{"id":"https://openalex.org/W2063972384","doi":"https://doi.org/10.1016/j.gpb.2013.11.001","title":"A TDG/CBP/RAR\u03b1 Ternary Complex Mediates the Retinoic Acid-Dependent Expression of DNA Methylation-Sensitive Genes","display_name":"A TDG/CBP/RAR\u03b1 Ternary Complex Mediates the Retinoic Acid-Dependent Expression of DNA Methylation-Sensitive Genes","publication_year":2014,"publication_date":"2014-01-03","ids":{"openalex":"https://openalex.org/W2063972384","doi":"https://doi.org/10.1016/j.gpb.2013.11.001","mag":"2063972384","pmid":"https://pubmed.ncbi.nlm.nih.gov/24394593"},"language":"en","primary_location":{"id":"doi:10.1016/j.gpb.2013.11.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gpb.2013.11.001","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.gpb.2013.11.001","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044213941","display_name":"H\u00e9l\u00e8ne L\u00e9ger","orcid":"https://orcid.org/0000-0003-1116-8637"},"institutions":[{"id":"https://openalex.org/I4210119150","display_name":"Institut de Recherche Vaccinale","ror":"https://ror.org/02f9r3321","country_code":"FR","type":"facility","lineage":["https://openalex.org/I197681013","https://openalex.org/I4210116296","https://openalex.org/I4210119150"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210159433","display_name":"Institut Mondor de Recherche Biom\u00e9dicale","ror":"https://ror.org/04qe59j94","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I17606148","https://openalex.org/I197681013","https://openalex.org/I197681013","https://openalex.org/I4210159433"]},{"id":"https://openalex.org/I84909340","display_name":"Institut des Hautes \u00c9tudes Scientifiques","ror":"https://ror.org/05d5m2r55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I84909340"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H\u00e9l\u00e8ne L\u00e9ger","raw_affiliation_strings":["Institut des Hautes \u00c9tudes Scientifiques , 91440 Bures sur Yvette , France","Vaccine Research Institute, INSERM U955, Institut Mondor de Recherche Biom\u00e9dicale , 94011 Cr\u00e9teil , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut des Hautes \u00c9tudes Scientifiques , 91440 Bures sur Yvette , France","institution_ids":["https://openalex.org/I84909340"]},{"raw_affiliation_string":"Vaccine Research Institute, INSERM U955, Institut Mondor de Recherche Biom\u00e9dicale , 94011 Cr\u00e9teil , France","institution_ids":["https://openalex.org/I4210159433","https://openalex.org/I154526488","https://openalex.org/I4210119150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035531241","display_name":"Caroline Smet\u2010Nocca","orcid":"https://orcid.org/0000-0002-9793-0882"},"institutions":[{"id":"https://openalex.org/I4210118174","display_name":"Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle","ror":"https://ror.org/02g6y2720","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I2279609970","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210118174"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Caroline Smet-Nocca","raw_affiliation_strings":["Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle \u2013 CNRS UMR 8576, Group of NMR and Structural Biology , 59655 Villeneuve d\u2019Ascq, Universit\u00e9 Lille 1 , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle \u2013 CNRS UMR 8576, Group of NMR and Structural Biology , 59655 Villeneuve d\u2019Ascq, Universit\u00e9 Lille 1 , France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210118174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045637425","display_name":"Amel Attmane-Elakeb","orcid":null},"institutions":[{"id":"https://openalex.org/I84909340","display_name":"Institut des Hautes \u00c9tudes Scientifiques","ror":"https://ror.org/05d5m2r55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I84909340"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Amel Attmane-Elakeb","raw_affiliation_strings":["Institut des Hautes \u00c9tudes Scientifiques , 91440 Bures sur Yvette , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut des Hautes \u00c9tudes Scientifiques , 91440 Bures sur Yvette , France","institution_ids":["https://openalex.org/I84909340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043761499","display_name":"Sara Morley\u2010Fletcher","orcid":"https://orcid.org/0000-0003-0423-5563"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210118174","display_name":"Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle","ror":"https://ror.org/02g6y2720","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I2279609970","https://openalex.org/I4210088668","https://openalex.org/I4210096427","https://openalex.org/I4210118174"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sara Morley-Fletcher","raw_affiliation_strings":["Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle \u2013 CNRS UMR 