{"id":"https://openalex.org/W2077925613","doi":"https://doi.org/10.1016/j.gpb.2012.05.007","title":"Comparative Analyses of H3K4 and H3K27 Trimethylations Between the Mouse Cerebrum and Testis","display_name":"Comparative Analyses of H3K4 and H3K27 Trimethylations Between the Mouse Cerebrum and Testis","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2077925613","doi":"https://doi.org/10.1016/j.gpb.2012.05.007","mag":"2077925613"},"language":"en","primary_location":{"id":"doi:10.1016/j.gpb.2012.05.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gpb.2012.05.007","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics &amp; Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.gpb.2012.05.007","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100774808","display_name":"Peng Cui","orcid":"https://orcid.org/0000-0003-3076-0070"},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN","SA"],"is_corresponding":false,"raw_author_name":"Peng Cui","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China","Computational Bioscience Research Center, 4700 King Abdullah University of Science and Technology , Thuwal 23955-6900 , Kingdom of Saudi Arabia"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China","institution_ids":["https://openalex.org/I2801577699","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Computational Bioscience Research Center, 4700 King Abdullah University of Science and Technology , Thuwal 23955-6900 , Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031917673","display_name":"Wanfei Liu","orcid":"https://orcid.org/0000-0002-6637-6807"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wanfei Liu","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China","Graduate University of Chinese Academy of Sciences , Beijing 100049 , China"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China","institution_ids":["https://openalex.org/I2801577699","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Graduate University of Chinese Academy of Sciences , Beijing 100049 , China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101736949","display_name":"Yuhui Zhao","orcid":"https://orcid.org/0000-0003-2760-9011"},"institutions":[{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhui Zhao","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China","Graduate University of Chinese Academy of Sciences , Beijing 100049 , China"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China","institution_ids":["https://openalex.org/I2801577699","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Graduate University of Chinese Academy of Sciences , Beijing 100049 , China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022568385","display_name":"Qiang Lin","orcid":"https://orcid.org/0000-0001-8315-3464"},"institutions":[{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Lin","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China","Graduate University of Chinese Academy of Sciences , Beijing 100049 , China"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China","institution_ids":["https://openalex.org/I2801577699","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Graduate University of Chinese Academy of Sciences , Beijing 100049 , China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074557490","display_name":"Daoyong Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Daoyong Zhang","raw_affiliation_strings":["Institute of Epigenetics and Cancer Research, School of Medicine, Tsinghua University , Beijing 100080 , China"],"affiliations":[{"raw_affiliation_string":"Institute of Epigenetics and Cancer Research, School of Medicine, Tsinghua University , Beijing 100080 , China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100688608","display_name":"Feng Ding","orcid":"https://orcid.org/0000-0001-8237-4062"},"institutions":[{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["CN","SA"],"is_corresponding":false,"raw_author_name":"Feng Ding","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China","Computational Bioscience Research Center, 4700 King Abdullah University of Science and Technology , Thuwal 23955-6900 , Kingdom of Saudi Arabia"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China","institution_ids":["https://openalex.org/I2801577699","https://openalex.org/I19820366"]},{"raw_affiliation_string":"Computational Bioscience Research Center, 4700 King Abdullah University of Science and Technology , Thuwal 23955-6900 , Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108386783","display_name":"Chengqi Xin","orcid":null},"institutions":[{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengqi Xin","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China","institution_ids":["https://openalex.org/I2801577699","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100599306","display_name":"Zhang Zhang","orcid":"https://orcid.org/0000-0001-6603-5060"},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Zhang Zhang","raw_affiliation_strings":["Computational Bioscience Research Center, 4700 King Abdullah University of Science and Technology , Thuwal 23955-6900 , Kingdom of Saudi Arabia"],"affiliations":[{"raw_affiliation_string":"Computational Bioscience Research Center, 4700 King Abdullah University of Science