{"id":"https://openalex.org/W2849984630","doi":"https://doi.org/10.1016/j.gpb.2018.06.001","title":"Genome-Wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development","display_name":"Genome-Wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development","publication_year":2018,"publication_date":"2018-06-01","ids":{"openalex":"https://openalex.org/W2849984630","doi":"https://doi.org/10.1016/j.gpb.2018.06.001","mag":"2849984630","pmid":"https://pubmed.ncbi.nlm.nih.gov/29981854"},"language":"en","primary_location":{"id":"doi:10.1016/j.gpb.2018.06.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gpb.2018.06.001","pdf_url":"https://academic.oup.com/gpb/article-pdf/16/3/162/57578857/gpb_16_3_162.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics &amp; Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/gpb/article-pdf/16/3/162/57578857/gpb_16_3_162.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020280119","display_name":"Andreas Keller","orcid":"https://orcid.org/0000-0002-5361-0895"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Keller","raw_affiliation_strings":["Chair for Clinical Bioinformatics, Saarland University , 66123 Saarbr\u00fccken , Germany"],"raw_orcid":"https://orcid.org/0000-0002-5361-0895","affiliations":[{"raw_affiliation_string":"Chair for Clinical Bioinformatics, Saarland University , 66123 Saarbr\u00fccken , Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075631508","display_name":"Tobias Fehlmann","orcid":"https://orcid.org/0000-0003-1967-2918"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Fehlmann","raw_affiliation_strings":["Chair for Clinical Bioinformatics, Saarland University , 66123 Saarbr\u00fccken , Germany"],"raw_orcid":"https://orcid.org/0000-0003-1967-2918","affiliations":[{"raw_affiliation_string":"Chair for Clinical Bioinformatics, Saarland University , 66123 Saarbr\u00fccken , Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034352333","display_name":"Nicole Ludwig","orcid":"https://orcid.org/0000-0003-4703-7567"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicole Ludwig","raw_affiliation_strings":["Department of Human Genetics, Saarland University Hospital , 66421 Homburg , Germany"],"raw_orcid":"https://orcid.org/0000-0003-4703-7567","affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Saarland University Hospital , 66421 Homburg , Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090441341","display_name":"Mustafa Kahraman","orcid":"https://orcid.org/0000-0002-5536-048X"},"institutions":[{"id":"https://openalex.org/I4210110653","display_name":"Hummingbird Diagnostics (Germany)","ror":"https://ror.org/01skhtc50","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210110653"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mustafa Kahraman","raw_affiliation_strings":["Chair for Clinical Bioinformatics, Saarland University , 66123 Saarbr\u00fccken , Germany","Hummingbird Diagnostics GmbH , 69120 Heidelberg , Germany"],"raw_orcid":"https://orcid.org/0000-0002-5536-048X","affiliations":[{"raw_affiliation_string":"Chair for Clinical Bioinformatics, Saarland University , 66123 Saarbr\u00fccken , Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Hummingbird Diagnostics GmbH , 69120 Heidelberg , Germany","institution_ids":["https://openalex.org/I4210110653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080831429","display_name":"Thomas Laufer","orcid":"https://orcid.org/0000-0002-7094-6999"},"institutions":[{"id":"https://openalex.org/I4210110653","display_name":"Hummingbird Diagnostics (Germany)","ror":"https://ror.org/01skhtc50","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210110653"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Laufer","raw_affiliation_strings":["Department of Human Genetics, Saarland University Hospital , 66421 Homburg , Germany","Hummingbird Diagnostics GmbH , 69120 Heidelberg , Germany"],"raw_orcid":"https://orcid.org/0000-0002-7094-6999","affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Saarland University Hospital , 66421 Homburg , Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Hummingbird Diagnostics GmbH , 69120 Heidelberg , Germany","institution_ids":["https://openalex.org/I4210110653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015677497","display_name":"Christina Backes","orcid":"https://orcid.org/0000-0001-9330-9290"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christina Backes","raw_affiliation_strings":["Chair for Clinical Bioinformatics, Saarland University , 66123 Saarbr\u00fccken , Germany"],"raw_orcid":"https://orcid.org/0000-0001-9330-9290","affiliations":[{"raw_affiliation_string":"Chair for Clinical Bioinformatics, Saarland University , 66123 Saarbr\u00fccken , Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059684830","display_name":"Claus Vogelmeier","orcid":"https://orcid.org/0000-0002-9798-2527"},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claus