{"id":"https://openalex.org/W7144088654","doi":"https://doi.org/10.1016/j.neuroimage.2026.121901","title":"Dissociated glymphatic pathways mediates the neuronal hypometabolism on consciousness","display_name":"Dissociated glymphatic pathways mediates the neuronal hypometabolism on consciousness","publication_year":2026,"publication_date":"2026-03-31","ids":{"openalex":"https://openalex.org/W7144088654","doi":"https://doi.org/10.1016/j.neuroimage.2026.121901","pmid":"https://pubmed.ncbi.nlm.nih.gov/41933847"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2026.121901","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2026.121901","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.neuroimage.2026.121901","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5131442635","display_name":"Kun Guo","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Guo","raw_affiliation_strings":["Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China","institution_ids":["https://openalex.org/I9916479","https://openalex.org/I4210158926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5131358437","display_name":"Yirong Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yirong Wang","raw_affiliation_strings":["Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China","institution_ids":["https://openalex.org/I9916479","https://openalex.org/I4210158926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5131345339","display_name":"Zhiyong Quan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyong Quan","raw_affiliation_strings":["Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China","institution_ids":["https://openalex.org/I9916479","https://openalex.org/I4210158926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5131279367","display_name":"Guiyu Li","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guiyu Li","raw_affiliation_strings":["Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China","institution_ids":["https://openalex.org/I9916479","https://openalex.org/I4210158926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5131175415","display_name":"Yifei Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Yifei Zhang","raw_affiliation_strings":["Department of Diagnostic and Interventional Neuroradiology, Klinikum R.d. Isar, Technical University Munich, Ismaninger Str. 22, Munich 81675, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic and Interventional Neuroradiology, Klinikum R.d. Isar, Technical University Munich, Ismaninger Str. 22, Munich 81675, Germany","institution_ids":["https://openalex.org/I2802619606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023159660","display_name":"Steven Laureys","orcid":"https://orcid.org/0000-0002-3096-3807"},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Steven Laureys","raw_affiliation_strings":["School of Basic Medicine, Hangzhou Normal University, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medicine, Hangzhou Normal University, Hangzhou, China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5131156375","display_name":"Fei Kang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fei Kang","raw_affiliation_strings":["Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China. Electronic address: fmmukangf@fmmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China. Electronic address: fmmukangf@fmmu.edu.cn","institution_ids":["https://openalex.org/I9916479","https://openalex.org/I4210158926"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5131206074","display_name":"Jing Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China. Electronic address: 13909245902@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China. Electronic address: 13909245902@163.com","institution_ids":["https://openalex.org/I9916479","https://openalex.org/I4210158926"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5131156375","https://openalex.org/A5131206074"],"corresponding_institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33236575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"332","issue":null,"first_page":"121901","last_page":"121901"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13966","display_name":"Neurological and metabolic disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glymphatic-system","display_name":"Glymphatic system","score":0.864799976348877},{"id":"https://openalex.org/keywords/consciousness","display_name":"Consciousness","score":0.5389000177383423},{"id":"https://openalex.org/keywords/human-brain","display_name":"Human brain","score":0.32850000262260437},{"id":"https://openalex.org/keywords/brain-mapping","display_name":"Brain mapping","score":0.2703000009059906},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"Cortical neurons","score":0.24770000576972961}],"concepts":[{"id":"https://openalex.org/C101054994","wikidata":"https://www.wikidata.org/wiki/Q15474254","display_name":"Glymphatic system","level":3,"score":0.864799976348877},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.734000027179718},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7009000182151794},{"id":"https://openalex.org/C186720457","wikidata":"https://www.wikidata.org/wiki/Q7087","display_name":"Consciousness","level":2,"score":0.5389000177383423},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.32850000262260437},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.2703000009059906},{"id":"https://openalex.org/C2983650178","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cortical neurons","level":2,"score":0.24770000576972961},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.23729999363422394},{"id":"https://openalex.org/C171525899","wikidata":"https://www.wikidata.org/wiki/Q17029618","display_name":"Level of consciousness","level":2,"score":0.22589999437332153},{"id":"https://openalex.org/C13019672","wikidata":"https://www.wikidata.org/wiki/Q282250","display_name":"Qualia","level":3,"score":0.22269999980926514}],"mesh":[{"descriptor_ui":"D000077502","descriptor_name":"Glymphatic