{"id":"https://openalex.org/W3204068536","doi":"https://doi.org/10.1016/j.patter.2021.100364","title":"Selection of 51 predictors from 13,782 candidate multimodal features using machine learning improves coronary artery disease prediction","display_name":"Selection of 51 predictors from 13,782 candidate multimodal features using machine learning improves coronary artery disease prediction","publication_year":2021,"publication_date":"2021-10-04","ids":{"openalex":"https://openalex.org/W3204068536","doi":"https://doi.org/10.1016/j.patter.2021.100364","mag":"3204068536","pmid":"https://pubmed.ncbi.nlm.nih.gov/34950898"},"language":"en","primary_location":{"id":"doi:10.1016/j.patter.2021.100364","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.patter.2021.100364","pdf_url":"http://www.cell.com/article/S2666389921002269/pdf","source":{"id":"https://openalex.org/S4210198061","display_name":"Patterns","issn_l":"2666-3899","issn":["2666-3899"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Patterns","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2666389921002269/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049434997","display_name":"Saaket Agrawal","orcid":"https://orcid.org/0000-0002-2535-4759"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saaket Agrawal","raw_affiliation_strings":["Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA","Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, 185 Cambridge Street, Simches Research Building | CPZN 6.256, Boston, MA 02114, USA","Department of Medicine, Harvard Medical School, Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, 185 Cambridge Street, Simches Research Building | CPZN 6.256, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086799592","display_name":"Marcus D. R. Klarqvist","orcid":"https://orcid.org/0000-0001-7630-2708"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus D.R. Klarqvist","raw_affiliation_strings":["Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061819343","display_name":"Connor A. Emdin","orcid":"https://orcid.org/0000-0002-2385-8259"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Connor Emdin","raw_affiliation_strings":["Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA","Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, 185 Cambridge Street, Simches Research Building | CPZN 6.256, Boston, MA 02114, USA","Department of Medicine, Harvard Medical School, Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, 185 Cambridge Street, Simches Research Building | CPZN 6.256, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077181516","display_name":"Aniruddh P. Patel","orcid":"https://orcid.org/0000-0001-7871-9638"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aniruddh P. Patel","raw_affiliation_strings":["Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA","Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, 185 Cambridge Street, Simches Research Building | CPZN 6.256, Boston, MA 02114, USA","Department of Medicine, Harvard Medical School, Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, 185 Cambridge Street, Simches Research Building | CPZN 6.256, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078790969","display_name":"Manish Paranjpe","orcid":"https://orcid.org/0000-0002-6463-8965"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manish D. Paranjpe","raw_affiliation_strings":["Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA","Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, 185 Cambridge Street, Simches Research Building | CPZN 6.256, Boston, MA 02114, USA","Department of Medicine, Harvard Medical School, Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, 185 Cambridge Street, Simches Research Building | CPZN 6.256, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069822855","display_name":"Patrick T. Ellinor","orcid":"https://orcid.org/0000-0002-2067-0533"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick T. Ellinor","raw_affiliation_strings":["Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA","Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, 185 Cambridge Street, Simches Research Building | CPZN 6.256, Boston, MA 02114, USA","Department of Medicine, Harvard Medical School, Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, 185 Cambridge Street, Simches Research Building | CPZN 6.256, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008444707","display_name":"Anthony Philippakis","orcid":"https://orcid.org/0000-0001-6953-3794"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony Philippakis","raw_affiliation_strings":["Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070430680","display_name":"Kenney Ng","orcid":"https://orcid.org/0000-0003-0792-070X"},"institutions":[{"id":"https://openalex.org/I4210138427","display_name":"Computational Physics (United States)","ror":"https://ror.org/03grsxg62","country_code":"US","type":"company","lineage":["https://openalex.org/I4210138427"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenney Ng","raw_affiliation_strings":["Center for Computational Health, IBM Research, Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Center for Computational Health, IBM Research, Cambridge, MA, USA","institution_ids":["https://openalex.org/I4210138427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005297730","display_name":"Puneet Batra","orcid":"https://orcid.org/0000-0001-6822-0593"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Puneet Batra","raw_affiliation_strings":["Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA"],"affiliations":[{"raw_affiliation_string":"Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030786234","display_name":"Amit