{"id":"https://openalex.org/W4414770386","doi":"https://doi.org/10.1016/j.compbiomed.2025.111170","title":"A rationally designed multi-epitope vaccine candidate targeting conserved FiuA for broad Pseudomonas aeruginosa protection","display_name":"A rationally designed multi-epitope vaccine candidate targeting conserved FiuA for broad Pseudomonas aeruginosa protection","publication_year":2025,"publication_date":"2025-10-03","ids":{"openalex":"https://openalex.org/W4414770386","doi":"https://doi.org/10.1016/j.compbiomed.2025.111170","pmid":"https://pubmed.ncbi.nlm.nih.gov/41043247"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiomed.2025.111170","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2025.111170","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088066129","display_name":"Anahita Hessami","orcid":null},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Anahita Hessami","raw_affiliation_strings":["School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: anna_hessami@yahoo.com"],"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: anna_hessami@yahoo.com","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065225165","display_name":"Mona Moosavi","orcid":null},"institutions":[{"id":"https://openalex.org/I1516879","display_name":"Tarbiat Modares University","ror":"https://ror.org/03mwgfy56","country_code":"IR","type":"education","lineage":["https://openalex.org/I1516879"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mona Moosavi","raw_affiliation_strings":["Poultry Immunology, Department of Poultry Science Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran. Electronic address: mona.moosavi61@gmail.com"],"affiliations":[{"raw_affiliation_string":"Poultry Immunology, Department of Poultry Science Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran. Electronic address: mona.moosavi61@gmail.com","institution_ids":["https://openalex.org/I1516879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113369638","display_name":"Fatemeh Rahim","orcid":null},"institutions":[{"id":"https://openalex.org/I1516879","display_name":"Tarbiat Modares University","ror":"https://ror.org/03mwgfy56","country_code":"IR","type":"education","lineage":["https://openalex.org/I1516879"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fatemeh Rahim","raw_affiliation_strings":["Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 14115- 111, Iran. Electronic address: fatemehrahim9675@gmail.com"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, 14115- 111, Iran. Electronic address: fatemehrahim9675@gmail.com","institution_ids":["https://openalex.org/I1516879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107018875","display_name":"Zahra Mogharari","orcid":null},"institutions":[{"id":"https://openalex.org/I119025939","display_name":"Shahed University","ror":"https://ror.org/01e8ff003","country_code":"IR","type":"education","lineage":["https://openalex.org/I119025939"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Zahra Mogharari","raw_affiliation_strings":["Shahed University, Faculty of Agriculture, Tehran, Iran. Electronic address: z.mogharari@shahed.ac.ir"],"affiliations":[{"raw_affiliation_string":"Shahed University, Faculty of Agriculture, Tehran, Iran. Electronic address: z.mogharari@shahed.ac.ir","institution_ids":["https://openalex.org/I119025939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006039148","display_name":"Manijeh B. Heidari","orcid":null},"institutions":[{"id":"https://openalex.org/I1516879","display_name":"Tarbiat Modares University","ror":"https://ror.org/03mwgfy56","country_code":"IR","type":"education","lineage":["https://openalex.org/I1516879"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mahdieh Heidari","raw_affiliation_strings":["Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: mahdiehheidari2015@gmail.com"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: mahdiehheidari2015@gmail.com","institution_ids":["https://openalex.org/I1516879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035695398","display_name":"Farnoosh Farzam","orcid":null},"institutions":[{"id":"https://openalex.org/I1516879","display_name":"Tarbiat Modares University","ror":"https://ror.org/03mwgfy56","country_code":"IR","type":"education","lineage":["https://openalex.org/I1516879"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Farnoosh Farzam","raw_affiliation_strings":["Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: farnooosh.farzam@gmail.com"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: farnooosh.farzam@gmail.com","institution_ids":["https://openalex.org/I1516879"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074137067","display_name":"Mohammad Reza Rahbar","orcid":"https://orcid.org/0000-0001-6358-3301"},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mohammad Reza Rahbar","raw_affiliation_strings":["Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: rrahbar58@gmail.com"],"affiliations":[{"raw_affiliation_string":"Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: rrahbar58@gmail.com","institution_ids":["https://openalex.org/I194604659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5074137067"],"corresponding_institution_ids":["https://openalex.org/I194604659"],"apc_list":{"value":2610,"currency":"USD","value_usd":2610},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24996142,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"198","issue":"Pt A","first_page":"111170","last_page":"111170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epitope","display_name":"Epitope","score":0.8988999724388123},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"Immunogenicity","score":0.758400022983551},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6211000084877014},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.550000011920929},{"id":"https://openalex.org/keywords/conserved-sequence","display_name":"Conserved sequence","score":0.5067999958992004},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.4893999993801117},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.4887000024318695}],"concepts":[{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.8988999724388123},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.758400022983551},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6211000084877014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6204000115394592},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5672000050544739},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.550000011920929},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.5067999958992004},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.4893999993801117},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4887000024318695},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.4564000070095062},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.40689998865127563},{"id":"https://openalex.org/C2776789287","wikidata":"https://www.wikidata.org/wiki/Q7166532","display_name":"Peptide