{"id":"https://openalex.org/W2021312236","doi":"https://doi.org/10.1016/s0169-2607(02)00017-2","title":"Bivariate linear mixed models using SAS proc MIXED","display_name":"Bivariate linear mixed models using SAS proc MIXED","publication_year":2002,"publication_date":"2002-10-08","ids":{"openalex":"https://openalex.org/W2021312236","doi":"https://doi.org/10.1016/s0169-2607(02)00017-2","mag":"2021312236","pmid":"https://pubmed.ncbi.nlm.nih.gov/12204452"},"language":"en","primary_location":{"id":"doi:10.1016/s0169-2607(02)00017-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0169-2607(02)00017-2","pdf_url":null,"source":{"id":"https://openalex.org/S138959710","display_name":"Computer Methods and Programs in Biomedicine","issn_l":"0169-2607","issn":["0169-2607","1872-7565"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computer Methods and Programs in Biomedicine","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/0705.0568","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109990828","display_name":"Rodolphe Thi\u00e9baut","orcid":null},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210106115","display_name":"Bordeaux Population Health","ror":"https://ror.org/00xzzba89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210106115"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Rodolphe Thi\u00e9baut","raw_affiliation_strings":["INSERM Unit\u00e9 330, ISPED, Universit\u00e9 Victor Segalen Bordeaux II, 146, rue L\u00e9o Saignat 33076, Cedex, Bordeaux, France. rodolphe.thiebaut@isped.u-bordeaux2.fr","INSERM Unit\u00e9 330, ISPED, Universit\u00e9 Victor Segalen Bordeaux II, 146, rue L\u00e9o Saignat 33076, Bordeaux, Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit\u00e9 330, ISPED, Universit\u00e9 Victor Segalen Bordeaux II, 146, rue L\u00e9o Saignat 33076, Cedex, Bordeaux, France. rodolphe.thiebaut@isped.u-bordeaux2.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210106115"]},{"raw_affiliation_string":"INSERM Unit\u00e9 330, ISPED, Universit\u00e9 Victor Segalen Bordeaux II, 146, rue L\u00e9o Saignat 33076, Bordeaux, Cedex, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027815413","display_name":"H\u00e9l\u00e8ne Jacqmin\u2010Gadda","orcid":"https://orcid.org/0000-0002-7727-6625"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H\u00e9l\u00e8ne Jacqmin-Gadda","raw_affiliation_strings":["INSERM Unit\u00e9 330, ISPED, Universit\u00e9 Victor Segalen Bordeaux II, 146, rue L\u00e9o Saignat 33076, Bordeaux, Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit\u00e9 330, ISPED, Universit\u00e9 Victor Segalen Bordeaux II, 146, rue L\u00e9o Saignat 33076, Bordeaux, Cedex, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081460531","display_name":"Genevi\u00e8ve Ch\u00eane","orcid":"https://orcid.org/0000-0002-8368-6460"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Genevi\u00e8ve Ch\u00eane","raw_affiliation_strings":["INSERM Unit\u00e9 330, ISPED, Universit\u00e9 Victor Segalen Bordeaux II, 146, rue L\u00e9o Saignat 33076, Bordeaux, Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit\u00e9 330, ISPED, Universit\u00e9 Victor Segalen Bordeaux II, 146, rue L\u00e9o Saignat 33076, Bordeaux, Cedex, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105689807","display_name":"Catherine Leport","orcid":null},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210145170","display_name":"H\u00f4pital Bichat-Claude-Bernard","ror":"https://ror.org/03fdnmv92","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210145170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Catherine Leport","raw_affiliation_strings":["H\u00f4pital Bichat Claude Bernard, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Bichat Claude Bernard, Paris, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I4210145170"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010295552","display_name":"Daniel Commenges","orcid":"https://orcid.org/0000-0001-8988-9114"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Commenges","raw_affiliation_strings":["INSERM Unit\u00e9 330, ISPED, Universit\u00e9 Victor Segalen Bordeaux II, 146, rue L\u00e9o Saignat 33076, Bordeaux, Cedex, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit\u00e9 330, ISPED, Universit\u00e9 Victor Segalen Bordeaux II, 146, rue L\u00e9o Saignat 