{"id":"https://openalex.org/W2791398277","doi":"https://doi.org/10.1016/j.gpb.2017.03.006","title":"Microvesicles as Emerging Biomarkers and Therapeutic Targets in Cardiometabolic Diseases","display_name":"Microvesicles as Emerging Biomarkers and Therapeutic Targets in Cardiometabolic Diseases","publication_year":2018,"publication_date":"2018-02-01","ids":{"openalex":"https://openalex.org/W2791398277","doi":"https://doi.org/10.1016/j.gpb.2017.03.006","mag":"2791398277","pmid":"https://pubmed.ncbi.nlm.nih.gov/29462670"},"language":"en","primary_location":{"id":"doi:10.1016/j.gpb.2017.03.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gpb.2017.03.006","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.gpb.2017.03.006","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100714645","display_name":"Yan Chen","orcid":"https://orcid.org/0000-0001-9302-3962"},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]},{"id":"https://openalex.org/I4210133270","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133270"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Chen","raw_affiliation_strings":["Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University , Tianjin, 300211 , China","Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China"],"affiliations":[{"raw_affiliation_string":"Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University , Tianjin, 300211 , China","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I4210133270"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I4210133270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100771745","display_name":"Guangping Li","orcid":"https://orcid.org/0000-0003-2121-2873"},"institutions":[{"id":"https://openalex.org/I4210133270","display_name":"Second Hospital of Tianjin Medical University","ror":"https://ror.org/03rc99w60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133270"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guangping Li","raw_affiliation_strings":["Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University , Tianjin, 300211 , China","Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China"],"affiliations":[{"raw_affiliation_string":"Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University , Tianjin, 300211 , China","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I4210133270"]},{"raw_affiliation_string":"Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China","institution_ids":["https://openalex.org/I5740404","https://openalex.org/I4210133270"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055279293","display_name":"Ming\u2010Lin Liu","orcid":"https://orcid.org/0000-0001-8827-2024"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I4210133394","display_name":"Philadelphia VA Medical Center","ror":"https://ror.org/03j05zz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133394","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ming-Lin Liu","raw_affiliation_strings":["Department of Dermatology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA, 19140 , USA","Philadelphia VA Medical Center , Philadelphia, PA, 19140 , USA","Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Temple University School of Medicine , Philadelphia, PA, 19140 , USA","Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA","Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19140, USA","Philadelphia VA Medical Center, Philadelphia, PA 19140, USA"],"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA, 19140 , USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Philadelphia VA Medical Center , Philadelphia, PA, 19140 , USA","institution_ids":["https://openalex.org/I4210133394"]},{"raw_affiliation_string":"Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Temple University School of Medicine , Philadelphia, PA, 19140 , USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Philadelphia VA Medical Center, Philadelphia, PA 19140, USA","institution_ids":["https://openalex.org/I4210133394"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055279293","https://openalex.org/A5100771745"],"corresponding_institution_ids":["https://openalex.org/I4210133270","https://openalex.org/I4210133394","https://openalex.org/I5740404","https://openalex.org/I79576946","https://openalex.org/I84392919"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":7.2331,"has_fulltext":false,"cited_by_count":123,"citation_normalized_percentile":{"value":0.97992802,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"16","issue":"1","first_page":"50","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9753999710083008,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microvesicles","display_name":"Microvesicles","score":0.9595999121665955},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"Pathogenesis","score":0.7063449621200562},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"Extracellular vesicles","score":0.6738541126251221},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.6261460185050964},{"id":"https://openalex.org/keywords/microvesicle","display_name":"Microvesicle","score":0.5899092555046082},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5310331583023071},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.46299490332603455},{"id":"https://openalex.org/keywords/diagnostic-biomarker","display_name":"Diagnostic