and Technology , Thuwal 23955-6900 , Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109488866","display_name":"Shuhui Song","orcid":"https://orcid.org/0000-0003-2409-8770"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuhui Song","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China","institution_ids":["https://openalex.org/I2801577699","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059241628","display_name":"Fang-Lin Sun","orcid":"https://orcid.org/0000-0003-4729-1610"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fanglin Sun","raw_affiliation_strings":["Institute of Epigenetics and Cancer Research, School of Medicine, Tsinghua University , Beijing 100080 , China"],"affiliations":[{"raw_affiliation_string":"Institute of Epigenetics and Cancer Research, School of Medicine, Tsinghua University , Beijing 100080 , China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100728445","display_name":"Jun Yu","orcid":"https://orcid.org/0000-0002-2702-055X"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Yu","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China","institution_ids":["https://openalex.org/I2801577699","https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010235808","display_name":"Songnian Hu","orcid":"https://orcid.org/0000-0003-3966-3111"},"institutions":[{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Songnian Hu","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China"],"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100029 , China","institution_ids":["https://openalex.org/I2801577699","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5010235808","https://openalex.org/A5100728445"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.4746,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.81378982,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10","issue":"2","first_page":"82","last_page":"93"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/h3k4me3","display_name":"H3K4me3","score":0.9479157328605652},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7069659233093262},{"id":"https://openalex.org/keywords/cerebrum","display_name":"Cerebrum","score":0.5577008724212646},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5574018359184265},{"id":"https://openalex.org/keywords/bivalent","display_name":"Bivalent (engine)","score":0.503915011882782},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.43974170088768005},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4134826958179474},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.38605910539627075},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.37229281663894653},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.1075834333896637},{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.07872095704078674},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.05481898784637451}],"concepts":[{"id":"https://openalex.org/C2780914512","wikidata":"https://www.wikidata.org/wiki/Q25323943","display_name":"H3K4me3","level":5,"score":0.9479157328605652},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7069659233093262},{"id":"https://openalex.org/C533869091","wikidata":"https://www.wikidata.org/wiki/Q75855","display_name":"Cerebrum","level":3,"score":0.5577008724212646},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5574018359184265},{"id":"https://openalex.org/C2776620830","wikidata":"https://www.wikidata.org/wiki/Q4919211","display_name":"Bivalent (engine)","level":3,"score":0.503915011882782},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.43974170088768005},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4134826958179474},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.38605910539627075},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37229281663894653},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1075834333896637},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.07872095704078674},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.05481898784637451},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.0},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.gpb.2012.05.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gpb.2012.05.007","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics &amp; Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4016545","is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5054206","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5054206","is_oa":true,"landing_page_url":"http://doi.org/10.1016/j.gpb.2012.05.007","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:repository.kaust.edu.sa:10754/552426","is_oa":false,"landing_page_url":"http://hdl.handle.net/10754/552426","pdf_url":null,"source":{"id":"https://openalex.org/S4306401596","display_name":"King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I71920554","host_organization_name":"King Abdullah University of Science and Technology","host_organization_lineage":["https://openalex.org/I71920554"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.gpb.2012.05.