Vogelmeier","raw_affiliation_strings":["Department of Internal Medicine, Division for Pulmonary Diseases, Philipps University of Marburg , 35043 Marburg , Germany"],"raw_orcid":"https://orcid.org/0000-0002-9798-2527","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division for Pulmonary Diseases, Philipps University of Marburg , 35043 Marburg , Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067874269","display_name":"Caroline Diener","orcid":"https://orcid.org/0000-0002-3222-8419"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Caroline Diener","raw_affiliation_strings":["Department of Human Genetics, Saarland University Hospital , 66421 Homburg , Germany"],"raw_orcid":"https://orcid.org/0000-0002-3222-8419","affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Saarland University Hospital , 66421 Homburg , Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036293206","display_name":"Frank Biertz","orcid":"https://orcid.org/0000-0003-0686-6123"},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Biertz","raw_affiliation_strings":["Institute for Biostatistics, Hannover Medical School , 30625 Hanover , Germany"],"raw_orcid":"https://orcid.org/0000-0003-0686-6123","affiliations":[{"raw_affiliation_string":"Institute for Biostatistics, Hannover Medical School , 30625 Hanover , Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067661870","display_name":"Christian Herr","orcid":"https://orcid.org/0000-0001-9422-6569"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Herr","raw_affiliation_strings":["Department of Internal Medicine V \u2013 Pulmonology, Allergology, Intensive Care Medicine, Saarland University Hospital , 66421 Homburg , Germany"],"raw_orcid":"https://orcid.org/0000-0001-9422-6569","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine V \u2013 Pulmonology, Allergology, Intensive Care Medicine, Saarland University Hospital , 66421 Homburg , Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027287575","display_name":"Rudolf A. J\u00f6rres","orcid":"https://orcid.org/0000-0002-9782-1117"},"institutions":[{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rudolf A. J\u00f6rres","raw_affiliation_strings":["Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Comprehensive Pneumology Center Munich (CPC-M), Ludwig-Maximilians-University Munich, Member of the German Center for Lung Research (DZL) , 80539 Munich , Germany"],"raw_orcid":"https://orcid.org/0000-0002-9782-1117","affiliations":[{"raw_affiliation_string":"Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Comprehensive Pneumology Center Munich (CPC-M), Ludwig-Maximilians-University Munich, Member of the German Center for Lung Research (DZL) , 80539 Munich , Germany","institution_ids":["https://openalex.org/I8204097","https://openalex.org/I4210129183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085594740","display_name":"Hans\u2010Peter Lenhof","orcid":"https://orcid.org/0000-0002-5820-9961"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Peter Lenhof","raw_affiliation_strings":["Center for Bioinformatics, Saarland University , 66123 Saarbr\u00fccken , Germany","Chair for Bioinformatics, Saarland University , 66123 Saarbr\u00fccken , Germany"],"raw_orcid":"https://orcid.org/0000-0002-5820-9961","affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Saarland University , 66123 Saarbr\u00fccken , Germany","institution_ids":["https://openalex.org/I91712215"]},{"raw_affiliation_string":"Chair for Bioinformatics, Saarland University , 66123 Saarbr\u00fccken , Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054514348","display_name":"Eckart Meese","orcid":"https://orcid.org/0000-0001-7569-819X"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eckart Meese","raw_affiliation_strings":["Department of Human Genetics, Saarland University Hospital , 66421 Homburg , Germany"],"raw_orcid":"https://orcid.org/0000-0001-7569-819X","affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Saarland University Hospital , 66421 Homburg , Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051567097","display_name":"Robert Bals","orcid":"https://orcid.org/0000-0002-1472-9535"},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert Bals","raw_affiliation_strings":["Department of Internal Medicine V \u2013 Pulmonology, Allergology, Intensive Care Medicine, Saarland University Hospital , 66421 Homburg , Germany"],"raw_orcid":"https://orcid.org/0000-0002-1472-9535","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine V \u2013 Pulmonology, Allergology, Intensive Care Medicine, Saarland University Hospital , 66421 Homburg , Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"last","author":{"id":null,"display_name":"COSYCONET Study Group","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"COSYCONET Study