{"id":"https://openalex.org/W2089357374","doi":"https://doi.org/10.1016/s0097-8485(00)80008-x","title":"A global compositional complexity measure for biological sequences: AT-rich and GC-rich genomes encode less complex proteins","display_name":"A global compositional complexity measure for biological sequences: AT-rich and GC-rich genomes encode less complex proteins","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2089357374","doi":"https://doi.org/10.1016/s0097-8485(00)80008-x","mag":"2089357374","pmid":"https://pubmed.ncbi.nlm.nih.gov/10642881"},"language":"en","primary_location":{"id":"doi:10.1016/s0097-8485(00)80008-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0097-8485(00)80008-x","pdf_url":null,"source":{"id":"https://openalex.org/S4210194753","display_name":"Computers & Chemistry","issn_l":"0097-8485","issn":["0097-8485","1879-0763"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers & Chemistry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111858543","display_name":"Honghui Wan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Honghui Wan","raw_affiliation_strings":["Computational Biology Branch National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8th Floor, 8600 Rockville Pike, Bethesda, MD 20894, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology Branch National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8th Floor, 8600 Rockville Pike, Bethesda, MD 20894, USA","institution_ids":["https://openalex.org/I4210109390","https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110276911","display_name":"John C. Wootton","orcid":null},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Wootton","raw_affiliation_strings":["Computational Biology Branch National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8th Floor, 8600 Rockville Pike, Bethesda, MD 20894, USA"],"affiliations":[{"raw_affiliation_string":"Computational Biology Branch National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8th Floor, 8600 Rockville Pike, Bethesda, MD 20894, USA","institution_ids":["https://openalex.org/I4210109390","https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111858543"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210109390"],"apc_list":null,"apc_paid":null,"fwci":1.7055,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.84084075,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"24","issue":"1","first_page":"71","last_page":"94"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/encode","display_name":"ENCODE","score":0.48802486062049866},{"id":"https://openalex.org/keywords/bacterial-genome-size","display_name":"Bacterial genome size","score":0.43200093507766724},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4184494912624359},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.3589321970939636},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3009756803512573},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.15804991126060486},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15041789412498474}],"concepts":[{"id":"https://openalex.org/C66746571","wikidata":"https://www.wikidata.org/wiki/Q1134833","display_name":"ENCODE","level":3,"score":0.48802486062049866},{"id":"https://openalex.org/C3742359","wikidata":"https://www.wikidata.org/wiki/Q4839988","display_name":"Bacterial genome size","level":4,"score":0.43200093507766724},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4184494912624359},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3589321970939636},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3009756803512573},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15804991126060486},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15041789412498474}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0097-8485(00)80008-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0097-8485(00)80008-x","pdf_url":null,"source":{"id":"https://openalex.org/S4210194753","display_name":"Computers & Chemistry","issn_l":"0097-8485","issn":["0097-8485","1879-0763"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers & Chemistry","raw_type":"journal-article"},{"id":"pmid:10642881","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10642881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers & chemistry","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W132918488","https://openalex.org/W568536433","https://openalex.org/W1481293993","https://openalex.org/W1512176015","https://openalex.org/W1513332069","https://openalex.org/W1531679840","https://openalex.org/W1549664537","https://openalex.org/W1571382306","https://openalex.org/W1602255397","https://openalex.org/W1606365631","https://openalex.org/W1625574816","https://openalex.org/W1638203394","https://openalex.org/W1832728128","https://openalex.org/W1894205160","https://openalex.org/W1928030931","https://openalex.org/W1964501091","https://openalex.org/W1964832728","https://openalex.org/W1969678783","https://openalex.org/W1970437513","https://openalex.org/W1981608708","https://openalex.org/W1982600747","https://openalex.org/W1983477964","https://openalex.org/W1985556836","https://openalex.org/W1990092166","https://openalex.org/W1990436674","https://openalex.org/W1992649154","https://openalex.org/W1995875735","https://openalex.org/W1999948476","https://openalex.org/W2001644324","https://openalex.org/W2001713235","https://openalex.org/W2002180966","https://openalex.org/W2005097301","https://openalex.org/W2005470897","https://openalex.org/W2017363392","https://openalex.org/W2019316513","https://openalex.org/W2023998798","https://openalex.org/W2025417656","https://openalex.org/W2029674471","https://openalex.org/W2030564603","https://openalex.org/W2034667661","https://openalex.org/W2036792999","https://openalex.org/W2043592686","https://openalex.org/W2044532497","https://openalex.org/W2045069244","https://openalex.org/W2045162258","https://openalex.org/W2049709181","https://openalex.org/W2051119339","https://openalex.org/W2051916497","https://openalex.org/W2052376307","https://openalex.org/W2053501576","https://openalex.org/W2054218850","https://openalex.org/W2055092944","https://openalex.org/W2056268170","https://openalex.org/W2068691391","https://openalex.org/W2073449490","https://openalex.org/W2076597612","https://openalex.org/W2083421677","https://openalex.org/W2083715726","https://openalex.org/W2088730122","https://openalex.org/W2092464006","https://openalex.org/W2094519647","https://openalex.org/W2096406938","https://openalex.org/W2099970571","https://openalex.org/W2108808477","https://openalex.org/W2110381504","https://openalex.org/W2119490692","https://openalex.org/W2122882636","https://openalex.org/W2123838014","https://openalex.org/W2124871568","https://openalex.org/W2135625884","https://openalex.org/W2144729032","https://openalex.org/W2145295592","https://openalex.org/W2146819293","https://openalex.org/W2154462988","https://openalex.org/W2164618276","https://openalex.org/W2167764618","https://openalex.org/W2323065399","https://openalex.org/W2332258137","https://openalex.org/W2476123118","https://openalex.org/W2560743082","https://openalex.org/W2567782165","https://openalex.org/W2949766590","https://openalex.org/W2978725006","https://openalex.org/W2993383518","https://openalex.org/W3091332311","https://openalex.org/W4213350211","https://openalex.org/W6631882640","https://openalex.org/W6635968683","https://openalex.org/W6638863406","https://openalex.org/W6639593797","https://openalex.org/W6640326986","https://openalex.org/W6646499812","https://openalex.org/W6676599625","https://openalex.org/W6678323213","https://openalex.org/W6684041852","https://openalex.org/W6684491288","https://openalex.org/W6700890257","https://openalex.org/W6730464055","https://openalex.org/W6731496405"],"related_works":["https://openalex.org/W2889029343","https://openalex.org/W2079327011","https://openalex.org/W2056973287","https://openalex.org/W3111025641","https://openalex.org/W2061340009","https://openalex.org/W3202542829","https://openalex.org/W1965562485","https://openalex.org/W2340204314","https://openalex.org/W1956137100","https://openalex.org/W2046657386"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}