{"id":"https://openalex.org/W2141594757","doi":"https://doi.org/10.1016/j.neuroimage.2014.06.033","title":"Mapping track density changes in nigrostriatal and extranigral pathways in Parkinson's disease","display_name":"Mapping track density changes in nigrostriatal and extranigral pathways in Parkinson's disease","publication_year":2014,"publication_date":"2014-06-20","ids":{"openalex":"https://openalex.org/W2141594757","doi":"https://doi.org/10.1016/j.neuroimage.2014.06.033","mag":"2141594757","pmid":"https://pubmed.ncbi.nlm.nih.gov/24956065"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2014.06.033","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2014.06.033","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.neuroimage.2014.06.033","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028616268","display_name":"Erik Ziegler","orcid":"https://orcid.org/0000-0003-1857-8129"},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Erik Ziegler","raw_affiliation_strings":["Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"affiliations":[{"raw_affiliation_string":"Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018078700","display_name":"Maud Rouillard","orcid":null},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Maud Rouillard","raw_affiliation_strings":["MoVeRe Group, Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"affiliations":[{"raw_affiliation_string":"MoVeRe Group, Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000988679","display_name":"Elodie Andr\u00e9","orcid":null},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Elodie Andr\u00e9","raw_affiliation_strings":["Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"affiliations":[{"raw_affiliation_string":"Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091700907","display_name":"Tim Coolen","orcid":"https://orcid.org/0000-0002-5034-9265"},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Tim Coolen","raw_affiliation_strings":["MoVeRe Group, Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"affiliations":[{"raw_affiliation_string":"MoVeRe Group, Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007692352","display_name":"Johan Stender","orcid":null},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Johan Stender","raw_affiliation_strings":["Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"affiliations":[{"raw_affiliation_string":"Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054096836","display_name":"Evelyne Balteau","orcid":null},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Evelyne Balteau","raw_affiliation_strings":["Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"affiliations":[{"raw_affiliation_string":"Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005472608","display_name":"Christophe Phillips","orcid":"https://orcid.org/0000-0002-4990-425X"},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Christophe Phillips","raw_affiliation_strings":["Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium; Department of Electrical Engineering and Computer Science, University of Li\u00e8ge, Li\u00e8ge, Belgium. Electronic address: c.phillips@ulg.ac.be","Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium","Department of Electrical Engineering and Computer Science, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"affiliations":[{"raw_affiliation_string":"Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium; Department of Electrical Engineering and Computer Science, University of Li\u00e8ge, Li\u00e8ge, Belgium. Electronic address: c.phillips@ulg.ac.be","institution_ids":["https://openalex.org/I157674565"]},{"raw_affiliation_string":"Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012185674","display_name":"Ga\u00ebtan Garraux","orcid":"https://orcid.org/0000-0001-7829-2806"},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ga\u00ebtan Garraux","raw_affiliation_strings":["MoVeRe Group, Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium; Department of Neurology, University of Li\u00e8ge, Li\u00e8ge, Belgium","MoVeRe Group, Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium","Department of Neurology, University of Li\u00e8ge, Li\u00e8ge, Belgium"],"affiliations":[{"raw_affiliation_string":"MoVeRe Group, Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium; Department of Neurology, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]},{"raw_affiliation_string":"MoVeRe Group, Cyclotron Research Centre, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]},{"raw_affiliation_string":"Department of Neurology, University of Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5005472608"],"corresponding_institution_ids":["https://openalex.org/I157674565"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":5.9888,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.96473791,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"99","issue":null,"first_page":"498","last_page":"508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/putamen","display_name":"Putamen","score":0.5976296663284302},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"Substantia nigra","score":0.5736268758773804},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5678905248641968},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.5452114343643188},{"id":"https://openalex.org/keywords/striatum","display_name":"Striatum","score":0.5334904789924622},{"id":"https://openalex.org/keywords/pedunculopontine-nucleus","display_name":"Pedunculopontine nucleus","score":0.500302791595459},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.49434804916381836},{"id":"https://openalex.org/keywords/locus-coeruleus","display_name":"Locus