{"id":"https://openalex.org/W7167897770","doi":"https://doi.org/10.1016/j.media.2026.104200","title":"PathFound: An agentic multimodal model activating evidence-seeking pathological diagnosis","display_name":"PathFound: An agentic multimodal model activating evidence-seeking pathological diagnosis","publication_year":2026,"publication_date":"2026-07-10","ids":{"openalex":"https://openalex.org/W7167897770","doi":"https://doi.org/10.1016/j.media.2026.104200","pmid":"https://pubmed.ncbi.nlm.nih.gov/42442213"},"language":"en","primary_location":{"id":"doi:10.1016/j.media.2026.104200","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.media.2026.104200","pdf_url":null,"source":{"id":"https://openalex.org/S116571295","display_name":"Medical Image Analysis","issn_l":"1361-8415","issn":["1361-8415","1361-8423","1361-8431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Image Analysis","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5121624618","display_name":"Shengyi Hua","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengyi Hua","raw_affiliation_strings":["Qing Yuan Research Institute, Shanghai Jiao Tong University, Shanghai, 200240, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qing Yuan Research Institute, Shanghai Jiao Tong University, Shanghai, 200240, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101826689","display_name":"Jianfeng Wu","orcid":"https://orcid.org/0000-0003-3990-5897"},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianfeng Wu","raw_affiliation_strings":["State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Pathology, School of Basic Medicine and Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Pathology, School of Basic Medicine and Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110798582","display_name":"Tianle Shen","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianle Shen","raw_affiliation_strings":["Qing Yuan Research Institute, Shanghai Jiao Tong University, Shanghai, 200240, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qing Yuan Research Institute, Shanghai Jiao Tong University, Shanghai, 200240, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002742720","display_name":"Kangzhe Hu","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kangzhe Hu","raw_affiliation_strings":["Qing Yuan Research Institute, Shanghai Jiao Tong University, Shanghai, 200240, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qing Yuan Research Institute, Shanghai Jiao Tong University, Shanghai, 200240, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017431694","display_name":"Zhongzhen Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongzhen Huang","raw_affiliation_strings":["Qing Yuan Research Institute, Shanghai Jiao Tong University, Shanghai, 200240, Shanghai, China; SenseCare, Shanghai, 200232, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qing Yuan Research Institute, Shanghai Jiao Tong University, Shanghai, 200240, Shanghai, China; SenseCare, Shanghai, 200232, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140388887","display_name":"Shujuan Ni","orcid":null},"institutions":[{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shujuan Ni","raw_affiliation_strings":["Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140386377","display_name":"Zhihong Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhihong Zhang","raw_affiliation_strings":["Department of Pathology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102015798","display_name":"Yuan Li","orcid":"https://orcid.org/0000-0002-0133-7516"},"institutions":[{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Li","raw_affiliation_strings":["Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, Shanghai, China; Institute of Pathology, Fudan University, Shanghai, 200032, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, 200032, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, Shanghai, China; Institute of Pathology, Fudan University, Shanghai, 200032, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100407631","display_name":"Zhe Wang","orcid":"https://orcid.org/0009-0000-2387-784X"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhe Wang","raw_affiliation_strings":["State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Pathology, School of Basic Medicine and Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China; Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, Anhui, China; Intelligent Pathology Institute, Division of Life Sciences and Medicine, Hefei, 230036, Anhui, China. Electronic address: zhwang@fmmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Pathology, School of Basic Medicine and Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, Shaanxi, China; Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, Anhui, China; Intelligent Pathology Institute, Division of Life Sciences and Medicine, Hefei, 230036, Anhui, China. Electronic address: zhwang@fmmu.edu.cn","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5140435109","display_name":"Xiaofan Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaofan Zhang","raw_affiliation_strings":["Qing Yuan Research Institute, Shanghai Jiao Tong University, Shanghai, 200240, Shanghai, China; Shanghai Innovation Institute, Shanghai, 200231, Shanghai, China. Electronic address: xiaofan.zhang@sjtu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qing Yuan Research Institute, Shanghai Jiao Tong University, Shanghai, 200240, Shanghai, China; Shanghai Innovation Institute, Shanghai, 200231, Shanghai, China. Electronic address: xiaofan.zhang@sjtu.edu.cn","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100407631","https://openalex.org/A5140386377","https://openalex.org/A5140435109"],"corresponding_institution_ids":["https://openalex.org/I126520041","https://openalex.org/I183067930","https://openalex.org/I83519826"],"apc_list":{"value":4170,"currency":"USD","value_usd":4170},"apc_paid":null,"fwci":8.6773,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.9788874,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"113","issue":null,"first_page":"104200","last_page":"104200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12574","display_name":"Clinical Reasoning and Diagnostic Skills","score":0.1785999983549118,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12574","display_name":"Clinical Reasoning and Diagnostic Skills","score":0.1785999983549118,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10906","display_name":"AI-based Problem Solving and Planning","score":0.050200000405311584,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11714","display_name":"Multimodal Machine Learning Applications","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pathological","display_name":"Pathological","score":0.4255000054836273},{"id":"https://openalex.org/keywords/multimodal-therapy","display_name":"Multimodal therapy","score":0.38100001215934753},{"id":"https://openalex.org/keywords/focus","display_name":"Focus (optics)","score":0.3677000105381012},{"id":"https://openalex.org/keywords/perspective","display_name":"Perspective (graphical)","score":0.27129998803138733},{"id":"https://openalex.org/keywords/action","display_name":"Action (physics)","score":0.266400009393692}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.46219998598098755},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4255000054836273},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4221999943256378},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.40560001134872437},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4007999897003174},{"id":"https://openalex.org/C4441509","wikidata":"https://www.wikidata.org/wiki/Q6418787","display_name":"Multimodal therapy","level":2,"score":0.38100001215934753},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.3677000105381012},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.34709998965263367},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3082999885082245},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.3034000098705292},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.27129998803138733},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.266400009393692},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.2655999958515167},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.250900000333786}],"mesh":[{"descriptor_ui":"D000098342","descriptor_name":"Large Language Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098408","descriptor_name":"Reinforcement Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.media.2026.104200","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.media.2026.104200","pdf_url":null,"source":{"id":"https://openalex.org/S116571295","display_name":"Medical Image Analysis","issn_l":"1361-8415","issn":["1361-8415","1361-8423","1361-8431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Image Analysis","raw_type":"journal-article"},{"id":"pmid:42442213","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42442213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical image analysis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4692574196","display_name":null,"funder_award_id":"62301311","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W2344480160","https://openalex.org/W2892938835","https://openalex.org/W3038704997","https://openalex.org/W3096109860","https://openalex.org/W3211190672","https://openalex.org/W4288809219","https://openalex.org/W4385948838","https://openalex.org/W4387321091","https://openalex.org/W4392947521","https://openalex.org/W4392947532","https://openalex.org/W4396781237","https://openalex.org/W4398201291","https://openalex.org/W4399567248","https://openalex.org/W4400889241","https://openalex.org/W4401198708","https://openalex.org/W4402220065","https://openalex.org/W4402727946","https://openalex.org/W4403825982","https://openalex.org/W4406168947","https://openalex.org/W4413147798","https://openalex.org/W4416389231","https://openalex.org/W7133208019"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2026-07-11T00:00:00"}