{"id":"https://openalex.org/W4416426307","doi":"https://doi.org/10.1016/j.visinf.2025.100289","title":"Sharper insights: Discrimination-enhanced semantic segmentation of similar morphology nuclei in breast cancer pathology images","display_name":"Sharper insights: Discrimination-enhanced semantic segmentation of similar morphology nuclei in breast cancer pathology images","publication_year":2025,"publication_date":"2025-11-20","ids":{"openalex":"https://openalex.org/W4416426307","doi":"https://doi.org/10.1016/j.visinf.2025.100289"},"language":"en","primary_location":{"id":"doi:10.1016/j.visinf.2025.100289","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.visinf.2025.100289","pdf_url":null,"source":{"id":"https://openalex.org/S2898150413","display_name":"Visual Informatics","issn_l":"2468-502X","issn":["2468-502X","2543-2656"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Visual Informatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/j.visinf.2025.100289","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017503364","display_name":"Rui Yang","orcid":"https://orcid.org/0000-0001-5695-3773"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I141962983","display_name":"Shanghai University of Engineering Science","ror":"https://ror.org/0557b9y08","country_code":"CN","type":"education","lineage":["https://openalex.org/I141962983"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rui Yang","raw_affiliation_strings":["School of Computer Engineering and Science, Shanghai University, Baoshan District, Shanghai, 200444, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Engineering and Science, Shanghai University, Baoshan District, Shanghai, 200444, China","institution_ids":["https://openalex.org/I113940042","https://openalex.org/I141962983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103044916","display_name":"Guoxin Sun","orcid":"https://orcid.org/0009-0008-4924-7617"},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoxin Sun","raw_affiliation_strings":["Clinical Medical College, Qingdao University, Ningxia Road, QingDao, 266102, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Medical College, Qingdao University, Ningxia Road, QingDao, 266102, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021500337","display_name":"Yunfei Bai","orcid":"https://orcid.org/0000-0001-8084-6281"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunfei Bai","raw_affiliation_strings":["School of Mechatronic Engineering and Automation, Shanghai University, Baoshan District, Shanghai, 200444, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mechatronic Engineering and Automation, Shanghai University, Baoshan District, Shanghai, 200444, China","institution_ids":["https://openalex.org/I113940042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100747880","display_name":"Yuehua Liu","orcid":"https://orcid.org/0000-0002-2660-0675"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I141962983","display_name":"Shanghai University of Engineering Science","ror":"https://ror.org/0557b9y08","country_code":"CN","type":"education","lineage":["https://openalex.org/I141962983"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuehua Liu","raw_affiliation_strings":["School of Computer Engineering and Science, Shanghai University, Baoshan District, Shanghai, 200444, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Engineering and Science, Shanghai University, Baoshan District, Shanghai, 200444, China","institution_ids":["https://openalex.org/I113940042","https://openalex.org/I141962983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050388470","display_name":"Liming Xin","orcid":"https://orcid.org/0000-0002-3447-9932"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I141962983","display_name":"Shanghai University of Engineering Science","ror":"https://ror.org/0557b9y08","country_code":"CN","type":"education","lineage":["https://openalex.org/I141962983"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liming Xin","raw_affiliation_strings":["School of Computer Engineering and Science, Shanghai University, Baoshan District, Shanghai, 200444, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Engineering and Science, Shanghai University, Baoshan District, Shanghai, 200444, China","institution_ids":["https://openalex.org/I113940042","https://openalex.org/I141962983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101287249","display_name":"Zou Xiao","orcid":null},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Zou","raw_affiliation_strings":["Clinical Medical College, Qingdao University, Ningxia Road, QingDao, 266102, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Medical College, Qingdao University, Ningxia Road, QingDao, 266102, Shandong, China","institution_ids":["https://openalex.org/I108688024"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103252624","display_name":"Shaorong Xie","orcid":"https://orcid.org/0000-0001-6591-6202"},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]},{"id":"https://openalex.org/I141962983","display_name":"Shanghai University of Engineering Science","ror":"https://ror.org/0557b9y08","country_code":"CN","type":"education","lineage":["https://openalex.org/I141962983"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaorong Xie","raw_affiliation_strings":["School of Computer Engineering and Science, Shanghai University, Baoshan District, Shanghai, 200444, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Engineering and Science, Shanghai University, Baoshan District, Shanghai, 200444, China","institution_ids":["https://openalex.org/I113940042","https://openalex.org/I141962983"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017503364"],"corresponding_institution_ids":["https://openalex.org/I113940042","https://openalex.org/I141962983"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12932222,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"2","first_page":"100289","last_page":"100289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9860000014305115,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9860000014305115,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10036","display_name":"Advanced Neural Network Applications","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.7508999705314636},{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.739300012588501},{"id":"https://openalex.org/keywords/confusion","display_name":"Confusion","score":0.6883999705314636},{"id":"https://openalex.org/keywords/generalization","display_name":"Generalization","score":0.5939000248908997},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.531499981880188},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5180000066757202},{"id":"https://openalex.org/keywords/focus","display_name":"Focus (optics)","score":0.4794999957084656},{"id":"https://openalex.org/keywords/macro","display_name":"Macro","score":0.32120001316070557}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.7508999705314636},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.739300012588501},{"id":"https://openalex.org/C2781140086","wikidata":"https://www.wikidata.org/wiki/Q557945","display_name":"Confusion","level":2,"score":0.6883999705314636},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6046000123023987},{"id":"https://openalex.org/C177148314","wikidata":"https://www.wikidata.org/wiki/Q170084","display_name":"Generalization","level":2,"score":0.5939000248908997},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5496000051498413},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.531499981880188},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5180000066757202},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.4794999957084656},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40290001034736633},{"id":"https://openalex.org/C166955791","wikidata":"https://www.wikidata.org/wiki/Q629579","display_name":"Macro","level":2,"score":0.32120001316070557},{"id":"https://openalex.org/C3020109028","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Breast tissue","level":4,"score":0.310699999332428},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.28929999470710754},{"id":"https://openalex.org/C138602881","wikidata":"https://www.wikidata.org/wiki/Q2709591","display_name":"Confusion matrix","level":2,"score":0.2892000079154968},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2858999967575073},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.2800000011920929},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.2757999897003174},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C3017399102","wikidata":"https://www.wikidata.org/wiki/Q397254","display_name":"Macro level","level":2,"score":0.2529999911785126},{"id":"https://openalex.org/C2777522853","wikidata":"https://www.wikidata.org/wiki/Q5276128","display_name":"Digital pathology","level":2,"score":0.25220000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.visinf.2025.100289","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.visinf.2025.100289","pdf_url":null,"source":{"id":"https://openalex.org/S2898150413","display_name":"Visual Informatics","issn_l":"2468-502X","issn":["2468-502X","2543-2656"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Visual Informatics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.visinf.2025.100289","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.visinf.2025.100289","pdf_url":null,"source":{"id":"https://openalex.org/S2898150413","display_name":"Visual Informatics","issn_l":"2468-502X","issn":["2468-502X","2543-2656"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Visual Informatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1970120446","https://openalex.org/W2175543269","https://openalex.org/W2340897893","https://openalex.org/W2521736072","https://openalex.org/W2560023338","https://openalex.org/W2716665989","https://openalex.org/W2737258237","https://openalex.org/W2752782242","https://openalex.org/W2753234324","https://openalex.org/W2790813572","https://openalex.org/W2795587607","https://openalex.org/W2884585870","https://openalex.org/W2884822772","https://openalex.org/W2885343725","https://openalex.org/W2922239620","https://openalex.org/W2946877213","https://openalex.org/W2952833648","https://openalex.org/W2953894958","https://openalex.org/W2955058313","https://openalex.org/W2963351448","https://openalex.org/W2964309882","https://openalex.org/W2981994674","https://openalex.org/W2996290406","https://openalex.org/W3009610350","https://openalex.org/W3034552520","https://openalex.org/W3034958977","https://openalex.org/W3116886510","https://openalex.org/W3169865585","https://openalex.org/W3170581063","https://openalex.org/W3188337644","https://openalex.org/W4214901231","https://openalex.org/W4280494974","https://openalex.org/W4312689172","https://openalex.org/W4313023122","https://openalex.org/W4390873132"],"related_works":[],"abstract_inverted_index":{"Similar":[0],"Morphology":[1],"Cells":[2],"(SMCs)":[3],"play":[4],"a":[5,83,96,126,159],"critical":[6],"role":[7],"in":[8,68,176],"pathology":[9,36,184],"diagnosis.":[10],"This":[11,111],"study":[12],"identifies":[13],"and":[14,150],"defines":[15],"two":[16,58,114],"primary":[17],"challenges":[18,59],"for":[19],"SMCs":[20,54,69],"segmentation":[21,72],"based":[22],"on":[23,122,168,181],"detailed":[24],"investigation.":[25],"At":[26,46],"the":[27,32,47,89,103,119,148,153,187,191],"macro":[28],"level":[29,49],"of":[30,50,152,190],"slides,":[31],"sample":[33],"distribution":[34,138],"within":[35],"images":[37,185],"is":[38,134],"highly":[39],"imbalanced":[40],"due":[41],"to":[42,61,87,101,106,117,136,146],"varying":[43],"cell":[44,66],"functionalities.":[45],"micro":[48],"cells,":[51],"differences":[52],"between":[53,63],"are":[55],"imperceptible.":[56],"These":[57],"lead":[60],"confusion":[62],"visually":[64],"similar":[65],"classes":[67],"segmentation,":[70],"reducing":[71],"accuracy.":[73],"To":[74],"address":[75],"these":[76],"issues,":[77],"we":[78,94,157],"propose":[79],"Sharper":[80],"Insights":[81],"(SI),":[82],"novel":[84,127],"approach":[85],"designed":[86],"enhance":[88],"model\u2019s":[90,104,120],"discriminative":[91],"capabilities.":[92],"Specifically,":[93],"introduce":[95],"Discrimination":[97],"Enhancement":[98],"Module":[99],"(DEM)":[100],"increase":[102],"sensitivity":[105],"subtle":[107],"variations":[108],"among":[109],"SMCs.":[110],"module":[112],"utilizes":[113],"attention":[115],"mechanisms":[116],"sharpen":[118],"focus":[121],"minute":[123],"differences.":[124],"Additionally,":[125],"loss":[128],"function,":[129],"Minority":[130],"Categories":[131],"Augmentation":[132],"(MCA),":[133],"introduced":[135],"mitigate":[137],"imbalance":[139],"by":[140],"dynamically":[141],"adjusting":[142],"category-specific":[143],"weights.":[144],"Finally,":[145],"verify":[147],"effectiveness":[149],"generalization":[151],"proposed":[154,175,192],"method":[155],"SI,":[156],"curate":[158],"comprehensive":[160],"breast":[161,182],"cancer":[162,183],"dataset":[163],"SimMorphBC.":[164],"It":[165],"primarily":[166],"focuses":[167],"SMCs,":[169],"which":[170],"have":[171],"not":[172],"been":[173],"explicitly":[174],"previous":[177],"datasets.":[178],"Extensive":[179],"experiments":[180],"demonstrate":[186],"superior":[188],"performance":[189],"approach.":[193]},"counts_by_year":[],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-11-20T00:00:00"}