coeruleus","score":0.49422934651374817},{"id":"https://openalex.org/keywords/pons","display_name":"Pons","score":0.48360103368759155},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.43078845739364624},{"id":"https://openalex.org/keywords/functional-magnetic-resonance-imaging","display_name":"Functional magnetic resonance imaging","score":0.42747607827186584},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.42669111490249634},{"id":"https://openalex.org/keywords/thalamus","display_name":"Thalamus","score":0.4221479594707489},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.38364851474761963},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.2574847340583801},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.1990537941455841},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.15844783186912537},{"id":"https://openalex.org/keywords/dopamine","display_name":"Dopamine","score":0.10507851839065552},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.0912022590637207}],"concepts":[{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.5976296663284302},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.5736268758773804},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5678905248641968},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.5452114343643188},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.5334904789924622},{"id":"https://openalex.org/C2781153452","wikidata":"https://www.wikidata.org/wiki/Q3345673","display_name":"Pedunculopontine nucleus","level":5,"score":0.500302791595459},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.49434804916381836},{"id":"https://openalex.org/C2778468602","wikidata":"https://www.wikidata.org/wiki/Q1470452","display_name":"Locus coeruleus","level":3,"score":0.49422934651374817},{"id":"https://openalex.org/C2778897929","wikidata":"https://www.wikidata.org/wiki/Q192570","display_name":"Pons","level":2,"score":0.48360103368759155},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.43078845739364624},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.42747607827186584},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.42669111490249634},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.4221479594707489},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38364851474761963},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2574847340583801},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1990537941455841},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.15844783186912537},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.10507851839065552},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0912022590637207},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008032","descriptor_name":"Limbic System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008032","descriptor_name":"Limbic System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008032","descriptor_name":"Limbic System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neuroimage.2014.06.033","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2014.06.033","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:24956065","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24956065","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":null},{"id":"pmh:oai:orbi.ulg.ac.be:2268/171173","is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/171173","pdf_url":null,"source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NeuroImage, 99, 498-508 (2014-10)","raw_type":"peer reviewed"},{"id":"pmh:oai:pubmedcentral.nih.gov:4121087","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4121087","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuroimage","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2014.06.033","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2014.06.033","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.699999988079071,"display_name":"Quality Education","id":"https://metadata.un.org/sdg/4"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310598","display_name":"Amazon Web Services","ror":"https://ror.org/04mv4n011"},{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"},{"id":"https://openalex.org/F4320323329","display_name":"Universit\u00e9 de Li\u00e8ge","ror":"https://ror.org/00afp2z80"},{"id":"https://openalex.org/F4320331740","display_name":"Fondation M\u00e9dicale Reine Elisabeth","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W42708503","https://openalex.org/W603663909","https://openalex.org/W1514787407","https://openalex.org/W1562509261","https://openalex.org/W1847168837","https://openalex.org/W1896275438","https://openalex.org/W1967251218","https://openalex.org/W1967396591","https://openalex.org/W1969661963","https://openalex.org/W1970242734","https://openalex.org/W1971690948","https://openalex.org/W1972352018","https://openalex.org/W1972685664","https://openalex.org/W1973397887","https://openalex.org/W1974438823","https://openalex.org/W1974898145","https://openalex.org/W1977776486","https://openalex.org/W1981804878","https://openalex.org/W1984935060","https://openalex.org/W1986269945","https://openalex.org/W1992290626","https://openalex.org/W1992633971","https://openalex.org/W1995138343","https://openalex.org/W1996271059","https://openalex.org/W2001617943","https://openalex.org/W2006096283","https://openalex.org/W2009546549","https://openalex.org/W2009837079","https://openalex.org/W2010125850","https://openalex.org/W2015808525","https://openalex.org/W2017431521","https://openalex.org/W2027053794","https://openalex.org/W2027947474","https://openalex.org/W2030235290","https://openalex.org/W2032689087","https://openalex.org/W2033832477","https://openalex.org/W2034252184","https