{"id":"https://openalex.org/W4308389032","doi":"https://doi.org/10.1016/j.neuroimage.2022.119740","title":"Neurometabolic timecourse of healthy aging","display_name":"Neurometabolic timecourse of healthy aging","publication_year":2022,"publication_date":"2022-11-07","ids":{"openalex":"https://openalex.org/W4308389032","doi":"https://doi.org/10.1016/j.neuroimage.2022.119740","pmid":"https://pubmed.ncbi.nlm.nih.gov/36356822"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2022.119740","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2022.119740","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.neuroimage.2022.119740","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026626272","display_name":"Tao Gong","orcid":"https://orcid.org/0000-0001-9689-0420"},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Gong","raw_affiliation_strings":["Departments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China; Departments of Radiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China","Departments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China","Departments of Radiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China; Departments of Radiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Departments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Departments of Radiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052146287","display_name":"Steve C. N. Hui","orcid":"https://orcid.org/0000-0002-1523-4040"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve C.N. Hui","raw_affiliation_strings":["The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America","F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I1298154867","https://openalex.org/I145311948"]},{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I1298154867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021332146","display_name":"Helge J. Z\u00f6llner","orcid":"https://orcid.org/0000-0002-7148-292X"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helge J. Z\u00f6llner","raw_affiliation_strings":["The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I1298154867","https://openalex.org/I145311948"]},{"raw_affiliation_string":"F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I1298154867"]},{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078545244","display_name":"Mark K. Britton","orcid":"https://orcid.org/0000-0003-4261-1806"},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037"]},{"id":"https://openalex.org/I4210097518","display_name":"McKnight Brain Research Foundation","ror":"https://ror.org/00vsf1v04","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210097518"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210159958","display_name":"Cognitive Research (United States)","ror":"https://ror.org/04s361q55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159958"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Britton","raw_affiliation_strings":["Center for Cognitive Aging and Memory, University of Florida, Gainesville, FL, United States of America; McKnight Brain Research Foundation, University of Florida, FL, United States of America; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States of America","Center for Cognitive Aging and Memory, University of Florida, Gainesville, FL, United States of America","Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States of America","McKnight Brain Research Foundation, University of Florida, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cognitive Aging and Memory, University of Florida, Gainesville, FL, United States of America; McKnight Brain Research Foundation, University of Florida, FL, United States of America; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States of America","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I2800717037"]},{"raw_affiliation_string":"Center for Cognitive Aging and Memory, University of Florida, Gainesville, FL, United States of America","institution_ids":["https://openalex.org/I4210159958","https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States of America","institution_ids":["https://openalex.org/I2800717037"]},{"raw_affiliation_string":"McKnight Brain Research Foundation, University of Florida, FL, United States of America","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4210097518"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076268554","display_name":"Yulu Song","orcid":"https://orcid.org/0000-0002-4416-7959"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yulu Song","raw_affiliation_strings":["The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America","F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I1298154867","https://openalex.org/I145311948"]},{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I1298154867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100628851","display_name":"Yufan Chen","orcid":"https://orcid.org/0000-0002-3501-9807"},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yufan Chen","raw_affiliation_strings":["Departments of Radiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I154099455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023304492","display_name":"Aaron T. Gudmundson","orcid":"https://orcid.org/0000-0001-5104-0959"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron T. Gudmundson","raw_affiliation_strings":["Department of Neurobiology and Behavior, University of California, Irvine, CA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Behavior, University of California, Irvine, CA, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006652565","display_name":"Kathleen E. Hupfeld","orcid":"https://orcid.org/0000-0001-5086-4841"},"institutions":[{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen