{"id":"https://openalex.org/W1968967126","doi":"https://doi.org/10.1016/s0097-8485(01)00095-x","title":"Medical target prediction from genome sequence: combining different sequence analysis algorithms with expert knowledge and input from artificial intelligence approaches","display_name":"Medical target prediction from genome sequence: combining different sequence analysis algorithms with expert knowledge and input from artificial intelligence approaches","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W1968967126","doi":"https://doi.org/10.1016/s0097-8485(01)00095-x","mag":"1968967126","pmid":"https://pubmed.ncbi.nlm.nih.gov/11765847"},"language":"en","primary_location":{"id":"doi:10.1016/s0097-8485(01)00095-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0097-8485(01)00095-x","pdf_url":null,"source":{"id":"https://openalex.org/S4210194753","display_name":"Computers & Chemistry","issn_l":"0097-8485","issn":["0097-8485","1879-0763"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers & Chemistry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086202312","display_name":"Thomas Dandekar","orcid":"https://orcid.org/0000-0003-1886-7625"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas Dandekar","raw_affiliation_strings":["European Molecular Biology Laboratory, PO Box 102209, Meyerhostrasse 1, D-69012 Heidelberg, Germany. dandekar@embl-heidelberg.de","European Molecular Biology Laboratory, PO Box 102209, Meyerhostra\u00dfe 1, D-69012 Heidelberg, Germany","Abteilung f\u00fcr Parasitologie, INF 324, 69120 University of Heidelberg, Heidelberg, Germany","Institute for Molecular Medicine, 79106 University of Freiburg, Freiburg, Germany"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, PO Box 102209, Meyerhostrasse 1, D-69012 Heidelberg, Germany. dandekar@embl-heidelberg.de","institution_ids":["https://openalex.org/I4210153543"]},{"raw_affiliation_string":"European Molecular Biology Laboratory, PO Box 102209, Meyerhostra\u00dfe 1, D-69012 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210153543"]},{"raw_affiliation_string":"Abteilung f\u00fcr Parasitologie, INF 324, 69120 University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Institute for Molecular Medicine, 79106 University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015292085","display_name":"Fuli Du","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fuli Du","raw_affiliation_strings":["Abteilung f\u00fcr Parasitologie, INF 324, 69120 University of Heidelberg, Heidelberg, Germany","European Molecular Biology Laboratory, PO Box 102209, Meyerhostra\u00dfe 1, D-69012 Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Abteilung f\u00fcr Parasitologie, INF 324, 69120 University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"European Molecular Biology Laboratory, PO Box 102209, Meyerhostra\u00dfe 1, D-69012 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210153543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047628393","display_name":"R. Heiner Schirmer","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R.Heiner Schirmer","raw_affiliation_strings":["Biochemistry Center (BZH), INF 328, 69120 University of Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Biochemistry Center (BZH), INF 328, 69120 University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084421039","display_name":"Steffen Schmidt","orcid":"https://orcid.org/0000-0001-9077-6010"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210153543","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/050589e39","country_code":"DE","type":"government","lineage":["https://openalex.org/I4210138560","https://openalex.org/I4210153543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen Schmidt","raw_affiliation_strings":["Abteilung f\u00fcr Parasitologie, INF 324, 69120 University of Heidelberg, Heidelberg, Germany","European Molecular Biology Laboratory, PO Box 102209, Meyerhostra\u00dfe 1, D-69012 Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Abteilung f\u00fcr Parasitologie, INF 324, 69120 University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"European Molecular Biology Laboratory, PO Box 102209, Meyerhostra\u00dfe 1, D-69012 Heidelberg, Germany","institution_ids":["https://openalex.org/I4210153543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5086202312"],"corresponding_institution_ids":["https://openalex.org/I161046081","https://openalex.org/I223822909","https://openalex.org/I4210153543"],"apc_list":null,"apc_paid":null,"fwci":0.5772,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.63846208,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"26","issue":"1","first_page":"15","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.7280171513557434},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5791921615600586},{"id":"https://openalex.org/keywords/sequence-analysis","display_name":"Sequence analysis","score":0.5373157262802124},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4615021347999573},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44329115748405457},{"id":"https://openalex.org/keywords/alignment-free-sequence-analysis","display_name":"Alignment-free sequence