{"id":"https://openalex.org/W7161480263","doi":"https://doi.org/10.1016/j.media.2026.104131","title":"Electrophysiologically-informed digital twins for atrial fibrillation","display_name":"Electrophysiologically-informed digital twins for atrial fibrillation","publication_year":2026,"publication_date":"2026-05-17","ids":{"openalex":"https://openalex.org/W7161480263","doi":"https://doi.org/10.1016/j.media.2026.104131","pmid":"https://pubmed.ncbi.nlm.nih.gov/42172939"},"language":"en","primary_location":{"id":"doi:10.1016/j.media.2026.104131","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.media.2026.104131","pdf_url":null,"source":{"id":"https://openalex.org/S116571295","display_name":"Medical Image Analysis","issn_l":"1361-8415","issn":["1361-8415","1361-8423","1361-8431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Image Analysis","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.media.2026.104131","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5098660812","display_name":"Mar\u00eda Termen\u00f3n-Rivas","orcid":"https://orcid.org/0009-0001-7092-2401"},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda Termen\u00f3n-Rivas","raw_affiliation_strings":["Computational Multiscale Simulation Lab (CoMMLab), Department of Computer Science and Department of Electronic Engineering, Universitat de Val\u00e8ncia, Avinguda de l'Universitat s/n, Burjassot, 46100, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Multiscale Simulation Lab (CoMMLab), Department of Computer Science and Department of Electronic Engineering, Universitat de Val\u00e8ncia, Avinguda de l'Universitat s/n, Burjassot, 46100, Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122877191","display_name":"G S Romitti","orcid":null},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Giada S. Romitti","raw_affiliation_strings":["Computational Multiscale Simulation Lab (CoMMLab), Department of Computer Science and Department of Electronic Engineering, Universitat de Val\u00e8ncia, Avinguda de l'Universitat s/n, Burjassot, 46100, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Multiscale Simulation Lab (CoMMLab), Department of Computer Science and Department of Electronic Engineering, Universitat de Val\u00e8ncia, Avinguda de l'Universitat s/n, Burjassot, 46100, Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114161686","display_name":"Javier Barrios-\u00c1lvarez de Arcaya","orcid":"https://orcid.org/0009-0001-0618-0263"},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Barrios-\u00c1lvarez de Arcaya","raw_affiliation_strings":["Computational Multiscale Simulation Lab (CoMMLab), Department of Computer Science and Department of Electronic Engineering, Universitat de Val\u00e8ncia, Avinguda de l'Universitat s/n, Burjassot, 46100, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Multiscale Simulation Lab (CoMMLab), Department of Computer Science and Department of Electronic Engineering, Universitat de Val\u00e8ncia, Avinguda de l'Universitat s/n, Burjassot, 46100, Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026533006","display_name":"Sanjiv M. Narayan","orcid":"https://orcid.org/0000-0001-7552-5053"},"institutions":[{"id":"https://openalex.org/I25790992","display_name":"Cardiovascular Institute of the South","ror":"https://ror.org/02c2gwm94","country_code":"US","type":"other","lineage":["https://openalex.org/I25790992"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sanjiv M. Narayan","raw_affiliation_strings":["Cardiovascular Department, Stanford University, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Department, Stanford University, Stanford, CA, USA","institution_ids":["https://openalex.org/I97018004","https://openalex.org/I25790992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051771670","display_name":"Alejandro Liberos","orcid":"https://orcid.org/0000-0002-6963-6328"},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandro Liberos","raw_affiliation_strings":["Computational Multiscale Simulation Lab (CoMMLab), Department of Computer Science and Department of Electronic Engineering, Universitat de Val\u00e8ncia, Avinguda de l'Universitat s/n, Burjassot, 46100, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Multiscale Simulation Lab (CoMMLab), Department of Computer Science and Department of Electronic Engineering, Universitat de Val\u00e8ncia, Avinguda de l'Universitat s/n, Burjassot, 46100, Spain","institution_ids":["https://openalex.org/I16097986"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5122883862","display_name":"M Rodrigo","orcid":null},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Miguel Rodrigo","raw_affiliation_strings":["Computational Multiscale Simulation Lab (CoMMLab), Department of Computer Science and Department of Electronic Engineering, Universitat de Val\u00e8ncia, Avinguda de l'Universitat s/n, Burjassot, 46100, Spain. Electronic address: miguel.rodrigo@uv.