{"id":"https://openalex.org/W2054597983","doi":"https://doi.org/10.1016/s0020-0255(02)00231-1","title":"Evolutionary analysis of functional divergence in TGF-\u03b2 signaling pathway","display_name":"Evolutionary analysis of functional divergence in TGF-\u03b2 signaling pathway","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W2054597983","doi":"https://doi.org/10.1016/s0020-0255(02)00231-1","mag":"2054597983"},"language":"en","primary_location":{"id":"doi:10.1016/s0020-0255(02)00231-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0020-0255(02)00231-1","pdf_url":null,"source":{"id":"https://openalex.org/S192650101","display_name":"Information Sciences","issn_l":"0020-0255","issn":["0020-0255","1872-6291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Information Sciences","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090573566","display_name":"Jianying Gu","orcid":"https://orcid.org/0000-0003-4972-8054"},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianying Gu","raw_affiliation_strings":["Department of Zoology and Genetics, 332 Science II Hall, Center for Bioinformatics and Biological Statistics, Iowa State University, Ames, IA 50011, USA","Department of Zoology and Genetics, 332 Science II Hall, Center for Bioinformatics and Biological Statistics, Iowa State University, Ames, IA#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Zoology and Genetics, 332 Science II Hall, Center for Bioinformatics and Biological Statistics, Iowa State University, Ames, IA 50011, USA","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Department of Zoology and Genetics, 332 Science II Hall, Center for Bioinformatics and Biological Statistics, Iowa State University, Ames, IA#TAB#","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080712092","display_name":"Xun Gu","orcid":"https://orcid.org/0000-0001-9845-6986"},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xun Gu","raw_affiliation_strings":["Department of Zoology and Genetics, 332 Science II Hall, Center for Bioinformatics and Biological Statistics, Iowa State University, Ames, IA 50011, USA","Department of Zoology and Genetics, 332 Science II Hall, Center for Bioinformatics and Biological Statistics, Iowa State University, Ames, IA#TAB#"],"affiliations":[{"raw_affiliation_string":"Department of Zoology and Genetics, 332 Science II Hall, Center for Bioinformatics and Biological Statistics, Iowa State University, Ames, IA 50011, USA","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Department of Zoology and Genetics, 332 Science II Hall, Center for Bioinformatics and Biological Statistics, Iowa State University, Ames, IA#TAB#","institution_ids":["https://openalex.org/I173911158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080712092"],"corresponding_institution_ids":["https://openalex.org/I173911158"],"apc_list":{"value":3330,"currency":"USD","value_usd":3330},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.09508725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"145","issue":"3-4","first_page":"195","last_page":"204"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9703999757766724,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9264000058174133,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/functional-divergence","display_name":"Functional divergence","score":0.8073924779891968},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.6394425630569458},{"id":"https://openalex.org/keywords/divergence","display_name":"Divergence (linguistics)","score":0.6019941568374634},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5785646438598633},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.5090615153312683},{"id":"https://openalex.org/keywords/transforming-growth-factor","display_name":"Transforming growth factor","score":0.44359689950942993},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4424346387386322},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.39656808972358704},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.366626501083374},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.3595593571662903},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.31148290634155273},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2842313051223755},{"id":"https://openalex.org/keywords/gene-family","display_name":"Gene family","score":0.23568546772003174}],"concepts":[{"id":"https://openalex.org/C103077935","wikidata":"https://www.wikidata.org/wiki/Q5508811","display_name":"Functional divergence","level":5,"score":0.8073924779891968},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6394425630569458},{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.6019941568374634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5785646438598633},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5090615153312683},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.44359689950942993},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4424346387386322},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39656808972358704},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.366626501083374},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3595593571662903},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31148290634155273},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2842313051223755},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.23568546772003174},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0020-0255(02)00231-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0020-0255(02)00231-1","pdf_url":null,"source":{"id":"https://openalex.org/S192650101","display_name":"Information Sciences","issn_l":"0020-0255","issn":["0020-0255","1872-6291"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Information Sciences","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1503889771","https://openalex.org/W1594381616","https://openalex.org/W1863348815","https://openalex.org/W1967780336","https://openalex.org/W1972628065","https://openalex.org/W1986469118","https://openalex.org/W2046938605","https://openalex.org/W2048535898","https://openalex.org/W2049203248","https://openalex.org/W2088012478","https://openalex.org/W2092414509","https://openalex.org/W2101829206","https://openalex.org/W2103031848","https://openalex.org/W2120157258","https://openalex.org/W2125228440","https://openalex.org/W2137137210","https://openalex.org/W2158156603"],"related_works":["https://openalex.org/W2419656700","https://openalex.org/W4247531298","https://openalex.org/W4252569736","https://openalex.org/W4233148870","https://openalex.org/W2051461989","https://openalex.org/W4247009923","https://openalex.org/W2081033912","https://openalex.org/W2006800383","https://openalex.org/W4233646568","https://openalex.org/W1596060041"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}