E. Hupfeld","raw_affiliation_strings":["The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I1298154867","https://openalex.org/I145311948"]},{"raw_affiliation_string":"F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I1298154867"]},{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080343973","display_name":"Christopher W. Davies\u2010Jenkins","orcid":"https://orcid.org/0000-0002-6015-762X"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher W. Davies-Jenkins","raw_affiliation_strings":["The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I1298154867","https://openalex.org/I145311948"]},{"raw_affiliation_string":"F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I1298154867"]},{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063439400","display_name":"Saipavitra Murali\u2010Manohar","orcid":"https://orcid.org/0000-0002-4978-0736"},"institutions":[{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Saipavitra Murali-Manohar","raw_affiliation_strings":["The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America","F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I1298154867","https://openalex.org/I145311948"]},{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I1298154867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068080913","display_name":"Eric C. Porges","orcid":"https://orcid.org/0000-0003-3885-5859"},"institutions":[{"id":"https://openalex.org/I4210097518","display_name":"McKnight Brain Research Foundation","ror":"https://ror.org/00vsf1v04","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210097518"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037"]},{"id":"https://openalex.org/I4210159958","display_name":"Cognitive Research (United States)","ror":"https://ror.org/04s361q55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210159958"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric C. Porges","raw_affiliation_strings":["Center for Cognitive Aging and Memory, University of Florida, Gainesville, FL, United States of America; McKnight Brain Research Foundation, University of Florida, FL, United States of America; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States of America","Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States of America","McKnight Brain Research Foundation, University of Florida, FL, United States of America","Center for Cognitive Aging and Memory, University of Florida, Gainesville, FL, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cognitive Aging and Memory, University of Florida, Gainesville, FL, United States of America; McKnight Brain Research Foundation, University of Florida, FL, United States of America; Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States of America","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I2800717037"]},{"raw_affiliation_string":"Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States of America","institution_ids":["https://openalex.org/I2800717037"]},{"raw_affiliation_string":"McKnight Brain Research Foundation, University of Florida, FL, United States of America","institution_ids":["https://openalex.org/I33213144","https://openalex.org/I4210097518"]},{"raw_affiliation_string":"Center for Cognitive Aging and Memory, University of Florida, Gainesville, FL, United States of America","institution_ids":["https://openalex.org/I4210159958","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025672631","display_name":"Georg Oeltzschner","orcid":"https://orcid.org/0000-0003-3083-9811"},"institutions":[{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Georg Oeltzschner","raw_affiliation_strings":["The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America","F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I1298154867","https://openalex.org/I145311948"]},{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I1298154867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101909857","display_name":"Weibo Chen","orcid":"https://orcid.org/0000-0002-4727-3642"},"institutions":[{"id":"https://openalex.org/I4210086647","display_name":"Philips (China)","ror":"https://ror.org/001tk4253","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210086647","https://openalex.org/I4210122849"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weibo Chen","raw_affiliation_strings":["Philips Healthcare, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philips Healthcare, Shanghai, China","institution_ids":["https://openalex.org/I4210086647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017257163","display_name":"Guangbin Wang","orcid":"https://orcid.org/0000-0001-7410-5540"},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]},{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guangbin Wang","raw_affiliation_strings":["Departments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China; Departments of Radiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China. Electronic address: wgb7932596@hotmail.com","Departments of Radiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China","Departments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China; Departments of Radiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China. Electronic address: wgb7932596@hotmail.com","institution_ids":[]},{"raw_affiliation_string":"Departments of Radiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I154099455"]},{"raw_affiliation_string":"Departments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040347516","display_name":"Richard A.E. Edden","orcid":"https://orcid.org/0000-0002-0671-7374"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I1298154867","display_name":"Kennedy Krieger