biomarker","score":0.45834824442863464},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4144819676876068},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3977097272872925},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3974614441394806},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.3931463360786438},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.32569313049316406},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.21336787939071655},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09111958742141724},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07676336169242859}],"concepts":[{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.9595999121665955},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7063449621200562},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.6738541126251221},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6261460185050964},{"id":"https://openalex.org/C2909763251","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicle","level":5,"score":0.5899092555046082},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5310331583023071},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46299490332603455},{"id":"https://openalex.org/C3017616150","wikidata":"https://www.wikidata.org/wiki/Q1069330","display_name":"Diagnostic biomarker","level":3,"score":0.45834824442863464},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4144819676876068},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3977097272872925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3974614441394806},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.3931463360786438},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32569313049316406},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21336787939071655},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09111958742141724},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07676336169242859}],"mesh":[{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008659","descriptor_name":"Metabolic Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055252","descriptor_name":"Cell-Derived Microparticles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055252","descriptor_name":"Cell-Derived Microparticles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055252","descriptor_name":"Cell-Derived Microparticles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.gpb.2017.03.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gpb.2017.03.006","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},{"id":"pmid:29462670","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29462670","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, proteomics & bioinformatics","raw_type":null},{"id":"pmh:oai:doaj.org/article:a9c676e8006d4a368ddd912610a7921c","is_oa":true,"landing_page_url":"https://doaj.org/article/a9c676e8006d4a368ddd912610a7921c","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genomics, Proteomics & Bioinformatics, Vol 16, Iss 1, Pp 50-62 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4952757","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6000161","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.gpb.2017.03.006","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gpb.2017.03.006","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6700000166893005,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3904479700","display_name":null,"funder_award_id":"81370422","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":169,"referenced_works":["https://openalex.org/W1850586","https://openalex.org/W171351566","https://openalex.org/W1536097606","https://openalex.org/W1540597915","https://openalex.org/W1543846943","https://openalex.org/W1759129926","https://openalex.org/W1808455042","https://openalex.org/W1837519471","https://openalex.org/W1846893549","https://openalex.org/W1934537842","https://openalex.org/W1947199869","https://openalex.org/W1965147416","https://openalex.org/W1966606134","https://openalex.org/W1967265610","https://openalex.org/W1968171440","https://openalex.org/W1968944244","https://openalex.org/W1969208019","https://openalex.org/W1969327353","https://openalex.org/W1971981037","https://openalex.org/W1972070926","https://openalex.org/W1973894250","https://openalex.org/W1976460214","https://openalex.org/W1978294289","https://openalex.org/W1979493465","https://openalex.org/W1979861324","https://openalex.org/W1983432306","https://openalex.org/W1983501902","https://openalex.org/W1984211032","https://openalex.org/W1985265801","https://openalex.org/W1988665495","https://openalex.org/W1990356838","https://openalex.org/W1992066470","https://openalex.org/W1997323470","https://openalex.org/W2004656105","https://openalex.org/W2006453001","https://openalex.org/W2007499410","https://openalex.org/W2010203036","https://openalex.org/W2010498435","https://openalex.org/W2013544411","https://openalex.org/W2015234447","https://openalex.org/W2015372874","https://openalex.org/W2016894696","https://openalex.org/W2017906741","https://openalex.org/W2018484402","https://openalex.org/W2019260611","https://openalex.org/W2019917125","https://openalex.org/W2020992406","https://openalex.org/W2021861291","https://openalex.org/W2022177860","https://openalex.org/W2022413810","https://openalex.org/W2026230250","https://openalex.org/W2027909766","https://openalex.org/W2029094459","https://openalex.org/W2033827133","https://openalex.org/W2037072041","https://openalex.org/W2041165407","https://openalex.org/W2042714431","https://openalex.org/W2045511108","https://openalex.org/W2046758915","https://openalex.org/W2048378608","https://openalex.org/W2049203104","https://openalex.org/W2049921493","https://openalex.org/W2055154202","https://openalex.org/W2055313665","https://openalex.org/W2055539939","https://openalex.org/W2055911204","https://openalex.org/W2056765905","https://openalex.org/W2058184747","https://openalex.org/W2059548056","https://openalex.org/W2060049638","https://openalex.org/W2061650392","https://openalex.org/W2062011959","https://openalex.org/W2063948464","https://openalex.org/W2066426973","https