{"id":"https://openalex.org/W2900954375","doi":"https://doi.org/10.1016/j.neuroimage.2018.11.010","title":"Age-related changes in brain deactivation but not in activation after motor learning","display_name":"Age-related changes in brain deactivation but not in activation after motor learning","publication_year":2018,"publication_date":"2018-11-12","ids":{"openalex":"https://openalex.org/W2900954375","doi":"https://doi.org/10.1016/j.neuroimage.2018.11.010","mag":"2900954375","pmid":"https://pubmed.ncbi.nlm.nih.gov/30439511"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2018.11.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2018.11.010","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.neuroimage.2018.11.010","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072308210","display_name":"Kelly M.M. Berghuis","orcid":null},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"funder","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["IT","NL"],"is_corresponding":true,"raw_author_name":"K.M.M. Berghuis","raw_affiliation_strings":["University of Groningen, University Medical Center Groningen, Center for Human Movement Sciences, Groningen, the Netherlands; IRCCS Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy; IRCCS Santa Lucia Foundation, Non-Invasive Brain Stimulation Unit, Rome, Italy. Electronic address: k.m.m.berghuis@umcg.nl","IRCCS Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy","University of Groningen, University Medical Center Groningen, Center for Human Movement Sciences, Groningen, the Netherlands","IRCCS Santa Lucia Foundation, Non-Invasive Brain Stimulation Unit, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Center for Human Movement Sciences, Groningen, the Netherlands; IRCCS Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy; IRCCS Santa Lucia Foundation, Non-Invasive Brain Stimulation Unit, Rome, Italy. Electronic address: k.m.m.berghuis@umcg.nl","institution_ids":[]},{"raw_affiliation_string":"IRCCS Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]},{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Center for Human Movement Sciences, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"IRCCS Santa Lucia Foundation, Non-Invasive Brain Stimulation Unit, Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033141499","display_name":"Sabrina Fagioli","orcid":"https://orcid.org/0000-0002-6381-0989"},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I119003972","display_name":"Roma Tre University","ror":"https://ror.org/05vf0dg29","country_code":"IT","type":"education","lineage":["https://openalex.org/I119003972"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Fagioli","raw_affiliation_strings":["IRCCS Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy; University of Roma Tre, Department of Education, Rome, Italy","University of Roma Tre, Department of Education, Rome, Italy","IRCCS Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"IRCCS Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy; University of Roma Tre, Department of Education, Rome, Italy","institution_ids":[]},{"raw_affiliation_string":"University of Roma Tre, Department of Education, Rome, Italy","institution_ids":["https://openalex.org/I119003972"]},{"raw_affiliation_string":"IRCCS Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065911879","display_name":"Natasha M. Maurits","orcid":"https://orcid.org/0000-0001-6231-7044"},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"funder","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"N.M. Maurits","raw_affiliation_strings":["University of Groningen, University Medical Center Groningen, Department of Neurology, Groningen, the Netherlands"],"affiliations":[{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Neurology, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019256826","display_name":"Inge Zijdewind","orcid":"https://orcid.org/0000-0003-2146-1212"},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"funder","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"I. Zijdewind","raw_affiliation_strings":["University of Groningen, University Medical Center Groningen, Department of Neuroscience, Groningen, the Netherlands"],"affiliations":[{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Department of Neuroscience, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000300595","display_name":"Jan-Bernard Marsman","orcid":"https://orcid.org/0000-0002-6341-4388"},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"funder","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J.B.C. Marsman","raw_affiliation_strings":["University of Groningen, University Medical Center Groningen, Cognitive Neuroscience Center, Biomedical Sciences of Cells and Systems, Groningen, the Netherlands"],"affiliations":[{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Cognitive Neuroscience Center, Biomedical Sciences of Cells and Systems, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062588593","display_name":"Tibor