{"id":"https://openalex.org/W4286687906","doi":"https://doi.org/10.1016/j.neuroimage.2022.119504","title":"Towards the interpretability of deep learning models for multi-modal neuroimaging: Finding structural changes of the ageing brain","display_name":"Towards the interpretability of deep learning models for multi-modal neuroimaging: Finding structural changes of the ageing brain","publication_year":2022,"publication_date":"2022-07-23","ids":{"openalex":"https://openalex.org/W4286687906","doi":"https://doi.org/10.1016/j.neuroimage.2022.119504","pmid":"https://pubmed.ncbi.nlm.nih.gov/35882272"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2022.119504","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2022.119504","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.neuroimage.2022.119504","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065181864","display_name":"S. Hofmann","orcid":"https://orcid.org/0000-0003-0958-501X"},"institutions":[{"id":"https://openalex.org/I2800274787","display_name":"Fraunhofer Institute for Telecommunications, Heinrich Hertz Institute","ror":"https://ror.org/02tbr6331","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2800274787","https://openalex.org/I4923324"]},{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Simon M. Hofmann","raw_affiliation_strings":["Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Department of Artificial Intelligence, Fraunhofer Institute Heinrich Hertz, 10587 Berlin, Germany; Clinic for Cognitive Neurology, University of Leipzig Medical Center, 04103 Leipzig, Germany. Electronic address: simon.hofmann@cbs.mpg.de","Clinic for Cognitive Neurology, University of Leipzig Medical Center, 04103 Leipzig, Germany","Department of Artificial Intelligence, Fraunhofer Institute Heinrich Hertz, 10587 Berlin, Germany","Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0958-501X","affiliations":[{"raw_affiliation_string":"Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Department of Artificial Intelligence, Fraunhofer Institute Heinrich Hertz, 10587 Berlin, Germany; Clinic for Cognitive Neurology, University of Leipzig Medical Center, 04103 Leipzig, Germany. Electronic address: simon.hofmann@cbs.mpg.de","institution_ids":["https://openalex.org/I4210130445"]},{"raw_affiliation_string":"Clinic for Cognitive Neurology, University of Leipzig Medical Center, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"Department of Artificial Intelligence, Fraunhofer Institute Heinrich Hertz, 10587 Berlin, Germany","institution_ids":["https://openalex.org/I2800274787"]},{"raw_affiliation_string":"Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I4210130445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082637425","display_name":"Frauke Beyer","orcid":"https://orcid.org/0000-0001-5401-852X"},"institutions":[{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frauke Beyer","raw_affiliation_strings":["Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Clinic for Cognitive Neurology, University of Leipzig Medical Center, 04103 Leipzig, Germany","Clinic for Cognitive Neurology, University of Leipzig Medical Center, 04103 Leipzig, Germany","Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Clinic for Cognitive Neurology, University of Leipzig Medical Center, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I4210130445"]},{"raw_affiliation_string":"Clinic for Cognitive Neurology, University of Leipzig Medical Center, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I4210130445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017608155","display_name":"Sebastian Lapuschkin","orcid":"https://orcid.org/0000-0002-0762-7258"},"institutions":[{"id":"https://openalex.org/I2800274787","display_name":"Fraunhofer Institute for Telecommunications, Heinrich Hertz Institute","ror":"https://ror.org/02tbr6331","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2800274787","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Lapuschkin","raw_affiliation_strings":["Department of Artificial Intelligence, Fraunhofer Institute Heinrich Hertz, 10587 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Artificial Intelligence, Fraunhofer Institute Heinrich Hertz, 10587 Berlin, Germany","institution_ids":["https://openalex.org/I2800274787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089395840","display_name":"Ole Goltermann","orcid":"https://orcid.org/0000-0002-8566-6009"},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]},{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ole Goltermann","raw_affiliation_strings":["Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Max Planck School of Cognition, 04103 Leipzig, Germany; Institute of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany","Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany","Institute of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany","Max Planck School of Cognition, 04103 Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Max Planck School of Cognition, 04103 Leipzig, Germany; Institute