{"id":"https://openalex.org/W4415601401","doi":"https://doi.org/10.1016/j.compbiomed.2025.111218","title":"Advances in human thermophysiology modelling: Methodological review of a century of developments","display_name":"Advances in human thermophysiology modelling: Methodological review of a century of developments","publication_year":2025,"publication_date":"2025-10-28","ids":{"openalex":"https://openalex.org/W4415601401","doi":"https://doi.org/10.1016/j.compbiomed.2025.111218","pmid":"https://pubmed.ncbi.nlm.nih.gov/41151504"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiomed.2025.111218","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2025.111218","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.compbiomed.2025.111218","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087655720","display_name":"Jaafar Younes","orcid":"https://orcid.org/0000-0002-5610-3186"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Jaafar Younes","raw_affiliation_strings":["Laboratory of Integrated Comfort Engineering (ICE), \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1700, Fribourg, Switzerland. Electronic address: Jaafar.younes@epfl.ch"],"affiliations":[{"raw_affiliation_string":"Laboratory of Integrated Comfort Engineering (ICE), \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1700, Fribourg, Switzerland. Electronic address: Jaafar.younes@epfl.ch","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062596898","display_name":"Dolaana Khovalyg","orcid":"https://orcid.org/0000-0001-6064-2513"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Dolaana Khovalyg","raw_affiliation_strings":["Laboratory of Integrated Comfort Engineering (ICE), \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1700, Fribourg, Switzerland"],"affiliations":[{"raw_affiliation_string":"Laboratory of Integrated Comfort Engineering (ICE), \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL), 1700, Fribourg, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087655720"],"corresponding_institution_ids":["https://openalex.org/I5124864"],"apc_list":{"value":2610,"currency":"USD","value_usd":2610},"apc_paid":{"value":2610,"currency":"USD","value_usd":2610},"fwci":2.2109,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.89465195,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"198","issue":"Pt B","first_page":"111218","last_page":"111218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.3305000066757202,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.3305000066757202,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11565","display_name":"Thermoelastic and Magnetoelastic Phenomena","score":0.12919999659061432,"subfield":{"id":"https://openalex.org/subfields/2211","display_name":"Mechanics of Materials"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.12890000641345978,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/personalization","display_name":"Personalization","score":0.6395999789237976},{"id":"https://openalex.org/keywords/sophistication","display_name":"Sophistication","score":0.593500018119812},{"id":"https://openalex.org/keywords/resource","display_name":"Resource (disambiguation)","score":0.412200003862381},{"id":"https://openalex.org/keywords/pace","display_name":"Pace","score":0.3555000126361847},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.3440999984741211},{"id":"https://openalex.org/keywords/diversity","display_name":"Diversity (politics)","score":0.3124000132083893}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6474000215530396},{"id":"https://openalex.org/C183003079","wikidata":"https://www.wikidata.org/wiki/Q1000371","display_name":"Personalization","level":2,"score":0.6395999789237976},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.6255000233650208},{"id":"https://openalex.org/C168725872","wikidata":"https://www.wikidata.org/wiki/Q991663","display_name":"Sophistication","level":2,"score":0.593500018119812},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.412200003862381},{"id":"https://openalex.org/C2777526511","wikidata":"https://www.wikidata.org/wiki/Q691543","display_name":"Pace","level":2,"score":0.3555000126361847},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.3440999984741211},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.32179999351501465},{"id":"https://openalex.org/C2781316041","wikidata":"https://www.wikidata.org/wiki/Q1230584","display_name":"Diversity (politics)","level":2,"score":0.3124000132083893},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.2971000075340271},{"id":"https://openalex.org/C2779808786","wikidata":"https://www.wikidata.org/wiki/Q6664603","display_name":"Locality","level":2,"score":0.2881999909877777},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.265500009059906},{"id":"https://openalex.org/C2777615720","wikidata":"https://www.wikidata.org/wiki/Q11888847","display_name":"Prioritization","level":2,"score":0.26409998536109924},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.2567000091075897},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2556000053882599},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.2506999969482422}],"mesh":[{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001833","descriptor_name":"Body Temperature Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.compbiomed.2025.111218","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2025.111218","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:41151504","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41151504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in biology and medicine","raw_type":null},{"id":"pmh:oai:infoscience.epfl.ch:20.500.14299/255463","is_oa":true,"landing_page_url":"https://infoscience.epfl.ch/handle/20.500.14299/255463","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"doi:10.1016/j.compbiomed.2025.111218","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2025.111218","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320915","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":151,"referenced_works":["https://openalex.org/W24344940","https://openalex.org/W37229937","https://openalex.org/W202013199","https://openalex.org/W340424771","https://openalex.org/W1501481990","https://openalex.org/W1570190923","https://openalex.org/W1576320143","https://openalex.org/W1847591196","https://openalex.org/W1936620128","https://openalex.org/W1965079305","https://openalex.org/W1969340481","https://openalex.org/W1972023626","https://openalex.org/W1972101599","https://openalex.org/W1973627792","https://openalex.org/W1974417139","https://openalex.org/W1974809183","https://openalex.org/W1977651828","https://openalex.org/W1978251986","https://openalex.org/W1979351203","https://openalex.org/W1980562712","https://openalex.org/W1981881575","https://openalex.org/W1988908416","https://openalex.org/W1990396193","https://openalex.org/W1991203144","https://openalex.org/W2004112310","https://openalex.org/W2004929636","https://openalex.org/W2005745320","https://openalex.org/W2008447533","https://openalex.org/W2014867017","https://openalex.org/W2018396031","https://openalex.org/W2020531072","https://openalex.org/W2022492484","https://openalex.org/W2022629530","https://openalex.org/W2023055583","https://openalex.org/W2024928397","https://openalex.org/W2026428933","https://openalex.org/W2031756724","https://openalex.org/W2034426656","https://openalex.org/W2038084650","https://openalex.org/W2038946284","https://openalex.org/W2039872625","https://openalex.org/W2042389218","https://openalex.org/W2048816192","https://openalex.org/W2050439186","https://openalex.org/W2050615011","https://openalex.org/W2053016818","https://openalex.org/W2054422048","https://openalex.org/W2055421765","https://openalex.org/W2055591282","https://openalex.org/W2059874579","https://openalex.org/W2062463752","https://openalex.org/W2063826711","https://openalex.org/W2070532945","https://openalex.org/W2071697812","https://openalex.org/W2072632881","https://openalex.org/W2075299916","https://openalex.org/W2078027570","https://openalex.org/W2080495302","https://openalex.org/W2085840799","https://openalex.org/W2087612559","https://openalex.org/W2090364774","https://openalex.org/W2094997167","https://openalex.org/W2107883810","https://openalex.org/W2108969121","https://openalex.org/W2116707992","https://openalex.org/W2134306736","https://openalex.org/W2140700771","https://openalex.org/W2141453351","https://openalex.org/W2147907319","https://openalex.org/W2148435759","https://openalex.org/W2150930940","https://openalex.org/W2151545498","https://openalex.org/W2159118485","https://openalex.org/W2159711712","https://openalex.org/W2160695972","https://openalex.org/W2162557586","https://openalex.org/W2164803343","https://openalex.org/W2166143114","https://openalex.org/W2170721297","https://openalex.org/W2175498837","https://openalex.org/W2187788312","https://openalex.org/W2212530770","https://openalex.org/W2253010661","https://openalex.org/W2260531445","https://openalex.org/W2281169198","https://openalex.org/W2291108370","https://openalex.org/W2291959648","https://openalex.org/W2320931619","https://openalex.org/W2323025517","https://openalex.org/W2326098496","https://openalex.org/W2399429556","https://openalex.org/W2412292758","https://openalex.org/W2424245877","https://openalex.org/W2