{"id":"https://openalex.org/W7155506614","doi":"https://doi.org/10.1016/j.eswa.2026.132559","title":"From Heuristics to Deep Generative Models: A Critical Review of Protein Sequence Analysis Architectures for Clinical Decision Support Systems (CDSS)","display_name":"From Heuristics to Deep Generative Models: A Critical Review of Protein Sequence Analysis Architectures for Clinical Decision Support Systems (CDSS)","publication_year":2026,"publication_date":"2026-04-24","ids":{"openalex":"https://openalex.org/W7155506614","doi":"https://doi.org/10.1016/j.eswa.2026.132559"},"language":"en","primary_location":{"id":"doi:10.1016/j.eswa.2026.132559","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.eswa.2026.132559","pdf_url":null,"source":{"id":"https://openalex.org/S13144211","display_name":"Expert Systems with Applications","issn_l":"0957-4174","issn":["0957-4174","1873-6793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Systems with Applications","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084269819","display_name":"Faezeh Rahimzadeh","orcid":null},"institutions":[{"id":"https://openalex.org/I41832843","display_name":"University of Tabriz","ror":"https://ror.org/01papkj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I41832843"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Faezeh Rahimzadeh","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Tabriz, Tabriz, Iran"],"raw_orcid":"https://orcid.org/0009-0000-8460-364X","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Tabriz, Tabriz, Iran","institution_ids":["https://openalex.org/I41832843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011203676","display_name":"Leyli Mohammad Khanli","orcid":"https://orcid.org/0000-0001-7394-5054"},"institutions":[{"id":"https://openalex.org/I41832843","display_name":"University of Tabriz","ror":"https://ror.org/01papkj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I41832843"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Leyli Mohammad Khanli","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Tabriz, Tabriz, Iran"],"raw_orcid":"https://orcid.org/0000-0001-7394-5054","affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Tabriz, Tabriz, Iran","institution_ids":["https://openalex.org/I41832843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081500332","display_name":"Pedram Salehpour","orcid":"https://orcid.org/0000-0002-1300-7848"},"institutions":[{"id":"https://openalex.org/I41832843","display_name":"University of Tabriz","ror":"https://ror.org/01papkj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I41832843"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Pedram Salehpour","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Tabriz, Tabriz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Tabriz, Tabriz, Iran","institution_ids":["https://openalex.org/I41832843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062451672","display_name":"Faegheh Golabi","orcid":"https://orcid.org/0000-0001-9648-2283"},"institutions":[{"id":"https://openalex.org/I163205636","display_name":"Tabriz University of Medical Sciences","ror":"https://ror.org/04krpx645","country_code":"IR","type":"education","lineage":["https://openalex.org/I163205636"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Faegheh Golabi","raw_affiliation_strings":["Department of Biomedical Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran","institution_ids":["https://openalex.org/I163205636"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5011203676"],"corresponding_institution_ids":["https://openalex.org/I41832843"],"apc_list":{"value":3220,"currency":"USD","value_usd":3220},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85909647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"324","issue":null,"first_page":"132559","last_page":"132559"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.2705000042915344,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.2705000042915344,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.17919999361038208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.12250000238418579,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heuristics","display_name":"Heuristics","score":0.7257999777793884},{"id":"https://openalex.org/keywords/decision-support-system","display_name":"Decision support system","score":0.607699990272522},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5748000144958496},{"id":"https://openalex.org/keywords/generative-grammar","display_name":"Generative grammar","score":0.5622000098228455},{"id":"https://openalex.org/keywords/intelligent-decision-support-system","display_name":"Intelligent decision support system","score":0.43880000710487366},{"id":"https://openalex.org/keywords/clinical-decision-support-system","display_name":"Clinical decision support system","score":0.3643999993801117}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7868000268936157},{"id":"https://openalex.org/C127705205","wikidata":"https://www.wikidata.org/wiki/Q5748245","display_name":"Heuristics","level":2,"score":0.7257999777793884},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6281999945640564},{"id":"https://openalex.org/C107327155","wikidata":"https://www.wikidata.org/wiki/Q330268","display_name":"Decision support system","level":2,"score":0.607699990272522},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5748000144958496},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.5622000098228455},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4986000061035156},{"id":"https://openalex.org/C56397880","wikidata":"https://www.wikidata.org/wiki/Q6044094","display_name":"Intelligent