Group","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":15,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":3.8511,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.94098888,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"16","issue":"3","first_page":"162","last_page":"171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7959384322166443},{"id":"https://openalex.org/keywords/copd","display_name":"COPD","score":0.7512377500534058},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5270065665245056},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.523466944694519},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5175411105155945},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4808148145675659},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.36546245217323303},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3369569778442383},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3309641182422638},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2540328800678253},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20823350548744202}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7959384322166443},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7512377500534058},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5270065665245056},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.523466944694519},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5175411105155945},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4808148145675659},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36546245217323303},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3369569778442383},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3309641182422638},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2540328800678253},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20823350548744202}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1016/j.gpb.2018.06.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gpb.2018.06.001","pdf_url":"https://academic.oup.com/gpb/article-pdf/16/3/162/57578857/gpb_16_3_162.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics &amp; Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29981854","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29981854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, proteomics & bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:bb366ddabc894a2bb255e375df93f7a2","is_oa":true,"landing_page_url":"https://doaj.org/article/bb366ddabc894a2bb255e375df93f7a2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genomics, Proteomics & Bioinformatics, Vol 16, Iss 3, Pp 162-171 (2018)","raw_type":"article"},{"id":"pmh:oai:epub.ub.uni-muenchen.de:63290","is_oa":true,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-63290-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401845","display_name":"Open access LMU (Ludwid Maxmilian's Universitat Munchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genomics Proteomics &amp; Bioinformatics","raw_type":"doc-type:article"},{"id":"pmh:oai:europepmc.org:5032636","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6076380","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:publikationen.sulb.uni-saarland.de:20.500.11880/32340","is_oa":true,"landing_page_url":"http://dx.doi.org/10.22028/D291-35404","pdf_url":null,"source":{"id":"https://openalex.org/S4377196499","display_name":"Publications of the UdS (Saarland University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I91712215","host_organization_name":"Saarland University","host_organization_lineage":["https://openalex.org/I91712215"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doc-type:article"},{"id":"doi:10.22028/d291-35404","is_oa":true,"landing_page_url":"https://doi.org/10.22028/d291-35404","pdf_url":null,"source":{"id":"https://openalex.org/S7407052975","display_name":"Universit\u00e4t des Saarlandes","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.gpb.2018.06.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gpb.2018.06.001","pdf_url":"https://academic.oup.com/gpb/article-pdf/16/3/162/57578857/gpb_16_3_162.pdf","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics &amp; Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3260313982","display_name":null,"funder_award_id":"01GI1001","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G987171090","display_name":null,"funder_award_id":"111450","funder_id":"https://openalex.org/F4320323556","funder_display_name":"Deutsche Krebshilfe"}],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"},{"id":"https://openalex.org/F4320329568","display_name":"Grifols","ror":"https://ror.org/02ed64f32"},{"id":"https://openalex.org/F4320332736","display_name":"Novartis Pharma","ror":"https://ror.org/0013shd50"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2849984630.pdf","grobid_xml":"https://content.openalex.org/works/W2849984630.