analysis","score":0.4375237822532654},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.4341932535171509},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.41706719994544983},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3844582140445709},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3806375563144684},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18187031149864197},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.16624340415000916},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16548100113868713},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07948783040046692}],"concepts":[{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.7280171513557434},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5791921615600586},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.5373157262802124},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4615021347999573},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44329115748405457},{"id":"https://openalex.org/C180384323","wikidata":"https://www.wikidata.org/wiki/Q16335137","display_name":"Alignment-free sequence analysis","level":5,"score":0.4375237822532654},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.4341932535171509},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.41706719994544983},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3844582140445709},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3806375563144684},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18187031149864197},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.16624340415000916},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16548100113868713},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07948783040046692}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005103","descriptor_name":"Expert Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005103","descriptor_name":"Expert Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005103","descriptor_name":"Expert Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009161","descriptor_name":"Mycobacterium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0097-8485(01)00095-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0097-8485(01)00095-x","pdf_url":null,"source":{"id":"https://openalex.org/S4210194753","display_name":"Computers & Chemistry","issn_l":"0097-8485","issn":["0097-8485","1879-0763"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers & Chemistry","raw_type":"journal-article"},{"id":"pmid:11765847","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11765847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers & chemistry","raw_type":null},{"id":"pmh:oai:freidok.uni-freiburg.de:41013","is_oa":false,"landing_page_url":"https://freidok.uni-freiburg.de/data/41013","pdf_url":null,"source":{"id":"https://openalex.org/S4306401057","display_name":"FreiDok plus (Universit\u00e4tsbibliothek Freiburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I161046081","host_organization_name":"University of Freiburg","host_organization_lineage":["https://openalex.org/I161046081"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computers & Chemistry. - 26, 1 (2001) , 15-21, ISSN: 0097-8485","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6899999976158142,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G3317018093","display_name":null,"funder_award_id":"SFB 544/B2","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7445720971","display_name":null,"funder_award_id":"DFG-SPP Bo 1033/5","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W53898165","https://openalex.org/W82107855","https://openalex.org/W1497782867","https://openalex.org/W1839423960","https://openalex.org/W1969995117","https://openalex.org/W1970190847","https://openalex.org/W1974699512","https://openalex.org/W1997869261","https://openalex.org/W1999024161","https://openalex.org/W2005591679","https://openalex.org/W2011544219","https://openalex.org/W2011560289","https://openalex.org/W2011734083","https://openalex.org/W2022849555","https://openalex.org/W2026649417","https://openalex.org/W2056503383","https://openalex.org/W2059899216","https://openalex.org/W2060747860","https://openalex.org/W2074354374","https://openalex.org/W2077393973","https://openalex.org/W2078613245","https://openalex.org/W2090382722","https://openalex.org/W2101783948","https://openalex.org/W2102424043","https://openalex.org/W2112744958","https://openalex.org/W2131941208","https://openalex.org/W2134517171","https://openalex.org/W2145380863","https://openalex.org/W2145454254","https://openalex.org/W2147694156","https://openalex.org/W2149010450","https://openalex.org/W2158023121","https://openalex.org/W2159266221","https://openalex.org/W2165918713","https://openalex.org/W2166699767","https://openalex.org/W2399215454","https://openalex.org/W4213257530","https://openalex.org/W4235848672","https://openalex.org/W4249836181"],"related_works":["https://openalex.org/W2596471045","https://openalex.org/W1725737257","https://openalex.org/W3012600779","https://openalex.org/W2035698531","https://openalex.org/W2184990081","https://openalex.org/W4200088497","https://openalex.org/W3000366369","https://openalex.org/W1590480705","https://openalex.org/W3027238885","https://openalex.org/W2350198651"],"abstract_inverted_index":null,"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}