Hortob\u00e1gyi","orcid":"https://orcid.org/0000-0001-5732-7942"},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"funder","lineage":["https://openalex.org/I1334415907"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"T. Hortob\u00e1gyi","raw_affiliation_strings":["University of Groningen, University Medical Center Groningen, Center for Human Movement Sciences, Groningen, the Netherlands"],"affiliations":[{"raw_affiliation_string":"University of Groningen, University Medical Center Groningen, Center for Human Movement Sciences, Groningen, the Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065074874","display_name":"Giacomo Koch","orcid":"https://orcid.org/0000-0001-6155-9439"},"institutions":[{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. Koch","raw_affiliation_strings":["IRCCS Santa Lucia Foundation, Non-Invasive Brain Stimulation Unit, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"IRCCS Santa Lucia Foundation, Non-Invasive Brain Stimulation Unit, Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078205854","display_name":"Marco Bozzali","orcid":"https://orcid.org/0000-0002-0568-2026"},"institutions":[{"id":"https://openalex.org/I162608824","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656","country_code":"GB","type":"education","lineage":["https://openalex.org/I162608824"]},{"id":"https://openalex.org/I100063501","display_name":"Brighton and Sussex Medical School","ror":"https://ror.org/01qz7fr76","country_code":"GB","type":"education","lineage":["https://openalex.org/I100063501","https://openalex.org/I162608824","https://openalex.org/I71637028"]},{"id":"https://openalex.org/I4210150112","display_name":"Fondazione Santa Lucia","ror":"https://ror.org/05rcxtd95","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210150112","https://openalex.org/I4210153126"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"M. Bozzali","raw_affiliation_strings":["IRCCS Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy; University of Sussex, Brighton & Sussex Medical School, Department of Neuroscience, Brighton, United Kingdom","University of Sussex, Brighton & Sussex Medical School, Department of Neuroscience, Brighton, United Kingdom","IRCCS Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"IRCCS Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy; University of Sussex, Brighton & Sussex Medical School, Department of Neuroscience, Brighton, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"University of Sussex, Brighton & Sussex Medical School, Department of Neuroscience, Brighton, United Kingdom","institution_ids":["https://openalex.org/I100063501","https://openalex.org/I162608824"]},{"raw_affiliation_string":"IRCCS Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy","institution_ids":["https://openalex.org/I4210150112"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5072308210"],"corresponding_institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384","https://openalex.org/I4210150112"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":2.6927,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.90820518,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"186","issue":null,"first_page":"358","last_page":"368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/young-adult","display_name":"Young adult","score":0.6398367285728455},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.6346419453620911},{"id":"https://openalex.org/keywords/motor-learning","display_name":"Motor learning","score":0.5790808200836182},{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.5164316296577454},{"id":"https://openalex.org/keywords/motor-skill","display_name":"Motor skill","score":0.4939461350440979},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"Fractional anisotropy","score":0.46774011850357056},{"id":"https://openalex.org/keywords/motor-cortex","display_name":"Motor cortex","score":0.42748916149139404},{"id":"https://openalex.org/keywords/functional-magnetic-resonance-imaging","display_name":"Functional magnetic resonance imaging","score":0.4119721055030823},{"id":"https://openalex.org/keywords/audiology","display_name":"Audiology","score":0.40452444553375244},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.39680615067481995},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.39094579219818115},{"id":"https://openalex.org/keywords/developmental-psychology","display_name":"Developmental psychology","score":0.2877017855644226},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2426077425479889}],"concepts":[{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.6398367285728455},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6346419453620911},{"id":"https://openalex.org/C107690735","wikidata":"https://www.wikidata.org/wiki/Q852461","display_name":"Motor