33076, Bordeaux, Cedex, France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5109990828"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210106115"],"apc_list":{"value":2880,"currency":"USD","value_usd":2880},"apc_paid":null,"fwci":3.1896,"has_fulltext":true,"cited_by_count":117,"citation_normalized_percentile":{"value":0.92166172,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"69","issue":"3","first_page":"249","last_page":"256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11901","display_name":"Bayesian Methods and Mixture Models","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bivariate-analysis","display_name":"Bivariate analysis","score":0.9048745036125183},{"id":"https://openalex.org/keywords/mixed-model","display_name":"Mixed model","score":0.893568754196167},{"id":"https://openalex.org/keywords/generalized-linear-mixed-model","display_name":"Generalized linear mixed model","score":0.8493510484695435},{"id":"https://openalex.org/keywords/random-effects-model","display_name":"Random effects model","score":0.698673665523529},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.5693728923797607},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5416001677513123},{"id":"https://openalex.org/keywords/linear-model","display_name":"Linear model","score":0.5018188953399658},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.42917516827583313},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2889782786369324},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.08036234974861145}],"concepts":[{"id":"https://openalex.org/C64341305","wikidata":"https://www.wikidata.org/wiki/Q4919225","display_name":"Bivariate analysis","level":2,"score":0.9048745036125183},{"id":"https://openalex.org/C16012445","wikidata":"https://www.wikidata.org/wiki/Q1501135","display_name":"Mixed model","level":2,"score":0.893568754196167},{"id":"https://openalex.org/C153720581","wikidata":"https://www.wikidata.org/wiki/Q5532490","display_name":"Generalized linear mixed model","level":2,"score":0.8493510484695435},{"id":"https://openalex.org/C168743327","wikidata":"https://www.wikidata.org/wiki/Q1826427","display_name":"Random effects model","level":3,"score":0.698673665523529},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.5693728923797607},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5416001677513123},{"id":"https://openalex.org/C163175372","wikidata":"https://www.wikidata.org/wiki/Q3339222","display_name":"Linear model","level":2,"score":0.5018188953399658},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.42917516827583313},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2889782786369324},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08036234974861145},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0169-2607(02)00017-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0169-2607(02)00017-2","pdf_url":null,"source":{"id":"https://openalex.org/S138959710","display_name":"Computer Methods and Programs in Biomedicine","issn_l":"0169-2607","issn":["0169-2607","1872-7565"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computer Methods and Programs in Biomedicine","raw_type":"journal-article"},{"id":"pmid:12204452","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12204452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computer methods and programs in biomedicine","raw_type":null},{"id":"pmh:oai:arXiv.org:0705.0568","is_oa":true,"landing_page_url":"http://arxiv.org/abs/0705.0568","pdf_url":"https://arxiv.org/pdf/0705.0568","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:0705.0568","is_oa":true,"landing_page_url":"http://arxiv.org/abs/0705.0568","pdf_url":"https://arxiv.org/pdf/0705.0568","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2021312236.pdf","grobid_xml":"https://content.openalex.org/works/W2021312236.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1512719169","https://openalex.org/W1989383115","https://openalex.org/W2010453346","https://openalex.org/W2034474216","https://openalex.org/W2039181086","https://openalex.org/W2073453589","https://openalex.org/W2081283602","https://openalex.org/W2082246284","https://openalex.org/W2142635246","https://openalex.org/W2330413962","https://openalex.org/W2478445791","https://openalex.org/W4232278877"],"related_works":["https://openalex.org/W4307324678","https://openalex.org/W2021312236","https://openalex.org/W4239710992","https://openalex.org/W2895736713","https://openalex.org/W2953058310","https://openalex.org/W1551599973","https://openalex.org/W225107685","https://openalex.org/W2913341770","https://openalex.org/W2048941127","https://openalex.org/W144895551"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":12}],"updated_date":"2026-08-12T21:12:35.861297","created_date":"2025-10-10T00:00:00"}