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W786806679","https://openalex.org/W1180530098","https://openalex.org/W1842452185","https://openalex.org/W1883683241","https://openalex.org/W1966931970","https://openalex.org/W1977060570","https://openalex.org/W1978202982","https://openalex.org/W1986508764","https://openalex.org/W1994732338","https://openalex.org/W1997921822","https://openalex.org/W2032395102","https://openalex.org/W2042218286","https://openalex.org/W2054841768","https://openalex.org/W2066521429","https://openalex.org/W2074931217","https://openalex.org/W2103209361","https://openalex.org/W2108559026","https://openalex.org/W2115121274","https://openalex.org/W2117927200","https://openalex.org/W2118106787","https://openalex.org/W2131423215","https://openalex.org/W2136958060","https://openalex.org/W2142320210","https://openalex.org/W2158427432","https://openalex.org/W2163267243","https://openalex.org/W2179775023","https://openalex.org/W2202546071","https://openalex.org/W2234145498","https://openalex.org/W2263794508","https://openalex.org/W2279137520","https://openalex.org/W2288482887","https://openalex.org/W2290557121","https://openalex.org/W2293841445","https://openalex.org/W2293917369","https://openalex.org/W2297990721","https://openalex.org/W2343700030","https://openalex.org/W2470277042","https://openalex.org/W2519076894","https://openalex.org/W2525775794","https://openalex.org/W2555332535","https://openalex.org/W2569672165","https://openalex.org/W2573109541","https://openalex.org/W2593899959","https://openalex.org/W2626420049","https://openalex.org/W2725073276","https://openalex.org/W2765817331","https://openalex.org/W2769448668","https://openalex.org/W2773892600","https://openalex.org/W4234236664","https://openalex.org/W6685477884"],"related_works":["https://openalex.org/W2624812451","https://openalex.org/W3146691973","https://openalex.org/W2077427688","https://openalex.org/W2460301894","https://openalex.org/W2319967452","https://openalex.org/W3021010435","https://openalex.org/W3142286882","https://openalex.org/W4245372082","https://openalex.org/W3215586121","https://openalex.org/W2252383104"],"abstract_inverted_index":{"Abstract":[0],"Chronic":[1],"obstructive":[2],"pulmonary":[3],"disease":[4,26],"(COPD)":[5],"significantly":[6,148],"increases":[7],"the":[8,36,47,84,106,164,175,186,192,197,212],"risk":[9,238],"of":[10,79,83,90,109,163,188,199,222,239],"developing":[11,141,240],"cancer.":[12,241],"Biomarker":[13],"studies":[14,33],"frequently":[15],"follow":[16],"a":[17,25,71],"case-control":[18],"set-up":[19],"in":[20,63,220],"which":[21,225],"patients":[22,68,101,114,140,236],"diagnosed":[23,92],"with":[24,93,147],"are":[27],"compared":[28],"to":[29,70,210,232],"controls.":[30],"Longitudinal":[31],"cohort":[32],"such":[34],"as":[35,228],"COPD-centered":[37],"German":[38],"COPD":[39,67,223,235],"and":[40,49,112,125,133],"SYstemic":[41],"consequences-COmorbidities":[42],"NETwork":[43],"(COSYCONET)":[44],"study":[45],"provide":[46],"patient":[48],"biomaterial":[50],"base":[51],"for":[52,155,230],"discovering":[53],"predictive":[54],"molecular":[55],"markers.":[56],"We":[57,183],"asked":[58],"whether":[59],"microRNA":[60],"(miRNA)":[61],"profiles":[62,130],"blood":[64,221],"collected":[65],"from":[66],"prior":[69],"tumor":[72,80,85],"diagnosis":[73,78],"could":[74,226],"support":[75],"an":[76],"early":[77],"development":[81],"independent":[82],"type.":[86],"From":[87],"2741":[88],"participants":[89],"COSYCONET":[91],"COPD,":[94],"we":[95,143,216],"selected":[96,204],"534":[97],"individuals":[98],"including":[99,161,174],"33":[100],"who":[102,115],"developed":[103],"cancer":[104,142],"during":[105],"follow-up":[107],"period":[108],"54":[110],"months":[111],"501":[113],"did":[116],"not":[117],"develop":[118],"cancer,":[119],"but":[120],"had":[121],"similar":[122],"age,":[123],"gender":[124],"smoking":[126],"history.":[127],"Genome-wide":[128],"miRNA":[129,194],"were":[131],"generated":[132,193],"evaluated":[134],"using":[135],"machine":[136],"learning":[137],"techniques.":[138],"For":[139,203],"identified":[144,168,217],"nine":[145],"miRNAs":[146,169,219],"decreased":[149],"abundance":[150],"(two-tailed":[151],"unpaired":[152],"t-test":[153],"adjusted":[154],"multiple":[156],"testing":[157],"P":[158],"&amp;lt;":[159],"0.05),":[160],"members":[162],"miR-320":[165],"family.":[166],"The":[167],"regulate":[170],"different":[171],"cancer-related":[172],"pathways":[173],"MAPK":[176],"pathway":[177],"(P":[178],"=":[179],"2.3":[180],"\u00d7":[181],"10\u22125).":[182],"also":[184],"observed":[185],"impact":[187],"confounding":[189],"factors":[190],"on":[191],"profiles,":[195],"underlining":[196],"value":[198],"our":[200],"matched":[201],"analysis.":[202],"miRNAs,":[205],"qRT-PCR":[206],"analysis":[207],"was":[208],"applied":[209],"validate":[211],"results.":[213],"In":[214],"conclusion,":[215],"several":[218],"patients,":[224],"serve":[227],"candidates":[229],"biomarkers":[231],"help":[233],"identify":[234],"at":[237]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
