{"id":"https://openalex.org/W3127728138","doi":"https://doi.org/10.1016/j.neuroimage.2021.117839","title":"Investigating the microstructural properties of normal-appearing white matter (NAWM) preceding conversion to white matter hyperintensities (WMHs) in stroke survivors","display_name":"Investigating the microstructural properties of normal-appearing white matter (NAWM) preceding conversion to white matter hyperintensities (WMHs) in stroke survivors","publication_year":2021,"publication_date":"2021-02-09","ids":{"openalex":"https://openalex.org/W3127728138","doi":"https://doi.org/10.1016/j.neuroimage.2021.117839","mag":"3127728138","pmid":"https://pubmed.ncbi.nlm.nih.gov/33577935"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2021.117839","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2021.117839","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.neuroimage.2021.117839","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000289224","display_name":"Wasim Khan","orcid":"https://orcid.org/0000-0002-4489-4945"},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU","GB"],"is_corresponding":true,"raw_author_name":"Wasim Khan","raw_affiliation_strings":["Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia; Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience (IoPPN), King's College London, United Kingdom. Electronic address: will.khan@monash.edu","Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia","Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience (IoPPN), King's College London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia; Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience (IoPPN), King's College London, United Kingdom. Electronic address: will.khan@monash.edu","institution_ids":["https://openalex.org/I242743682"]},{"raw_affiliation_string":"Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I242743682"]},{"raw_affiliation_string":"Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience (IoPPN), King's College London, United Kingdom","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048062218","display_name":"Mohamed Salah Khlif","orcid":"https://orcid.org/0000-0002-0096-434X"},"institutions":[{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mohamed Salah Khlif","raw_affiliation_strings":["Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia. Electronic address: mohamed.khlif@florey.edu.au","Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia. Electronic address: mohamed.khlif@florey.edu.au","institution_ids":["https://openalex.org/I242743682"]},{"raw_affiliation_string":"Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033942773","display_name":"Remika Mito","orcid":"https://orcid.org/0000-0003-3945-2293"},"institutions":[{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Remika Mito","raw_affiliation_strings":["Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia. Electronic address: remika.mito@florey.edu.au","Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia"],"raw_orcid":"https://orcid.org/0000-0003-3945-2293","affiliations":[{"raw_affiliation_string":"Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia. Electronic address: remika.mito@florey.edu.au","institution_ids":["https://openalex.org/I242743682"]},{"raw_affiliation_string":"Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I242743682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052540216","display_name":"Thijs Dhollander","orcid":"https://orcid.org/0000-0003-3088-3636"},"institutions":[{"id":"https://openalex.org/I4210150290","display_name":"Murdoch Children's Research Institute","ror":"https://ror.org/048fyec77","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I4210150290"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Thijs Dhollander","raw_affiliation_strings":["Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0003-3088-3636","affiliations":[{"raw_affiliation_string":"Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I4210150290"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041029206","display_name":"Amy Brodtmann","orcid":"https://orcid.org/0000-0001-9466-2862"},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I242743682","display_name":"Florey Institute of Neuroscience and Mental Health","ror":"https://ror.org/03a2tac74","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165779595","https://openalex.org/I242743682"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Amy Brodtmann","raw_affiliation_strings":["Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia; Melbourne Dementia Research Centre, University of Melbourne, Victoria, Australia. Electronic address: agbrod@unimelb.edu.au","Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia","Melbourne Dementia Research Centre, University of Melbourne, Victoria, Australia"],"raw_orcid":"https://orcid.org/0000-0001-9466-2862","affiliations":[{"raw_affiliation_string":"Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia; Melbourne Dementia Research Centre, University of Melbourne, Victoria, Australia. Electronic address: agbrod@unimelb.edu.au","institution_ids":["https://openalex.org/I242743682"]},{"raw_affiliation_string":"Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia","institution_ids":["https://openalex.org/I242743682"]},{"raw_affiliation_string":"Melbourne