decision support system","level":2,"score":0.43880000710487366},{"id":"https://openalex.org/C63527458","wikidata":"https://www.wikidata.org/wiki/Q5133829","display_name":"Clinical decision support system","level":3,"score":0.3643999993801117},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2953000068664551},{"id":"https://openalex.org/C167966045","wikidata":"https://www.wikidata.org/wiki/Q5532625","display_name":"Generative model","level":3,"score":0.29010000824928284},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.2791999876499176},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.2687000036239624}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.eswa.2026.132559","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.eswa.2026.132559","pdf_url":null,"source":{"id":"https://openalex.org/S13144211","display_name":"Expert Systems with Applications","issn_l":"0957-4174","issn":["0957-4174","1873-6793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Systems with Applications","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16","score":0.7252336740493774}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W1803102843","https://openalex.org/W1987134040","https://openalex.org/W1988966248","https://openalex.org/W2005275235","https://openalex.org/W2015292449","https://openalex.org/W2021312899","https://openalex.org/W2027668375","https://openalex.org/W2041392558","https://openalex.org/W2045204781","https://openalex.org/W2051210555","https://openalex.org/W2055043387","https://openalex.org/W2081741335","https://openalex.org/W2101291993","https://openalex.org/W2101882794","https://openalex.org/W2103083136","https://openalex.org/W2108187446","https://openalex.org/W2109867978","https://openalex.org/W2110417468","https://openalex.org/W2111373249","https://openalex.org/W2117486996","https://openalex.org/W2121627241","https://openalex.org/W2122026259","https://openalex.org/W2132926880","https://openalex.org/W2135621733","https://openalex.org/W2138122982","https://openalex.org/W2143210482","https://openalex.org/W2147285856","https://openalex.org/W2151831732","https://openalex.org/W2153187042","https://openalex.org/W2153544371","https://openalex.org/W2155201844","https://openalex.org/W2274066308","https://openalex.org/W2396881363","https://openalex.org/W2485045083","https://openalex.org/W2518582440","https://openalex.org/W2558272290","https://openalex.org/W2607268717","https://openalex.org/W2611138580","https://openalex.org/W2620185010","https://openalex.org/W2750791471","https://openalex.org/W2794004073","https://openalex.org/W2799982041","https://openalex.org/W2807818025","https://openalex.org/W2895239334","https://openalex.org/W2900569176","https://openalex.org/W2908201961","https://openalex.org/W2927351257","https://openalex.org/W2943407516","https://openalex.org/W2945976633","https://openalex.org/W2950954328","https://openalex.org/W2951934944","https://openalex.org/W2952317511","https://openalex.org/W2957436444","https://openalex.org/W2958089299","https://openalex.org/W2972411752","https://openalex.org/W2987090428","https://openalex.org/W3004237620","https://openalex.org/W3004612364","https://openalex.org/W3037888463","https://openalex.org/W3095583226","https://openalex.org/W3111174583","https://openalex.org/W3119780302","https://openalex.org/W3133458480","https://openalex.org/W3138819813","https://openalex.org/W3141406169","https://openalex.org/W3146944767","https://openalex.org/W3164046276","https://openalex.org/W3177500196","https://openalex.org/W3177828909","https://openalex.org/W3183475563","https://openalex.org/W3199468887","https://openalex.org/W3214759144","https://openalex.org/W3214897310","https://openalex.org/W4205773061","https://openalex.org/W4213112325","https://openalex.org/W4220681836","https://openalex.org/W4220685469","https://openalex.org/W4236358448","https://openalex.org/W4281790889","https://openalex.org/W4286669150","https://openalex.org/W4296032638","https://openalex.org/W4296354070","https://openalex.org/W4296564676","https://openalex.org/W4308463927","https://openalex.org/W4312097792","https://openalex.org/W4317033517","https://openalex.org/W4317815057","https://openalex.org/W4323926397","https://openalex.org/W4327550249","https://openalex.org/W4378745398","https://openalex.org/W4383957026","https://openalex.org/W4385409403","https://openalex.org/W4385416124","https://openalex.org/W4387765686","https://openalex.org/W4387934645","https://openalex.org/W4388694364","https://openalex.org/W4389919417","https://openalex.org/W4390501271","https://openalex.org/W4391431979","https://openalex.org/W4391483046","https://openalex.org/W4392520150","https://openalex.org/W4392968035","https://openalex.org/W4393188994","https://openalex.org/W4396721167","https://openalex.org/W4396722127","https://openalex.org/W4399283681","https://openalex.org/W4399766525","https://openalex.org/W4401649637","https://openalex.org/W4401834264","https://openalex.org/W4402518895","https://openalex.org/W4403052529","https://openalex.org/W4406521461","https://openalex.org/W4407181028","https://openalex.org/W4410572064","https://openalex.org/W4411191927","https://openalex.org/W4412983454","https://openalex.org/W4414206983","https://openalex.org/W4414704439","https://openalex.org/W4414760252","https://openalex.org/W4416337423"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-05-05T08:41:31.759640","created_date":"2026-04-25T00:00:00"}
