{"id":"https://openalex.org/W3069025233","doi":"https://doi.org/10.1016/j.neuroimage.2020.117269","title":"The effects of voluntary running on cerebrovascular morphology and spatial short-term memory in a mouse model of amyloidosis","display_name":"The effects of voluntary running on cerebrovascular morphology and spatial short-term memory in a mouse model of amyloidosis","publication_year":2020,"publication_date":"2020-08-17","ids":{"openalex":"https://openalex.org/W3069025233","doi":"https://doi.org/10.1016/j.neuroimage.2020.117269","mag":"3069025233","pmid":"https://pubmed.ncbi.nlm.nih.gov/32818618"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2020.117269","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2020.117269","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.neuroimage.2020.117269","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024195654","display_name":"Ewelina Maliszewska\u2010Cyna","orcid":"https://orcid.org/0000-0002-8301-2642"},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801862477","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801862477","https://openalex.org/I2802286613"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":null,"type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Ewelina Maliszewska-Cyna","raw_affiliation_strings":["Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada","Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada","Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada"],"affiliations":[{"raw_affiliation_string":"Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I2801862477"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I2801862477","https://openalex.org/I185261750"]},{"raw_affiliation_string":"Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089610135","display_name":"Laura M. Vecchio","orcid":"https://orcid.org/0000-0003-1520-9336"},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801862477","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801862477","https://openalex.org/I2802286613"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":null,"type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Laura M. Vecchio","raw_affiliation_strings":["Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada. Electronic address: laura.vecchio@mail.utoronto.ca","Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada","Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada"],"affiliations":[{"raw_affiliation_string":"Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada. Electronic address: laura.vecchio@mail.utoronto.ca","institution_ids":["https://openalex.org/I2801862477"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I2801862477","https://openalex.org/I185261750"]},{"raw_affiliation_string":"Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088635351","display_name":"Lynsie A.M. Thomason","orcid":"https://orcid.org/0000-0001-8725-7471"},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":null,"type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lynsie A.M. Thomason","raw_affiliation_strings":["Hurvitz Brain Sciences, Physical Sciences, Sunnybrook Research Institute, Canada"],"affiliations":[{"raw_affiliation_string":"Hurvitz Brain Sciences, Physical Sciences, Sunnybrook Research Institute, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066202055","display_name":"Jonathan Oore","orcid":"https://orcid.org/0000-0003-4574-3601"},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":null,"type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jonathan J. Oore","raw_affiliation_strings":["Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada"],"affiliations":[{"raw_affiliation_string":"Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062475614","display_name":"Joe Steinman","orcid":"https://orcid.org/0000-0002-1354-4221"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Joe Steinman","raw_affiliation_strings":["Mouse Imaging Centre, Hospital for Sick Children, Canada; Department of Medical Biophysics, University of Toronto, Canada","Department of Medical Biophysics, University of Toronto, Canada","Mouse Imaging Centre, Hospital for Sick Children, Canada"],"affiliations":[{"raw_affiliation_string":"Mouse Imaging Centre, Hospital for Sick Children, Canada; Department of Medical Biophysics, University of Toronto, Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Mouse Imaging Centre, Hospital for Sick Children, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072666189","display_name":"Illsung L. Joo","orcid":"https://orcid.org/0000-0002-0325-495X"},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":null,"type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Illsung Lewis Joo","raw_affiliation_strings":["Hurvitz Brain Sciences, Physical Sciences, Sunnybrook Research Institute, Canada"],"affiliations":[{"raw_affiliation_string":"Hurvitz Brain Sciences, Physical Sciences, Sunnybrook Research Institute, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055634028","display_name":"Adrienne Dorr","orcid":"https://orcid.org/0009-0004-7628-1678"},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":null,"type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Adrienne