learning","level":2,"score":0.5790808200836182},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.5164316296577454},{"id":"https://openalex.org/C169976356","wikidata":"https://www.wikidata.org/wiki/Q13208902","display_name":"Motor skill","level":2,"score":0.4939461350440979},{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.46774011850357056},{"id":"https://openalex.org/C2778373776","wikidata":"https://www.wikidata.org/wiki/Q18696","display_name":"Motor cortex","level":3,"score":0.42748916149139404},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.4119721055030823},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.40452444553375244},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39680615067481995},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.39094579219818115},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.2877017855644226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2426077425479889},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073656","descriptor_name":"Healthy Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073656","descriptor_name":"Healthy Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073656","descriptor_name":"Healthy Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009048","descriptor_name":"Motor Skills","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009048","descriptor_name":"Motor Skills","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009048","descriptor_name":"Motor Skills","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060830","descriptor_name":"Consolidation Chemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060830","descriptor_name":"Consolidation Chemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060830","descriptor_name":"Consolidation Chemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1016/j.neuroimage.2018.11.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2018.11.010","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:30439511","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30439511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":null},{"id":"pmh:oai:pure.rug.nl:openaire/5be7a885-9923-4641-8c45-faff072fe6ca","is_oa":false,"landing_page_url":"https://research.rug.nl/en/publications/5be7a885-9923-4641-8c45-faff072fe6ca","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Berghuis, K M M, Fagioli, S, Maurits, N M, Zijdewind, I, Marsman, J B C, Hortob\u00e1gyi, T, Koch, G & Bozzali, M 2019, 'Age-related changes in brain deactivation but not in activation after motor learning', Neuroimage, vol. 186, pp. 358-368. https://doi.org/10.1016/j.neuroimage.2018.11.010","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pure.rug.nl:publications/5be7a885-9923-4641-8c45-faff072fe6ca","is_oa":true,"landing_page_url":"https://hdl.handle.net/11370/5be7a885-9923-4641-8c45-faff072fe6ca","pdf_url":"https://pure.rug.nl/ws/files/71231506/Age_related_changes_in_brain_deactivation_but_not_in_activation_after_motor_learning.pdf","source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Berghuis, K M M, Fagioli, S, Maurits, N M, Zijdewind, I, Marsman, J B C, Hortob\u00e1gyi, T, Koch, G & Bozzali, M 2019, 'Age-related changes in brain deactivation but not in activation after motor learning', Neuroimage, vol. 186, pp. 358-368. https://doi.org/10.1016/j.neuroimage.2018.11.010","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:iris.uniecampus.it:11389/28626","is_oa":false,"landing_page_url":"http://hdl.handle.net/11389/28626","pdf_url":null,"source":{"id":"https://openalex.org/S4306400077","display_name":"IRIS eCampus Telematic University (Universit\u00e0 degli Studi eCampus)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I167322064","host_organization_name":"Universit\u00e0 degli Studi eCampus","host_organization_lineage":["https://openalex.org/I167322064"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unife.it:11392/2447326","is_oa":true,"landing_page_url":"http://hdl.handle.net/11392/2447326","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma3.it:11590/348214","is_oa":false,"landing_page_url":"https://hdl.handle.net/11590/348214","pdf_url":null,"source":{"id":"https://openalex.org/S4377196120","display_name":"Iris (Roma Tre University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I119003972","host_organization_name":"Roma Tre University","host_organization_lineage":["https://openalex.org/I119003972"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unito.it:2318/1738531","is_oa":true,"landing_page_url":"http://hdl.handle.net/2318/1738531","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2018.11.010","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2018.11.010","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7200000286102295,"id":"https://metadata.un.org/sdg/4","display_name":"Quality Education"}],"awards":[{"id":"https://openalex.org/G176340327","display_name":null,"funder_award_id":"653013","funder_id":"https://openalex.org/F4320323105","funder_display_name":"Universitair Medisch Centrum