{"id":"https://openalex.org/W1588955600","doi":"https://doi.org/10.1016/s0169-7161(96)13004-2","title":"2 Clinical trials in drug development: Some statistical issues","display_name":"2 Clinical trials in drug development: Some statistical issues","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W1588955600","doi":"https://doi.org/10.1016/s0169-7161(96)13004-2","mag":"1588955600"},"language":"en","primary_location":{"id":"doi:10.1016/s0169-7161(96)13004-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0169-7161(96)13004-2","pdf_url":null,"source":{"id":"https://openalex.org/S44500590","display_name":"Handbook of statistics","issn_l":"0169-7161","issn":["0169-7161","1875-7448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Statistics","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082561545","display_name":"H. I. Patel","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"H.I. Patel","raw_affiliation_strings":[],"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082561545"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.18541997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"31","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.991599977016449,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10206","display_name":"Meta-analysis and systematic reviews","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.617030918598175},{"id":"https://openalex.org/keywords/government","display_name":"Government (linguistics)","score":0.6145010590553284},{"id":"https://openalex.org/keywords/confounding","display_name":"Confounding","score":0.5729337334632874},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.5295366048812866},{"id":"https://openalex.org/keywords/statistical-analysis","display_name":"Statistical analysis","score":0.478179007768631},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4749736189842224},{"id":"https://openalex.org/keywords/drug-trial","display_name":"Drug trial","score":0.46561360359191895},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.39460939168930054},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.38042667508125305},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.358764111995697},{"id":"https://openalex.org/keywords/operations-research","display_name":"Operations research","score":0.3552989959716797},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.34760570526123047},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.3460080921649933},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.24659302830696106},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24648109078407288},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.18788307905197144},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.08993637561798096}],"concepts":[{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.617030918598175},{"id":"https://openalex.org/C2778137410","wikidata":"https://www.wikidata.org/wiki/Q2732820","display_name":"Government (linguistics)","level":2,"score":0.6145010590553284},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.5729337334632874},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.5295366048812866},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.478179007768631},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4749736189842224},{"id":"https://openalex.org/C2992672634","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Drug trial","level":3,"score":0.46561360359191895},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.39460939168930054},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38042667508125305},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.358764111995697},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.3552989959716797},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.34760570526123047},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.3460080921649933},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.24659302830696106},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24648109078407288},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.18788307905197144},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08993637561798096},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0169-7161(96)13004-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0169-7161(96)13004-2","pdf_url":null,"source":{"id":"https://openalex.org/S44500590","display_name":"Handbook of