{"id":"https://openalex.org/W7125128958","doi":"https://doi.org/10.1016/j.compbiomed.2026.111471","title":"HybridDeepSynergy: A hybrid deep learning model integrating CNN, LSTM, and attention mechanisms for cancer drug synergy prediction","display_name":"HybridDeepSynergy: A hybrid deep learning model integrating CNN, LSTM, and attention mechanisms for cancer drug synergy prediction","publication_year":2026,"publication_date":"2026-01-21","ids":{"openalex":"https://openalex.org/W7125128958","doi":"https://doi.org/10.1016/j.compbiomed.2026.111471","pmid":"https://pubmed.ncbi.nlm.nih.gov/41570613"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiomed.2026.111471","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2026.111471","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113893490","display_name":"Sajid Naveed","orcid":"https://orcid.org/0000-0003-1815-7156"},"institutions":[{"id":"https://openalex.org/I174731842","display_name":"Islamia University of Bahawalpur","ror":"https://ror.org/002rc4w13","country_code":"PK","type":"education","lineage":["https://openalex.org/I174731842"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Sajid Naveed","raw_affiliation_strings":["Department of Computer Science, Faculty of Computing, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan. Electronic address: xajidnaveed@gmail.com"],"raw_orcid":"https://orcid.org/0000-0003-1815-7156","affiliations":[{"raw_affiliation_string":"Department of Computer Science, Faculty of Computing, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan. Electronic address: xajidnaveed@gmail.com","institution_ids":["https://openalex.org/I174731842"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008302404","display_name":"Mujtaba Husnain","orcid":"https://orcid.org/0000-0002-9964-4716"},"institutions":[{"id":"https://openalex.org/I174731842","display_name":"Islamia University of Bahawalpur","ror":"https://ror.org/002rc4w13","country_code":"PK","type":"education","lineage":["https://openalex.org/I174731842"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Mujtaba Husnain","raw_affiliation_strings":["Department of Information Technology, Faculty of Computing, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan"],"raw_orcid":"https://orcid.org/0000-0002-9964-4716","affiliations":[{"raw_affiliation_string":"Department of Information Technology, Faculty of Computing, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan","institution_ids":["https://openalex.org/I174731842"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059877458","display_name":"Najah Alsubaie","orcid":"https://orcid.org/0000-0002-6381-9019"},"institutions":[{"id":"https://openalex.org/I106778892","display_name":"Princess Nourah bint Abdulrahman University","ror":"https://ror.org/05b0cyh02","country_code":"SA","type":"education","lineage":["https://openalex.org/I106778892"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Najah Alsubaie","raw_affiliation_strings":["Department of Computer Sciences, College of Computer and Information Sciences, Princess Nourah bint Abdulrahman University (PNU), Riyadh, 11671, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Sciences, College of Computer and Information Sciences, Princess Nourah bint Abdulrahman University (PNU), Riyadh, 11671, Saudi Arabia","institution_ids":["https://openalex.org/I106778892"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113893490"],"corresponding_institution_ids":["https://openalex.org/I174731842"],"apc_list":{"value":2610,"currency":"USD","value_usd":2610},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.15271461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"203","issue":null,"first_page":"111471","last_page":"111471"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8252000212669373,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.8252000212669373,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.06480000168085098,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.718500018119812},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5259000062942505},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.4410000145435333},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.435699999332428},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.41290000081062317},{"id":"https://openalex.org/keywords/mean-squared-error","display_name":"Mean squared error","score":0.4120999872684479},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.4049000144004822},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.3917999863624573},{"id":"https://openalex.org/keywords/predictive-modelling","display_name":"Predictive modelling","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.718500018119812},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6830999851226807},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6674000024795532},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.6520000100135803},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5259000062942505},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.4410000145435333},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.435699999332428},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.41290000081062317},{"id":"https://openalex.org/C139945424","wikidata":"https://www.wikidata.org/wiki/Q1940696","display_name":"Mean squared error","level":2,"score":0.4120999872684479},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.4049000144004822},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.3917999863624573},{"id":"https://openalex.org/C45804977","wikidata":"https://www.wikidata.org/wiki/Q7239673","display_name":"Predictive modelling","level":2,"score":0.3889999985694885},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.35510000586509705},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.35089999437332153},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3452000021934509},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.3278999924659729},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32589998841285706},{"id":"https://openalex.org/C163175372","wikidata":"https://www.wikidata.org/wiki/Q3339222","display_name":"Linear model","level":2,"score":0.3091000020503998},{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.2858999967575073},{"id":"https://openalex.org/C2993561819","wikidata":"https://www.wikidata.org/wiki/Q5097977","display_name":"Pediatric cancer","level":3,"score":0.2741999924182892},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.2718000113964081},{"id":"https://openalex.org/C107908354","wikidata":"https://www.wikidata.org/wiki/Q4781456","display_name":"Applicability domain","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.2646999955177307},{"id":"https://openalex.org/C55078378","wikidata":"https://www.wikidata.org/wiki/Q1136628","display_name":"Pearson product-moment correlation coefficient","level":2,"score":0.2637999951839447},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.26339998841285706},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.260699987411499},{"id":"https://openalex.org/C3020340455","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Cancer drugs","level":3,"score":0.2590999901294708},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.2508000135421753}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiomed.2026.111471","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2026.111471","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:41570613","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41570613","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in biology and medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6346194744110107,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G7988822833","display_name":null,"funder_award_id":"PNURSP2025R321","funder_id":"https://openalex.org/F4320322484","funder_display_name":"Princess Nourah Bint Abdulrahman University"}],"funders":[{"id":"https://openalex.org/F4320322484","display_name":"Princess Nourah Bint Abdulrahman University","ror":"https://ror.org/05b0cyh02"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W2299417213","https://openalex.org/W2775061087","https://openalex.org/W2950182476","https://openalex.org/W2950860419","https://openalex.org/W3088123593","https://openalex.org/W3164087725","https://openalex.org/W3183848791","https://openalex.org/W3196304395","https://openalex.org/W4206907302","https://openalex.org/W4210428539","https://openalex.org/W4281672524","https://openalex.org/W4309490745","https://openalex.org/W4309842604","https://openalex.org/W4312067483","https://openalex.org/W4360608719","https://openalex.org/W4362657842","https://openalex.org/W4367609826","https://openalex.org/W4384818885","https://openalex.org/W4390640274","https://openalex.org/W4391324572","https://openalex.org/W4391724175","https://openalex.org/W4393374578","https://openalex.org/W4394566709","https://openalex.org/W4394812234","https://openalex.org/W4398174014","https://openalex.org/W4404509077","https://openalex.org/W4411718365"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2026-01-22T00:00:00"}