Dorr","raw_affiliation_strings":["Hurvitz Brain Sciences, Physical Sciences, Sunnybrook Research Institute, Canada"],"affiliations":[{"raw_affiliation_string":"Hurvitz Brain Sciences, Physical Sciences, Sunnybrook Research Institute, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I4391768120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014013622","display_name":"JoAnne McLaurin","orcid":"https://orcid.org/0000-0002-7428-9105"},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801862477","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801862477","https://openalex.org/I2802286613"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":null,"type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"JoAnne McLaurin","raw_affiliation_strings":["Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada","Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada","Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada"],"affiliations":[{"raw_affiliation_string":"Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I2801862477"]},{"raw_affiliation_string":"Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I4391768120"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I2801862477","https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091593779","display_name":"John G. Sled","orcid":"https://orcid.org/0000-0002-4461-283X"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John G. Sled","raw_affiliation_strings":["Mouse Imaging Centre, Hospital for Sick Children, Canada; Department of Medical Biophysics, University of Toronto, Canada","Mouse Imaging Centre, Hospital for Sick Children, Canada","Department of Medical Biophysics, University of Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"Mouse Imaging Centre, Hospital for Sick Children, Canada; Department of Medical Biophysics, University of Toronto, Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Mouse Imaging Centre, Hospital for Sick Children, Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041218352","display_name":"Bojana Stefanovic","orcid":"https://orcid.org/0000-0002-8439-7601"},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":null,"type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bojana Stefanovic","raw_affiliation_strings":["Hurvitz Brain Sciences, Physical Sciences, Sunnybrook Research Institute, Canada; Department of Medical Biophysics, University of Toronto, Canada","Hurvitz Brain Sciences, Physical Sciences, Sunnybrook Research Institute, Canada","Department of Medical Biophysics, University of Toronto, Canada"],"affiliations":[{"raw_affiliation_string":"Hurvitz Brain Sciences, Physical Sciences, Sunnybrook Research Institute, Canada; Department of Medical Biophysics, University of Toronto, Canada","institution_ids":["https://openalex.org/I1323843004"]},{"raw_affiliation_string":"Hurvitz Brain Sciences, Physical Sciences, Sunnybrook Research Institute, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I4391768120"]},{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056395849","display_name":"Isabelle Aubert","orcid":"https://orcid.org/0000-0001-5163-9961"},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801862477","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17","country_code":"CA","type":"government","lineage":["https://openalex.org/I2801862477","https://openalex.org/I2802286613"]},{"id":"https://openalex.org/I4391768120","display_name":"Sunnybrook Research Institute","ror":"https://ror.org/05n0tzs53","country_code":null,"type":"facility","lineage":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I4391768120"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Isabelle Aubert","raw_affiliation_strings":["Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada","Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada","Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada"],"affiliations":[{"raw_affiliation_string":"Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I2801862477"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada","institution_ids":["https://openalex.org/I2801862477","https://openalex.org/I185261750"]},{"raw_affiliation_string":"Hurvitz Brain Sciences, Biological Sciences, Sunnybrook Research Institute, 2075 Bayview Ave, S112, Toronto, Ontario M4N 3M5, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I4391768120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5024195654","https://openalex.org/A5089610135"],"corresponding_institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I185261750","https://openalex.org/I2801862477","https://openalex.org/I4391768120"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":0.5388,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.70962351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"222","issue":null,"first_page":"117269","last_page":"117269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9854999780654907,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9815999865531921,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/term","display_name":"Term (time)","score":0.6554040908813477},{"id":"https://openalex.org/keywords/amyloidosis","display_name":"Amyloidosis","score":0.6448146104812622},{"id":"https://openalex.org/keywords/physical-medicine-and-rehabilitation","display_name":"Physical medicine and rehabilitation","score":0.43900057673454285},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.34284716844558716},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.334747850894928},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.30979299545288086},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.27295565605163574},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10510784387588501}],"concepts":[{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.6554040908813477},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.6448146104812622},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.43900057673454285},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34284716844558716},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.334747850894928},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30979299545288086},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27295565605163574},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10510784387588501},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008570","descriptor_name":"Memory, Short-Term","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008570","descriptor_name":"Memory, Short-Term","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008570","descriptor_name":"Memory, Short-Term","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.neuroimage.2020.117269","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2020.117269","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:32818618","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32818618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":null},{"id":"pmh:oai:doaj.org/article:fb853e4ad16b4a81b84c17e1b1c69a26","is_oa":true,"landing_page_url":"https://doaj.org/article/fb853e4ad16b4a81b84c17e1b1c69a26","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NeuroImage, Vol 222, Iss , Pp 117269- (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2020.117269","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2020.117269","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6700000166893005,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2197089349","display_name":null,"funder_award_id":"04659","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G7217092453","display_name":null,"funder_award_id":"137064","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320320994","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":123,"referenced_works":["https://openalex.org/W1531365070","https://openalex.org/W1567524252","https://openalex.org/W1580703614","https://openalex.org/W1679229092","https://openalex.org/W1923262640","https://openalex.org/W1955624635","https://openalex.org/W1959902108","https://openalex.org/W1964699341","https://openalex.org/W1965080574","https://openalex.org/W1969584460","https://openalex.org/W1977071831","https://openalex.org/W1980748384","https://openalex.org/W1984139645","https://openalex.org/W1995147563","https://openalex.org/W1995188451","https://openalex.org/W2003025783","https://openalex.org/W2003762128","https://openalex.org/W2005627616","https://openalex.org/W2005824957","https://openalex.org/W2006039944","https://openalex.org/W2006408095","https://openalex.org/W2006688743","https://openalex.org/W2007818439","https://openalex.org/W2008150751","https://openalex.org/W2015723583","https://openalex.org/W2019085715","https://openalex.org/W2021625064","https://openalex.org/W2022213447","https://openalex.org/W2031832388","https://openalex.org/W2034275438","https://openalex.org/W2036234078","https://openalex.org/W2038145816","https://openalex.org/W2040490831","https://openalex.org/W2043522411","https://openalex.org/W2049742542","https://openalex.org/W2052640859","https://openalex.org/W2057164916","https://openalex.org/W2059093737","https://openalex.org/W2063038783","https://openalex.org/W2066746555","https://openalex.org/W2069974562","https://openalex.org/W2070155357","https://openalex.org/W2070386868","https://openalex.org/W2071488736","https://openalex.org/W2072602970","https://openalex.org/W2073982465","https://openalex.org/W2074546602","https://openalex.org/W2075059538","https://openalex.org/W2077601824","https://openalex.org/W2079363741","https://openalex.org/W2079385213","https://openalex.org/W2081164888","https://openalex.org/W2083448891","https://openalex.org/W2084484659","https://openalex.org/W2084571649","https://openalex.org/W2087607255","https://openalex.org/W2089964302","https://openalex.org/W2091990223","https://openalex.org/W2092674727","https://openalex.org/W2095613667","https://openalex.org/W2097443346","https://openalex.org/W2097903222","https://openalex.org/W2104792456","https://openalex.org/W2104855192","https://openalex.org/W2107501599","https://openalex.org/W2111605497","https://openalex.org/W2119757776","https://openalex.org/W2121930919","https://openalex.org/W2131196982","https://openalex.org/W2134579258","https://openalex.org/W2134613265","https://openalex.org/W2143246362","https://openalex.org/W2146