8576, Neuroplasticity Team , 59655 Villeneuve d\u2019Ascq, Universit\u00e9 Lille 1 , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle \u2013 CNRS UMR 8576, Neuroplasticity Team , 59655 Villeneuve d\u2019Ascq, Universit\u00e9 Lille 1 , France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210118174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054769886","display_name":"Arndt Benecke","orcid":"https://orcid.org/0000-0002-7121-823X"},"institutions":[{"id":"https://openalex.org/I84909340","display_name":"Institut des Hautes \u00c9tudes Scientifiques","ror":"https://ror.org/05d5m2r55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I84909340"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Arndt G. Benecke","raw_affiliation_strings":["CNRS UMR 7224, Universit\u00e9 Pierre et Marie Curie , 75005 Paris , France","Institut des Hautes \u00c9tudes Scientifiques , 91440 Bures sur Yvette , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS UMR 7224, Universit\u00e9 Pierre et Marie Curie , 75005 Paris , France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Institut des Hautes \u00c9tudes Scientifiques , 91440 Bures sur Yvette , France","institution_ids":["https://openalex.org/I84909340"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031990643","display_name":"Sebastian Eilebrecht","orcid":"https://orcid.org/0000-0002-8111-950X"},"institutions":[{"id":"https://openalex.org/I84909340","display_name":"Institut des Hautes \u00c9tudes Scientifiques","ror":"https://ror.org/05d5m2r55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I84909340"]},{"id":"https://openalex.org/I4210159433","display_name":"Institut Mondor de Recherche Biom\u00e9dicale","ror":"https://ror.org/04qe59j94","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I17606148","https://openalex.org/I197681013","https://openalex.org/I197681013","https://openalex.org/I4210159433"]},{"id":"https://openalex.org/I4210119150","display_name":"Institut de Recherche Vaccinale","ror":"https://ror.org/02f9r3321","country_code":"FR","type":"facility","lineage":["https://openalex.org/I197681013","https://openalex.org/I4210116296","https://openalex.org/I4210119150"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sebastian Eilebrecht","raw_affiliation_strings":["Institut des Hautes \u00c9tudes Scientifiques , 91440 Bures sur Yvette , France","Vaccine Research Institute, INSERM U955, Institut Mondor de Recherche Biom\u00e9dicale , 94011 Cr\u00e9teil , France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut des Hautes \u00c9tudes Scientifiques , 91440 Bures sur Yvette , France","institution_ids":["https://openalex.org/I84909340"]},{"raw_affiliation_string":"Vaccine Research Institute, INSERM U955, Institut Mondor de Recherche Biom\u00e9dicale , 94011 Cr\u00e9teil , France","institution_ids":["https://openalex.org/I4210159433","https://openalex.org/I154526488","https://openalex.org/I4210119150"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5054769886"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I39804081","https://openalex.org/I84909340"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.8496,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.85191478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"12","issue":"1","first_page":"8","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6510884165763855},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.5899410843849182},{"id":"https://openalex.org/keywords/dna-demethylation","display_name":"DNA demethylation","score":0.5195608139038086},{"id":"https://openalex.org/keywords/retinoic-acid-receptor","display_name":"Retinoic acid receptor","score":0.48594892024993896},{"id":"https://openalex.org/keywords/creb-binding-protein","display_name":"CREB-binding protein","score":0.4779098927974701},{"id":"https://openalex.org/keywords/base-excision-repair","display_name":"Base excision repair","score":0.4431012272834778},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4356154501438141},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.43124687671661377},{"id":"https://openalex.org/keywords/transcription","display_name":"Transcription (linguistics)","score":0.41940921545028687},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"Retinoic acid","score":0.416595458984375},{"id":"https://openalex.org/keywords/dna-glycosylase","display_name":"DNA glycosylase","score":0.4149046540260315},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.403264582157135},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.3791740834712982},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.3239295780658722},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3144969344139099},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.23690378665924072},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2296983301639557},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.19229069352149963}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6510884165763855},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5899410843849182},{"id":"https://openalex.org/C16824249","wikidata":"https://www.wikidata.org/wiki/Q5205753","display_name":"DNA