461364046","https://openalex.org/W2466019999","https://openalex.org/W2471084824","https://openalex.org/W2475216556","https://openalex.org/W2483792378","https://openalex.org/W2543212209","https://openalex.org/W2591053570","https://openalex.org/W2605770019","https://openalex.org/W2617258603","https://openalex.org/W2734383842","https://openalex.org/W2744703974","https://openalex.org/W2773084109","https://openalex.org/W2901056465","https://openalex.org/W2901377368","https://openalex.org/W2920063289","https://openalex.org/W2952163474","https://openalex.org/W2976584998","https://openalex.org/W2984392304","https://openalex.org/W3006489719","https://openalex.org/W3011074997","https://openalex.org/W3080718143","https://openalex.org/W3093777756","https://openalex.org/W3094041304","https://openalex.org/W3107996938","https://openalex.org/W3142374365","https://openalex.org/W3165255096","https://openalex.org/W3171182843","https://openalex.org/W3186531306","https://openalex.org/W3194625974","https://openalex.org/W3202144884","https://openalex.org/W3206661784","https://openalex.org/W3208599281","https://openalex.org/W4229653650","https://openalex.org/W4239526824","https://openalex.org/W4240578390","https://openalex.org/W4247265059","https://openalex.org/W4283777289","https://openalex.org/W4313731532","https://openalex.org/W4319066565","https://openalex.org/W4362657734","https://openalex.org/W4365999494","https://openalex.org/W4366759100","https://openalex.org/W4385431374","https://openalex.org/W4386703905","https://openalex.org/W4387259156","https://openalex.org/W4387941039","https://openalex.org/W4389166088","https://openalex.org/W4392652605","https://openalex.org/W4404434563","https://openalex.org/W4405401212","https://openalex.org/W4406281345","https://openalex.org/W4406329437","https://openalex.org/W4407189199","https://openalex.org/W4407711657","https://openalex.org/W4408979257","https://openalex.org/W4409009772","https://openalex.org/W4409117389","https://openalex.org/W4410971386"],"related_works":[],"abstract_inverted_index":{"Human":[0],"thermophysiology":[1],"models":[2,27,59],"are":[3,140],"indispensable":[4],"tools":[5],"for":[6,32,67,167,186],"predicting":[7],"the":[8,19,45,111,130,143,152],"human":[9],"thermal":[10],"response":[11],"across":[12],"diverse":[13],"scientific":[14],"and":[15,22,49,73,86,100,121,134,151,169,180,199],"engineering":[16],"domains.":[17],"However,":[18,103],"rapid":[20],"evolution":[21],"methodological":[23,144],"diversity":[24],"of":[25,44,113,155,177],"these":[26,58],"have":[28],"created":[29],"a":[30,33,40,92,107,156,164,173,183],"need":[31],"unified,":[34],"systematic":[35],"overview.":[36],"This":[37,160],"paper":[38],"provides":[39],"comprehensive,":[41],"methodology-centric":[42],"review":[43,161],"state-of-the-art,":[46],"systematically":[47],"cataloging":[48],"analyzing":[50],"96":[51],"distinct":[52],"whole-body":[53],"thermoregulation":[54],"models.":[55],"We":[56],"deconstruct":[57],"into":[60],"their":[61,68],"fundamental":[62],"components,":[63],"establishing":[64,200],"classification":[65],"frameworks":[66],"passive":[69],"systems":[70,77],"(e.g.,":[71,78],"geometric":[72,133],"anatomical":[74,101,135],"representation),":[75],"active":[76,117,192],"skin":[79],"blood":[80],"flow,":[81],"sweating),":[82],"circulatory":[83],"system":[84,118,193],"modeling,":[85],"personalization":[87,122,196],"schemes.":[88],"The":[89],"analysis":[90,176],"reveals":[91],"persistent":[93],"evolutionary":[94],"trend":[95],"towards":[96],"greater":[97],"spatial":[98],"resolution":[99],"fidelity.":[102,136],"it":[104],"also":[105],"uncovers":[106],"developmental":[108],"asymmetry,":[109],"where":[110],"sophistication":[112],"physiological":[114],"sub-models,":[115],"particularly":[116],"control":[119],"logic":[120],"schemes,":[123,197],"has":[124],"often":[125],"not":[126],"kept":[127],"pace":[128],"with":[129],"advances":[131],"in":[132],"Key":[137],"research":[138],"gaps":[139],"identified,":[141],"including":[142],"confounding":[145],"that":[146],"hinders":[147],"direct":[148],"inter-model":[149],"comparisons":[150],"critical":[153],"lack":[154],"standardized":[157],"validation":[158,202],"framework.":[159],"serves":[162],"as":[163],"foundational":[165],"resource":[166],"researchers":[168],"developers":[170],"by":[171,181],"providing":[172],"structured":[174],"technical":[175],"existing":[178],"methodologies":[179],"outlining":[182],"clear":[184],"roadmap":[185],"future":[187],"advancements":[188],"focused":[189],"on":[190],"enhancing":[191],"modelling,":[194],"developing":[195,198],"robust":[201],"protocols.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-28T00:00:00"}