{"id":"https://openalex.org/W1987075705","doi":"https://doi.org/10.1016/s0377-2217(01)00122-9","title":"An application of nonlinear optimization in molecular biology","display_name":"An application of nonlinear optimization in molecular biology","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W1987075705","doi":"https://doi.org/10.1016/s0377-2217(01)00122-9","mag":"1987075705"},"language":"en","primary_location":{"id":"doi:10.1016/s0377-2217(01)00122-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0377-2217(01)00122-9","pdf_url":null,"source":{"id":"https://openalex.org/S103321696","display_name":"European Journal of Operational Research","issn_l":"0377-2217","issn":["0377-2217","1872-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Operational Research","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108743085","display_name":"J. G. Ecker","orcid":null},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.G Ecker","raw_affiliation_strings":["Department of Mathematical Sciences, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180-3590, USA","Department of Mathematical Sciences, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY, 12180-3590 USA"],"affiliations":[{"raw_affiliation_string":"Department of Mathematical Sciences, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180-3590, USA","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Department of Mathematical Sciences, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY, 12180-3590 USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071724032","display_name":"Michael Kupferschmid","orcid":null},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M Kupferschmid","raw_affiliation_strings":["Academic Computing Services, Alan M. Voorhees Computing Center, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180-3590, USA"],"affiliations":[{"raw_affiliation_string":"Academic Computing Services, Alan M. Voorhees Computing Center, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180-3590, USA","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026511725","display_name":"Charles E. Lawrence","orcid":"https://orcid.org/0000-0003-4011-6692"},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.E Lawrence","raw_affiliation_strings":["New York State Department of Health, Wadsworth Biometric Laboratory, Albany, NY 12201, USA"],"affiliations":[{"raw_affiliation_string":"New York State Department of Health, Wadsworth Biometric Laboratory, Albany, NY 12201, USA","institution_ids":["https://openalex.org/I1298060332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113601422","display_name":"Andrew Reilly","orcid":null},"institutions":[{"id":"https://openalex.org/I1298060332","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57","country_code":"US","type":"government","lineage":["https://openalex.org/I1298060332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A.A Reilly","raw_affiliation_strings":["New York State Department of Health, Wadsworth Biometric Laboratory, Albany, NY 12201, USA"],"affiliations":[{"raw_affiliation_string":"New York State Department of Health, Wadsworth Biometric Laboratory, Albany, NY 12201, USA","institution_ids":["https://openalex.org/I1298060332"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084926110","display_name":"Alexandre Scott","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A.C.H Scott","raw_affiliation_strings":["Aereal Inc., San Francisco, CA 94107, USA"],"affiliations":[{"raw_affiliation_string":"Aereal Inc., San Francisco, CA 94107, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5071724032"],"corresponding_institution_ids":["https://openalex.org/I165799507"],"apc_list":{"value":3290,"currency":"USD","value_usd":3290},"apc_paid":null,"fwci":0.3437,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.56774212,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"138","issue":"2","first_page":"452","last_page":"458"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9768000245094299,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.48874330520629883},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4848683774471283},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.43848392367362976},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.4375094771385193},{"id":"https://openalex.org/keywords/maximum-likelihood","display_name":"Maximum likelihood","score":0.4292868375778198},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3916192948818207},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38642582297325134},{"id":"https://openalex.org/keywords/operations-research","display_name":"Operations research","score":0.3526926040649414},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.293374240398407},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2855483889579773},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.22940102219581604},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1976359784603119},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.13557764887809753},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.08362999558448792}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48874330520629883},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4848683774471283},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.43848392367362976},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.4375094771385193},{"id":"https://openalex.org/C49781872","wikidata":"https://www.wikidata.org/wiki/Q1045555","display_name":"Maximum likelihood","level":2,"score":0.4292868375778198},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3916192948818207},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38642582297325134},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.3526926040649414},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.293374240398407},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2855483889579773},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22940102219581604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1976359784603119},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.13557764887809753},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.08362999558448792},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/s0377-2217(01)00122-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0377-2217(01)00122-9","pdf_url":null,"source":{"id":"https://openalex.org/S103321696","display_name":"European Journal of Operational Research","issn_l":"0377-2217","issn":["0377-2217","1872-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Operational Research","raw_type":"journal-article"},{"id":"pmh:oai:RePEc:eee:ejores:v:138:y:2002:i:2:p:452-458","is_oa":false,"landing_page_url":"http://www.sciencedirect.com/science/article/pii/S0377-2217(01)00122-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1539402525","https://openalex.org/W1975924111","https://openalex.org/W2044197565","https://openalex.org/W2048869777","https://openalex.org/W2128501923","https://openalex.org/W2751335644","https://openalex.org/W3022555213"],"related_works":["https://openalex.org/W2898732673","https://openalex.org/W2410053581","https://openalex.org/W2383658677","https://openalex.org/W3123203398","https://openalex.org/W3107784576","https://openalex.org/W2154204858","https://openalex.org/W623104033","https://openalex.org/W1972473893","https://openalex.org/W2466435674","https://openalex.org/W2765200542"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}