{"id":"https://openalex.org/W4415513787","doi":"https://doi.org/10.1016/j.compbiomed.2025.111247","title":"A computational study of venom as drug library: Discovery of multifunctional astacin-like metalloproteases from Androctonus zagrosensis venom gland transcriptome","display_name":"A computational study of venom as drug library: Discovery of multifunctional astacin-like metalloproteases from Androctonus zagrosensis venom gland transcriptome","publication_year":2025,"publication_date":"2025-10-24","ids":{"openalex":"https://openalex.org/W4415513787","doi":"https://doi.org/10.1016/j.compbiomed.2025.111247","pmid":"https://pubmed.ncbi.nlm.nih.gov/41138361"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiomed.2025.111247","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2025.111247","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080356752","display_name":"Fatemeh Salabi","orcid":"https://orcid.org/0000-0002-1753-5162"},"institutions":[{"id":"https://openalex.org/I1336229394","display_name":"Razi Vaccine and Serum Research Institute","ror":"https://ror.org/011xesh37","country_code":"IR","type":"company","lineage":["https://openalex.org/I1336229394"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Fatemeh Salabi","raw_affiliation_strings":["Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Ahvaz, Iran. Electronic address: f.salabi@rvsri.ac.ir"],"affiliations":[{"raw_affiliation_string":"Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Ahvaz, Iran. Electronic address: f.salabi@rvsri.ac.ir","institution_ids":["https://openalex.org/I1336229394"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080356752"],"corresponding_institution_ids":["https://openalex.org/I1336229394"],"apc_list":{"value":2610,"currency":"USD","value_usd":2610},"apc_paid":null,"fwci":1.7279,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.87873738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"198","issue":"Pt B","first_page":"111247","last_page":"111247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.9883999824523926,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/venom","display_name":"Venom","score":0.7766000032424927},{"id":"https://openalex.org/keywords/scorpion-venoms","display_name":"Scorpion Venoms","score":0.6093999743461609},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.5981000065803528},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5967000126838684},{"id":"https://openalex.org/keywords/homology","display_name":"Homology (biology)","score":0.5616999864578247},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5422000288963318},{"id":"https://openalex.org/keywords/scorpion","display_name":"Scorpion","score":0.44909998774528503},{"id":"https://openalex.org/keywords/protein-subunit","display_name":"Protein subunit","score":0.44519999623298645},{"id":"https://openalex.org/keywords/uniprot","display_name":"UniProt","score":0.4050999879837036}],"concepts":[{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.7766000032424927},{"id":"https://openalex.org/C2910159647","wikidata":"https://www.wikidata.org/wiki/Q19125","display_name":"Scorpion Venoms","level":4,"score":0.6093999743461609},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5981000065803528},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5967000126838684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.593999981880188},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.5616999864578247},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5422000288963318},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5008000135421753},{"id":"https://openalex.org/C2777884321","wikidata":"https://www.wikidata.org/wiki/Q19125","display_name":"Scorpion","level":3,"score":0.44909998774528503},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.44519999623298645},{"id":"https://openalex.org/C202264299","wikidata":"https://www.wikidata.org/wiki/Q905695","display_name":"UniProt","level":3,"score":0.4050999879837036},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.39800000190734863},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.391400009393692},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3783000111579895},{"id":"https://openalex.org/C132677234","wikidata":"https://www.wikidata.org/wiki/Q3273544","display_name":"Structural motif","level":2,"score":0.3504999876022339},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.32600000500679016},{"id":"https://openalex.org/C171897839","wikidata":"https://www.wikidata.org/wiki/Q417841","display_name":"Protein family","level":3,"score":0.32199999690055847},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.31150001287460327},{"id":"https://openalex.org/C117287731","wikidata":"https://www.wikidata.org/wiki/Q424427","display_name":"Antivenom","level":3,"score":0.3091000020503998},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.3089999854564667},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3075000047683716},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.3052999973297119},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.30480000376701355},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.3037000000476837},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2930000126361847},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2897000014781952},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.27320000529289246},{"id":"https://openalex.org/C2779315201","wikidata":"https://www.wikidata.org/wiki/Q414601","display_name":"Sequence