Institute","ror":"https://ror.org/05q6tgt32","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298154867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A.E. Edden","raw_affiliation_strings":["The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I1298154867","https://openalex.org/I145311948"]},{"raw_affiliation_string":"F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I1298154867"]},{"raw_affiliation_string":"The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":15,"corresponding_author_ids":["https://openalex.org/A5017257163"],"corresponding_institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517","https://openalex.org/I4210163399"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":5.1539,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.96184038,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"264","issue":null,"first_page":"119740","last_page":"119740"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9233999848365784,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9233999848365784,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.0681999996304512,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12603","display_name":"NMR spectroscopy and applications","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/3106","display_name":"Nuclear and High Energy Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.8571106195449829},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.4639301896095276},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4576718807220459},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.38124948740005493},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.38103264570236206},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3314089775085449},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1968713104724884}],"concepts":[{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.8571106195449829},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4639301896095276},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4576718807220459},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.38124948740005493},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38103264570236206},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3314089775085449},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1968713104724884}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006179","descriptor_name":"Gyrus Cinguli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006179","descriptor_name":"Gyrus Cinguli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006179","descriptor_name":"Gyrus Cinguli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neuroimage.2022.119740","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2022.119740","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:36356822","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36356822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":null},{"id":"pmh:oai:doaj.org/article:da5227215f264392ad46028c61b5af47","is_oa":true,"landing_page_url":"https://doaj.org/article/da5227215f264392ad46028c61b5af47","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NeuroImage, Vol 264, Iss , Pp 119740- (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9902072","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9902072","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuroimage","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2022.119740","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2022.119740","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1175871295","display_name":null,"funder_award_id":"R01 EB016089","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4075960706","display_name":null,"funder_award_id":"ZR2020QH267","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G5073075787","display_name":null,"funder_award_id":"P41 EB031771","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5437159035","display_name":null,"funder_award_id":"R00 AG062230","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6083600273","display_name":null,"funder_award_id":"K00 AG068440","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6377332026","display_name":null,"funder_award_id":"2022M711987","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G66452515","display_name":null,"funder_award_id":"R21 AG060245","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7059787106","display_name":null,"funder_award_id":"2019QL023","funder_id":"https://openalex.org/F4320328999","funder_display_name":"Shandong First Medical University"}],"funders":[{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null},{"id":"https://openalex.org/F4320328999","display_name":"Shandong First Medical University","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1557485257","https://openalex.org/W1963557149","https://openalex.org/W1970933144","https://openalex.org/W1987738982","https://openalex.org/W1991413275","https://openalex.org/W1994958750","https://openalex.org/W2007248168","https://openalex.org/W2010754167","https://openalex.org/W2017019336","https://openalex.org/W2023798788","https://openalex.org/W2024047266","https://openalex.org/W2032216596","https://openalex.org/W2051344348","https://openalex.org/W2074666700","https://openalex.org/W2086709157","https://openalex.org/W2088315332","https://openalex.org/W2093057630","https://openalex.org/W2109195157","https://openalex.org/W2116649573","https://openalex.org/W2126348672","https://openalex.org/W2149746172","https://openalex.org/W2216103876","https://openalex.org/W2258754493","https://openalex.org/W2262247517","https://openalex.org/W2279193171","https://openalex.org/W2346663901","https://openalex.org/W2405174010","https://openalex.org/W2463876516","https://openalex.org/W2585397751","https://openalex.org/W2596906495","https://openalex.org/W2605487185","https://openalex.org/W2610163897","https://openalex.org/W2906903840","https://openalex.org/W2932841