V. Khera","orcid":"https://orcid.org/0000-0001-6535-5839"},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amit V. Khera","raw_affiliation_strings":["Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA","Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, 185 Cambridge Street, Simches Research Building | CPZN 6.256, Boston, MA 02114, USA","Department of Medicine, Harvard Medical School, Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265"]},{"raw_affiliation_string":"Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, 185 Cambridge Street, Simches Research Building | CPZN 6.256, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Medicine, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5030786234"],"corresponding_institution_ids":["https://openalex.org/I107606265","https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":5.5389,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.96359354,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"2","issue":"12","first_page":"100364","last_page":"100364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.9891999959945679,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9866999983787537,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/framingham-risk-score","display_name":"Framingham Risk Score","score":0.7255945205688477},{"id":"https://openalex.org/keywords/proportional-hazards-model","display_name":"Proportional hazards model","score":0.7136391997337341},{"id":"https://openalex.org/keywords/waist","display_name":"Waist","score":0.6252455115318298},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6250296235084534},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"Coronary artery disease","score":0.6044766902923584},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.5995075702667236},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.5034489035606384},{"id":"https://openalex.org/keywords/biobank","display_name":"Biobank","score":0.48645922541618347},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.4596002697944641},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.3815804719924927},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.381197988986969},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.364172101020813},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3405926823616028},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2612225413322449},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"Body mass index","score":0.15735918283462524},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.12369325757026672}],"concepts":[{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.7255945205688477},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.7136391997337341},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.6252455115318298},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6250296235084534},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.6044766902923584},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5995075702667236},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5034489035606384},{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.48645922541618347},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.4596002697944641},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3815804719924927},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.381197988986969},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.364172101020813},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3405926823616028},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2612225413322449},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.15735918283462524},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.12369325757026672},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.patter.2021.100364","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.patter.2021.100364","pdf_url":"http://www.cell.com/article/S2666389921002269/pdf","source":{"id":"https://openalex.org/S4210198061","display_name":"Patterns","issn_l":"2666-3899","issn":["2666-3899"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Patterns","raw_type":"journal-article"},{"id":"pmid:34950898","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34950898","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Patterns (New York, N.Y.)","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8672148","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8672148","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Patterns (N Y)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.patter.2021.100364","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.patter.2021.100364","pdf_url":"http://www.cell.com/article/S2666389921002269/pdf","source":{"id":"https://openalex.org/S4210198061","display_name":"Patterns","issn_l":"2666-3899","issn":["2666-3899"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Patterns","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5,"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16"},{"score":0.4399999976158142,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"awards":[{"id":"https://openalex.org/G5641919823","display_name":null,"funder_award_id":"T32HL007208","funder_id":"https://openalex.org/F4320314646","funder_display_name":"Sarnoff Cardiovascular Research Foundation"},{"id":"https://openalex.org/G5850737185","display_name":null,"funder_award_id":"MC_PC_17228","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6439313208","display_name":null,"funder_award_id":"1U01HG011719","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7770045845","display_name":null,"funder_award_id":"1K08HG010155","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320307762","display_name":"International