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Multiscale Simulation Lab (CoMMLab), Department of Computer Science and Department of Electronic Engineering, Universitat de Val\u00e8ncia, Avinguda de l'Universitat s/n, Burjassot, 46100, Spain. Electronic address: miguel.rodrigo@uv.es","institution_ids":["https://openalex.org/I16097986"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5122883862"],"corresponding_institution_ids":["https://openalex.org/I16097986"],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":{"value":3970,"currency":"USD","value_usd":3970},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.75578038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"112","issue":null,"first_page":"104131","last_page":"104131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9631999731063843,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9631999731063843,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"Atrial fibrillation","score":0.8170999884605408},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.6712999939918518},{"id":"https://openalex.org/keywords/atrium","display_name":"Atrium (architecture)","score":0.4593000113964081},{"id":"https://openalex.org/keywords/left-atrium","display_name":"Left atrium","score":0.4277999997138977},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"Cardiac electrophysiology","score":0.420199990272522},{"id":"https://openalex.org/keywords/fibrillation","display_name":"Fibrillation","score":0.34049999713897705}],"concepts":[{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.8170999884605408},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6765000224113464},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.6712999939918518},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.633899986743927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6080999970436096},{"id":"https://openalex.org/C114021368","wikidata":"https://www.wikidata.org/wiki/Q189265","display_name":"Atrium (architecture)","level":3,"score":0.4593000113964081},{"id":"https://openalex.org/C2777615863","wikidata":"https://www.wikidata.org/wiki/Q1074839","display_name":"Left atrium","level":3,"score":0.4277999997138977},{"id":"https://openalex.org/C61381695","wikidata":"https://www.wikidata.org/wiki/Q3302130","display_name":"Cardiac electrophysiology","level":3,"score":0.420199990272522},{"id":"https://openalex.org/C2777356233","wikidata":"https://www.wikidata.org/wiki/Q1001150","display_name":"Fibrillation","level":3,"score":0.34049999713897705},{"id":"https://openalex.org/C179253579","wikidata":"https://www.wikidata.org/wiki/Q6276958","display_name":"Nerve conduction velocity","level":2,"score":0.3305000066757202},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.32109999656677246},{"id":"https://openalex.org/C2909456097","wikidata":"https://www.wikidata.org/wiki/Q189331","display_name":"Conduction abnormalities","level":2,"score":0.30379998683929443},{"id":"https://openalex.org/C2776459999","wikidata":"https://www.wikidata.org/wiki/Q2119376","display_name":"Fidelity","level":2,"score":0.28690001368522644},{"id":"https://openalex.org/C104397207","wikidata":"https://www.wikidata.org/wiki/Q72711","display_name":"Electrical conduction system of the heart","level":3,"score":0.2775000035762787},{"id":"https://openalex.org/C2777001951","wikidata":"https://www.wikidata.org/wiki/Q1074839","display_name":"Right atrium","level":2,"score":0.2678999900817871}],"mesh":[{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018780","descriptor_name":"Body Surface Potential Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D066230","descriptor_name":"Patient-Specific Modeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.media.2026.104131","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.media.2026.104131","pdf_url":null,"source":{"id":"https://openalex.org/S116571295","display_name":"Medical Image Analysis","issn_l":"1361-8415","issn":["1361-8415","1361-8423","1361-8431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Image Analysis","raw_type":"journal-article"},{"id":"pmid:42172939","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42172939","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical image analysis","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.media.2026.104131","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.media.2026.104131","pdf_url":null,"source":{"id":"https://openalex.org/S116571295","display_name":"Medical Image Analysis","issn_l":"1361-8415","issn":["1361-8415","1361-8423","1361-8431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Image Analysis","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320321864","display_name":"Generalitat