{"id":"https://openalex.org/W7165681142","doi":"https://doi.org/10.1016/j.neuroimage.2026.122076","title":"Convergent imaging and genetic signatures of gray matter atrophy in Parkinson\u2019s disease","display_name":"Convergent imaging and genetic signatures of gray matter atrophy in Parkinson\u2019s disease","publication_year":2026,"publication_date":"2026-06-23","ids":{"openalex":"https://openalex.org/W7165681142","doi":"https://doi.org/10.1016/j.neuroimage.2026.122076","pmid":"https://pubmed.ncbi.nlm.nih.gov/42336304"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2026.122076","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2026.122076","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.neuroimage.2026.122076","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101566906","display_name":"Yingying Xie","orcid":"https://orcid.org/0000-0001-7575-6185"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingying Xie","raw_affiliation_strings":["Department of Radiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005, China; Department of Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350212, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005, China; Department of Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350212, China","institution_ids":["https://openalex.org/I4210121761","https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139206745","display_name":"Zihe Dong","orcid":null},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zihe Dong","raw_affiliation_strings":["Department of Radiology, Tianjin Key Laboratory of Functional Imaging & Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin, 300052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Tianjin Key Laboratory of Functional Imaging & Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin, 300052, China","institution_ids":["https://openalex.org/I2802534033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139135419","display_name":"Yurong Jiang","orcid":null},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yurong Jiang","raw_affiliation_strings":["Department of Radiology, Tianjin Key Laboratory of Functional Imaging & Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin, 300052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Tianjin Key Laboratory of Functional Imaging & Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin, 300052, China","institution_ids":["https://openalex.org/I2802534033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008073479","display_name":"Shiqi Lin","orcid":"https://orcid.org/0000-0003-1874-5900"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiqi Lin","raw_affiliation_strings":["Department of Radiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005, China; Department of Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350212, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005, China; Department of Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350212, China","institution_ids":["https://openalex.org/I4210121761","https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079148925","display_name":"xinying wang","orcid":null},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinying Wang","raw_affiliation_strings":["Department of Radiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005, China; Department of Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350212, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005, China; Department of Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350212, China","institution_ids":["https://openalex.org/I4210121761","https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031039106","display_name":"Jie Sun","orcid":"https://orcid.org/0000-0001-9848-3888"},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Sun","raw_affiliation_strings":["Department of Radiology, Tianjin Key Laboratory of Functional Imaging & Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin, 300052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Tianjin Key Laboratory of Functional Imaging & Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin, 300052, China","institution_ids":["https://openalex.org/I2802534033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029594874","display_name":"Ningnannan Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ningnannan Zhang","raw_affiliation_strings":["Department of Radiology, Tianjin Key Laboratory of Functional Imaging & Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin, 300052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Tianjin Key Laboratory of Functional Imaging & Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin, 300052, China","institution_ids":["https://openalex.org/I2802534033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139206257","display_name":"Zhang Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhang Zhang","raw_affiliation_strings":["Department of Radiology, Tianjin Key Laboratory of Functional Imaging & Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin, 300052, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Tianjin Key Laboratory of Functional Imaging & Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin, 