Groningen"}],"funders":[{"id":"https://openalex.org/F4320323105","display_name":"Universitair Medisch Centrum Groningen","ror":"https://ror.org/03cv38k47"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1504497433","https://openalex.org/W1809589163","https://openalex.org/W1847168837","https://openalex.org/W1960756182","https://openalex.org/W1969336180","https://openalex.org/W1975097416","https://openalex.org/W1982802306","https://openalex.org/W1983112713","https://openalex.org/W1987065396","https://openalex.org/W1988793076","https://openalex.org/W1990234940","https://openalex.org/W1995505238","https://openalex.org/W2001555513","https://openalex.org/W2009621566","https://openalex.org/W2017318064","https://openalex.org/W2022530159","https://openalex.org/W2024365408","https://openalex.org/W2034690693","https://openalex.org/W2045308379","https://openalex.org/W2046104092","https://openalex.org/W2053646390","https://openalex.org/W2061195971","https://openalex.org/W2066285067","https://openalex.org/W2073025039","https://openalex.org/W2078166267","https://openalex.org/W2082367798","https://openalex.org/W2097015231","https://openalex.org/W2101476799","https://openalex.org/W2104011235","https://openalex.org/W2104897414","https://openalex.org/W2110431535","https://openalex.org/W2117800611","https://openalex.org/W2136022845","https://openalex.org/W2136406126","https://openalex.org/W2140513167","https://openalex.org/W2143316684","https://openalex.org/W2147546041","https://openalex.org/W2162010696","https://openalex.org/W2167929622","https://openalex.org/W2167944546","https://openalex.org/W2168301247","https://openalex.org/W2168844688","https://openalex.org/W2470594653","https://openalex.org/W2473662145","https://openalex.org/W2521566269","https://openalex.org/W2688675906","https://openalex.org/W2737094118","https://openalex.org/W2766692132","https://openalex.org/W2794696542","https://openalex.org/W4238809637","https://openalex.org/W4376849352"],"related_works":["https://openalex.org/W4308126387","https://openalex.org/W2353511225","https://openalex.org/W1970523025","https://openalex.org/W2513692752","https://openalex.org/W2801972429","https://openalex.org/W2013588380","https://openalex.org/W2071080072","https://openalex.org/W3185285019","https://openalex.org/W2368697114","https://openalex.org/W1967161469"],"abstract_inverted_index":{"It":[0],"is":[1],"poorly":[2],"understood":[3],"how":[4],"healthy":[5],"aging":[6],"affects":[7],"neural":[8],"mechanisms":[9],"underlying":[10],"motor":[11,89,114,117,183,186],"learning.":[12],"We":[13],"used":[14,47],"blood-oxygen-level":[15],"dependent":[16],"(BOLD)":[17],"contrasts":[18],"to":[19,48,195],"examine":[20,49],"age-related":[21,50,221,234],"changes":[22,52,222],"in":[23,53,94,120,131,143,154,159,173,175,197,209,223],"brain":[24,134],"activation":[25,135,141,152,224],"after":[26,148,157,169,180],"acquisition":[27,150],"and":[28,42,67,83,145,200],"consolidation":[29,158],"(24":[30],"h)":[31],"of":[32],"a":[33,230],"visuomotor":[34],"tracking":[35],"skill.":[36],"Additionally,":[37],"structural":[38,51,235],"magnetic":[39],"resonance":[40],"imaging":[41,45],"diffusion":[43],"tensor":[44],"were":[46,178],"the":[54,126,182,210],"brain.":[55],"Older":[56],"adults":[57,78,106,129,189,205],"had":[58],"reduced":[59],"gray":[60],"matter":[61,70],"volume":[62],"(628":[63],"\u00b1":[64,73,80,85],"57":[65],"ml)":[66],"mean":[68,99,110],"white":[69],"anisotropy":[71],"(0.18":[72],"0.03)":[74],"compared":[75,103,136],"with":[76,104,137],"young":[77,105,138],"(741":[79],"59":[81],"ml":[82],"0.22":[84],"0.02,":[86],"respectively).":[87],"Although":[88],"performance":[90,118],"was":[91,216],"53%":[92],"lower":[93],"older":[95,128,204],"(n":[96,107],"=":[97,108],"15,":[98,109],"age":[100,111,122,161,219],"63.1":[101],"years)":[102],"25.5":[112],"years),":[113],"practice":[115],"improved":[116],"similarly":[119],"both":[121,160],"groups.":[123],"While":[124],"executing":[125],"task,":[127],"showed":[130,190,206],"general":[132],"greater":[133,191],"adults.":[139],"BOLD":[140],"decreased":[142],"parietal":[144],"occipital":[146,199],"areas":[147,156,177],"skill":[149,170,184],"but":[151],"increased":[153],"these":[155],"groups,":[162,220],"indicating":[163],"more":[164],"efficient":[165],"visuospatial":[166],"processing":[167],"immediately":[168],"acquisition.":[171],"Changes":[172],"deactivation":[174,208],"specific":[176],"age-dependent":[179],"consolidating":[181],"into":[185],"memory.":[187],"Young":[188],"deactivations":[192],"from":[193],"post-test":[194],"retention":[196],"parietal,":[198],"temporal":[201],"cortices,":[202],"whereas":[203],"smaller":[207],"frontal":[211],"cortex.":[212],"Since":[213],"learning":[214],"rate":[215],"similar":[217],"between":[218],"patterns":[225],"may":[226],"be":[227],"interpreted":[228],"as":[229],"compensatory":[231],"mechanism":[232],"for":[233],"decline.":[236]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}