statistics","issn_l":"0169-7161","issn":["0169-7161","1875-7448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Statistics","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":143,"referenced_works":["https://openalex.org/W16600814","https://openalex.org/W38009143","https://openalex.org/W59644142","https://openalex.org/W101236184","https://openalex.org/W133827248","https://openalex.org/W148880490","https://openalex.org/W254259392","https://openalex.org/W972118569","https://openalex.org/W1963599622","https://openalex.org/W1966397120","https://openalex.org/W1967449535","https://openalex.org/W1968578768","https://openalex.org/W1970211758","https://openalex.org/W1973278468","https://openalex.org/W1976566530","https://openalex.org/W1977689816","https://openalex.org/W1978136073","https://openalex.org/W1978942896","https://openalex.org/W1979249873","https://openalex.org/W1981271777","https://openalex.org/W1981517657","https://openalex.org/W1982585616","https://openalex.org/W1988310943","https://openalex.org/W1991536033","https://openalex.org/W1991597992","https://openalex.org/W1993147091","https://openalex.org/W1993506505","https://openalex.org/W1997318672","https://openalex.org/W1997846058","https://openalex.org/W1998219047","https://openalex.org/W2003087668","https://openalex.org/W2003882616","https://openalex.org/W2005920914","https://openalex.org/W2009117635","https://openalex.org/W2009632219","https://openalex.org/W2013194198","https://openalex.org/W2014013976","https://openalex.org/W2015581436","https://openalex.org/W2018143015","https://openalex.org/W2021142183","https://openalex.org/W2024085858","https://openalex.org/W2024940361","https://openalex.org/W2026598211","https://openalex.org/W2026614687","https://openalex.org/W2029615513","https://openalex.org/W2029996144","https://openalex.org/W2034021999","https://openalex.org/W2036397763","https://openalex.org/W2037698344","https://openalex.org/W2039918489","https://openalex.org/W2042152193","https://openalex.org/W2048405347","https://openalex.org/W2049558150","https://openalex.org/W2049633694","https://openalex.org/W2050583934","https://openalex.org/W2051347111","https://openalex.org/W2053068905","https://openalex.org/W2054383376","https://openalex.org/W2056430771","https://openalex.org/W2056590334","https://openalex.org/W2058558131","https://openalex.org/W2059936183","https://openalex.org/W2060413403","https://openalex.org/W2063067495","https://openalex.org/W2064279221","https://openalex.org/W2067873446","https://openalex.org/W2070013574","https://openalex.org/W2074960943","https://openalex.org/W2075384682","https://openalex.org/W2076108528","https://openalex.org/W2076761576","https://openalex.org/W2078941137","https://openalex.org/W2080913272","https://openalex.org/W2082102453","https://openalex.org/W2082246284","https://openalex.org/W2085042988","https://openalex.org/W2085791034","https://openalex.org/W2088041869","https://openalex.org/W2088051167","https://openalex.org/W2092132313","https://openalex.org/W2093651810","https://openalex.org/W2095538101","https://openalex.org/W2100358124","https://openalex.org/W2107328434","https://openalex.org/W2114903378","https://openalex.org/W2116879114","https://openalex.org/W2116982867","https://openalex.org/W2118840867","https://openalex.org/W2125300671","https://openalex.org/W2125511847","https://openalex.org/W2125664736","https://openalex.org/W2130280946","https://openalex.org/W2135731698","https://openalex.org/W2136283380","https://openalex.org/W2137086214","https://openalex.org/W2138613293","https://openalex.org/W2145816995","https://openalex.org/W2146889100","https://openalex.org/W2149860264","https://openalex.org/W2155346756","https://openalex.org/W2157710408","https://openalex.org/W2158714606","https://openalex.org/W2161123385","https://openalex.org/W2161792533","https://openalex.org/W2165094385","https://openalex.org/W2172005333","https://openalex.org/W2282330890","https://openalex.org/W2284967628","https://openalex.org/W2312652702","https://openalex.org/W2318747720","https://openalex.org/W2321410450","https://openalex.org/W2321599771","https://openalex.org/W2323732410","https://openalex.org/W2324055461","https://openalex.org/W2328608067","https://openalex.org/W2328625265","https://openalex.org/W2328867190","https://openalex.org/W2329902133","https://openalex.org/W2329914742","https://openalex.org/W2331809824","https://openalex.org/W2333933909","https://openalex.org/W2335504121","https://openalex.org/W2464699241","https://openalex.org/W2527882685","https://openalex.org/W2797120013","https://openalex.org/W2797948216","https://openalex.org/W2922447696","https://openalex.org/W3023361036","https://openalex.org/W4232605254","https://openalex.org/W4242321097","https://openalex.org/W4243155135","https://openalex.org/W4248699641","https://openalex.org/W4248795795","https://openalex.org/W4294481990","https://openalex.org/W4297782897","https://openalex.org/W4300015894","https://openalex.org/W4300429268","https://openalex.org/W4300637493","https://openalex.org/W4302811579","https://openalex.org/W6606083778","https://openalex.org/W6695260021","https://openalex.org/W6699693224","https://openalex.org/W6814192679"],"related_works":["https://openalex.org/W2417673096","https://openalex.org/W2470067656","https://openalex.org/W3022946860","https://openalex.org/W198631773","https://openalex.org/W2388318977","https://openalex.org/W2188607138","https://openalex.org/W2372770165","https://openalex.org/W2352848781","https://openalex.org/W4298265451","https://openalex.org/W4312094381"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
