{"id":"https://openalex.org/W4311448611","doi":"https://doi.org/10.1016/j.neuroimage.2022.119782","title":"Whole-brain modeling explains the context-dependent effects of cholinergic neuromodulation","display_name":"Whole-brain modeling explains the context-dependent effects of cholinergic neuromodulation","publication_year":2022,"publication_date":"2022-12-01","ids":{"openalex":"https://openalex.org/W4311448611","doi":"https://doi.org/10.1016/j.neuroimage.2022.119782","pmid":"https://pubmed.ncbi.nlm.nih.gov/36464098"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2022.119782","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2022.119782","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.neuroimage.2022.119782","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004551398","display_name":"Carlos Coronel\u2010Oliveros","orcid":"https://orcid.org/0000-0002-9428-2410"},"institutions":[{"id":"https://openalex.org/I21067949","display_name":"Adolfo Ib\u00e1\u00f1ez University","ror":"https://ror.org/0326knt82","country_code":"CL","type":"education","lineage":["https://openalex.org/I21067949"]},{"id":"https://openalex.org/I79274474","display_name":"University of Valpara\u00edso","ror":"https://ror.org/00h9jrb69","country_code":"CL","type":"education","lineage":["https://openalex.org/I79274474"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Carlos Coronel-Oliveros","raw_affiliation_strings":["Doctorado en Ciencias Menci\u00f3n Biof\u00edsica y Biolog\u00eda Computacional, Universidad de Valpara\u00edso, Valpara\u00edso, Chile; Latin American Health Brain Institute (BrainLat), Universidad Adolfo Ib\u00e1\u00f1ez, Santiago, Chile; Centro Interdisciplinario de Neurociencia de Valpara\u00edso (CINV), Universidad de Valpara\u00edso, Valpara\u00edso, Chile","Centro Interdisciplinario de Neurociencia de Valpara\u00edso (CINV), Universidad de Valpara\u00edso, Valpara\u00edso, Chile","Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ib\u00e1\u00f1ez, Santiago, Chile","Doctorado en Ciencias Menci\u00f3n Biof\u00edsica y Biolog\u00eda Computacional, Universidad de Valpara\u00edso, Valpara\u00edso, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctorado en Ciencias Menci\u00f3n Biof\u00edsica y Biolog\u00eda Computacional, Universidad de Valpara\u00edso, Valpara\u00edso, Chile; Latin American Health Brain Institute (BrainLat), Universidad Adolfo Ib\u00e1\u00f1ez, Santiago, Chile; Centro Interdisciplinario de Neurociencia de Valpara\u00edso (CINV), Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]},{"raw_affiliation_string":"Centro Interdisciplinario de Neurociencia de Valpara\u00edso (CINV), Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]},{"raw_affiliation_string":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ib\u00e1\u00f1ez, Santiago, Chile","institution_ids":["https://openalex.org/I21067949"]},{"raw_affiliation_string":"Doctorado en Ciencias Menci\u00f3n Biof\u00edsica y Biolog\u00eda Computacional, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000285220","display_name":"Carsten Gie\u00dfing","orcid":"https://orcid.org/0000-0002-3293-0937"},"institutions":[{"id":"https://openalex.org/I129877168","display_name":"Carl von Ossietzky Universit\u00e4t Oldenburg","ror":"https://ror.org/033n9gh91","country_code":"DE","type":"education","lineage":["https://openalex.org/I129877168"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carsten Gie\u00dfing","raw_affiliation_strings":["Carl von Ossietzky University of Oldenburg, Department of Psychology, Oldenburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carl von Ossietzky University of Oldenburg, Department of Psychology, Oldenburg, Germany","institution_ids":["https://openalex.org/I129877168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021928342","display_name":"Vicente Medel","orcid":"https://orcid.org/0000-0003-2443-8683"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I21067949","display_name":"Adolfo Ib\u00e1\u00f1ez University","ror":"https://ror.org/0326knt82","country_code":"CL","type":"education","lineage":["https://openalex.org/I21067949"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["AU","CL"],"is_corresponding":false,"raw_author_name":"Vicente Medel","raw_affiliation_strings":["Latin American Health Brain Institute (BrainLat), Universidad Adolfo Ib\u00e1\u00f1ez, Santiago, Chile; University of Sydney, Brain and Mind Centre, Sydney, Australia; Universidad de Chile, Departamento de Neurociencia, Santiago, Chile","University of Sydney, Brain and Mind Centre, Sydney, Australia","Universidad de Chile, Departamento de Neurociencia, Santiago, Chile","Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ib\u00e1\u00f1ez, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Latin American Health Brain Institute (BrainLat), Universidad Adolfo Ib\u00e1\u00f1ez, Santiago, Chile; University of Sydney, Brain and Mind Centre, Sydney, Australia; Universidad de Chile, Departamento de Neurociencia, Santiago, Chile","institution_ids":["https://openalex.org/I21067949"]},{"raw_affiliation_string":"University of Sydney, Brain and Mind Centre, Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"Universidad de Chile, Departamento de