{"id":"https://openalex.org/W7164201515","doi":"https://doi.org/10.1016/j.compmedimag.2026.102788","title":"HiCAF-Net: A Hierarchical Cross-Attention Fusion framework for cross-cancer subtype classification using histopathological and genomic data","display_name":"HiCAF-Net: A Hierarchical Cross-Attention Fusion framework for cross-cancer subtype classification using histopathological and genomic data","publication_year":2026,"publication_date":"2026-06-11","ids":{"openalex":"https://openalex.org/W7164201515","doi":"https://doi.org/10.1016/j.compmedimag.2026.102788","pmid":"https://pubmed.ncbi.nlm.nih.gov/42287936"},"language":"en","primary_location":{"id":"doi:10.1016/j.compmedimag.2026.102788","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compmedimag.2026.102788","pdf_url":null,"source":{"id":"https://openalex.org/S198823948","display_name":"Computerized Medical Imaging and Graphics","issn_l":"0895-6111","issn":["0895-6111","1879-0771"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computerized Medical Imaging and Graphics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101084816","display_name":"Junyi Wu","orcid":"https://orcid.org/0000-0001-5167-1822"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junyi Wu","raw_affiliation_strings":["The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138357514","display_name":"Chenyu Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenyu Zhao","raw_affiliation_strings":["The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138337902","display_name":"Jiaqi Yuan","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaqi Yuan","raw_affiliation_strings":["The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138361304","display_name":"Qingyin Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingyin Zhou","raw_affiliation_strings":["The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China; Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China; Cixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, China","institution_ids":["https://openalex.org/I2801769982","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138375704","display_name":"Yilin Wei","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yilin Wei","raw_affiliation_strings":["The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138384675","display_name":"Jianmin Li","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianmin Li","raw_affiliation_strings":["Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138378052","display_name":"Eugene Edzeafene-Mensah","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Eugene Edzeafene-Mensah","raw_affiliation_strings":["The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138363863","display_name":"Ouchen Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ouchen Wang","raw_affiliation_strings":["Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069056157","display_name":"Chenhui Yang","orcid":"https://orcid.org/0000-0002-8580-5451"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenhui Yang","raw_affiliation_strings":["Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138311766","display_name":"Meihao Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210099512","display_name":"Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University","ror":"https://ror.org/0156rhd17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099512"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meihao Wang","raw_affiliation_strings":["Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, China","institution_ids":["https://openalex.org/I4210099512","https://openalex.org/I27781120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088316353","display_name":"Zhifang Pan","orcid":"https://orcid.org/0000-0002-3683-6657"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhifang Pan","raw_affiliation_strings":["The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. Electronic address: panzhifang@wmu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-3683-6657","affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. Electronic address: panzhifang@wmu.edu.cn","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5088316353"],"corresponding_institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"],"apc_list":{"value":2760,"currency":"USD","value_usd":2760},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.74174317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"133","issue":null,"first_page":"102788","last_page":"102788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.314300000667572,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.314300000667572,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.22179999947547913,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.06830000132322311,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.41339999437332153},{"id":"https://openalex.org/keywords/fusion","display_name":"Fusion","score":0.40880000591278076},{"id":"https://openalex.org/keywords/sensor-fusion","display_name":"Sensor fusion","score":0.3352999985218048},{"id":"https://openalex.org/keywords/genomics","display_name":"Genomics","score":0.3009999990463257},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.298799991607666}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5773000121116638},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5432999730110168},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48080000281333923},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.41339999437332153},{"id":"https://openalex.org/C158525013","wikidata":"https://www.wikidata.org/wiki/Q2593739","display_name":"Fusion","level":2,"score":0.40880000591278076},{"id":"https://openalex.org/C33954974","wikidata":"https://www.wikidata.org/wiki/Q486494","display_name":"Sensor fusion","level":2,"score":0.3352999985218048},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3052999973297119},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.3009999990463257},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.298799991607666},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.2971000075340271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2540000081062317}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compmedimag.2026.102788","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compmedimag.2026.102788","pdf_url":null,"source":{"id":"https://openalex.org/S198823948","display_name":"Computerized Medical Imaging and Graphics","issn_l":"0895-6111","issn":["0895-6111","1879-0771"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computerized Medical Imaging and Graphics","raw_type":"journal-article"},{"id":"pmid:42287936","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42287936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324224","display_name":"Wenzhou Municipal Science and Technology Bureau","ror":"https://ror.org/02fr0s482"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W2162888803","https://openalex.org/W2164241627","https://openalex.org/W2194775991","https://openalex.org/W2470965540","https://openalex.org/W2741544066","https://openalex.org/W2753870844","https://openalex.org/W2963677766","https://openalex.org/W2974825848","https://openalex.org/W2996092187","https://openalex.org/W3124474911","https://openalex.org/W3135547872","https://openalex.org/W3157093734","https://openalex.org/W3176719058","https://openalex.org/W3185381167","https://openalex.org/W3188404242","https://openalex.org/W4213418123","https://openalex.org/W4213449432","https://openalex.org/W4281257868","https://openalex.org/W4291286390","https://openalex.org/W4292264787","https://openalex.org/W4312468136","https://openalex.org/W4319300975","https://openalex.org/W4323309632","https://openalex.org/W4362673398","https://openalex.org/W4380446840","https://openalex.org/W4382502768","https://openalex.org/W4390705217","https://openalex.org/W4391947857","https://openalex.org/W4392947532","https://openalex.org/W4396939663","https://openalex.org/W4402313626","https://openalex.org/W4402581324","https://openalex.org/W4402716098","https://openalex.org/W4403693618","https://openalex.org/W4404970450","https://openalex.org/W4405950743","https://openalex.org/W4406113622","https://openalex.org/W4407151613","https://openalex.org/W4407403519","https://openalex.org/W4408551712","https://openalex.org/W4409079813","https://openalex.org/W4409864521","https://openalex.org/W4410013225","https://openalex.org/W4410082395","https://openalex.org/W4411172514","https://openalex.org/W4413265704","https://openalex.org/W4413972333","https://openalex.org/W4417122867","https://openalex.org/W7134181365"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-07-13T07:31:44.756512","created_date":"2026-06-11T00:00:00"}
