{"id":"https://openalex.org/W2771049431","doi":"https://doi.org/10.1016/j.neuroimage.2017.11.060","title":"Developing 3D microscopy with CLARITY on human brain tissue: Towards a tool for informing and validating MRI-based histology","display_name":"Developing 3D microscopy with CLARITY on human brain tissue: Towards a tool for informing and validating MRI-based histology","publication_year":2017,"publication_date":"2017-11-28","ids":{"openalex":"https://openalex.org/W2771049431","doi":"https://doi.org/10.1016/j.neuroimage.2017.11.060","mag":"2771049431","pmid":"https://pubmed.ncbi.nlm.nih.gov/29196268"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2017.11.060","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2017.11.060","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.neuroimage.2017.11.060","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043070566","display_name":"Markus Morawski","orcid":"https://orcid.org/0000-0002-3817-5186"},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Markus Morawski","raw_affiliation_strings":["Paul Flechsig Institute of Brain Research, University of Leipzig, Liebigstr. 19, 04103, Leipzig, Germany. Electronic address: markus.morawski@medizin.uni-leipzig.de","Paul Flechsig Institute of Brain Research, University of Leipzig, Liebigstr. 19, 04103, Leipzig, Germany"],"affiliations":[{"raw_affiliation_string":"Paul Flechsig Institute of Brain Research, University of Leipzig, Liebigstr. 19, 04103, Leipzig, Germany. Electronic address: markus.morawski@medizin.uni-leipzig.de","institution_ids":[]},{"raw_affiliation_string":"Paul Flechsig Institute of Brain Research, University of Leipzig, Liebigstr. 19, 04103, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060624754","display_name":"Evgeniya Kirilina","orcid":"https://orcid.org/0000-0003-1304-4363"},"institutions":[{"id":"https://openalex.org/I4210160373","display_name":"Einstein Center for Neurosciences Berlin","ror":"https://ror.org/05s5xvk70","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210160373"]},{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Evgeniya Kirilina","raw_affiliation_strings":["Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstra\u00dfe 1a, 04103, Leipzig, Germany; Center for Cognitive Neuroscience Berlin, Free University Berlin, Habelschwerdter Allee 45, 14195, Berlin, Germany. Electronic address: kirilina@cbs.mpg.de","Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstra\u00dfe 1a, 04103, Leipzig, Germany","Center for Cognitive Neuroscience Berlin, Free University Berlin, Habelschwerdter Allee 45, 14195, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstra\u00dfe 1a, 04103, Leipzig, Germany; Center for Cognitive Neuroscience Berlin, Free University Berlin, Habelschwerdter Allee 45, 14195, Berlin, Germany. Electronic address: kirilina@cbs.mpg.de","institution_ids":[]},{"raw_affiliation_string":"Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstra\u00dfe 1a, 04103, Leipzig, Germany","institution_ids":["https://openalex.org/I4210130445"]},{"raw_affiliation_string":"Center for Cognitive Neuroscience Berlin, Free University Berlin, Habelschwerdter Allee 45, 14195, Berlin, Germany","institution_ids":["https://openalex.org/I4210160373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085986753","display_name":"Nico Scherf","orcid":"https://orcid.org/0000-0003-4003-9121"},"institutions":[{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nico Scherf","raw_affiliation_strings":["Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstra\u00dfe 1a, 04103, Leipzig, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstra\u00dfe 1a, 04103, Leipzig, Germany","institution_ids":["https://openalex.org/I4210130445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030835256","display_name":"Carsten J\u00e4ger","orcid":"https://orcid.org/0000-0002-1134-9692"},"institutions":[{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carsten J\u00e4ger","raw_affiliation_strings":["Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstra\u00dfe 1a, 04103, Leipzig, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstra\u00dfe 1a, 04103, Leipzig, Germany","institution_ids":["https://openalex.org/I4210130445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069605688","display_name":"Katja Reimann","orcid":null},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katja Reimann","raw_affiliation_strings":["Paul Flechsig Institute of Brain Research, University of Leipzig, Liebigstr. 19, 04103, Leipzig, Germany"],"affiliations":[{"raw_affiliation_string":"Paul Flechsig Institute of Brain Research, University of Leipzig, Liebigstr. 