Neurociencia, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ib\u00e1\u00f1ez, Santiago, Chile","institution_ids":["https://openalex.org/I21067949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036519378","display_name":"Rodrigo Cofr\u00e9","orcid":"https://orcid.org/0000-0002-7498-7122"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210086740","display_name":"Institut des Neurosciences Paris-Saclay","ror":"https://ror.org/002v40q27","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I4210086740"]},{"id":"https://openalex.org/I79274474","display_name":"University of Valpara\u00edso","ror":"https://ror.org/00h9jrb69","country_code":"CL","type":"education","lineage":["https://openalex.org/I79274474"]}],"countries":["CL","FR"],"is_corresponding":false,"raw_author_name":"Rodrigo Cofr\u00e9","raw_affiliation_strings":["Institute of Neuroscience (NeuroPSI), Paris-Saclay University, Centre National de la Recherche Scientifique (CNRS), Gif-sur-Yvette, France; CIMFAV-Ingemat, Facultad de Ingenier\u00eda, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","Institute of Neuroscience (NeuroPSI), Paris-Saclay University, Centre National de la Recherche Scientifique (CNRS), Gif-sur-Yvette, France","CIMFAV-Ingemat, Facultad de Ingenier\u00eda, Universidad de Valpara\u00edso, Valpara\u00edso, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience (NeuroPSI), Paris-Saclay University, Centre National de la Recherche Scientifique (CNRS), Gif-sur-Yvette, France; CIMFAV-Ingemat, Facultad de Ingenier\u00eda, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I79274474","https://openalex.org/I4210086740","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Institute of Neuroscience (NeuroPSI), Paris-Saclay University, Centre National de la Recherche Scientifique (CNRS), Gif-sur-Yvette, France","institution_ids":["https://openalex.org/I4210086740","https://openalex.org/I277688954","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"CIMFAV-Ingemat, Facultad de Ingenier\u00eda, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042230025","display_name":"Patricio Orio","orcid":"https://orcid.org/0000-0003-0332-8098"},"institutions":[{"id":"https://openalex.org/I21067949","display_name":"Adolfo Ib\u00e1\u00f1ez University","ror":"https://ror.org/0326knt82","country_code":"CL","type":"education","lineage":["https://openalex.org/I21067949"]},{"id":"https://openalex.org/I79274474","display_name":"University of Valpara\u00edso","ror":"https://ror.org/00h9jrb69","country_code":"CL","type":"education","lineage":["https://openalex.org/I79274474"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Patricio Orio","raw_affiliation_strings":["Latin American Health Brain Institute (BrainLat), Universidad Adolfo Ib\u00e1\u00f1ez, Santiago, Chile; Instituto de Neurociencia, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile. Electronic address: patricio.orio@uv.cl","Centro Interdisciplinario de Neurociencia de Valpara\u00edso (CINV), Universidad de Valpara\u00edso, Valpara\u00edso, Chile","Instituto de Neurociencia, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile"],"raw_orcid":"https://orcid.org/0000-0003-0332-8098","affiliations":[{"raw_affiliation_string":"Latin American Health Brain Institute (BrainLat), Universidad Adolfo Ib\u00e1\u00f1ez, Santiago, Chile; Instituto de Neurociencia, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile. Electronic address: patricio.orio@uv.cl","institution_ids":["https://openalex.org/I79274474","https://openalex.org/I21067949"]},{"raw_affiliation_string":"Centro Interdisciplinario de Neurociencia de Valpara\u00edso (CINV), Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]},{"raw_affiliation_string":"Instituto de Neurociencia, Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile","institution_ids":["https://openalex.org/I79274474"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5042230025"],"corresponding_institution_ids":["https://openalex.org/I21067949","https://openalex.org/I79274474"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":2.3671,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.89098673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"265","issue":null,"first_page":"119782","last_page":"119782"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuromodulation","display_name":"Neuromodulation","score":0.7499879002571106},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7354564666748047},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6802275776863098},{"id":"https://openalex.org/keywords/cholinergic","display_name":"Cholinergic","score":0.6737115979194641},{"id":"https://openalex.org/keywords/connectome","display_name":"Connectome","score":0.5652600526809692},{"id":"https://openalex.org/keywords/resting-state-fmri","display_name":"Resting state fMRI","score":0.56346195936203},{"id":"https://openalex.org/keywords/nicotine","display_name":"Nicotine","score":0.5316627025604248},{"id":"https://openalex.org/keywords/nicotinic-agonist","display_name":"Nicotinic agonist","score":0.4398497939109802},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.4298016428947449},{"id":"https://openalex.org/keywords/human-connectome-project","display_name":"Human Connectome Project","score":0.4161931276321411},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.39962926506996155},{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"Functional