of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany","institution_ids":["https://openalex.org/I159176309","https://openalex.org/I4210108711","https://openalex.org/I4210130445"]},{"raw_affiliation_string":"Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I4210130445"]},{"raw_affiliation_string":"Institute of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany","institution_ids":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Max Planck School of Cognition, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I4210130445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025964385","display_name":"Markus Loeffler","orcid":"https://orcid.org/0000-0002-0424-9933"},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Loeffler","raw_affiliation_strings":["IMISE, University of Leipzig, 04103 Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMISE, University of Leipzig, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107838719","display_name":"Klaus\u2010Robert M\u00fcller","orcid":null},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I4210109712","display_name":"Max Planck Institute for Informatics","ror":"https://ror.org/01w19ak89","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210109712"]},{"id":"https://openalex.org/I4210113520","display_name":"Brain (Germany)","ror":"https://ror.org/01gamcy45","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210113520"]},{"id":"https://openalex.org/I4210142348","display_name":"Max Planck Institute for the History of Science","ror":"https://ror.org/0492sjc74","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210142348"]},{"id":"https://openalex.org/I4401727010","display_name":"Berlin Institute for the Foundations of Learning and Data","ror":"https://ror.org/05dsfb086","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4401727010","https://openalex.org/I4577782","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I4577782","display_name":"Technische Universit\u00e4t Berlin","ror":"https://ror.org/03v4gjf40","country_code":"DE","type":"education","lineage":["https://openalex.org/I4577782"]}],"countries":["DE","KR"],"is_corresponding":false,"raw_author_name":"Klaus-Robert M\u00fcller","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, Technical University Berlin, 10623 Berlin, Germany; Department of Artificial Intelligence, Korea University, 02841 Seoul, Korea (the Republic of); Brain Team, Google Research, 10117 Berlin, Germany; Max Planck Institute for Informatics, 66123 Saarbr\u00fccken, Germany; BIFOLD - Berlin Institute for the Foundations of Learning and Data, 10587 Berlin, Germany","BIFOLD - Berlin Institute for the Foundations of Learning and Data, 10587 Berlin, Germany","Brain Team, Google Research, 10117 Berlin, Germany","Department of Artificial Intelligence, Korea University, 02841 Seoul, Korea (the Republic of)","Department of Electrical Engineering and Computer Science, Technical University Berlin, 10623 Berlin, Germany","Max Planck Institute for Informatics, 66123 Saarbr\u00fccken, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Technical University Berlin, 10623 Berlin, Germany; Department of Artificial Intelligence, Korea University, 02841 Seoul, Korea (the Republic of); Brain Team, Google Research, 10117 Berlin, Germany; Max Planck Institute for Informatics, 66123 Saarbr\u00fccken, Germany; BIFOLD - Berlin Institute for the Foundations of Learning and Data, 10587 Berlin, Germany","institution_ids":["https://openalex.org/I4210142348"]},{"raw_affiliation_string":"BIFOLD - Berlin Institute for the Foundations of Learning and Data, 10587 Berlin, Germany","institution_ids":["https://openalex.org/I4401727010"]},{"raw_affiliation_string":"Brain Team, Google Research, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I4210113520"]},{"raw_affiliation_string":"Department of Artificial Intelligence, Korea University, 02841 Seoul, Korea (the Republic of)","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Technical University Berlin, 10623 Berlin, Germany","institution_ids":["https://openalex.org/I4577782"]},{"raw_affiliation_string":"Max Planck Institute for Informatics, 66123 Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210109712"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020270555","display_name":"Arno Villringer","orcid":"https://orcid.org/0000-0003-2604-2404"},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Arno Villringer","raw_affiliation_strings":["Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Clinic for Cognitive Neurology, University of Leipzig Medical Center, 04103 Leipzig, Germany; MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt-Universit\u00e4t zu Berlin, 10099 Berlin, Germany; Center for Stroke Research, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, 10117 Berlin, Germany","Center for Stroke Research, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, 10117 Berlin, Germany","Clinic for Cognitive Neurology, University of Leipzig Medical Center, 04103 Leipzig, Germany","Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany","MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt-Universit\u00e4t