Dementia Research Centre, University of Melbourne, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000289224"],"corresponding_institution_ids":["https://openalex.org/I183935753","https://openalex.org/I242743682"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":2.9537,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.91280843,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"232","issue":null,"first_page":"117839","last_page":"117839"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.8384068012237549},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.7074950933456421},{"id":"https://openalex.org/keywords/hyperintensity","display_name":"Hyperintensity","score":0.6473073959350586},{"id":"https://openalex.org/keywords/voxel","display_name":"Voxel","score":0.6211203932762146},{"id":"https://openalex.org/keywords/stroke","display_name":"Stroke (engine)","score":0.43446996808052063},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.4284823536872864},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3650323748588562},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.35075074434280396},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3190055787563324},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.2909741997718811},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.127017080783844},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.05940556526184082}],"concepts":[{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.8384068012237549},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.7074950933456421},{"id":"https://openalex.org/C146638467","wikidata":"https://www.wikidata.org/wiki/Q10529587","display_name":"Hyperintensity","level":3,"score":0.6473073959350586},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.6211203932762146},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.43446996808052063},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4284823536872864},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3650323748588562},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35075074434280396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3190055787563324},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.2909741997718811},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.127017080783844},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.05940556526184082},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017741","descriptor_name":"Survivors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017741","descriptor_name":"Survivors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017741","descriptor_name":"Survivors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D049292","descriptor_name":"Leukoaraiosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D049292","descriptor_name":"Leukoaraiosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D049292","descriptor_name":"Leukoaraiosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D049292","descriptor_name":"Leukoaraiosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D049292","descriptor_name":"Leukoaraiosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D049292","descriptor_name":"Leukoaraiosis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neuroimage.2021.117839","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2021.117839","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:33577935","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33577935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":null},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/7c014d8b-6fc9-4b9b-8272-522147395d63","is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/7c014d8b-6fc9-4b9b-8272-522147395d63","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Khan, W, Khlif, M S, Mito, R, Dhollander, T & Brodtmann, A 2021, 'Investigating the microstructural properties of normal-appearing white matter (NAWM) preceding conversion to white matter hyperintensities (WMHs) in stroke survivors', NeuroImage, vol. 232, 117839. https://doi.org/10.1016/j.neuroimage.2021.117839","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:2dc3bf1454064c29ab6a881faabbcdbe","is_oa":true,"landing_page_url":"https://doaj.org/article/2dc3bf1454064c29ab6a881faabbcdbe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NeuroImage, Vol 232, Iss , Pp 117839- (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2021.117839","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2021.117839","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8100000023841858,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"awards":[{"id":"https://openalex.org/G6383446509","display_name":null,"funder_award_id":"APP1094974","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320322858","display_name":"State Government of