{"id":"https://openalex.org/W2040054565","doi":"https://doi.org/10.1016/s0096-3003(02)00190-x","title":"Parameter estimation of nonlinear models in biochemistry: a comparative study on optimization methods","display_name":"Parameter estimation of nonlinear models in biochemistry: a comparative study on optimization methods","publication_year":2002,"publication_date":"2002-12-30","ids":{"openalex":"https://openalex.org/W2040054565","doi":"https://doi.org/10.1016/s0096-3003(02)00190-x","mag":"2040054565"},"language":"en","primary_location":{"id":"doi:10.1016/s0096-3003(02)00190-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0096-3003(02)00190-x","pdf_url":null,"source":{"id":"https://openalex.org/S50372074","display_name":"Applied Mathematics and Computation","issn_l":"0096-3003","issn":["0096-3003","1873-5649"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Mathematics and Computation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015739294","display_name":"Necmettin Y\u0131ld\u0131r\u0131m","orcid":"https://orcid.org/0000-0001-5650-2462"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Necmettin Yildirim","raw_affiliation_strings":["Department of Physiology, Center for Nonlinear Dynamics in Physiology and Medicine, McGill University, 3655 Drummond Street, McIntyre Building 1125, Montreal, PQ, Canada H3G lY6"],"affiliations":[{"raw_affiliation_string":"Department of Physiology, Center for Nonlinear Dynamics in Physiology and Medicine, McGill University, 3655 Drummond Street, McIntyre Building 1125, Montreal, PQ, Canada H3G lY6","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109087416","display_name":"Fatih Ak\u00e7ay","orcid":null},"institutions":[{"id":"https://openalex.org/I64134780","display_name":"Atat\u00fcrk University","ror":"https://ror.org/03je5c526","country_code":"TR","type":"education","lineage":["https://openalex.org/I64134780"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Fatih Ak\u00e7ay","raw_affiliation_strings":["Faculty of Medicine, Department of Biochemistry, Ataturk University, 25240 Erzurum, Turkey"],"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Biochemistry, Ataturk University, 25240 Erzurum, Turkey","institution_ids":["https://openalex.org/I64134780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077242056","display_name":"H\u00fcseyin Okur","orcid":null},"institutions":[{"id":"https://openalex.org/I64134780","display_name":"Atat\u00fcrk University","ror":"https://ror.org/03je5c526","country_code":"TR","type":"education","lineage":["https://openalex.org/I64134780"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"H\u00fcseyin Okur","raw_affiliation_strings":["Faculty of Engineering, Department of Chemistry, Ataturk University, 25240 Erzurum, Turkey","Faculty of Engineering, Department of Chemistry, Ataturk University, 25240 Erzurum, Turkey#TAB#"],"affiliations":[{"raw_affiliation_string":"Faculty of Engineering, Department of Chemistry, Ataturk University, 25240 Erzurum, Turkey","institution_ids":["https://openalex.org/I64134780"]},{"raw_affiliation_string":"Faculty of Engineering, Department of Chemistry, Ataturk University, 25240 Erzurum, Turkey#TAB#","institution_ids":["https://openalex.org/I64134780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064932585","display_name":"Derya Yildirim","orcid":null},"institutions":[{"id":"https://openalex.org/I64134780","display_name":"Atat\u00fcrk University","ror":"https://ror.org/03je5c526","country_code":"TR","type":"education","lineage":["https://openalex.org/I64134780"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Derya Yildirim","raw_affiliation_strings":["Faculty of Medicine, Department of Pharmacology, Ataturk University, 25240 Erzurum, Turkey","Faculty of MedicineDepartment of PharmacologyAtaturk University25240, Erzurum, Turkey"],"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Pharmacology, Ataturk University, 25240 Erzurum, Turkey","institution_ids":["https://openalex.org/I64134780"]},{"raw_affiliation_string":"Faculty of MedicineDepartment of PharmacologyAtaturk University25240, Erzurum, Turkey","institution_ids":["https://openalex.org/I64134780"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015739294"],"corresponding_institution_ids":["https://openalex.org/I5023651"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.13639167,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"140","issue":"1","first_page":"29","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5115000009536743,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5115000009536743,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.4569000005722046,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.451200008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simplex-algorithm","display_name":"Simplex algorithm","score":0.6604500412940979},{"id":"https://openalex.org/keywords/simplex","display_name":"Simplex","score":0.6213477253913879},{"id":"https://openalex.org/keywords/computation","display_name":"Computation","score":0.5850136280059814},{"id":"https://openalex.org/keywords/fortran","display_name":"Fortran","score":0.5832712650299072},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.5582754611968994},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.4918391704559326},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4740811586380005},{"id":"https://openalex.org/keywords/numerical-analysis","display_name":"Numerical analysis","score":0.46842706203460693},{"id":"https://openalex.org/keywords/nonlinear-programming","display_name":"Nonlinear programming","score":0.466813325881958},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.44273531436920166},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.439935564994812},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4268026053905487},{"id":"https://openalex.org/keywords/linear-programming","display_name":"Linear programming","score":0.17521297931671143},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.07438904047012329}],"concepts":[{"id":"https://openalex.org/C144521790","wikidata":"https://www.wikidata.org/wiki/Q134164","display_name":"Simplex algorithm","level":3,"score":0.6604500412940979},{"id":"https://openalex.org/C62438384","wikidata":"https://www.wikidata.org/wiki/Q331350","display_name":"Simplex","level":2,"score":0.6213477253913879},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.5850136280059814},{"id":"https://openalex.org/C2778241615","wikidata":"https://www.wikidata.org/wiki/Q83303","display_name":"Fortran","level":2,"score":0.5832712650299072},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.5582754611968994},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.4918391704559326},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4740811586380005},{"id":"https://openalex.org/C48753275","wikidata":"https://www.wikidata.org/wiki/Q11216","display_name":"Numerical analysis","level":2,"score":0.46842706203460693},{"id":"https://openalex.org/C115527620","wikidata":"https://www.wikidata.org/wiki/Q769909","display_name":"Nonlinear programming","level":3,"score":0.466813325881958},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.44273531436920166},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.439935564994812},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4268026053905487},{"id":"https://openalex.org/C41045048","wikidata":"https://www.wikidata.org/wiki/Q202843","display_name":"Linear programming","level":2,"score":0.17521297931671143},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.07438904047012329},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0096-3003(02)00190-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0096-3003(02)00190-x","pdf_url":null,"source":{"id":"https://openalex.org/S50372074","display_name":"Applied Mathematics and Computation","issn_l":"0096-3003","issn":["0096-3003","1873-5649"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Mathematics and Computation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W291003596","https://openalex.org/W1576919957","https://openalex.org/W2171212541","https://openalex.org/W2288305088","https://openalex.org/W7009171728"],"related_works":["https://openalex.org/W2048470382","https://openalex.org/W2384679317","https://openalex.org/W1591528168","https://openalex.org/W2911215968","https://openalex.org/W1583787753","https://openalex.org/W1570109187","https://openalex.org/W2366013513","https://openalex.org/W2139369605","https://openalex.org/W3125083766","https://openalex.org/W1560144822"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}