zu Berlin, 10099 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Clinic for Cognitive Neurology, University of Leipzig Medical Center, 04103 Leipzig, Germany; MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt-Universit\u00e4t zu Berlin, 10099 Berlin, Germany; Center for Stroke Research, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I4210130445"]},{"raw_affiliation_string":"Center for Stroke Research, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Clinic for Cognitive Neurology, University of Leipzig Medical Center, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I4210130445"]},{"raw_affiliation_string":"MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt-Universit\u00e4t zu Berlin, 10099 Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026451495","display_name":"Wojciech Samek","orcid":"https://orcid.org/0000-0002-6283-3265"},"institutions":[{"id":"https://openalex.org/I2800274787","display_name":"Fraunhofer Institute for Telecommunications, Heinrich Hertz Institute","ror":"https://ror.org/02tbr6331","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2800274787","https://openalex.org/I4923324"]},{"id":"https://openalex.org/I4401727010","display_name":"Berlin Institute for the Foundations of Learning and Data","ror":"https://ror.org/05dsfb086","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4401727010","https://openalex.org/I4577782","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I4577782","display_name":"Technische Universit\u00e4t Berlin","ror":"https://ror.org/03v4gjf40","country_code":"DE","type":"education","lineage":["https://openalex.org/I4577782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wojciech Samek","raw_affiliation_strings":["Department of Artificial Intelligence, Fraunhofer Institute Heinrich Hertz, 10587 Berlin, Germany; Department of Electrical Engineering and Computer Science, Technical University Berlin, 10623 Berlin, Germany; BIFOLD - Berlin Institute for the Foundations of Learning and Data, 10587 Berlin, Germany","BIFOLD - Berlin Institute for the Foundations of Learning and Data, 10587 Berlin, Germany","Department of Artificial Intelligence, Fraunhofer Institute Heinrich Hertz, 10587 Berlin, Germany","Department of Electrical Engineering and Computer Science, Technical University Berlin, 10623 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Artificial Intelligence, Fraunhofer Institute Heinrich Hertz, 10587 Berlin, Germany; Department of Electrical Engineering and Computer Science, Technical University Berlin, 10623 Berlin, Germany; BIFOLD - Berlin Institute for the Foundations of Learning and Data, 10587 Berlin, Germany","institution_ids":["https://openalex.org/I2800274787"]},{"raw_affiliation_string":"BIFOLD - Berlin Institute for the Foundations of Learning and Data, 10587 Berlin, Germany","institution_ids":["https://openalex.org/I4401727010"]},{"raw_affiliation_string":"Department of Artificial Intelligence, Fraunhofer Institute Heinrich Hertz, 10587 Berlin, Germany","institution_ids":["https://openalex.org/I2800274787"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, Technical University Berlin, 10623 Berlin, Germany","institution_ids":["https://openalex.org/I4577782"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039738060","display_name":"A. Veronica Witte","orcid":"https://orcid.org/0000-0001-9054-6688"},"institutions":[{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"A. Veronica Witte","raw_affiliation_strings":["Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Clinic for Cognitive Neurology, University of Leipzig Medical Center, 04103 Leipzig, Germany","Clinic for Cognitive Neurology, University of Leipzig Medical Center, 04103 Leipzig, Germany","Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany; Clinic for Cognitive Neurology, University of Leipzig Medical Center, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I4210130445"]},{"raw_affiliation_string":"Clinic for Cognitive Neurology, University of Leipzig Medical Center, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany","institution_ids":["https://openalex.org/I4210130445"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5039738060","https://openalex.org/A5065181864"],"corresponding_institution_ids":["https://openalex.org/I2800274787","https://openalex.org/I4210130445","https://openalex.org/I926574661"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":5.3299,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.97012491,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"261","issue":null,"first_page":"119504","last_page":"119504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9860000014305115,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.7403465509414673},{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.7292166948318481},{"id":"https://openalex.org/keywords/ageing","display_name":"Ageing","score":0.5935742855072021},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.5675165057182312},{"id":"https://openalex.org/keywords/aging-brain","display_name":"Aging