{"id":"https://openalex.org/W7167584407","doi":"https://doi.org/10.1016/j.neuroimage.2026.122110","title":"DTI-ALPS index correlates with poor neuromodulation outcomes of bilateral STN-DBS in Parkinson's disease patients: A prospective cohort study","display_name":"DTI-ALPS index correlates with poor neuromodulation outcomes of bilateral STN-DBS in Parkinson's disease patients: A prospective cohort study","publication_year":2026,"publication_date":"2026-07-07","ids":{"openalex":"https://openalex.org/W7167584407","doi":"https://doi.org/10.1016/j.neuroimage.2026.122110","pmid":"https://pubmed.ncbi.nlm.nih.gov/42413886"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2026.122110","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2026.122110","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1053811926004258/pdf","source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S1053811926004258/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5140170953","display_name":"Sai Li","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sai Li","raw_affiliation_strings":["Department of Radiology, Xiangya Hospital Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Xiangya Hospital Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140210430","display_name":"Fangfang Xie","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangfang Xie","raw_affiliation_strings":["Department of Radiology, Xiangya Hospital Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Xiangya Hospital Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140202566","display_name":"Yazhi Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yazhi Chen","raw_affiliation_strings":["Department of Radiology, Xiangya Hospital Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Xiangya Hospital Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140172755","display_name":"Ruiting Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruiting Chen","raw_affiliation_strings":["Department of Radiology, Xiangya Hospital Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Xiangya Hospital Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140200822","display_name":"Weiwei Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiwei Zhang","raw_affiliation_strings":["Department of Radiology, Xiangya Hospital Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Xiangya Hospital Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042550493","display_name":"Dongcui Wang","orcid":"https://orcid.org/0000-0002-4435-2214"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dongcui Wang","raw_affiliation_strings":["Department of Radiology, Xiangya Hospital Central South University, Changsha, China; National Clinical Research Center for Geriatric Disease, Xiangya Hospital Central South University, Changsha, China; Hunan Engineering Research Center for Intelligent Medical Imaging, Furong Laboratory, Xiangya Hospital Central South University, Changsha, China. Electronic address: wangdongcui_bme@csu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-4435-2214","affiliations":[{"raw_affiliation_string":"Department of Radiology, Xiangya Hospital Central South University, Changsha, China; National Clinical Research Center for Geriatric Disease, Xiangya Hospital Central South University, Changsha, China; Hunan Engineering Research Center for Intelligent Medical Imaging, Furong Laboratory, Xiangya Hospital Central South University, Changsha, China. Electronic address: wangdongcui_bme@csu.edu.cn","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029851124","display_name":"Gaofeng Zhou","orcid":"https://orcid.org/0000-0002-1208-266X"},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gaofeng Zhou","raw_affiliation_strings":["Department of Radiology, Xiangya Hospital Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Xiangya Hospital Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5140191870","display_name":"Weihua Liao","orcid":null},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weihua Liao","raw_affiliation_strings":["Department of Radiology, Xiangya Hospital Central South University, Changsha, China; National Clinical Research Center for Geriatric Disease, Xiangya Hospital Central South University, Changsha, China; Hunan Engineering Research Center for Intelligent Medical Imaging, Furong Laboratory, Xiangya Hospital Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Xiangya Hospital Central South University, Changsha, China; National Clinical Research Center for Geriatric Disease, Xiangya Hospital Central South University, Changsha, China; Hunan Engineering Research Center for Intelligent Medical Imaging, Furong Laboratory, Xiangya Hospital Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042550493"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85544861,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"338","issue":null,"first_page":"122110","last_page":"122110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.4659999907016754,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.4659999907016754,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.19499999284744263,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.06750000268220901,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prospective-cohort-study","display_name":"Prospective cohort study","score":0.7519000172615051},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"Neuromodulation","score":0.6262000203132629},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5662000179290771},{"id":"https://openalex.org/keywords/cohort-study","display_name":"Cohort study","score":0.4986000061035156},{"id":"https://openalex.org/keywords/index","display_name":"Index (typography)","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8574000000953674},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.7519000172615051},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.6262000203132629},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5662000179290771},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4986000061035156},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45170000195503235},{"id":"https://openalex.org/C2777382242","wikidata":"https://www.wikidata.org/wiki/Q6017816","display_name":"Index (typography)","level":2,"score":0.44699999690055847},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3882000148296356},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2757999897003174},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2660999894142151},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.2574999928474426},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.2565999925136566}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neuroimage.2026.122110","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2026.122110","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1053811926004258/pdf","source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:42413886","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42413886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2026.122110","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2026.122110","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1053811926004258/pdf","source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"No poverty","score":0.6752470135688782,"id":"https://metadata.un.org/sdg/1"}],"awards":[{"id":"https://openalex.org/G105264036","display_name":null,"funder_award_id":"82471984","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1329747427","display_name":null,"funder_award_id":"91959117","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4291575008","display_name":null,"funder_award_id":"82071894","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8763999630","display_name":null,"funder_award_id":"U25A20137","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7167584407.pdf","grobid_xml":"https://content.openalex.org/works/W7167584407.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W2032254014","https://openalex.org/W2141499686","https://openalex.org/W2337323496","https://openalex.org/W2566072579","https://openalex.org/W2588487507","https://openalex.org/W2884183601","https://openalex.org/W2945136852","https://openalex.org/W2995052791","https://openalex.org/W2999695880","https://openalex.org/W3044413849","https://openalex.org/W3134185177","https://openalex.org/W3160795068","https://openalex.org/W3177112485","https://openalex.org/W3198793097","https://openalex.org/W3207156486","https://openalex.org/W3215813087","https://openalex.org/W4200239217","https://openalex.org/W4200513940","https://openalex.org/W4225133080","https://openalex.org/W4244530412","https://openalex.org/W4312128833","https://openalex.org/W4322719878","https://openalex.org/W4327685819","https://openalex.org/W4382278941","https://openalex.org/W4382658047","https://openalex.org/W4385295662","https://openalex.org/W4390697668","https://openalex.org/W4391348323","https://openalex.org/W4392294054","https://openalex.org/W4393376837","https://openalex.org/W4399971807","https://openalex.org/W4400563996","https://openalex.org/W4404586392","https://openalex.org/W4406098736","https://openalex.org/W4406536949","https://openalex.org/W4406748195","https://openalex.org/W4408301578","https://openalex.org/W4408465295","https://openalex.org/W4408967604","https://openalex.org/W4410601572","https://openalex.org/W4411449144","https://openalex.org/W4412089202","https://openalex.org/W4412198296","https://openalex.org/W4413050116","https://openalex.org/W4413164806","https://openalex.org/W4414064547","https://openalex.org/W4417281769","https://openalex.org/W7125493432","https://openalex.org/W7125948067","https://openalex.org/W7127284794","https://openalex.org/W7131301605","https://openalex.org/W7138905460"],"related_works":[],"abstract_inverted_index":{"This":[0],"prospective":[1],"study":[2],"evaluated":[3],"whether":[4],"preoperative":[5,43,211],"glymphatic":[6,173,186],"magnetic":[7],"resonance":[8],"imaging":[9],"(MRI)":[10],"markers":[11,174],"predict":[12],"subthalamic":[13],"nucleus":[14],"deep":[15],"brain":[16],"stimulation":[17],"(STN-DBS)":[18],"outcomes":[19],"in":[20,197],"Parkinson's":[21],"disease":[22],"(PD)":[23],"and":[24,66,87,108,131],"examined":[25],"the":[26,55,147,169],"mediating":[27],"role":[28],"of":[29,168],"levodopa":[30,132],"responsiveness.":[31],"111":[32],"patients":[33],"with":[34,121,179,193],"idiopathic":[35],"PD":[36],"scheduled":[37],"for":[38,166],"bilateral":[39,110],"STN-DBS":[40,123,151,195],"underwent":[41],"multimodal":[42],"MRI.":[44],"Glymphatic":[45],"indices-choroid":[46],"plexus":[47,63],"volume":[48],"(CPV),":[49],"diffusion":[50],"tensor":[51],"image":[52],"analysis":[53,144],"along":[54],"perivascular":[56,59],"space":[57,60],"(DTI-ALPS),":[58],"burden,":[61],"choroid":[62],"free-water":[64],"fraction,":[65],"global":[67],"blood-oxygen-level-dependent":[68],"cerebrospinal":[69],"fluid":[70],"coupling-were":[71],"quantified.":[72],"Patients":[73],"were":[74],"stratified":[75],"by":[76,156,189],"median":[77],"postoperative":[78],"motor":[79],"improvement":[80],"(52.4%)":[81],"into":[82],"high-":[83],"(n":[84,89],"=":[85,90,106,116,126,129,138,141],"55)":[86],"low-improvement":[88,94],"56)":[91],"groups.":[92],"The":[93],"group":[95],"showed":[96,175],"significantly":[97],"larger":[98],"total":[99,170],"CPV":[100],"(3353.7":[101],"vs":[102,113],"3199.4":[103],"mm\u00b3,":[104],"p":[105,115,128,140],"0.039)":[107],"lower":[109],"DTI-ALPS":[111,118,148,205],"(1.34":[112],"1.42,":[114],"0.004).":[117],"correlated":[119],"positively":[120],"both":[122],"outcome":[124,152],"(r":[125,137],"0.246,":[127],"0.009)":[130],"challenge":[133],"test":[134],"(LCT)":[135],"efficacy":[136],"0.196,":[139],"0.039).":[142],"Mediation":[143],"revealed":[145],"that":[146,185],"effect":[149,159],"on":[150],"was":[153],"partially":[154],"mediated":[155],"LCT":[157],"(indirect":[158],"0.096,":[160],"95%":[161],"bootstrap":[162],"CI":[163],"0.013-0.188),":[164],"accounting":[165],"50.8%":[167],"effect.":[171],"Other":[172],"no":[176],"significant":[177],"associations":[178],"DBS":[180],"outcome.":[181],"These":[182],"findings":[183],"indicate":[184],"dysfunction,":[187],"indexed":[188],"reduced":[190],"DTI-ALPS,":[191],"associates":[192],"poorer":[194],"response":[196],"PD,":[198],"acting":[199],"partly":[200],"through":[201],"diminished":[202],"dopaminergic":[203],"reserve.":[204],"may":[206],"serve":[207],"as":[208],"an":[209],"adjunctive":[210],"marker":[212],"to":[213],"improve":[214],"patient":[215],"selection":[216],"beyond":[217],"conventional":[218],"LCT.":[219]},"counts_by_year":[],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2026-07-08T00:00:00"}