300052, China","institution_ids":["https://openalex.org/I2802534033"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139178134","display_name":"Jiaojiao Du","orcid":null},"institutions":[{"id":"https://openalex.org/I2802573037","display_name":"Tianjin Medical University Cancer Institute and Hospital","ror":"https://ror.org/0152hn881","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802573037"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaojiao Du","raw_affiliation_strings":["Department of Breast Imaging, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin, China. Electronic address: du_9981@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Imaging, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, 300060, China; Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Tianjin, China. Electronic address: du_9981@163.com","institution_ids":["https://openalex.org/I2802573037"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009623493","display_name":"Huaigui Liu","orcid":"https://orcid.org/0000-0003-3660-3770"},"institutions":[{"id":"https://openalex.org/I2802534033","display_name":"Tianjin Medical University General Hospital","ror":"https://ror.org/003sav965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802534033"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huaigui Liu","raw_affiliation_strings":["Department of Radiology, Tianjin Key Laboratory of Functional Imaging & Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin, 300052, China; Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA. Electronic address: huaigui.liu@yale.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Tianjin Key Laboratory of Functional Imaging & Tianjin Institute of Radiology, Tianjin Medical University General Hospital, Tianjin, 300052, China; Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA. Electronic address: huaigui.liu@yale.edu","institution_ids":["https://openalex.org/I2802534033"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008972665","display_name":"Dairong Cao","orcid":"https://orcid.org/0000-0002-0051-3143"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dairong Cao","raw_affiliation_strings":["Department of Radiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005, China; Department of Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350212, China; Department of Radiology, Fujian Key Laboratory of Precision Medicine for Cancer, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005, China; Key Laboratory of Radiation Biology of Fujian Higher Education Institutions, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005, China. Electronic address: dairongcao@fjmu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-0051-3143","affiliations":[{"raw_affiliation_string":"Department of Radiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005, China; Department of Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350212, China; Department of Radiology, Fujian Key Laboratory of Precision Medicine for Cancer, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005, China; Key Laboratory of Radiation Biology of Fujian Higher Education Institutions, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, 350005, China. Electronic address: dairongcao@fjmu.edu.cn","institution_ids":["https://openalex.org/I4210121761","https://openalex.org/I129708740"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.91472024,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"338","issue":null,"first_page":"122076","last_page":"122076"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.6396999955177307,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.6396999955177307,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.2345000058412552,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrophy","display_name":"Atrophy","score":0.6337000131607056},{"id":"https://openalex.org/keywords/gray","display_name":"Gray (unit)","score":0.47429999709129333},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.46880000829696655},{"id":"https://openalex.org/keywords/convergent-evolution","display_name":"Convergent evolution","score":0.3912999927997589},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.36169999837875366}],"concepts":[{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.6337000131607056},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5403000116348267},{"id":"https://openalex.org/C166275286","wikidata":"https://www.wikidata.org/wiki/Q190095","display_name":"Gray (unit)","level":2,"score":0.47429999709129333},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.46880000829696655},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41370001435279846},{"id":"https://openalex.org/C62142553","wikidata":"https://www.wikidata.org/wiki/Q200312","display_name":"Convergent