19, 04103, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033789564","display_name":"Robert Trampel","orcid":"https://orcid.org/0000-0002-3080-9412"},"institutions":[{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert Trampel","raw_affiliation_strings":["Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstra\u00dfe 1a, 04103, Leipzig, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstra\u00dfe 1a, 04103, Leipzig, Germany","institution_ids":["https://openalex.org/I4210130445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079513512","display_name":"Filippos Gavriilidis","orcid":null},"institutions":[{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Filippos Gavriilidis","raw_affiliation_strings":["Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstra\u00dfe 1a, 04103, Leipzig, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstra\u00dfe 1a, 04103, Leipzig, Germany","institution_ids":["https://openalex.org/I4210130445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004274650","display_name":"Stefan Geyer","orcid":"https://orcid.org/0000-0002-1015-5765"},"institutions":[{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Geyer","raw_affiliation_strings":["Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstra\u00dfe 1a, 04103, Leipzig, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstra\u00dfe 1a, 04103, Leipzig, Germany","institution_ids":["https://openalex.org/I4210130445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022316248","display_name":"Bernd Biedermann","orcid":null},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd Biedermann","raw_affiliation_strings":["Paul Flechsig Institute of Brain Research, University of Leipzig, Liebigstr. 19, 04103, Leipzig, Germany"],"affiliations":[{"raw_affiliation_string":"Paul Flechsig Institute of Brain Research, University of Leipzig, Liebigstr. 19, 04103, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003366066","display_name":"Thomas Arendt","orcid":"https://orcid.org/0000-0003-4553-1625"},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Arendt","raw_affiliation_strings":["Paul Flechsig Institute of Brain Research, University of Leipzig, Liebigstr. 19, 04103, Leipzig, Germany"],"affiliations":[{"raw_affiliation_string":"Paul Flechsig Institute of Brain Research, University of Leipzig, Liebigstr. 19, 04103, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024555751","display_name":"Nikolaus Weiskopf","orcid":"https://orcid.org/0000-0001-5239-1881"},"institutions":[{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nikolaus Weiskopf","raw_affiliation_strings":["Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstra\u00dfe 1a, 04103, Leipzig, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstra\u00dfe 1a, 04103, Leipzig, Germany","institution_ids":["https://openalex.org/I4210130445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5043070566","https://openalex.org/A5060624754"],"corresponding_institution_ids":["https://openalex.org/I4210130445","https://openalex.org/I4210160373","https://openalex.org/I926574661"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":7.5207,"has_fulltext":false,"cited_by_count":117,"citation_normalized_percentile":{"value":0.97868371,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"182","issue":null,"first_page":"417","last_page":"428"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voxel","display_name":"Voxel","score":0.621170699596405},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.601959228515625},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.5933752655982971},{"id":"https://openalex.org/keywords/relaxometry","display_name":"Relaxometry","score":0.5223358869552612},{"id":"https://openalex.org/keywords/histology","display_name":"Histology","score":0.4684469997882843},{"id":"https://openalex.org/keywords/human-brain","display_name":"Human brain","score":0.4425513446331024},{"id":"https://openalex.org/keywords/optical-transparency","display_name":"Optical transparency","score":0.4236270785331726},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.37803274393081665},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.35060375928878784},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.33942335844039917},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3156014680862427},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2638859152793884},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.16987350583076477}],"concepts":[{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.621170699596405},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.601959228515625},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5933752655982971},{"id":"https://openalex.org/C73286259","wikidata":"https://www.wikidata.org/wiki/Q7310885","display_name":"Relaxometry","level":4,"score":0.5223358869552612},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.4684469997882843},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.4425513446331024},{"id":"https://openalex.org/C2987818599","wikidata":"https://www.wikidata.org/wiki/Q487623","display_name":"Optical