brain","score":0.50943523645401},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.46284574270248413},{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.45903280377388},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.4199373722076416},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.41984865069389343},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.35160064697265625},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3399996757507324},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.27538198232650757},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2534005045890808},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.13649046421051025},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.11913129687309265}],"concepts":[{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.7403465509414673},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.7292166948318481},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.5935742855072021},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5675165057182312},{"id":"https://openalex.org/C2779695026","wikidata":"https://www.wikidata.org/wiki/Q4692577","display_name":"Aging brain","level":3,"score":0.50943523645401},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.46284574270248413},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.45903280377388},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4199373722076416},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41984865069389343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35160064697265625},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3399996757507324},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.27538198232650757},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2534005045890808},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13649046421051025},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.11913129687309265}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neuroimage.2022.119504","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2022.119504","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:35882272","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35882272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:0d09130bc78e4522951993ba088fda1d","is_oa":true,"landing_page_url":"https://doaj.org/article/0d09130bc78e4522951993ba088fda1d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NeuroImage, Vol 261, Iss , Pp 119504- (2022)","raw_type":"article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/442263","is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/442263","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2022.119504","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2022.119504","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1479485356","display_name":"SFB 1052: Mechanismen der Adipositas","funder_award_id":"209933838","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2804209865","display_name":null,"funder_award_id":"2019\u20130\u201300079","funder_id":"https://openalex.org/F4320335489","funder_display_name":"Institute for Information and Communications Technology Promotion"},{"id":"https://openalex.org/G3411782263","display_name":null,"funder_award_id":"01IS18037 A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G4253563803","display_name":null,"funder_award_id":"WI 3342/3\u20131","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5113337935","display_name":null,"funder_award_id":"14505/2470","funder_id":"https://openalex.org/F4320325298","funder_display_name":"Universit\u00e4t Leipzig"},{"id":"https://openalex.org/G6475764323","display_name":null,"funder_award_id":"01IS18025 A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320325298","display_name":"Universit\u00e4t Leipzig","ror":"https://ror.org/03s7gtk40"},{"id":"https://openalex.org/F4320328735","display_name":"Freistaat Sachsen","ror":"https://ror.org/02hyyn853"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335489","display_name":"Institute for Information and Communications Technology Promotion","ror":"https://ror.org/01g0hqq23"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W189742998","https://openalex.org/W1517530889","https://openalex.org/W1522301498","https://openalex.org/W1583837637","https://openalex.org/W1588434295","https://openalex.org/W1787224781","https://openalex.org/W1901020111","https://openalex.org/W1983364832","https://openalex.org/W2006409771","https://openalex.org/W2009448627","https://openalex.org/W2010605130","https://openalex.org/W2016629996","https://openalex.org/W2020745232","https://openalex.org/W2023049058","https://openalex.org/W2043447152","https://openalex.org/W2082704080","https://openalex.org/W2091931051","https://openalex.org/W2102848905","https://openalex.org/W2103069600","https://openalex.org/W2103374433","https://openalex.org/W2108103428","https://openalex.org/W2108948752","https://openalex.org/W2112796928","https://openalex.org/W2116114482","https://openalex.org/W2120694577","https://openalex.org/W2125988557