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.gpb.2012.05.007","pdf_url":null,"source":{"id":"https://openalex.org/S155547894","display_name":"Genomics Proteomics & Bioinformatics","issn_l":"1672-0229","issn":["1672-0229","2210-3244"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genomics, Proteomics &amp; Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1840366754","display_name":null,"funder_award_id":"2011CB944100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G439206716","display_name":null,"funder_award_id":"2011CB965300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4723953380","display_name":null,"funder_award_id":"KSCX2-EW-R-0","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G5201834461","display_name":null,"funder_award_id":"KSCX2-EW-R-01","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G70340526","display_name":null,"funder_award_id":"KSCX2-EW-R-01-04","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"}],"funders":[{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320335773","display_name":"National High-tech Research and Development Program","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1967841068","https://openalex.org/W1968931043","https://openalex.org/W1969015262","https://openalex.org/W1969491708","https://openalex.org/W1974979111","https://openalex.org/W1978104691","https://openalex.org/W1981509058","https://openalex.org/W2000501974","https://openalex.org/W2006489768","https://openalex.org/W2007684630","https://openalex.org/W2012671266","https://openalex.org/W2015416439","https://openalex.org/W2017840637","https://openalex.org/W2021292600","https://openalex.org/W2022636167","https://openalex.org/W2038182828","https://openalex.org/W2038774969","https://openalex.org/W2049868369","https://openalex.org/W2053317015","https://openalex.org/W2061128706","https://openalex.org/W2067563155","https://openalex.org/W2070359888","https://openalex.org/W2077132193","https://openalex.org/W2083245183","https://openalex.org/W2092015664","https://openalex.org/W2092345398","https://openalex.org/W2094538472","https://openalex.org/W2095002834","https://openalex.org/W2103336074","https://openalex.org/W2107903949","https://openalex.org/W2110019612","https://openalex.org/W2112192177","https://openalex.org/W2118681186","https://openalex.org/W2124985265","https://openalex.org/W2133342079","https://openalex.org/W2133938268","https://openalex.org/W2137001129","https://openalex.org/W2154431984","https://openalex.org/W2158948118","https://openalex.org/W2161224111","https://openalex.org/W2168602111","https://openalex.org/W2170728895","https://openalex.org/W2398210598","https://openalex.org/W2736918808","https://openalex.org/W4230932396","https://openalex.org/W6712093684"],"related_works":["https://openalex.org/W1999591642","https://openalex.org/W1977020475","https://openalex.org/W2514524887","https://openalex.org/W2463553079","https://openalex.org/W4386273890","https://openalex.org/W2073635296","https://openalex.org/W2099084807","https://openalex.org/W4234839822","https://openalex.org/W2072087349","https://openalex.org/W2009053352"],"abstract_inverted_index":{"Abstract":[0],"The":[1,189],"global":[2,62],"features":[3],"of":[4,21,38,42,64,126,142],"H3K4":[5],"and":[6,10,40,45,49,66,71,81,88,111,118,168,182],"H3K27":[7],"trimethylations":[8],"(H3K4me3":[9],"H3K27me3)":[11],"have":[12],"been":[13],"well":[14],"studied":[15],"in":[16,26,68,92,99,115,151,159,166,186],"recent":[17],"years,":[18],"but":[19],"most":[20],"these":[22],"studies":[23],"were":[24],"performed":[25],"mammalian":[27],"cell":[28],"lines.":[29],"In":[30,170],"this":[31],"work,":[32],"we":[33,84,103,172],"generated":[34],"the":[35,61,97,124,130,140,148,157],"genome-wide":[36],"maps":[37],"H3K4me3":[39,65,87,110,181],"H3K27me3":[41,67,89,183],"mouse":[43,152],"cerebrum":[44,167],"testis":[46],"using":[47,53],"ChIP-seq":[48],"their":[50],"high-coverage":[51],"transcriptomes":[52],"ribominus":[54],"RNA-seq":[55],"with":[56,77,108,164],"SOLiD":[57],"technology.":[58],"We":[59,145],"examined":[60],"patterns":[63],"both":[69,109,116],"tissues":[70,117],"found":[72],"that":[73,86,105,180,192],"modifications":[74],"are":[75,162],"closely-associated":[76],"tissue-specific":[78],"expression,":[79],"function":[80],"development.":[82],"Moreover,":[83],"revealed":[85],"rarely":[90,184],"occur":[91,185],"silent":[93,187],"genes,":[94],"which":[95],"contradicts":[96],"findings":[98],"previous":[100],"studies.":[101],"Finally,":[102],"observed":[104],"bivalent":[106,131,193],"domains,":[107],"H3K27me3,":[112],"existed":[113],"ubiquitously":[114],"demonstrated":[119],"an":[120],"invariable":[121],"preference":[122],"for":[123],"regulation":[125],"developmentally-related":[127],"genes.":[128,144,188],"However,":[129],"domains":[132,194],"tend":[133],"towards":[134],"a":[135,197],"\u201cwinner-takes-all\u201d":[136,198],"approach":[137],"to":[138,200],"regulate":[139,201],"expression":[141],"associated":[143],"also":[146],"verified":[147],"above":[149],"results":[150,158],"ES":[153,160],"cells.":[154],"As":[155],"expected,":[156],"cells":[161],"consistent":[163],"those":[165],"testis.":[169],"conclusion,":[171],"present":[173],"two":[174],"very":[175],"important":[176],"findings.":[177],"One":[178],"is":[179,191],"other":[190],"may":[195],"adopt":[196],"principle":[199],"gene":[202],"expression.":[203]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-03-13T16:22:10.518609","created_date":"2016-06-24T00:00:00"}