demethylation","level":5,"score":0.5195608139038086},{"id":"https://openalex.org/C120197328","wikidata":"https://www.wikidata.org/wiki/Q2838685","display_name":"Retinoic acid receptor","level":4,"score":0.48594892024993896},{"id":"https://openalex.org/C2776603820","wikidata":"https://www.wikidata.org/wiki/Q906517","display_name":"CREB-binding protein","level":5,"score":0.4779098927974701},{"id":"https://openalex.org/C187206112","wikidata":"https://www.wikidata.org/wiki/Q3113091","display_name":"Base excision repair","level":4,"score":0.4431012272834778},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4356154501438141},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.43124687671661377},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.41940921545028687},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.416595458984375},{"id":"https://openalex.org/C192396546","wikidata":"https://www.wikidata.org/wiki/Q413156","display_name":"DNA glycosylase","level":4,"score":0.4149046540260315},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.403264582157135},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3791740834712982},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3239295780658722},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3144969344139099},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23690378665924072},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2296983301639557},{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.19229069352149963},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072482","descriptor_name":"Retinoic Acid Receptor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072482","descriptor_name":"Retinoic Acid Receptor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072482","descriptor_name":"Retinoic Acid Receptor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018168","descriptor_name":"Receptors, Retinoic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044502","descriptor_name":"Thymine DNA Glycosylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044502","descriptor_name":"Thymine DNA Glycosylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044502","descriptor_name":"Thymine DNA Glycosylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044502","descriptor_name":"Thymine DNA Glycosylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044502","descriptor_name":"Thymine DNA Glycosylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044502","descriptor_name":"Thymine DNA Glycosylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044502","descriptor_name":"Thymine DNA Glycosylase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044502","descriptor_name":"Thymine DNA Glycosylase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044502","descriptor_name":"Thymine DNA Glycosylase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050882","descriptor_name":"CREB-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050882","descriptor_name":"CREB-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050882","descriptor_name":"CREB-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050882","descriptor_name":"CREB-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050882","descriptor_name":"CREB-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050882","descriptor_name":"CREB-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.gpb.2013.11.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gpb.2013.11.001","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24394593","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24394593","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, proteomics & bioinformatics","raw_type":null},{"id":"pmh:oai:HAL:hal-01544142v1","is_oa":false,"landing_page_url":"https://hal.science/hal-01544142","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genomics, Proteomics and Bioinformatics, 2014, 12 (1), pp.8-18. ⟨10.1016/j.gpb.2013.11.001⟩","raw_type":"Journal articles"},{"id":"pmh:oai:doaj.org/article:d4cc15f5c82043b9bf2ac7cb982092ac","is_oa":false,"landing_page_url":"https://doaj.org/article/d4cc15f5c82043b9bf2ac7cb982092ac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genomics, Proteomics & Bioinformatics, Vol 12, Iss 1, Pp 8-18 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3385048","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4411359","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.gpb.2013.11.001","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gpb.2013.11.001","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","display_name":"Life