evolution","level":4,"score":0.3912999927997589},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3714999854564667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36579999327659607},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.36169999837875366},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.2985000014305115},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2939999997615814}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neuroimage.2026.122076","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2026.122076","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:42336304","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42336304","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2026.122076","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2026.122076","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1974687978","https://openalex.org/W1982535961","https://openalex.org/W2009573330","https://openalex.org/W2018363492","https://openalex.org/W2044240685","https://openalex.org/W2077347400","https://openalex.org/W2099085143","https://openalex.org/W2104549677","https://openalex.org/W2124649657","https://openalex.org/W2124757386","https://openalex.org/W2134967712","https://openalex.org/W2141820415","https://openalex.org/W2144048828","https://openalex.org/W2145954079","https://openalex.org/W2146738944","https://openalex.org/W2161633633","https://openalex.org/W2170576564","https://openalex.org/W2173304983","https://openalex.org/W2336893408","https://openalex.org/W2513927570","https://openalex.org/W2550736838","https://openalex.org/W2587082207","https://openalex.org/W2770092353","https://openalex.org/W2895486342","https://openalex.org/W2898896670","https://openalex.org/W2904647285","https://openalex.org/W2905452503","https://openalex.org/W2951617899","https://openalex.org/W2955341169","https://openalex.org/W2986932567","https://openalex.org/W2991564757","https://openalex.org/W3036199858","https://openalex.org/W3048484379","https://openalex.org/W3091722552","https://openalex.org/W3111678667","https://openalex.org/W3112344733","https://openalex.org/W3156441252","https://openalex.org/W3165269763","https://openalex.org/W3168436232","https://openalex.org/W3178180826","https://openalex.org/W3194973925","https://openalex.org/W3213562638","https://openalex.org/W4220838968","https://openalex.org/W4220974683","https://openalex.org/W4294215472","https://openalex.org/W4303984105","https://openalex.org/W4307494802","https://openalex.org/W4308834893","https://openalex.org/W4382182523","https://openalex.org/W4393227893","https://openalex.org/W4399128733","https://openalex.org/W4400848292","https://openalex.org/W4401713279","https://openalex.org/W4403048800","https://openalex.org/W4403414860","https://openalex.org/W4408593574","https://openalex.org/W4409972318","https://openalex.org/W4410900280","https://openalex.org/W4412038685","https://openalex.org/W4414601762","https://openalex.org/W4416413153"],"related_works":[],"abstract_inverted_index":{"Parkinson's":[0],"disease":[1],"(PD)":[2],"is":[3],"a":[4,56,175],"progressive":[5],"neurodegenerative":[6,196],"disorder":[7],"characterized":[8,155],"by":[9],"widespread":[10],"structural":[11,59,184],"brain":[12,19,183,197],"alterations,":[13],"yet":[14],"the":[15,42,95,156,179,193],"specific":[16],"patterns":[17,72,159],"of":[18,58,73,160,178],"atrophy":[20],"and":[21,67,76,98,120,129,147,199],"their":[22],"underlying":[23,195],"genetic":[24,43,180],"mechanisms":[25,194],"remain":[26],"incompletely":[27],"understood.":[28],"Here,":[29],"we":[30,90,116],"integrated":[31],"large-scale":[32],"neuroimaging":[33],"meta-analysis":[34,57],"with":[35,65,111,126],"population-scale":[36],"imaging":[37,88],"genetics":[38],"to":[39,51,186],"systematically":[40],"characterize":[41],"architecture":[44,181],"linking":[45,182],"gray":[46],"matter":[47],"volume":[48],"(GMV)":[49],"abnormalities":[50,185],"PD.":[52],"We":[53],"first":[54],"performed":[55,117],"MRI":[60],"studies":[61],"comprising":[62],"3212":[63],"patients":[64],"PD":[66,127],"2056":[68],"controls,":[69],"identifying":[70],"robust":[71],"GMV":[74,92,113,130],"reduction":[75],"assessing":[77],"differences":[78],"across":[79],"medication":[80],"states.":[81],"Using":[82],"these":[83,137,161,172],"meta-analytically":[84],"defined":[85],"regions":[86],"as":[87],"phenotypes,":[89],"extracted":[91],"measures":[93],"from":[94],"UK":[96],"Biobank":[97],"conducted":[99],"genome-wide":[100],"association":[101],"analysis":[102,105,119],"(GWAS).":[103],"This":[104],"identified":[106,121],"12":[107],"significant":[108],"SNPs":[109,123],"associated":[110,125],"PD-related":[112],"atrophy.":[114],"Furthermore,":[115],"pleiotropy":[118],"22":[122],"jointly":[124],"risk":[128],"reduction.":[131],"Functional":[132],"enrichment":[133],"analyses":[134,166],"revealed":[135],"that":[136],"shared":[138],"genes":[139],"converge":[140],"on":[141],"pathways":[142],"involved":[143],"in":[144],"clathrin-mediated":[145],"endocytosis":[146],"synaptic":[148],"vesicle":[149],"recycling.":[150],"Spatiotemporal":[151],"transcriptomic":[152],"profiling":[153],"further":[154],"developmental":[157],"expression":[158],"genes,":[162],"while":[163],"molecular":[164,190],"docking":[165],"suggested":[167],"potential":[168,200],"therapeutic":[169,203],"targets.":[170],"Together,":[171],"findings":[173],"provide":[174],"comprehensive":[176],"characterization":[177],"PD,":[187],"offering":[188],"new":[189],"insights":[191],"into":[192],"damage":[198],"avenues":[201],"for":[202],"intervention.":[204]},"counts_by_year":[],"updated_date":"2026-06-27T06:13:17.587685","created_date":"2026-06-24T00:00:00"}