System","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000077502","descriptor_name":"Glymphatic System","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000077502","descriptor_name":"Glymphatic System","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000077502","descriptor_name":"Glymphatic System","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000077502","descriptor_name":"Glymphatic System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000077502","descriptor_name":"Glymphatic System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000077502","descriptor_name":"Glymphatic System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000077502","descriptor_name":"Glymphatic System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000077502","descriptor_name":"Glymphatic System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000077502","descriptor_name":"Glymphatic System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003243","descriptor_name":"Consciousness","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003243","descriptor_name":"Consciousness","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003244","descriptor_name":"Consciousness Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003244","descriptor_name":"Consciousness Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003244","descriptor_name":"Consciousness Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003244","descriptor_name":"Consciousness Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D003244","descriptor_name":"Consciousness Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003244","descriptor_name":"Consciousness Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003244","descriptor_name":"Consciousness Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003244","descriptor_name":"Consciousness Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003244","descriptor_name":"Consciousness Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003244","descriptor_name":"Consciousness Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003244","descriptor_name":"Consciousness Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003244","descriptor_name":"Consciousness Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.neuroimage.2026.121901","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2026.121901","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:41933847","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41933847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":null},{"id":"pmh:oai:doaj.org/article:f1d8712d7263443d8faf5162a47d43ad","is_oa":true,"landing_page_url":"https://doaj.org/article/f1d8712d7263443d8faf5162a47d43ad","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NeuroImage, Vol 332, Iss , Pp 121901- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2026.121901","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2026.121901","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.5827533602714539}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1767010801","https://openalex.org/W2116913455","https://openalex.org/W2588487507","https://openalex.org/W2982626951","https://openalex.org/W3061859479","https://openalex.org/W3082563867","https://openalex.org/W3113180287","https://openalex.org/W3136604612","https://openalex.org/W3159612269","https://openalex.org/W4206120164","https://openalex.org/W4234288678","https://openalex.org/W4284965351","https://openalex.org/W4296343725","https://openalex.org/W4378516855","https://openalex.org/W4379508166","https://openalex.org/W4385329985","https://openalex.org/W4390109266","https://openalex.org/W4392185125","https://openalex.org/W4392242192","https://openalex.org/W4392710982","https://openalex.org/W4394739055","https://openalex.org/W4399817107","https://openalex.org/W4410481886","https://openalex.org/W4410961058","https://openalex.org/W4411263127","https://openalex.org/W4412645410","https://openalex.org/W4412679513","https://openalex.org/W4413305172"],"related_works":[],"abstract_inverted_index":{"We":[0,16],"examine":[1],"whether":[2],"glymphatic":[3,61],"metrics":[4],"play":[5],"a":[6,55,128],"mediating":[7],"role":[8],"between":[9,58],"regional":[10],"metabolic":[11],"deficits":[12],"and":[13,35,50,67,114],"impaired":[14,134],"consciousness.":[15,122,135],"find":[17],"that":[18],"compared":[19],"to":[20,118],"healthy":[21],"controls,":[22],"prolonged":[23],"disorders":[24],"of":[25],"consciousness":[26],"(pDoC)":[27],"patients":[28],"exhibited":[29],"significant":[30],"reduced":[31],"blood":[32],"oxygen":[33],"level-dependent":[34],"cerebrospinal":[36],"fluid":[37],"signals":[38],"(BOLD-CSF":[39],"coupling),":[40],"diffusion":[41],"tensor":[42],"imaging":[43],"along":[44],"the":[45,59],"perivascular":[46],"space":[47],"(DTI-ALPS)":[48],"index,":[49],"cerebral":[51],"glucose":[52,82,96],"metabolism,":[53,113],"alongside":[54],"disrupted":[56],"relationship":[57],"two":[60],"metrics.":[62],"Second,":[63],"both":[64],"BOLD-CSF":[65,107],"coupling":[66,108],"DTI-ALPS":[68,115],"index":[69],"correlated":[70,86],"positively":[71,85],"with":[72,87,111],"CRS-R":[73],"scores":[74,89],"(r":[75,90],"=":[76,91],"0.317-0.450,":[77],"p":[78],"<":[79],"0.001).":[80],"Cortical":[81],"metabolism":[83,97,120],"was":[84],"behavioral":[88],"0.365-0.414,":[92],"p<0.01),":[93],"whereas":[94],"subcortical":[95,119],"showed":[98],"non-significant":[99],"negative":[100],"correlation":[101],"(r=-0.018-0.159,":[102],"p>0.05).":[103],"Last,":[104],"we":[105],"reveal":[106],"preferentially":[109,116],"associated":[110],"cortical":[112],"linked":[117],"on":[121],"This":[123],"two-pathway":[124],"glymphatic-metabolic":[125],"framework":[126],"provides":[127],"novel":[129],"integrative":[130],"mechanism":[131],"for":[132],"understanding":[133]},"counts_by_year":[],"updated_date":"2026-07-17T09:13:05.818461","created_date":"2026-04-01T00:00:00"}