Victoria","ror":"https://ror.org/02xvc5r05"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1908464783","https://openalex.org/W1919821049","https://openalex.org/W1964580878","https://openalex.org/W1965730864","https://openalex.org/W1983090660","https://openalex.org/W1984453610","https://openalex.org/W1984742670","https://openalex.org/W1991766274","https://openalex.org/W1997378060","https://openalex.org/W1999664097","https://openalex.org/W2010125850","https://openalex.org/W2019836674","https://openalex.org/W2032756463","https://openalex.org/W2043618136","https://openalex.org/W2044677981","https://openalex.org/W2052644075","https://openalex.org/W2053509355","https://openalex.org/W2061984402","https://openalex.org/W2063258284","https://openalex.org/W2071881327","https://openalex.org/W2072290762","https://openalex.org/W2072736972","https://openalex.org/W2077240096","https://openalex.org/W2078103827","https://openalex.org/W2086465016","https://openalex.org/W2091163929","https://openalex.org/W2092403915","https://openalex.org/W2095446662","https://openalex.org/W2100809123","https://openalex.org/W2101052591","https://openalex.org/W2104855192","https://openalex.org/W2106430568","https://openalex.org/W2109274852","https://openalex.org/W2117340355","https://openalex.org/W2122477279","https://openalex.org/W2123029908","https://openalex.org/W2123782121","https://openalex.org/W2127309075","https://openalex.org/W2131078911","https://openalex.org/W2132874104","https://openalex.org/W2136573752","https://openalex.org/W2138595885","https://openalex.org/W2140621953","https://openalex.org/W2143060791","https://openalex.org/W2148726987","https://openalex.org/W2151432761","https://openalex.org/W2153796345","https://openalex.org/W2158742097","https://openalex.org/W2162903851","https://openalex.org/W2163718643","https://openalex.org/W2177917702","https://openalex.org/W2245834806","https://openalex.org/W2414066681","https://openalex.org/W2799775313","https://openalex.org/W2883730994","https://openalex.org/W2885047677","https://openalex.org/W2904250115","https://openalex.org/W2943727453","https://openalex.org/W2944253457","https://openalex.org/W2957206664","https://openalex.org/W2962681100","https://openalex.org/W2970898057","https://openalex.org/W2977883299","https://openalex.org/W3019036807","https://openalex.org/W3042593587","https://openalex.org/W4235770099","https://openalex.org/W6762118526"],"related_works":["https://openalex.org/W2292956239","https://openalex.org/W2327564191","https://openalex.org/W57104752","https://openalex.org/W2364198307","https://openalex.org/W2376425756","https://openalex.org/W2001037511","https://openalex.org/W1977760756","https://openalex.org/W2391066511","https://openalex.org/W2000186706","https://openalex.org/W2068008866"],"abstract_inverted_index":{"Using":[0],"advanced":[1],"diffusion":[2,25,119,234],"MRI,":[3],"we":[4],"aimed":[5],"to":[6,18,70,78,83,95,107,145,156,170,184,205,239,257],"assess":[7],"the":[8,35,245],"microstructural":[9,177,248],"properties":[10,114,178,212,220],"of":[11,123,179,227,232,247,254],"normal-appearing":[12],"white":[13,19,124],"matter":[14,20],"(NAWM)":[15],"preceding":[16,203],"conversion":[17,204],"hyperintensities":[21],"(WMHs)":[22],"using":[23,117],"3-tissue":[24,118],"signal":[26,120,137],"compositions":[27,121,153,249],"in":[28,151,192,235],"ischemic":[29],"stroke.":[30],"Data":[31],"were":[32,51,60,85,115,182],"obtained":[33],"from":[34],"Cognition":[36],"and":[37,46,55,63,132,161,167],"Neocortical":[38],"Volume":[39],"After":[40],"Stroke":[41],"(CANVAS)":[42],"study.":[43],"Diffusion-weighted":[44],"MR":[45],"high-resolution":[47],"structural":[48],"brain":[49],"images":[50],"acquired":[52],"3-":[53],"(baseline)":[54],"12-months":[56,67],"(follow-up)":[57],"post-stroke.":[58],"WMHs":[59,84,91,102,146,157,206],"automatically":[61],"segmented":[62],"longitudinal":[64],"assessment":[65],"at":[66,75,111,154],"was":[68,105],"used":[69],"retrospectively":[71],"delineate":[72],"NAWM":[73,80,93,104,143,181,202,236,255],"voxels":[74,81,109],"baseline":[76,155],"converting":[77,82,144],"WMHs.":[79],"further":[86],"dichotomized":[87],"into":[88],"either:":[89],"\u201cgrowing\u201d":[90],"if":[92,103],"adhered":[94],"existing":[96],"WMH":[97,108,186,196,240,258],"voxels,":[98],"or":[99],"\u201cisolated":[100],"de-novo\"":[101],"unconnected":[106],"identified":[110],"baseline.":[112],"Microstructural":[113],"assessed":[116],"consisting":[122],"matter-like":[125,129],"(WM-like:":[126],"TW),":[127],"gray":[128],"(GM-like:":[130],"TG),":[131],"cerebrospinal":[133],"fluid-like":[134,211],"(CSF-like:":[135],"TC)":[136],"fractions.":[138],"Our":[139],"findings":[140,199],"showed":[141],"that":[142,176,201],"already":[147],"exhibited":[148],"similar":[149],"changes":[150],"tissue":[152,215,228],"with":[158,188,194],"lower":[159],"TW":[160],"increased":[162,214],"TC":[163],"(fluid-like,":[164],"i.e.":[165],"free-water)":[166],"TG":[168],"compared":[169],"persistent":[171,180],"NAWM.":[172],"We":[173],"also":[174],"found":[175],"related":[183],"overall":[185],"burden":[187],"greater":[189,210],"free-water":[190],"content":[191],"patients":[193],"high":[195],"load.":[197],"These":[198,242],"suggest":[200],"are":[207],"accompanied":[208],"by":[209],"indicating":[213],"water":[216],"content.":[217],"Increased":[218],"GM-like":[219],"may":[221],"indicate":[222],"a":[223,230,251],"more":[224],"isotropic":[225],"microstructure":[226],"reflecting":[229],"degree":[231],"hindered":[233],"regions":[237],"vulnerable":[238],"development.":[241],"results":[243],"support":[244],"usefulness":[246],"as":[250],"sensitive":[252],"marker":[253],"vulnerability":[256],"pathogenesis.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}