","https://openalex.org/W2129277474","https://openalex.org/W2147800946","https://openalex.org/W2150165932","https://openalex.org/W2216073902","https://openalex.org/W2411731482","https://openalex.org/W2541711215","https://openalex.org/W2552208519","https://openalex.org/W2579617530","https://openalex.org/W2590082389","https://openalex.org/W2657631929","https://openalex.org/W2763132865","https://openalex.org/W2766141193","https://openalex.org/W2769249101","https://openalex.org/W2779429893","https://openalex.org/W2791848629","https://openalex.org/W2793260524","https://openalex.org/W2801629022","https://openalex.org/W2809427939","https://openalex.org/W2896165108","https://openalex.org/W2921802966","https://openalex.org/W2951042025","https://openalex.org/W2952574438","https://openalex.org/W2953073956","https://openalex.org/W2956993163","https://openalex.org/W2961560364","https://openalex.org/W2962851944","https://openalex.org/W2970468910","https://openalex.org/W2971685841","https://openalex.org/W2977883299","https://openalex.org/W2984423913","https://openalex.org/W2990366895","https://openalex.org/W2995013609","https://openalex.org/W2995406462","https://openalex.org/W2999757271","https://openalex.org/W3000716014","https://openalex.org/W3003257820","https://openalex.org/W3008921454","https://openalex.org/W3010138595","https://openalex.org/W3017066732","https://openalex.org/W3035965352","https://openalex.org/W3037286432","https://openalex.org/W3080827239","https://openalex.org/W3089258874","https://openalex.org/W3092037825","https://openalex.org/W3092783643","https://openalex.org/W3098786448","https://openalex.org/W3099878876","https://openalex.org/W3111266999","https://openalex.org/W3111518260","https://openalex.org/W3120894151","https://openalex.org/W3131059059","https://openalex.org/W3132191748","https://openalex.org/W3132478226","https://openalex.org/W3134751001","https://openalex.org/W3135345798","https://openalex.org/W3212053370","https://openalex.org/W4241074797","https://openalex.org/W4283692816","https://openalex.org/W4287811112","https://openalex.org/W6607672814","https://openalex.org/W6631190155","https://openalex.org/W6632075054","https://openalex.org/W6635294431","https://openalex.org/W6639204139","https://openalex.org/W6639765830","https://openalex.org/W6681608319","https://openalex.org/W6684823039","https://openalex.org/W6685133223","https://openalex.org/W6734194636","https://openalex.org/W6761152222","https://openalex.org/W6768447915","https://openalex.org/W6769335399","https://openalex.org/W6770562767","https://openalex.org/W6780016132","https://openalex.org/W6786794669","https://openalex.org/W6790385504","https://openalex.org/W6790956184"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W2888392564","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W4390569940","https://openalex.org/W4361193272","https://openalex.org/W2963326959","https://openalex.org/W4388685194","https://openalex.org/W4253558403","https://openalex.org/W3083724788"],"abstract_inverted_index":{"Brain-age":[0],"(BA)":[1],"estimates":[2,85],"based":[3,65],"on":[4,45,66],"deep":[5,140],"learning":[6,141],"are":[7],"increasingly":[8],"used":[9],"as":[10,102,104],"neuroimaging":[11],"biomarker":[12],"for":[13],"brain":[14,39],"health;":[15],"however,":[16],"the":[17,113,130],"underlying":[18],"neural":[19,29],"features":[20,40],"have":[21],"remained":[22],"unclear.":[23],"We":[24,81],"combined":[25],"ensembles":[26],"of":[27,51,97],"convolutional":[28],"networks":[30],"with":[31],"Layer-wise":[32],"Relevance":[33],"Propagation":[34],"(LRP)":[35],"to":[36,42],"detect":[37,143],"which":[38],"contribute":[41],"BA.":[43],"Trained":[44],"magnetic":[46],"resonance":[47],"imaging":[48],"(MRI)":[49],"data":[50],"a":[52],"population-based":[53],"study":[54,136],"(n":[55],"=":[56],"2637,":[57],"18-82":[58],"years),":[59],"our":[60,135],"models":[61,142],"estimated":[62],"age":[63],"accurately":[64],"single":[67],"and":[68,73,91,99,108,123,147],"multiple":[69],"modalities,":[70],"regionally":[71],"restricted":[72],"whole-brain":[74],"images":[75],"(mean":[76],"absolute":[77],"errors":[78],"3.37-3.86":[79],"years).":[80],"find":[82],"that":[83,110],"BA":[84],"capture":[86],"ageing":[87,118,125],"at":[88],"both":[89],"small":[90],"large-scale":[92],"changes,":[93],"revealing":[94],"gross":[95],"enlargements":[96],"ventricles":[98],"subarachnoid":[100],"spaces,":[101],"well":[103],"white":[105],"matter":[106],"lesions,":[107],"atrophies":[109],"appear":[111],"throughout":[112,150],"brain.":[114],"Divergence":[115],"from":[116],"expected":[117],"reflected":[119],"cardiovascular":[120],"risk":[121],"factors":[122],"accelerated":[124],"was":[126],"more":[127],"pronounced":[128],"in":[129,145],"frontal":[131],"lobe.":[132],"Applying":[133],"LRP,":[134],"demonstrates":[137],"how":[138],"superior":[139],"brain-ageing":[144],"healthy":[146],"at-risk":[148],"individuals":[149],"adulthood.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":1}],"updated_date":"2026-09-08T07:41:39.490200","created_date":"2025-10-10T00:00:00"}