connectivity","score":0.3995167016983032},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19398581981658936},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.10834646224975586}],"concepts":[{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.7499879002571106},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7354564666748047},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6802275776863098},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.6737115979194641},{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.5652600526809692},{"id":"https://openalex.org/C66324658","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Resting state fMRI","level":2,"score":0.56346195936203},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.5316627025604248},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.4398497939109802},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4298016428947449},{"id":"https://openalex.org/C97820695","wikidata":"https://www.wikidata.org/wiki/Q387749","display_name":"Human Connectome Project","level":3,"score":0.4161931276321411},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.39962926506996155},{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.3995167016983032},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19398581981658936},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.10834646224975586},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018678","descriptor_name":"Cholinergic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018678","descriptor_name":"Cholinergic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018678","descriptor_name":"Cholinergic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D063132","descriptor_name":"Connectome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063132","descriptor_name":"Connectome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063132","descriptor_name":"Connectome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.neuroimage.2022.119782","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2022.119782","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:36464098","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36464098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":null},{"id":"pmh:oai:doaj.org/article:d66384a39d924885b7b5d4dfb6cb1602","is_oa":true,"landing_page_url":"https://doaj.org/article/d66384a39d924885b7b5d4dfb6cb1602","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NeuroImage, Vol 265, Iss , Pp 119782- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2022.119782","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2022.119782","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.75}],"awards":[{"id":"https://openalex.org/G304931185","display_name":null,"funder_award_id":"ACE210014","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G3581527718","display_name":null,"funder_award_id":"1211750","funder_id":"https://openalex.org/F4320338073","funder_display_name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico"},{"id":"https://openalex.org/G5725698890","display_name":null,"funder_award_id":"GI 682/2-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7976644409","display_name":null,"funder_award_id":"H2020-945539","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320331146","display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","ror":null},{"id":"https://openalex.org/F4320338073","display_name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","ror":"https://ror.org/02ap3w078"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":116,"referenced_works":["https://openalex.org/W175152164","https://openalex.org/W1886029756","https://openalex.org/W1974105735","https://openalex.org/W1980074774","https://openalex.org/W1986212001","https://openalex.org/W1987430298","https://openalex.org/W1987883688","https://openalex.org/W1990134753","https://openalex.org/W1993770350","https://openalex.org/W1999653836","https://openalex.org/W2001241739","https://openalex.org/W2005821483","https://openalex.org/W2007913356","https://openalex.org/W2014604103","https://openalex.org/W2015303758","https://openalex.org/W2018843105","https://openalex.org/W2024729467","https://openalex.org/W2026868086","https://openalex.org/W2032970627","https://openalex.org/W2035946761","https://openalex.org/W2036322060","https://openalex.org/W2043783389","https://openalex.org/W2055762844","https://openalex.org/W2058046532","https://openalex.org/W2060464767","https://openalex.org/W2068375947","https://openalex.org/W2070765152","https://openalex.org/W2085190125","https://openalex.org/W2085435800","https://openalex.org/W2090264816","https://openalex.org/W2093972428","https://openalex.org/W2096705406","https://openalex.org/W2099457853","https://openalex.org/W2100145912","https://openalex.org/W2100157657","https://openalex.org/W2100831964","https://openalex.org/W2109606373","https://openalex.org/W2110065044","https://openalex.org/W2117882336","https://openalex.org/W2126838454","https://openalex.org/W2132917711","https://openalex.org/W2133316979","https://openalex.org/W2138351621","https://openalex.org/W2138790588","https://openalex.org/W2145935269","https://openalex.org/W2148606196","https://openalex.org/W2149446634","https://openalex.org/W2153234270","https://openalex.org/W2167822639","https://openalex.org/W2171614525","https://openalex.