vaccine","level":4,"score":0.4066999852657318},{"id":"https://openalex.org/C2781241564","wikidata":"https://www.wikidata.org/wiki/Q1347450","display_name":"Epitope mapping","level":4,"score":0.37549999356269836},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.3580999970436096},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3255999982357025},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.31369999051094055},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.29649999737739563},{"id":"https://openalex.org/C2781152039","wikidata":"https://www.wikidata.org/wiki/Q7318278","display_name":"Reverse vaccinology","level":4,"score":0.28279998898506165},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27390000224113464},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.271699994802475}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018985","descriptor_name":"Epitopes, B-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018985","descriptor_name":"Epitopes, B-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018985","descriptor_name":"Epitopes, B-Lymphocyte","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018985","descriptor_name":"Epitopes, B-Lymphocyte","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054406","descriptor_name":"Pseudomonas Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D054406","descriptor_name":"Pseudomonas Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiomed.2025.111170","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2025.111170","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:41043247","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41043247","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in biology and medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W595684965","https://openalex.org/W1228613833","https://openalex.org/W1593914605","https://openalex.org/W1963885628","https://openalex.org/W1964344318","https://openalex.org/W1967641124","https://openalex.org/W1979287246","https://openalex.org/W1988252786","https://openalex.org/W1994272161","https://openalex.org/W2003204942","https://openalex.org/W2025190578","https://openalex.org/W2038990150","https://openalex.org/W2051975001","https://openalex.org/W2058720855","https://openalex.org/W2060976020","https://openalex.org/W2082443381","https://openalex.org/W2089321956","https://openalex.org/W2090350223","https://openalex.org/W2103360123","https://openalex.org/W2104720659","https://openalex.org/W2108503897","https://openalex.org/W2110298304","https://openalex.org/W2116744776","https://openalex.org/W2117333383","https://openalex.org/W2123595241","https://openalex.org/W2130874549","https://openalex.org/W2133038403","https://openalex.org/W2134308642","https://openalex.org/W2140405265","https://openalex.org/W2141596643","https://openalex.org/W2143397050","https://openalex.org/W2149984099","https://openalex.org/W2152065574","https://openalex.org/W2154714625","https://openalex.org/W2158714788","https://openalex.org/W2158781610","https://openalex.org/W2160397907","https://openalex.org/W2169197943","https://openalex.org/W2178096376","https://openalex.org/W2303008909","https://openalex.org/W2337471595","https://openalex.org/W2340149471","https://openalex.org/W2340859631","https://openalex.org/W2464440591","https://openalex.org/W2491550587","https://openalex.org/W2559849687","https://openalex.org/W2572080171","https://openalex.org/W2605158478","https://openalex.org/W2611314002","https://openalex.org/W2761623165","https://openalex.org/W2776648280","https://openalex.org/W2788954552","https://openalex.org/W2807161463","https://openalex.org/W2889991839","https://openalex.org/W2896872104","https://openalex.org/W2931815119","https://openalex.org/W2940595256","https://openalex.org/W2943407516","https://openalex.org/W3011106763","https://openalex.org/W3016073437","https://openalex.org/W3024570138","https://openalex.org/W3042755434","https://openalex.org/W3045549446","https://openalex.org/W3099088600","https://openalex.org/W3131316271","https://openalex.org/W3132796409","https://openalex.org/W3136918052","https://openalex.org/W3176236415","https://openalex.org/W3186714391","https://openalex.org/W3210500140","https://openalex.org/W3212852387","https://openalex.org/W4200515380","https://openalex.org/W4205100048","https://openalex.org/W4205192056","https://openalex.org/W4206503109","https://openalex.org/W4206908870","https://openalex.org/W4206950245","https://openalex.org/W4211066906","https://openalex.org/W4213048996","https://openalex.org/W4220748873","https://openalex.org/W4224312894","https://openalex.org/W4246353879","https://openalex.org/W4249869183","https://openalex.org/W4281484404","https://openalex.org/W4283277817","https://openalex.org/W4283745278","https://openalex.org/W4285014407","https://openalex.org/W4285390446","https://openalex.org/W4291378275","https://openalex.org/W4296850185","https://openalex.org/W4306736840","https://openalex.org/W4308388807","https://openalex.org/W4308681428","https://openalex.org/W4308773001","https://openalex.org/W4310114240","https://openalex.org/W4310213893","https://openalex.org/W4311809085","https://openalex.org/W4312173721","https://openalex.org/W4322741171","https://openalex.org/W4362469127","https://openalex.org/W4378188919","https://openalex.org/W4378229837","https://openalex.org/W4384701416","https://openalex.org/W4386258458","https://openalex.org/W4386861232","https://openalex.org/W4389206982","https://openalex.org/W4390535118","https://openalex.org/W4391648610","https://openalex.org/W4393984276","https://openalex.org/W4398194447","https://openalex.org/W4399364970","https://openalex.org/W4400445289","https://openalex.org/W4400506349","https://openalex.org/W4400602170","https://openalex.org/W4403449236","https://openalex.org/W4405299063","https://openalex.org/W4408870512","https://openalex.org/W4409436254","https://openalex.org/W4409507991","https://openalex.org/W4410494942"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-01-20T17:24:06.736184","created_date":"2025-10-10T00:00:00"}