://openalex.org/W2068322460","https://openalex.org/W2069735923","https://openalex.org/W2070307875","https://openalex.org/W2073592102","https://openalex.org/W2078522475","https://openalex.org/W2080418767","https://openalex.org/W2082237882","https://openalex.org/W2082412648","https://openalex.org/W2082588222","https://openalex.org/W2082604867","https://openalex.org/W2085034599","https://openalex.org/W2088623825","https://openalex.org/W2089943045","https://openalex.org/W2090335937","https://openalex.org/W2090475686","https://openalex.org/W2091630980","https://openalex.org/W2092830642","https://openalex.org/W2094941678","https://openalex.org/W2098259366","https://openalex.org/W2100471336","https://openalex.org/W2100927341","https://openalex.org/W2101460202","https://openalex.org/W2101467927","https://openalex.org/W2102186999","https://openalex.org/W2104232901","https://openalex.org/W2104919735","https://openalex.org/W2107383916","https://openalex.org/W2111164967","https://openalex.org/W2111213998","https://openalex.org/W2111686577","https://openalex.org/W2112024036","https://openalex.org/W2112187582","https://openalex.org/W2112254595","https://openalex.org/W2112746619","https://openalex.org/W2112892585","https://openalex.org/W2114224819","https://openalex.org/W2116510943","https://openalex.org/W2119376007","https://openalex.org/W2120677331","https://openalex.org/W2121354606","https://openalex.org/W2122187912","https://openalex.org/W2123355624","https://openalex.org/W2124304994","https://openalex.org/W2124480950","https://openalex.org/W2126336279","https://openalex.org/W2126601545","https://openalex.org/W2127572761","https://openalex.org/W2129062330","https://openalex.org/W2129206637","https://openalex.org/W2129994868","https://openalex.org/W2131069942","https://openalex.org/W2131523986","https://openalex.org/W2132785902","https://openalex.org/W2137375417","https://openalex.org/W2137742067","https://openalex.org/W2141863236","https://openalex.org/W2144158374","https://openalex.org/W2148373296","https://openalex.org/W2148912798","https://openalex.org/W2149776287","https://openalex.org/W2150400324","https://openalex.org/W2150540679","https://openalex.org/W2151079805","https://openalex.org/W2152936026","https://openalex.org/W2154215235","https://openalex.org/W2159835130","https://openalex.org/W2161619324","https://openalex.org/W2163294226","https://openalex.org/W2165689150","https://openalex.org/W2166195796","https://openalex.org/W2166846320","https://openalex.org/W2166872226","https://openalex.org/W2168183582","https://openalex.org/W2168781925","https://openalex.org/W2170640128","https://openalex.org/W2224328263","https://openalex.org/W2278906659","https://openalex.org/W2282960387","https://openalex.org/W2290646886","https://openalex.org/W2294395959","https://openalex.org/W2314778907","https://openalex.org/W2325663967","https://openalex.org/W2333672259","https://openalex.org/W2387634581","https://openalex.org/W2405780334","https://openalex.org/W2415742871","https://openalex.org/W2415943804","https://openalex.org/W2418443178","https://openalex.org/W2503880007","https://openalex.org/W4300916623","https://openalex.org/W6640137936","https://openalex.org/W6642642937","https://openalex.org/W6652581081","https://openalex.org/W6682538542","https://openalex.org/W6716474468"],"related_works":["https://openalex.org/W2601040185","https://openalex.org/W1998066731","https://openalex.org/W2084666131","https://openalex.org/W2008059238","https://openalex.org/W2004257346","https://openalex.org/W3188041304","https://openalex.org/W2945105722","https://openalex.org/W4224608758","https://openalex.org/W4327814780","https://openalex.org/W2890709780"],"abstract_inverted_index":{"Microvesicles":[0],"(MVs,":[1],"also":[2,158],"known":[3],"as":[4,26,43,100,138,145,147,150],"microparticles)":[5],"are":[6],"small":[7],"vesicles":[8],"that":[9,55,136],"originate":[10],"from":[11,33,78],"plasma":[12,73],"membrane":[13],"of":[14,67,75,123,128,134],"almost":[15],"all":[16],"eukaryotic":[17],"cells":[18,36],"during":[19],"apoptosis":[20],"or":[21,84,106],"activation.":[22],"MVs":[23,56,97,124,135],"can":[24],"serve":[25,99,137],"extracellular":[27],"vehicles":[28],"to":[29,37],"transport":[30],"bioactive":[31],"molecules":[32],"their":[34,148],"parental":[35],"recipient":[38],"target":[39],"cells,":[40,81],"thereby":[41],"serving":[42],"novel":[44,151],"mediators":[45],"for":[46,103,140],"intercellular":[47],"communication.":[48],"Importantly,":[49],"more":[50,52],"and":[51,64,69,87,119,143],"evidence":[53],"indicates":[54],"could":[57,98],"play":[58],"important":[59],"roles":[60,149],"in":[61,92,116,125,154],"early":[62],"pathogenesis":[63,127],"subsequent":[65],"progression":[66],"cardiovascular":[68],"metabolic":[70],"diseases.":[71,95,130],"Elevated":[72],"concentrations":[74],"MVs,":[76],"originating":[77],"red":[79],"blood":[80],"leukocytes,":[82],"platelets,":[83],"other":[85],"organs":[86],"tissues,":[88],"have":[89],"been":[90],"reported":[91],"various":[93],"cardiometabolic":[94,129,155],"Circulating":[96],"potential":[101],"biomarkers":[102],"disease":[104],"diagnosis":[105,142],"therapeutic":[107,152],"monitoring.":[108],"In":[109],"this":[110],"review,":[111],"we":[112],"summarized":[113],"recently-published":[114],"studies":[115],"the":[117,121,126],"field":[118],"discussed":[120],"role":[122],"The":[131],"emerging":[132],"values":[133],"biomarker":[139],"non-invasive":[141],"prognosis,":[144],"well":[146],"targets":[153],"diseases,":[156],"were":[157],"described.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":32},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":6}],"updated_date":"2026-03-10T16:38:18.471706","created_date":"2025-10-10T00:00:00"}