{"id":"https://openalex.org/W2738088587","doi":"https://doi.org/10.1016/j.neuroimage.2017.07.050","title":"AV-1451 PET imaging of tau pathology in preclinical Alzheimer disease: Defining a summary measure","display_name":"AV-1451 PET imaging of tau pathology in preclinical Alzheimer disease: Defining a summary measure","publication_year":2017,"publication_date":"2017-07-26","ids":{"openalex":"https://openalex.org/W2738088587","doi":"https://doi.org/10.1016/j.neuroimage.2017.07.050","mag":"2738088587","pmid":"https://pubmed.ncbi.nlm.nih.gov/28756238"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2017.07.050","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2017.07.050","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5696044","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083277633","display_name":"Shruti Mishra","orcid":"https://orcid.org/0000-0002-7384-009X"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shruti Mishra","raw_affiliation_strings":["Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090741969","display_name":"Brian A. Gordon","orcid":"https://orcid.org/0000-0003-2109-2955"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian A. Gordon","raw_affiliation_strings":["Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":[]},{"raw_affiliation_string":"Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004835193","display_name":"Yi Su","orcid":"https://orcid.org/0000-0002-1946-8063"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Su","raw_affiliation_strings":["Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108637778","display_name":"Jon Christensen","orcid":null},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon Christensen","raw_affiliation_strings":["Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002480456","display_name":"Karl A. Friedrichsen","orcid":"https://orcid.org/0000-0002-9233-1418"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karl Friedrichsen","raw_affiliation_strings":["Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031046038","display_name":"Kelley Jackson","orcid":null},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelley Jackson","raw_affiliation_strings":["Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090575393","display_name":"Russ C. Hornbeck","orcid":"https://orcid.org/0000-0002-9519-6223"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russ Hornbeck","raw_affiliation_strings":["Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":[]},{"raw_affiliation_string":"Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090442343","display_name":"David A. Balota","orcid":null},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Balota","raw_affiliation_strings":["Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Department of Psychological and Brain Sciences, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","Department of Psychological and Brain Sciences, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Department of Psychological and Brain Sciences, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":[]},{"raw_affiliation_string":"Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Psychological and Brain Sciences, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072010327","display_name":"Nigel J. Cairns","orcid":"https://orcid.org/0000-0001-9858-3344"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nigel J. Cairns","raw_affiliation_strings":["Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Department of Neurology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","Department of Pathology & Immunology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","Department of Neurology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Department of Neurology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology & Immunology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Neurology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063630764","display_name":"John C. Morris","orcid":"https://orcid.org/0000-0001-9820-5618"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Morris","raw_affiliation_strings":["Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Department of Neurology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","Department of Neurology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Department of Neurology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":[]},{"raw_affiliation_string":"Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Neurology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076073942","display_name":"Beau M. Ances","orcid":"https://orcid.org/0000-0003-3862-7397"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beau M. Ances","raw_affiliation_strings":["Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Department of Neurology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","Department of Neurology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Department of Neurology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":[]},{"raw_affiliation_string":"Department of Neurology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000597778","display_name":"Tammie L.S. Benzinger","orcid":"https://orcid.org/0000-0002-8114-0552"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210157890","display_name":"Neurological Surgery","ror":"https://ror.org/04r0gp612","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157890"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tammie L.S. Benzinger","raw_affiliation_strings":["Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Department of Neurological Surgery, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA. Electronic address: benzingert@wustl.edu","Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","Department of Neurological Surgery, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA; Department of Neurological Surgery, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA. Electronic address: benzingert@wustl.