Business Machines Corporation","ror":"https://ror.org/05hh8d621"},{"id":"https://openalex.org/F4320307771","display_name":"Bayer","ror":"https://ror.org/04hmn8g73"},{"id":"https://openalex.org/F4320307778","display_name":"Novartis","ror":"https://ror.org/02f9zrr09"},{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"},{"id":"https://openalex.org/F4320309111","display_name":"Columbia University","ror":"https://ror.org/00hj8s172"},{"id":"https://openalex.org/F4320309622","display_name":"Harvard University","ror":"https://ror.org/03vek6s52"},{"id":"https://openalex.org/F4320314070","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142"},{"id":"https://openalex.org/F4320314646","display_name":"Sarnoff Cardiovascular Research Foundation","ror":"https://ror.org/04csczr47"},{"id":"https://openalex.org/F4320315955","display_name":"Quest Diagnostics","ror":"https://ror.org/010g9bb70"},{"id":"https://openalex.org/F4320316729","display_name":"MyoKardia","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333796","display_name":"Novartis Institutes for BioMedical Research","ror":null},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3204068536.pdf","grobid_xml":"https://content.openalex.org/works/W3204068536.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W16445148","https://openalex.org/W1534477342","https://openalex.org/W1602160603","https://openalex.org/W2027486850","https://openalex.org/W2060219325","https://openalex.org/W2082704080","https://openalex.org/W2091139514","https://openalex.org/W2096750582","https://openalex.org/W2104355263","https://openalex.org/W2105577829","https://openalex.org/W2118310760","https://openalex.org/W2122825543","https://openalex.org/W2157076315","https://openalex.org/W2161569030","https://openalex.org/W2163697531","https://openalex.org/W2164434252","https://openalex.org/W2168536722","https://openalex.org/W2177870565","https://openalex.org/W2589093959","https://openalex.org/W2607031541","https://openalex.org/W2618596952","https://openalex.org/W2723723801","https://openalex.org/W2743269518","https://openalex.org/W2775393828","https://openalex.org/W2791673123","https://openalex.org/W2797120312","https://openalex.org/W2886752110","https://openalex.org/W2891822621","https://openalex.org/W2899469998","https://openalex.org/W2900295033","https://openalex.org/W2901728784","https://openalex.org/W2904059000","https://openalex.org/W2905879876","https://openalex.org/W2909786718","https://openalex.org/W2914874661","https://openalex.org/W2949495270","https://openalex.org/W2953059279","https://openalex.org/W2969693827","https://openalex.org/W3001764054","https://openalex.org/W3007698544","https://openalex.org/W3008788084","https://openalex.org/W3015631361","https://openalex.org/W3033773129","https://openalex.org/W3035885149","https://openalex.org/W3046684455","https://openalex.org/W3088425215","https://openalex.org/W3096943439","https://openalex.org/W3102476541","https://openalex.org/W3112624009","https://openalex.org/W3118545011","https://openalex.org/W3134600603","https://openalex.org/W3163870448","https://openalex.org/W4238251256","https://openalex.org/W6683362663","https://openalex.org/W6756049561","https://openalex.org/W6767281158","https://openalex.org/W6910681941"],"related_works":["https://openalex.org/W4285087457","https://openalex.org/W3113746618","https://openalex.org/W4226051228","https://openalex.org/W3017691140","https://openalex.org/W4384208482","https://openalex.org/W4244742767","https://openalex.org/W2470939431","https://openalex.org/W2024651825","https://openalex.org/W4401623684","https://openalex.org/W4395677717"],"abstract_inverted_index":{"Current":[0],"cardiovascular":[1],"risk":[2,64,86,111],"assessment":[3,127],"tools":[4],"use":[5],"a":[6,23,68,132],"small":[7],"number":[8],"of":[9,27,34,101,135],"predictors.":[10],"Here,":[11],"we":[12],"study":[13],"how":[14],"machine":[15],"learning":[16],"might:":[17],"(1)":[18],"enable":[19],"principled":[20],"selection":[21,124],"from":[22,58,94],"large":[24],"multimodal":[25],"set":[26],"candidate":[28],"variables":[29],"and":[30,48,75,116,125,138],"(2)":[31],"improve":[32],"prediction":[33],"incident":[35,102],"coronary":[36],"artery":[37],"disease":[38,139],"(CAD)":[39],"events.":[40],"An":[41],"elastic":[42],"net-based":[43],"Cox":[44],"model":[45,126],"(ML4H<sub>EN-COX</sub>)":[46],"trained":[47],"evaluated":[49],"in":[50,84],"173,274":[51],"UK":[52],"Biobank":[53],"participants":[54],"selected":[55,67],"51":[56],"predictors":[57],"13,782":[59],"candidates.":[60],"Beyond":[61],"most":[62],"traditional":[63],"factors,":[65],"ML4H<sub>EN-COX</sub>":[66,91,98],"polygenic":[69],"score,":[70,112],"waist":[71],"circumference,":[72],"socioeconomic":[73],"deprivation,":[74],"several":[76],"hematologic":[77],"indices.":[78],"A":[79],"more":[80],"than":[81],"30-fold":[82],"gradient":[83],"10-year":[85],"estimates":[87],"was":[88],"noted":[89],"across":[90],"quintiles,":[92],"ranging":[93],"0.25%":[95],"to":[96,122,131],"7.8%.":[97],"improved":[99],"discrimination":[100],"CAD":[103],"(C-statistic":[104],"=":[105],"0.796)":[106],"compared":[107],"with":[108],"the":[109],"Framingham":[110],"pooled":[113],"cohort":[114],"equations,":[115],"QRISK3":[117],"(range":[118],"0.754-0.761).":[119],"This":[120],"approach":[121],"variable":[123],"is":[128],"readily":[129],"generalizable":[130],"broad":[133],"range":[134],"complex":[136],"datasets":[137],"endpoints.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":11}],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-10T00:00:00"}