transparency","level":2,"score":0.4236270785331726},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37803274393081665},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.35060375928878784},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33942335844039917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3156014680862427},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2638859152793884},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.16987350583076477},{"id":"https://openalex.org/C83042744","wikidata":"https://www.wikidata.org/wiki/Q904043","display_name":"Spin echo","level":3,"score":0.0},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001344","descriptor_name":"Autopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001344","descriptor_name":"Autopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001344","descriptor_name":"Autopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001344","descriptor_name":"Autopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006652","descriptor_name":"Histological Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006652","descriptor_name":"Histological Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006652","descriptor_name":"Histological Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006652","descriptor_name":"Histological Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014015","descriptor_name":"Tissue Banks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014015","descriptor_name":"Tissue Banks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014015","descriptor_name":"Tissue Banks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014015","descriptor_name":"Tissue Banks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.neuroimage.2017.11.060","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2017.11.060","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:29196268","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29196268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":null},{"id":"pmh:oai:escidoc.org:escidoc:2506206","is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-002E-7529-8","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:5179388","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6189522","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6189522","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6189522","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuroimage","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2017.11.060","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2017.11.060","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1034069562","display_name":"Non-Invasive In-Vivo Histology in Health and Disease Using Magnetic Resonance Imaging (MRI)","funder_award_id":"616905","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G1457423747","display_name":null,"funder_award_id":"GE 2 967/1-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3829048491","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3981126665","display_name":null,"funder_award_id":"Seventh Framework Programme","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4869689085","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5351598298","display_name":null,"funder_award_id":"MO 2 249/3\u20131","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5593277320","display_name":null,"funder_award_id":"2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7404756931","display_name":null,"funder_award_id":"616905","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320333065","display_name":"Seventh Framework Programme","ror":null},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F4320334960","display_name":"Seventh Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W291418382","https://openalex.org/W563555122","https://openalex.org/W866661342","https://openalex.org/W1533361117","https://openalex.org/W1585273445","https://openalex.org/W1603300429","https://openalex.org/W1827542220","https://openalex.org/W1890720342","https://openalex.org/W1925396657","https://openalex.org/W1954972627","https://openalex.org/W1970189203","https://openalex.org/W1977024431","https://openalex.org/W1985220458","https://openalex.org/W1987263024","https://openalex.org/W1988632449","https://openalex.org/W1989266964","https://openalex.org/W1989514351","https://openalex.org/W2000558985","https://openalex.org/W2025244019","https://openalex.org/W2031703351","https://openalex.org/W2032254014","https://openalex.org/W2043932413","https://openalex.org/W2051036306","https://openalex.org/W2067214598","https