Valenciana","ror":"https://ror.org/0097mvx21"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W25713472","https://openalex.org/W1928634140","https://openalex.org/W1967857799","https://openalex.org/W1980072574","https://openalex.org/W1980541470","https://openalex.org/W1985148130","https://openalex.org/W1999184428","https://openalex.org/W2007594411","https://openalex.org/W2019371024","https://openalex.org/W2036816448","https://openalex.org/W2072245817","https://openalex.org/W2072267404","https://openalex.org/W2073134847","https://openalex.org/W2094426445","https://openalex.org/W2125693777","https://openalex.org/W2127748321","https://openalex.org/W2127890285","https://openalex.org/W2141361241","https://openalex.org/W2144704991","https://openalex.org/W2165334534","https://openalex.org/W2166966593","https://openalex.org/W2170627159","https://openalex.org/W2290973885","https://openalex.org/W2593692482","https://openalex.org/W2768907708","https://openalex.org/W2770323593","https://openalex.org/W2802851452","https://openalex.org/W2969852609","https://openalex.org/W3006299015","https://openalex.org/W3082794714","https://openalex.org/W3097416314","https://openalex.org/W3122226502","https://openalex.org/W3135356533","https://openalex.org/W3135477550","https://openalex.org/W4220931391","https://openalex.org/W4241261201","https://openalex.org/W4290773844","https://openalex.org/W4377047325","https://openalex.org/W4380225101","https://openalex.org/W4384924136","https://openalex.org/W4386781664","https://openalex.org/W4387296947","https://openalex.org/W4391319980","https://openalex.org/W4391344270","https://openalex.org/W4394859523","https://openalex.org/W4398142314","https://openalex.org/W4399367939","https://openalex.org/W4399676887","https://openalex.org/W4399781555","https://openalex.org/W4400646927","https://openalex.org/W4401835187","https://openalex.org/W4402321339","https://openalex.org/W4402580432","https://openalex.org/W4403689913","https://openalex.org/W4405435342","https://openalex.org/W4407095298","https://openalex.org/W4409704858","https://openalex.org/W4410176548"],"related_works":[],"abstract_inverted_index":{"Patient-specific":[0],"digital":[1],"twins":[2],"(DTs)":[3],"are":[4],"a":[5,36,227],"promising":[6],"tool":[7],"for":[8,39,49],"studying":[9],"cardiac":[10,214,235],"arrhythmias":[11],"and":[12,57,66,116,134,155,222],"planning":[13,233],"patient-specific":[14,55],"therapies.":[15],"Although":[16],"recent":[17],"DTs":[18,47],"have":[19],"begun":[20],"to":[21,60,97,109,147,176,184],"incorporate":[22],"functional":[23,204],"data,":[24],"comprehensive":[25],"regional":[26],"calibration":[27],"of":[28,72,192,213],"electrophysiological":[29,56,64,106],"activity":[30],"during":[31],"atrial":[32,50,193],"fibrillation":[33,51],"(AF)":[34],"remains":[35],"fundamental":[37],"challenge":[38],"improving":[40],"predictive":[41],"accuracy.":[42],"This":[43],"study":[44],"presents":[45],"electrophysiologically-informed":[46],"(EP-DTs)":[48],"that":[52],"integrate":[53],"detailed":[54],"anatomical":[58,206],"data":[59,207],"emulate":[61],"the":[62,73,210],"AF":[63,92,112],"phenotype":[65],"predict":[67],"therapy":[68],"outcomes.":[69],"Comprehensive":[70],"EP-DTs":[71,101,120,151,180,224],"left":[74],"atrium":[75],"(LA)":[76],"were":[77,87,181],"developed":[78],"in":[79,234],"12":[80],"patients":[81],"using":[82,90],"CT-derived":[83],"geometries.":[84],"These":[85],"models":[86],"regionally":[88],"calibrated":[89],"intracavitary":[91],"recordings":[93],"from":[94],"multipolar":[95],"catheters":[96],"capture":[98],"spatial":[99],"variability.":[100],"more":[102],"accurately":[103],"captured":[104],"key":[105],"phenotypes":[107],"related":[108],"prognosis,":[110],"including":[111],"cycle":[113],"length":[114],"(CL)":[115],"conduction":[117],"velocity":[118],"(CV).":[119],"reproduced":[121],"global":[122],"CL":[123,154,221],"(e.g.,":[124,136],"194":[125],"\u00b1":[126,131,138,143,159,163,166,170,196,200],"15":[127],"ms":[128],"vs.":[129,141,161,168,198],"192":[130],"10":[132],"ms)":[133],"CV":[135,156],"376":[137],"146":[139],"mm/s":[140],"372":[142],"54":[144,169],"mm/s)":[145],"referenced":[146],"patient":[148],"data.":[149],"Regionally,":[150],"reduced":[152],"mean":[153],"errors":[157],"(14":[158],"7%":[160],"23":[162],"9%;":[164],"37":[165],"12%":[167],"15%;":[171],"p":[172],"<":[173],"0.05)":[174],"compared":[175],"anatomic-only":[177],"models.":[178],"Notably,":[179],"also":[182],"able":[183],"specifically":[185],"identify":[186],"proarrhythmic":[187],"regions":[188],"representing":[189],"limited":[190],"areas":[191],"tissue":[194],"(8.7":[195],"8.1%":[197],"12.7":[199],"6.6%":[201],"area).":[202],"Incorporating":[203],"with":[205],"substantially":[208],"enhances":[209],"physiological":[211],"fidelity":[212],"DTs,":[215],"reproducing":[216],"significant":[217],"biomarkers":[218],"such":[219],"as":[220],"CVs.":[223],"therefore":[225],"represent":[226],"critical":[228],"step":[229],"toward":[230],"precision-guided":[231],"treatment":[232],"arrhythmias.":[236]},"counts_by_year":[],"updated_date":"2026-06-14T06:11:07.267592","created_date":"2026-05-18T00:00:00"}