org/W2343741871","https://openalex.org/W2468478141","https://openalex.org/W2503929286","https://openalex.org/W2505862500","https://openalex.org/W2526529257","https://openalex.org/W2557390385","https://openalex.org/W2583548943","https://openalex.org/W2606296795","https://openalex.org/W2608309726","https://openalex.org/W2729610843","https://openalex.org/W2752480938","https://openalex.org/W2753248866","https://openalex.org/W2755489713","https://openalex.org/W2788231085","https://openalex.org/W2793464911","https://openalex.org/W2799718848","https://openalex.org/W2808826367","https://openalex.org/W2893373014","https://openalex.org/W2896341253","https://openalex.org/W2908164247","https://openalex.org/W2911129983","https://openalex.org/W2915889284","https://openalex.org/W2944341921","https://openalex.org/W2946338965","https://openalex.org/W2951617899","https://openalex.org/W2952216243","https://openalex.org/W2958093451","https://openalex.org/W2961532790","https://openalex.org/W2966582223","https://openalex.org/W2969829800","https://openalex.org/W2994770413","https://openalex.org/W3007736625","https://openalex.org/W3033513666","https://openalex.org/W3035258118","https://openalex.org/W3047141578","https://openalex.org/W3081519314","https://openalex.org/W3089377940","https://openalex.org/W3093680025","https://openalex.org/W3108782277","https://openalex.org/W3112429219","https://openalex.org/W3118747434","https://openalex.org/W3143232882","https://openalex.org/W3156578882","https://openalex.org/W3159931622","https://openalex.org/W3163968030","https://openalex.org/W3164240626","https://openalex.org/W3180578469","https://openalex.org/W3186256997","https://openalex.org/W3203227088","https://openalex.org/W3207722339","https://openalex.org/W3208540452","https://openalex.org/W4220838968","https://openalex.org/W4224217494","https://openalex.org/W4254419114","https://openalex.org/W4280541240","https://openalex.org/W4281564634","https://openalex.org/W4294295396","https://openalex.org/W4303454044","https://openalex.org/W6601706622","https://openalex.org/W6639330730","https://openalex.org/W6771773045","https://openalex.org/W6787518488","https://openalex.org/W6791363546","https://openalex.org/W6798861073","https://openalex.org/W6802412284","https://openalex.org/W6802856029"],"related_works":["https://openalex.org/W3136590534","https://openalex.org/W4280586040","https://openalex.org/W2523870064","https://openalex.org/W4298370694","https://openalex.org/W4306360841","https://openalex.org/W3126842272","https://openalex.org/W3117051909","https://openalex.org/W2775079844","https://openalex.org/W4393477281","https://openalex.org/W4393909126"],"abstract_inverted_index":{"Integration":[0],"and":[1,15,29,57,70,79,103,120,143,146,174,218],"segregation":[2,139,213,222],"are":[3,149],"two":[4],"fundamental":[5],"principles":[6],"of":[7,36,44,65,101,131,187],"brain":[8,11,49],"organization.":[9],"The":[10,110],"manages":[12],"the":[13,42,45,63,99,117,127,147,153,158,180,184,188,194,203],"transitions":[14],"balance":[16],"between":[17,170],"different":[18],"functional":[19,50,68,138,165,171,197,212],"segregated":[20],"or":[21],"integrated":[22],"states":[23],"through":[24],"neuromodulatory":[25],"systems.":[26],"Recently,":[27],"computational":[28,58],"experimental":[30],"studies":[31],"suggest":[32,219],"a":[33,87,94,168,215],"pro-segregation":[34],"effect":[35,112],"cholinergic":[37,46,209],"neuromodulation.":[38],"Here,":[39],"we":[40,61,85,177],"studied":[41],"effects":[43,64,100,130,148],"system":[47],"on":[48,67],"connectivity":[51,69],"using":[52,93],"both":[53,116,141],"empirical":[54,142,181],"fMRI":[55],"data":[56,182],"modeling.":[59],"First,":[60],"analyzed":[62],"nicotine":[66,102,136,201],"network":[71,172],"topology":[72,173],"in":[73,140,157,179,196,214],"healthy":[74],"subjects":[75],"during":[76,80,152,202],"resting-state":[77],"conditions":[78],"an":[81],"attentional":[82],"task.":[83,204],"Then,":[84],"employed":[86],"whole-brain":[88],"neural":[89],"mass":[90],"model":[91],"interconnected":[92],"human":[95],"connectome":[96],"to":[97],"simulate":[98],"investigate":[104],"causal":[105],"mechanisms":[106],"for":[107,225],"these":[108],"changes.":[109],"drug":[111],"was":[113],"modeled":[114],"decreasing":[115],"global":[118],"coupling":[119],"local":[121],"feedback":[122],"inhibition":[123],"parameters,":[124],"consistent":[125],"with":[126,164,193],"known":[128],"cellular":[129],"acetylcholine.":[132],"We":[133],"found":[134,178],"that":[135,183,208,220],"incremented":[137],"simulated":[144],"data,":[145],"context-dependent:":[150],"observed":[151],"task,":[154],"but":[155],"not":[156],"resting":[159],"state.":[160],"In-task":[161],"performance":[162],"correlates":[163,192],"segregation,":[166],"establishing":[167],"link":[169],"behavior.":[175],"Furthermore,":[176],"regional":[185],"density":[186],"nicotinic":[189],"acetylcholine":[190],"\u03b14\u03b22":[191],"decrease":[195],"nodal":[198],"strength":[199],"by":[200],"Our":[205],"results":[206],"confirm":[207],"neuromodulation":[210],"promotes":[211],"context-dependent":[216],"fashion,":[217],"this":[221],"is":[223],"suited":[224],"simple":[226],"visual-attentional":[227],"tasks.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4}],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-10-10T00:00:00"}