below water","score":0.6499999761581421}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307875","display_name":"Styrelsen f\u00f6r Internationellt Utvecklingssamarbete","ror":"https://ror.org/01fn7me06"},{"id":"https://openalex.org/F4320316137","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W197372138","https://openalex.org/W1884928119","https://openalex.org/W1927684145","https://openalex.org/W1938041103","https://openalex.org/W1968625882","https://openalex.org/W1969504098","https://openalex.org/W1970316586","https://openalex.org/W1985063313","https://openalex.org/W1986730103","https://openalex.org/W1987723074","https://openalex.org/W1987801023","https://openalex.org/W1989007469","https://openalex.org/W2001168187","https://openalex.org/W2004988279","https://openalex.org/W2005219717","https://openalex.org/W2008821724","https://openalex.org/W2013240085","https://openalex.org/W2015580675","https://openalex.org/W2016889082","https://openalex.org/W2021537896","https://openalex.org/W2026529460","https://openalex.org/W2027627024","https://openalex.org/W2039875081","https://openalex.org/W2040057516","https://openalex.org/W2040105955","https://openalex.org/W2046478225","https://openalex.org/W2062211740","https://openalex.org/W2067837358","https://openalex.org/W2068494256","https://openalex.org/W2069532898","https://openalex.org/W2073102033","https://openalex.org/W2083550293","https://openalex.org/W2086492419","https://openalex.org/W2087957210","https://openalex.org/W2089166549","https://openalex.org/W2089316366","https://openalex.org/W2108019645","https://openalex.org/W2122043534","https://openalex.org/W2130722778","https://openalex.org/W2139077902","https://openalex.org/W2141478391","https://openalex.org/W2142415307","https://openalex.org/W2143241514","https://openalex.org/W2146103350","https://openalex.org/W2160366731","https://openalex.org/W2160762071","https://openalex.org/W4229958257","https://openalex.org/W6684058062"],"related_works":["https://openalex.org/W2070572828","https://openalex.org/W1975476520","https://openalex.org/W2400551783","https://openalex.org/W2601342235","https://openalex.org/W2082919291","https://openalex.org/W2528508621","https://openalex.org/W1970566518","https://openalex.org/W2129270269","https://openalex.org/W3175862813","https://openalex.org/W2546570943"],"abstract_inverted_index":{"The":[0,133],"thymine":[1],"DNA":[2,26,172],"glycosylase":[3],"(TDG)":[4],"is":[5,10],"a":[6,44,98,114,126,136,152,184],"multifunctional":[7],"enzyme,":[8],"which":[9,123,141],"essential":[11],"for":[12,94,180],"embryonic":[13],"development.":[14],"It":[15],"mediates":[16],"the":[17,30,49,60,76,84,95,161,181],"base":[18],"excision":[19],"repair":[20],"(BER)":[21],"of":[22,32,46,52,86,97,116,129,135,163,187],"G:T":[23],"and":[24,36,105,120,175,190,199],"G:U":[25],"mismatches":[27],"arising":[28],"from":[29],"deamination":[31],"5-methyl":[33],"cytosine":[34],"(5-MeC)":[35],"cytosine,":[37],"respectively.":[38],"Recent":[39],"studies":[40],"have":[41],"pointed":[42],"at":[43],"role":[45],"TDG":[47,57,72],"during":[48],"active":[50],"demethylation":[51],"5-MeC":[53],"within":[54],"CpG":[55],"islands.":[56],"interacts":[58,74],"with":[59,75,125,171,197],"histone":[61],"acetylase":[62],"CREB-binding":[63],"protein":[64,145],"(CBP)":[65],"to":[66,151],"activate":[67],"CBP-dependent":[68],"transcription.":[69],"In":[70],"addition,":[71],"also":[73],"retinoic":[77],"acid":[78],"receptor":[79],"\u03b1":[80],"(RAR\u03b1),":[81],"resulting":[82,159],"in":[83,139,155,160,167],"activation":[85],"RAR\u03b1":[87],"target":[88,131],"genes.":[89,132],"Here":[90],"we":[91,112],"provide":[92],"evidence":[93],"existence":[96],"functional":[99],"ternary":[100,156,195],"complex":[101,157],"containing":[102],"TDG,":[103,140],"CBP":[104,130,198],"activated":[106],"RAR\u03b1.":[107,200],"Using":[108],"global":[109],"transcriptome":[110],"profiling,":[111],"uncover":[113],"coupling":[115,186],"de":[117],"novo":[118],"methylation-sensitive":[119],"RA-dependent":[121],"transcription,":[122],"coincides":[124],"significant":[127,153],"subset":[128],"introduction":[134],"point":[137],"mutation":[138],"neither":[142],"affects":[143],"overall":[144],"structure":[146],"nor":[147],"BER":[148],"activity,":[149],"leads":[150],"loss":[154],"stability,":[158],"deregulation":[162],"RA":[164],"targets":[165],"involved":[166],"cellular":[168],"networks":[169],"associated":[170],"replication,":[173],"recombination":[174],"repair.":[176],"We":[177],"thus":[178],"demonstrate":[179],"first":[182],"time":[183],"direct":[185],"TDG's":[188],"epigenomic":[189],"transcription":[191],"regulatory":[192],"function":[193],"through":[194],"complexes":[196]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}