{"id":"https://openalex.org/W2016739065","doi":"https://doi.org/10.1016/j.gpb.2012.08.007","title":"iBIG: An Integrative Network Tool for Supporting Human Disease Mechanism Studies","display_name":"iBIG: An Integrative Network Tool for Supporting Human Disease Mechanism Studies","publication_year":2013,"publication_date":"2013-01-04","ids":{"openalex":"https://openalex.org/W2016739065","doi":"https://doi.org/10.1016/j.gpb.2012.08.007","mag":"2016739065","pmid":"https://pubmed.ncbi.nlm.nih.gov/23809576"},"language":"en","primary_location":{"id":"doi:10.1016/j.gpb.2012.08.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gpb.2012.08.007","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S1672022912001131-fx1.jpg","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ars.els-cdn.com/content/image/1-s2.0-S1672022912001131-fx1.jpg","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006334228","display_name":"Jiya Sun","orcid":"https://orcid.org/0000-0003-2191-6686"},"institutions":[{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiya Sun","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101 , China","Graduate University of Chinese Academy of Sciences, Beijing 100049, China"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101 , China","institution_ids":["https://openalex.org/I2801577699","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Graduate University of Chinese Academy of Sciences, Beijing 100049, China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016777664","display_name":"Yuyun Pan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuyun Pan","raw_affiliation_strings":["Graduate University of Chinese Academy of Sciences , Beijing 100049 , China","CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China"],"affiliations":[{"raw_affiliation_string":"Graduate University of Chinese Academy of Sciences , Beijing 100049 , China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China","institution_ids":["https://openalex.org/I2801577699","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103341802","display_name":"Xuemei Feng","orcid":null},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuemei Feng","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101 , China"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101 , China","institution_ids":["https://openalex.org/I2801577699","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420329","display_name":"Huijuan Zhang","orcid":"https://orcid.org/0000-0003-3539-9827"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huijuan Zhang","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101 , China","Graduate University of Chinese Academy of Sciences , Beijing 100049 , China"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101 , China","institution_ids":["https://openalex.org/I2801577699","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Graduate University of Chinese Academy of Sciences , Beijing 100049 , China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016265600","display_name":"Yong Duan","orcid":"https://orcid.org/0000-0003-3793-5099"},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yong Duan","raw_affiliation_strings":["UC Davis Genome Center and Department of Biomedical Engineering , Davis, CA 95616 , USA"],"affiliations":[{"raw_affiliation_string":"UC Davis Genome Center and Department of Biomedical Engineering , Davis, CA 95616 , USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049714411","display_name":"Hongxing Lei","orcid":"https://orcid.org/0000-0003-0496-0386"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Hongxing Lei","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101 , China","UC Davis Genome Center and Department of Biomedical Engineering , Davis, CA 95616 , USA"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101 , China","institution_ids":["https://openalex.org/I2801577699","https://openalex.org/I19820366"]},{"raw_affiliation_string":"UC Davis Genome Center and Department of Biomedical Engineering , Davis, CA 95616 , USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5016265600","https://openalex.org/A5049714411"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699","https://openalex.org/I84218800"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":0.8985,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.73716352,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"11","issue":"3","first_page":"166","last_page":"171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.7331722378730774},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.6716039180755615},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.515754222869873},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.5066943764686584},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.49403053522109985},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.4720609784126282},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.47046172618865967},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.46186286211013794},{"id":"https://openalex.org/keywords/variety","display_name":"Variety (cybernetics)","score":0.4414500892162323},{"id":"https://openalex.org/keywords/human-disease","display_name":"Human