619","https://openalex.org/W3008758753","https://openalex.org/W3016933447","https://openalex.org/W3037198595","https://openalex.org/W3044541683","https://openalex.org/W3087204261","https://openalex.org/W3097424190","https://openalex.org/W3107226841","https://openalex.org/W3128023714","https://openalex.org/W3159326432","https://openalex.org/W3165706650","https://openalex.org/W3216466190","https://openalex.org/W6656407729","https://openalex.org/W6656640407"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487"],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,458],"neurometabolic":[2,37,514],"timecourse":[3],"of":[4,15,26,42,59,67,125,190,214,517],"healthy":[5,53,518],"aging":[6,519],"is":[7],"not":[8,415],"well-established,":[9],"in":[10,64,103,193,248,265,282,304,317,326,334,351,357,365,383,400,412,434,443,454,471,481,500],"part":[11],"due":[12],"to":[13,35,141,165,182,200],"diversity":[14],"quantification":[16,49],"methodology.":[17],"In":[18,403],"this":[19],"study,":[20],"a":[21,40,88,122,132,274,369,419,506],"large":[22,228],"structured":[23],"cross-sectional":[24],"cohort":[25],"male":[27,60],"and":[28,61,75,108,131,147,174,186,196,198,205,244,251,261,280,294,315,320,324,339,347,379,386,396,425,432,437,441,452,469,474,479],"female":[29,62],"subjects":[30],"throughout":[31],"adulthood":[32],"was":[33,355,373,418],"recruited":[34,78],"investigate":[36],"changes":[38],"as":[39,188,212,341,343],"function":[41],"age,":[43,202],"using":[44,96,117,520],"consensus-recommended":[45],"magnetic":[46],"resonance":[47],"spectroscopy":[48],"methods.":[50],"METHODS:":[51],"102":[52],"volunteers,":[54],"with":[55,79,410,429],"approximately":[56],"equal":[57],"numbers":[58],"participants":[63],"each":[65,150],"decade":[66],"age":[68,148,185,281,293,411,463,486],"from":[69,219],"the":[70,104,118,172,194,249,266,283,318,327,384,401,435,444,472,482,513],"20s,":[71],"30s,":[72],"40s,":[73],"50s,":[74],"60s,":[76],"were":[77,85,94,115,139,154,159,163,180,222,235,290,349,446,488],"IRB":[80],"approval.":[81],"MR":[82],"spectroscopic":[83],"data":[84],"acquired":[86,95],"on":[87],"3T":[89],"MRI":[90],"scanner.":[91],"Metabolite":[92],"spectra":[93,114],"PRESS":[97],"localization":[98],"(TE=30":[99],"ms;":[100],"96":[101],"transients)":[102],"centrum":[105],"semiovale":[106],"(CSO)":[107],"posterior":[109],"cingulate":[110],"cortex":[111],"(PCC).":[112],"Water-suppressed":[113],"modeled":[116],"Osprey":[119],"algorithm,":[120],"employing":[121],"basis":[123,129],"set":[124],"18":[126],"simulated":[127],"metabolite":[128,145,157,168,191,215,407],"functions":[130],"cohort-mean":[133],"measured":[134],"macromolecular":[135],"spectrum.":[136],"Pearson":[137,233],"correlations":[138,153,234,269,289,487],"conducted":[140,155,181],"assess":[142,183,201],"relationships":[143,428,464],"between":[144,171,278,292,423],"concentrations":[146,169,192],"for":[149,237,252,270,311,321,332,375,450,465,475,490,509],"voxel;":[151],"Spearman":[152,268],"where":[156],"distributions":[158],"non-normal.":[160],"Paired":[161],"t-tests":[162],"run":[164],"determine":[166],"whether":[167],"differed":[170],"PCC":[173,195,328,344,353,445],"CSO.":[175],"Finally,":[176],"robust":[177,335,366,455],"linear":[178],"regressions":[179],"both":[184],"sex":[187,333],"predictors":[189,213],"CSO":[197,250,284,319,337,385,436,473],"separately,":[199],"signal-noise":[203],"ratio,":[204],"full":[206],"width":[207],"half":[208],"maximum":[209],"(FWHM)":[210],"linewidth":[211,424,451],"concentrations.":[216],"RESULTS:":[217],"Data":[218],"four":[220],"voxels":[221],"excluded":[223],"(2":[224],"ethanol;":[225],"2":[226],"unacceptably":[227],"lipid":[229],"signal).":[230],"Statistically-significant":[231],"age*metabolite":[232],"observed":[236],"tCho":[238,376,387],"(r(98)=0.33,":[239],"p<0.001),":[240,243,257,260],"tCr":[241,258,325,390],"(r(98)=0.60,":[242],"mI":[245,314,393,433],"(r(98)=0.32,":[246],"p=0.001)":[247,378],"NAAG":[253,338],"(r(98)=0.26,":[254],"p=0.008),":[255],"tCho(r(98)=0.33,":[256],"(r(98)=0.39,":[259],"Gln":[262,354,480],"(r(98)=0.21,":[263],"p=0.034)":[264],"PCC.":[267,402],"non-normal":[271],"variables":[272],"revealed":[273],"statistically":[275],"significant":[276,288,370,405,420,447],"correlation":[277,422],"sI":[279,316,442,470],"(r(86)=0.26,":[285],"p=0.013).":[286],"No":[287],"seen":[291,374],"tNAA,":[295,345,491],"NAA,":[296,492],"Glx,":[297,493],"Glu,":[298,494],"GSH,":[299,495],"PE,":[300,496],"Lac,":[301,497],"or":[302,498],"Asp":[303,499],"either":[305,501],"region":[306],"(all":[307],"p>0.20).":[308],"Age":[309,427],"associations":[310],"tCho,":[312,323,430,438,466,477],"tCr,":[313,431,439,467,478],"NAAG,":[322,476],"remained":[329],"when":[330],"controlling":[331,449],"regressions.":[336,456],"Asp,":[340],"well":[342],"sI,":[346],"Lac":[348,397],"higher":[350,356],"women;":[352],"men.":[358],"When":[359],"including":[360],"an":[361],"age*sex":[362,371],"interaction":[363,372],"term":[364],"regression":[367],"models,":[368],"(F(1,96)=11.53,":[377],"GSH":[380],"(F(1,96)=7.15,":[381],"p=0.009)":[382],"(F(1,96)=9.17,":[388],"p=0.003),":[389,392],"(F(1,96)=9.59,":[391],"(F(1,96)=6.48,":[394],"p=0.012),":[395],"(F(1,78)=6.50,":[398],"p=0.016)":[399],"all":[404],"interactions,":[406],"levels":[408],"increased":[409],"females,":[413],"but":[414],"males.":[416],"There":[417],"positive":[421],"age.":[426],"mI,":[440,468],"after":[448],"FWHM":[453],"CONCLUSION:":[457],"primary":[459],"(correlation)":[460],"results":[461,504],"indicated":[462],"PCC,":[483],"while":[484],"no":[485],"found":[489],"region.":[502],"Our":[503],"provide":[505],"normative":[507],"foundation":[508],"future":[510],"work":[511],"investigating":[512],"time":[515],"course":[516],"MRS.":[521]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