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Neurological Surgery, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210157890"]},{"raw_affiliation_string":"Knight Alzheimer's Disease Research Center, Washington University in St. Louis, School of Medicine, 510 S. Kingshighway, MC 8131, Saint Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5000597778"],"corresponding_institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210157890"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":null,"fwci":9.1221,"has_fulltext":false,"cited_by_count":166,"citation_normalized_percentile":{"value":0.98723574,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"161","issue":null,"first_page":"171","last_page":"178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/entorhinal-cortex","display_name":"Entorhinal cortex","score":0.6986688375473022},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"Positron emission tomography","score":0.6142098307609558},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5326492190361023},{"id":"https://openalex.org/keywords/alzheimers-disease","display_name":"Alzheimer's disease","score":0.5308846831321716},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.5272905826568604},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.46361786127090454},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.42776787281036377},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.39955490827560425},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3937810957431793},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.39128440618515015},{"id":"https://openalex.org/keywords/hippocampus","display_name":"Hippocampus","score":0.31916946172714233},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.28276991844177246}],"concepts":[{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.6986688375473022},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.6142098307609558},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5326492190361023},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5308846831321716},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.5272905826568604},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.46361786127090454},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42776787281036377},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39955490827560425},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3937810957431793},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.39128440618515015},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.31916946172714233},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28276991844177246},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069558","descriptor_name":"Unsupervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069558","descriptor_name":"Unsupervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069558","descriptor_name":"Unsupervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002243","descriptor_name":"Carbolines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002243","descriptor_name":"Carbolines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002243","descriptor_name":"Carbolines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D062706","descriptor_name":"Prodromal Symptoms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062706","descriptor_name":"Prodromal Symptoms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062706","descriptor_name":"Prodromal Symptoms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neuroimage.2017.07.050","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2017.07.050","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:28756238","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28756238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":null},{"id":"pmh:oai:europepmc.org:5155009","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5696044","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5696044","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5696044","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuroimage","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5696044","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5696044","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuroimage","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.7300000190734863,"id":"https://metadata.un.org/sdg/10"}],"awards":[{"id":"https://openalex.org/G6703672480","display_name":null,"funder_award_id":"P01 AG003991","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309700","display_name":"Foundation for Barnes-Jewish Hospital","ror":"https://ror.org/04wyvkr12"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W314658570","https://openalex.org/W1538814448","https://openalex.org/W1839388999","https://openalex.org/W1882762527","https://openalex.org/W1912212332","https://openalex.org/W1963599567","https://openalex.org/W1967642097","https://openalex.org/W1974806875","https://openalex.org/W1977541817","https://openalex.org/W1991952617","https://openalex.org/W1992974274","https://openalex.org/W2004293194","https://openalex.org/W2013146608","https://openalex.org/W2014659404","https://openalex.org/W2014897304","https://openalex.org/W2022095524","https://openalex.org/W2026331106","https://openalex.org/W2037473016","https://openalex.org/W2040434160","https://openalex.org/W2047205872","https://openalex.org/W2048178552","https://openalex.org/W2051489981","https://openalex.org/W2052742260","https://openalex.org/W2053116497","https://openalex.org/W2065535274","https://openalex.org/W2084954638","https://openalex.org/W2084957666","https://openalex.org/W2093650784","https://openalex.org/W2100610042","https://openalex.org/W2103440561","https://openalex.org/W2112579276","https://openalex.org/W2120576515","https://openalex.org/W2129497119","https://openalex.org/W2131001963","https://openalex.org/W2145828601","https://openalex.org/W2151986002","https://openalex.org/W2170937822","https://openalex.org/W2174753847","https://openalex.org/W2209078744","https://openalex.org/W2215958284","https://openalex.org/W2288973352","https://openalex.org/W2290262197","https://openalex.org/W2290598353","https://openalex.org/W2311427096","https://openalex.org/W2353776455","https://openalex.org/W2412942072","https://openalex.org/W2494504397","https://openalex.org/W2529649944","https://openalex.org/W2605281905","https://openalex.org/W4235092975","https://openalex.org/W6640090867","https://openalex.org/W6655716183","https://openalex.org/W6678007627","https://openalex.org/W6723302768","https://openalex.org/W6736450075"],"related_works":["https://openalex.org/W1976076281","https://openalex.org/W2385459031","https://openalex.org/W2071334059","https://openalex.org/W2004473215","https://openalex.org/W2111940573","https://openalex.org/W2038127357","https://openalex.org/W2033518573","https://openalex.org/W2146367411","https://openalex.org/W2430838905","https://openalex.org/W2140514880"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":3}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}