homology","level":4,"score":0.26969999074935913},{"id":"https://openalex.org/C44465124","wikidata":"https://www.wikidata.org/wiki/Q713623","display_name":"Clade","level":4,"score":0.26489999890327454},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.2572999894618988}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012604","descriptor_name":"Scorpion Venoms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012604","descriptor_name":"Scorpion Venoms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012604","descriptor_name":"Scorpion Venoms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012604","descriptor_name":"Scorpion Venoms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012604","descriptor_name":"Scorpion Venoms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012604","descriptor_name":"Scorpion Venoms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012605","descriptor_name":"Scorpions","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012605","descriptor_name":"Scorpions","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012605","descriptor_name":"Scorpions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012605","descriptor_name":"Scorpions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060829","descriptor_name":"Arthropod Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060829","descriptor_name":"Arthropod Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D060829","descriptor_name":"Arthropod Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D060829","descriptor_name":"Arthropod Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiomed.2025.111247","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2025.111247","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:41138361","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41138361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in biology and medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3814672283","display_name":null,"funder_award_id":"960354-020-18-83-2","funder_id":"https://openalex.org/F4320327863","funder_display_name":"Razi Vaccine and Serum Research Institute"}],"funders":[{"id":"https://openalex.org/F4320327863","display_name":"Razi Vaccine and Serum Research Institute","ror":"https://ror.org/011xesh37"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W16659746","https://openalex.org/W1539181678","https://openalex.org/W1565563859","https://openalex.org/W1709815505","https://openalex.org/W1913023179","https://openalex.org/W1967868924","https://openalex.org/W1973134563","https://openalex.org/W1979816412","https://openalex.org/W1980742802","https://openalex.org/W1985899388","https://openalex.org/W1991063206","https://openalex.org/W1992203325","https://openalex.org/W1993489509","https://openalex.org/W1994410340","https://openalex.org/W1995518402","https://openalex.org/W1997516024","https://openalex.org/W1998237324","https://openalex.org/W1999574084","https://openalex.org/W2000860171","https://openalex.org/W2004611201","https://openalex.org/W2005746041","https://openalex.org/W2006948326","https://openalex.org/W2007393307","https://openalex.org/W2009869955","https://openalex.org/W2011657487","https://openalex.org/W2019838731","https://openalex.org/W2033892012","https://openalex.org/W2041373561","https://openalex.org/W2046329404","https://openalex.org/W2048356493","https://openalex.org/W2049722271","https://openalex.org/W2050717189","https://openalex.org/W2068162419","https://openalex.org/W2072150717","https://openalex.org/W2078301833","https://openalex.org/W2079331123","https://openalex.org/W2084618020","https://openalex.org/W2092210558","https://openalex.org/W2102912402","https://openalex.org/W2103546835","https://openalex.org/W2107158607","https://openalex.org/W2115421961","https://openalex.org/W2122266747","https://openalex.org/W2131271579","https://openalex.org/W2131359209","https://openalex.org/W2133197433","https://openalex.org/W2146180782","https://openalex.org/W2146274451","https://openalex.org/W2150259815","https://openalex.org/W2154431984","https://openalex.org/W2154714625","https://openalex.org/W2159675211","https://openalex.org/W2160378127","https://openalex.org/W2163603537","https://openalex.org/W2170747616","https://openalex.org/W2347012456","https://openalex.org/W2520261645","https://openalex.org/W2578613951","https://openalex.org/W2734790238","https://openalex.org/W2769449671","https://openalex.org/W2771389242","https://openalex.org/W2804822363","https://openalex.org/W2906404741","https://openalex.org/W2921655640","https://openalex.org/W2963115036","https://openalex.org/W3045103008","https://openalex.org/W3095583226","https://openalex.org/W3112376646","https://openalex.org/W3129777060","https://openalex.org/W3132955349","https://openalex.org/W3215023849","https://openalex.org/W4205138537","https://openalex.org/W4240924657","https://openalex.org/W4293079358","https://openalex.org/W4295077928","https://openalex.org/W4295165394","https://openalex.org/W4308834893","https://openalex.org/W4313477417","https://openalex.org/W4389298457","https://openalex.org/W4389722071","https://openalex.org/W4391927423","https://openalex.org/W4396894040","https://openalex.org/W4399655737","https://openalex.org/W4404528234","https://openalex.org/W4404531735","https://openalex.org/W4405670661"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-24T00:00:00"}