088257},{"id":"https://openalex.org/keywords/domain-knowledge","display_name":"Domain knowledge","score":0.44714224338531494},{"id":"https://openalex.org/keywords/semantics","display_name":"Semantics (computer science)","score":0.43317484855651855},{"id":"https://openalex.org/keywords/decision-support-system","display_name":"Decision support system","score":0.4133763313293457},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3829859793186188},{"id":"https://openalex.org/keywords/knowledge-management","display_name":"Knowledge management","score":0.376515656709671},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.35727426409721375},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.34381362795829773},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15941041707992554}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7421404123306274},{"id":"https://openalex.org/C547195049","wikidata":"https://www.wikidata.org/wiki/Q1725664","display_name":"Terminology","level":2,"score":0.6492874622344971},{"id":"https://openalex.org/C2780522230","wikidata":"https://www.wikidata.org/wiki/Q1140419","display_name":"Ambiguity","level":2,"score":0.6252868175506592},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.6244134306907654},{"id":"https://openalex.org/C4554734","wikidata":"https://www.wikidata.org/wiki/Q593744","display_name":"Knowledge base","level":2,"score":0.49129384756088257},{"id":"https://openalex.org/C207685749","wikidata":"https://www.wikidata.org/wiki/Q2088941","display_name":"Domain knowledge","level":2,"score":0.44714224338531494},{"id":"https://openalex.org/C184337299","wikidata":"https://www.wikidata.org/wiki/Q1437428","display_name":"Semantics (computer science)","level":2,"score":0.43317484855651855},{"id":"https://openalex.org/C107327155","wikidata":"https://www.wikidata.org/wiki/Q330268","display_name":"Decision support system","level":2,"score":0.4133763313293457},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3829859793186188},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.376515656709671},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.35727426409721375},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.34381362795829773},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15941041707992554},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003658","descriptor_name":"Decision Making, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003658","descriptor_name":"Decision Making, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003658","descriptor_name":"Decision Making, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010600","descriptor_name":"Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011619","descriptor_name":"Psychotropic Drugs","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011619","descriptor_name":"Psychotropic Drugs","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011619","descriptor_name":"Psychotropic Drugs","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019359","descriptor_name":"Knowledge","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019359","descriptor_name":"Knowledge","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019359","descriptor_name":"Knowledge","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0933-3657(00)00113-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0933-3657(00)00113-5","pdf_url":null,"source":{"id":"https://openalex.org/S42468263","display_name":"Artificial Intelligence in Medicine","issn_l":"0933-3657","issn":["0933-3657","1873-2860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial Intelligence in Medicine","raw_type":"journal-article"},{"id":"pmid:11377151","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11377151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial intelligence in medicine","raw_type":null},{"id":"pmh:oai:repository.ubn.ru.nl:2066/144610","is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/144610","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Artificial Intelligence in Medicine, 22, 3, pp. 261--75","raw_type":"Article / Letter to editor"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W18900420","https://openalex.org/W124939224","https://openalex.org/W144014224","https://openalex.org/W185741359","https://openalex.org/W1495319021","https://openalex.org/W1582337834","https://openalex.org/W1609930672","https://openalex.org/W1993330063","https://openalex.org/W2020238417","https://openalex.org/W2021244134","https://openalex.org/W2032787361","https://openalex.org/W2035574339","https://openalex.org/W2040874107","https://openalex.org/W2045465655","https://openalex.org/W2059211930","https://openalex.org/W2089500837","https://openalex.org/W2114561888","https://openalex.org/W2126137834","https://openalex.org/W2133109597","https://openalex.org/W2154800182","https://openalex.org/W2156610741","https://openalex.org/W2170031790","https://openalex.org/W2172172820","https://openalex.org/W2214802288","https://openalex.org/W2283634963","https://openalex.org/W2410188006","https://openalex.org/W2742892609","https://openalex.org/W4285719527","https://openalex.org/W4302583821","https://openalex.org/W6678972017","https://openalex.org/W6685008325","https://openalex.org/W6820799268"],"related_works":["https://openalex.org/W2385621242","https://openalex.org/W2367629516","https://openalex.org/W2086580554","https://openalex.org/W2553860513","https://openalex.org/W1986001501","https://openalex.org/W2353740909","https://openalex.org/W2475408106","https://openalex.org/W2592721119","https://openalex.org/W4386298164","https://openalex.org/W2075096090"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-07-15T18:14:33.161393","created_date":"2016-06-24T00:00:00"}