://openalex.org/W2034609031","https://openalex.org/W2038944674","https://openalex.org/W2044908785","https://openalex.org/W2045527031","https://openalex.org/W2046213817","https://openalex.org/W2046557060","https://openalex.org/W2048345503","https://openalex.org/W2050551219","https://openalex.org/W2053465090","https://openalex.org/W2056189993","https://openalex.org/W2062791478","https://openalex.org/W2063381269","https://openalex.org/W2063416152","https://openalex.org/W2063920647","https://openalex.org/W2064386755","https://openalex.org/W2064996887","https://openalex.org/W2069402698","https://openalex.org/W2073449985","https://openalex.org/W2074086697","https://openalex.org/W2075126496","https://openalex.org/W2075252610","https://openalex.org/W2077240096","https://openalex.org/W2077455609","https://openalex.org/W2084454712","https://openalex.org/W2085844004","https://openalex.org/W2087102256","https://openalex.org/W2089289079","https://openalex.org/W2090187118","https://openalex.org/W2092462980","https://openalex.org/W2094435366","https://openalex.org/W2106841463","https://openalex.org/W2112111016","https://openalex.org/W2113502567","https://openalex.org/W2113619522","https://openalex.org/W2115957268","https://openalex.org/W2116219487","https://openalex.org/W2117987496","https://openalex.org/W2119030930","https://openalex.org/W2122683421","https://openalex.org/W2123363285","https://openalex.org/W2123621258","https://openalex.org/W2126255160","https://openalex.org/W2128928835","https://openalex.org/W2129597913","https://openalex.org/W2131298599","https://openalex.org/W2133955737","https://openalex.org/W2135654522","https://openalex.org/W2136145485","https://openalex.org/W2141214264","https://openalex.org/W2141417178","https://openalex.org/W2144982232","https://openalex.org/W2147111512","https://openalex.org/W2147133578","https://openalex.org/W2149092213","https://openalex.org/W2150667092","https://openalex.org/W2152111408","https://openalex.org/W2155298532","https://openalex.org/W2159132478","https://openalex.org/W2165020904","https://openalex.org/W2166281097","https://openalex.org/W2166609052","https://openalex.org/W2168844688","https://openalex.org/W2170600487","https://openalex.org/W2312955568","https://openalex.org/W2323830726","https://openalex.org/W2336893408","https://openalex.org/W2367835735","https://openalex.org/W2408369940","https://openalex.org/W2799379448","https://openalex.org/W2972597017","https://openalex.org/W4230920194","https://openalex.org/W4285719527","https://openalex.org/W6601739002","https://openalex.org/W6620191985","https://openalex.org/W6648537780","https://openalex.org/W6660147321","https://openalex.org/W6708302725"],"related_works":["https://openalex.org/W1994559013","https://openalex.org/W1989487268","https://openalex.org/W2350159966","https://openalex.org/W2095403170","https://openalex.org/W2047679272","https://openalex.org/W2772852820","https://openalex.org/W2038990480","https://openalex.org/W2145892209","https://openalex.org/W1964442944","https://openalex.org/W2044391154"],"abstract_inverted_index":{"In":[0],"Parkinson's":[1,35,111,202],"disease":[2,38],"(PD)":[3],"the":[4,45,82,110,129,133,139,143,150,154,162,179],"demonstration":[5],"of":[6,142,161,182,196],"neuropathological":[7,183],"disturbances":[8],"in":[9,76,104,109,119,149,169,185,201],"nigrostriatal":[10,172],"and":[11,60,80,94,125,135,146,152,171,198],"extranigral":[12],"brain":[13],"pathways":[14,173],"using":[15],"magnetic":[16],"resonance":[17],"imaging":[18,28,31],"remains":[19],"a":[20,25,175],"challenge.":[21],"Here,":[22],"we":[23],"applied":[24],"novel":[26],"diffusion-weighted":[27],"approach-track":[29],"density":[30,64,106],"(TDI).":[32],"Twenty-seven":[33],"non-demented":[34,186],"patients":[36],"(mean":[37],"duration:":[39],"5":[40],"years,":[41],"mean":[42],"score":[43],"on":[44],"Hoehn":[46],"&":[47],"Yahr":[48],"scale=1.5)":[49],"were":[50,66,107,117],"compared":[51],"with":[52,98,178],"26":[53],"elderly":[54],"controls":[55],"matched":[56],"for":[57],"age,":[58],"sex,":[59],"education":[61],"level.":[62],"Track":[63],"images":[65],"created":[67],"by":[68],"sampling":[69],"each":[70,87],"subject's":[71],"spatially":[72],"normalized":[73],"fiber":[74],"tracks":[75],"1mm":[77],"isotropic":[78],"intervals":[79],"counting":[81],"fibers":[83],"that":[84],"passed":[85],"through":[86],"voxel.":[88],"Whole-brain":[89],"voxel-based":[90],"analysis":[91],"was":[92,96],"performed":[93],"significance":[95],"assessed":[97],"permutation":[99],"testing.":[100],"Statistically":[101],"significant":[102],"increases":[103],"track":[105],"found":[108],"patients,":[112],"relative":[113],"to":[114,132,158],"controls.":[115],"Clusters":[116],"distributed":[118],"disease-relevant":[120],"areas":[121],"including":[122],"motor,":[123],"cognitive,":[124],"limbic":[126,197],"networks.":[127],"From":[128],"lower":[130],"medulla":[131],"diencephalon":[134],"striatum,":[136],"clusters":[137],"encompassed":[138],"known":[140,180],"location":[141],"locus":[144],"coeruleus":[145],"pedunculopontine":[147],"nucleus":[148],"pons,":[151],"from":[153],"substantia":[155],"nigra":[156],"up":[157],"medial":[159],"aspects":[160],"posterior":[163],"putamen,":[164],"bilaterally.":[165],"The":[166],"results":[167,190],"identified":[168],"brainstem":[170],"show":[174],"large":[176],"overlap":[177],"distribution":[181],"changes":[184],"PD":[187],"patients.":[188],"Our":[189],"also":[191],"support":[192],"an":[193],"early":[194],"involvement":[195],"cognitive":[199],"networks":[200],"disease.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3}],"updated_date":"2026-03-27T14:29:43.386196","created_date":"2025-10-10T00:00:00"}