://openalex.org/W2068391384","https://openalex.org/W2071718644","https://openalex.org/W2076507262","https://openalex.org/W2082629402","https://openalex.org/W2087396173","https://openalex.org/W2087451538","https://openalex.org/W2094735787","https://openalex.org/W2105134652","https://openalex.org/W2105552075","https://openalex.org/W2106000011","https://openalex.org/W2114507444","https://openalex.org/W2123663192","https://openalex.org/W2129534965","https://openalex.org/W2154107574","https://openalex.org/W2160041854","https://openalex.org/W2167279371","https://openalex.org/W2175340201","https://openalex.org/W2257769523","https://openalex.org/W2305716341","https://openalex.org/W2338294535","https://openalex.org/W2346595684","https://openalex.org/W2397071937","https://openalex.org/W2402046699","https://openalex.org/W2465504877","https://openalex.org/W2540220299","https://openalex.org/W2559784390","https://openalex.org/W2581687280","https://openalex.org/W2593976904","https://openalex.org/W2598427385","https://openalex.org/W2601810315","https://openalex.org/W2602293332","https://openalex.org/W2606556535","https://openalex.org/W2623064601","https://openalex.org/W2758180105","https://openalex.org/W2964012060","https://openalex.org/W3103749967","https://openalex.org/W4252814819","https://openalex.org/W4298306790","https://openalex.org/W6647969864","https://openalex.org/W6691778140","https://openalex.org/W6744636987"],"related_works":["https://openalex.org/W3112223792","https://openalex.org/W1954374319","https://openalex.org/W2782273750","https://openalex.org/W2126341063","https://openalex.org/W3022539865","https://openalex.org/W2998383577","https://openalex.org/W3093125726","https://openalex.org/W2777937401","https://openalex.org/W1767855133","https://openalex.org/W2007506293"],"abstract_inverted_index":{"Recent":[0],"breakthroughs":[1],"in":[2,27,35,41,67],"magnetic":[3],"resonance":[4],"imaging":[5,12,108,197],"(MRI)":[6],"enabled":[7],"quantitative":[8,92],"relaxometry":[9],"and":[10,32,53,146,168,185,190,219,242],"diffusion-weighted":[11],"with":[13,17,69,110,202,226],"sub-millimeter":[14],"resolution.":[15],"Combined":[16],"biophysical":[18],"models":[19],"of":[20,30,89,133,149,163,171,183,198,213,237,251],"MR":[21],"contrast":[22],"the":[23,131,199,209],"emerging":[24],"methods":[25,45],"promise":[26],"vivo":[28,36],"mapping":[29],"cyto-":[31],"myelo-architectonics,":[33],"i.e.,":[34],"histology":[37,71],"using":[38],"MRI":[39,60,232],"(hMRI)":[40],"humans.":[42],"The":[43,234],"hMRI":[44,90,126,134],"require":[46],"histological":[47,102],"reference":[48],"data":[49],"for":[50,125,211,249],"model":[51],"building":[52],"validation.":[54,127],"This":[55],"is":[56,79,135,245],"currently":[57],"provided":[58],"by":[59,180],"on":[61,72,95,105],"post":[62,151,176],"mortem":[63,152,177],"human":[64,153],"brain":[65,154,178],"tissue":[66,112,179],"combination":[68,182,236],"classical":[70],"sections.":[73],"However,":[74],"this":[75],"well":[76],"established":[77],"approach":[78],"limited":[80],"to":[81,130,138,165,173,229],"qualitative":[82],"2D":[83],"information,":[84],"while":[85],"a":[86,100,111,157,181,224,230,246],"systematic":[87],"validation":[88,250],"requires":[91],"3D":[93,107,195,239],"information":[94],"macroscopic":[96],"voxels.":[97],"We":[98,193,207],"present":[99],"promising":[101,247],"method":[103],"based":[104],"optical":[106,196,240],"combined":[109,194],"clearing":[113,189],"method,":[114],"Clear":[115],"Lipid-exchanged":[116],"Acrylamide-hybridized":[117],"Rigid":[118],"Imaging":[119],"compatible":[120],"Tissue":[121],"hYdrogel":[122],"(CLARITY),":[123],"adapted":[124],"Adapting":[128],"CLARITY":[129],"needs":[132],"challenging":[136],"due":[137],"poor":[139],"antibody":[140],"penetration":[141],"into":[142],"large":[143],"sample":[144],"volumes":[145],"high":[147],"opacity":[148],"aged":[150],"tissue.":[155],"In":[156],"pilot":[158],"experiment":[159],"we":[160],"achieved":[161],"transparency":[162],"up":[164,172],"8":[166],"mm-thick":[167,175],"immunohistochemical":[169],"staining":[170,191],"5":[174],"active":[184],"passive":[186],"clearing,":[187],"prolonged":[188],"times.":[192],"cleared":[200],"samples":[201],"tailored":[203],"image":[204,243],"processing":[205,244],"methods.":[206],"demonstrated":[208],"feasibility":[210],"quantification":[212],"neuron":[214],"density,":[215],"fiber":[216],"orientation":[217],"distribution":[218],"cell":[220],"type":[221],"classification":[222],"within":[223],"volume":[225],"size":[227],"similar":[228],"typical":[231],"voxel.":[233],"presented":[235],"MRI,":[238],"microscopy":[241],"tool":[248],"MRI-based":[252],"microstructure":[253],"estimates.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":5}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}