417688","https://openalex.org/W2150355634","https://openalex.org/W2150972825","https://openalex.org/W2153747061","https://openalex.org/W2158742097","https://openalex.org/W2164979547","https://openalex.org/W2213316970","https://openalex.org/W2262705777","https://openalex.org/W2329988659","https://openalex.org/W2342441590","https://openalex.org/W2346855476","https://openalex.org/W2359052552","https://openalex.org/W2421027944","https://openalex.org/W2468118445","https://openalex.org/W2469354249","https://openalex.org/W2510751330","https://openalex.org/W2514506319","https://openalex.org/W2525698066","https://openalex.org/W2527609605","https://openalex.org/W2530272476","https://openalex.org/W2543174917","https://openalex.org/W2586334933","https://openalex.org/W2587296353","https://openalex.org/W2591503454","https://openalex.org/W2605227384","https://openalex.org/W2607017794","https://openalex.org/W2724380411","https://openalex.org/W2738293734","https://openalex.org/W2739753320","https://openalex.org/W2752221960","https://openalex.org/W2756783629","https://openalex.org/W2764061390","https://openalex.org/W2765474481","https://openalex.org/W2767950341","https://openalex.org/W2767993413","https://openalex.org/W2780452922","https://openalex.org/W2784733460","https://openalex.org/W2808340672","https://openalex.org/W2809174813","https://openalex.org/W2896976060","https://openalex.org/W2901087297","https://openalex.org/W2903772775","https://openalex.org/W2911407981","https://openalex.org/W2911720476","https://openalex.org/W2921482002","https://openalex.org/W2945012379","https://openalex.org/W2972005432","https://openalex.org/W3016083481","https://openalex.org/W6663309735","https://openalex.org/W6719818206","https://openalex.org/W6762505923"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W42295635","https://openalex.org/W1973996291","https://openalex.org/W2931662336","https://openalex.org/W2077865380","https://openalex.org/W2330575325","https://openalex.org/W2765597752","https://openalex.org/W2134894512","https://openalex.org/W2083375246"],"abstract_inverted_index":{"Physical":[0],"activity":[1,103,143,228],"has":[2],"been":[3],"correlated":[4],"with":[5,15,72,215],"a":[6,41,84,139,147],"reduced":[7],"risk":[8],"of":[9,46,52,93,101,114,141,155,195,204,226,282,295],"cognitive":[10,19],"decline,":[11],"including":[12],"that":[13,89,274],"associated":[14],"vascular":[16,58,105,127,283],"dementia,":[17],"mild":[18],"impairment":[20],"(MCI)":[21],"and":[22,56,66,121,128,171,185,211,221,231,247,285],"Alzheimer's":[23],"disease":[24],"(AD);":[25],"recent":[26],"literature":[27],"suggests":[28],"this":[29],"may":[30],"in":[31,83,107,131,168,173,192,208,234,258,264,288,292],"part":[32],"result":[33],"from":[34,77,150],"benefits":[35,225],"to":[36,80,97,125,146,152,165,177,199,267,279],"the":[37,50,78,81,90,169,174,193,259,280,293],"cerebrovascular":[38],"network.":[39],"Using":[40],"transgenic":[42],"(Tg)":[43],"mouse":[44],"model":[45],"AD,":[47],"we":[48],"evaluated":[49,255],"effect":[51,297],"running":[53,148,206,265,277],"on":[54,104,229,245,298],"cortical":[55,210,230],"hippocampal":[57,212,232],"morphology,":[59,214],"cerebral":[60,248],"amyloid":[61,63,74,129,249,299],"angiopathy,":[62],"plaque":[64],"load,":[65],"spatial":[67,252,286],"memory.":[68],"TgCRND8":[69,133,159,197,220,237,269,289],"mice":[70,134,238],"present":[71],"progressive":[73],"pathology,":[75],"advancing":[76],"cortex":[79,170],"hippocampus":[82,175,194],"time-dependent":[85,99],"manner.":[86],"We":[87,116],"postulated":[88],"characteristic":[91],"progression":[92],"pathology":[94,130],"could":[95],"lead":[96],"differential,":[98],"effects":[100],"physical":[102,142,227],"morphology":[106,284],"these":[108],"brain":[109],"regions":[110],"at":[111],"6":[112,153],"months":[113,154,203],"age.":[115],"used":[117],"two-photon":[118],"fluorescent":[119],"microscopy":[120],"3D":[122],"vessel":[123,183,187],"tracking":[124],"characterize":[126],"sedentary":[132,158,196,268],"compared":[135,176,198,266],"those":[136],"who":[137],"have":[138],"history":[140],"(unlimited":[144],"access":[145],"wheel,":[149],"3":[151],"age).":[156],"In":[157],"mice,":[160,290],"capillary":[161],"density":[162],"was":[163,261],"found":[164],"be":[166],"lower":[167],"higher":[172,191],"non-transgenic":[178],"(nonTg)":[179],"littermates.":[180],"Capillary":[181],"length,":[182],"branching,":[184],"non-capillary":[186],"tortuosity":[188],"were":[189,239],"also":[190],"nonTg":[200,222],"mice.":[201,223,270],"Three":[202],"voluntary":[205,276],"resulted":[207],"normalizing":[209],"microvascular":[213],"no":[216],"significant":[217,243],"difference":[218],"between":[219],"The":[224],"vasculature":[233],"6-month":[235],"old":[236],"not":[240],"paralleled":[241],"by":[242,256],"changes":[244],"parenchymal":[246],"pathology.":[250,300],"Short-term":[251],"memory-":[253],"as":[254],"performance":[257],"Y-maze-":[260],"significantly":[262],"improved":[263],"These":[271],"results":[272],"suggest":[273],"long-term":[275],"contributes":[278],"maintenance":[281],"memory":[287],"even":[291],"absence":[294],"an":[296]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