disease","score":0.4274081587791443},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.41656625270843506},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3195876479148865},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2779121994972229},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1974787712097168},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.16240403056144714},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12594115734100342}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.7331722378730774},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.6716039180755615},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.515754222869873},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5066943764686584},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.49403053522109985},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.4720609784126282},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.47046172618865967},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46186286211013794},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.4414500892162323},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.4274081587791443},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.41656625270843506},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3195876479148865},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2779121994972229},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1974787712097168},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16240403056144714},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12594115734100342},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012985","descriptor_name":"Software Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012985","descriptor_name":"Software Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012985","descriptor_name":"Software Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.gpb.2012.08.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gpb.2012.08.007","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S1672022912001131-fx1.jpg","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},{"id":"pmid:23809576","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23809576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, proteomics & bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:3384674","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4357780","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.gpb.2012.08.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gpb.2012.08.007","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S1672022912001131-fx1.jpg","source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics & Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3085993365","display_name":null,"funder_award_id":"(Grant No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6258415954","display_name":null,"funder_award_id":"Chinese","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7726157001","display_name":null,"funder_award_id":"Grant No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G790790087","display_name":null,"funder_award_id":"30870474","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2016739065.pdf","grobid_xml":"https://content.openalex.org/works/W2016739065.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W102699897","https://openalex.org/W1779682141","https://openalex.org/W1891078220","https://openalex.org/W1966327575","https://openalex.org/W1971425971","https://openalex.org/W1980602971","https://openalex.org/W1994219871","https://openalex.org/W2017199818","https://openalex.org/W2022636167","https://openalex.org/W2030371558","https://openalex.org/W2075037447","https://openalex.org/W2075668179","https://openalex.org/W2081010896","https://openalex.org/W2094679544","https://openalex.org/W2107249189","https://openalex.org/W2109652029","https://openalex.org/W2110601338","https://openalex.org/W2122863289","https://openalex.org/W2125052662","https://openalex.org/W2132448421","https://openalex.org/W2132582966","https://openalex.org/W2134118500","https://openalex.org/W2146078095","https://openalex.org/W2152135248","https://openalex.org/W2159675211","https://openalex.org/W2162379361","https://openalex.org/W2164298117","https://openalex.org/W2170652857","https://openalex.org/W2916767477","https://openalex.org/W2917375902","https://openalex.org/W3024441585","https://openalex.org/W4212942074","https://openalex.org/W6604189647"],"related_works":["https://openalex.org/W2158714033","https://openalex.org/W4386628104","https://openalex.org/W78967844","https://openalex.org/W3213185671","https://openalex.org/W4206945140","https://openalex.org/W2130939068","https://openalex.org/W3163717165","https://openalex.org/W2114466827","https://openalex.org/W2509687359","https://openalex.org/W2127864418"],"abstract_inverted_index":{"Understanding":[0],"the":[1,56,123,144,157],"mechanism":[2,158],"of":[3,31,47,89,134,159],"complex":[4],"human":[5,109,140,160],"diseases":[6,110,116],"is":[7,79,163],"a":[8,17,29,67,75,87,132],"major":[9],"scientific":[10],"challenge.":[11],"Towards":[12],"this":[13],"end,":[14],"we":[15,103],"developed":[16],"web-based":[18],"network":[19,40,133],"tool":[20],"named":[21],"iBIG":[22,162],"(stands":[23],"for":[24,97],"integrative":[25],"BIoloGy),":[26],"which":[27],"incorporates":[28],"variety":[30],"information":[32,48],"on":[33,60,107],"gene":[34,57,150],"interaction":[35],"and":[36,49,62,85,117,130],"regulation.":[37],"The":[38],"generated":[39],"can":[41,70],"be":[42,72,93],"annotated":[43],"with":[44,126,149],"various":[45],"types":[46],"visualized":[50],"directly":[51],"online.":[52],"In":[53],"addition":[54],"to":[55,81,92],"networks":[58,65,151],"based":[59],"physical":[61],"pathway":[63],"interactions,":[64],"at":[66,143,166],"functional":[68,135,145],"level":[69,146],"also":[71],"constructed.":[73],"Furthermore,":[74],"supplementary":[76],"R":[77,128],"package":[78,129],"provided":[80],"process":[82],"microarray":[83,124],"data":[84,125],"generate":[86],"list":[88],"important":[90],"genes":[91],"used":[94],"as":[95],"input":[96],"iBIG.":[98],"To":[99],"demonstrate":[100],"its":[101],"usefulness,":[102],"collected":[104],"54":[105],"microarrays":[106],"common":[108,119,139],"including":[111],"cancer,":[112],"neurological":[113],"disorders,":[114],"infectious":[115],"other":[118],"diseases.":[120,141,161],"We":[121],"processed":[122],"our":[127],"constructed":[131],"modules":[136],"perturbed":[137],"in":[138,147],"Networks":[142],"combination":[148],"may":[152],"provide":[153],"new":[154],"insight":[155],"into":[156],"freely":[164],"available":[165],"http://lei.big.ac.cn/ibig.":[167]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-04-13T07:58:08.660418","created_date":"2025-10-10T00:00:00"}