{"id":"https://openalex.org/W4311455576","doi":"https://doi.org/10.1016/j.compbiomed.2022.106437","title":"A novel risk signature based on autophagy-related genes to evaluate tumor immune microenvironment and predict prognosis in hepatocellular carcinoma","display_name":"A novel risk signature based on autophagy-related genes to evaluate tumor immune microenvironment and predict prognosis in hepatocellular carcinoma","publication_year":2022,"publication_date":"2022-12-14","ids":{"openalex":"https://openalex.org/W4311455576","doi":"https://doi.org/10.1016/j.compbiomed.2022.106437"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiomed.2022.106437","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2022.106437","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.compbiomed.2022.106437","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006044998","display_name":"Quanxiao Li","orcid":"https://orcid.org/0000-0002-3866-3868"},"institutions":[{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quanxiao Li","raw_affiliation_strings":["Department of Interventional Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, 510080, China","Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China"],"affiliations":[{"raw_affiliation_string":"Department of Interventional Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, 510080, China","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I157773358"]},{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012840703","display_name":"Jiaqiao Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210093384","display_name":"Chengdu Third People's Hospital","ror":"https://ror.org/00ebdgr24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093384"]},{"id":"https://openalex.org/I4800084","display_name":"Southwest Jiaotong University","ror":"https://ror.org/00hn7w693","country_code":"CN","type":"education","lineage":["https://openalex.org/I4800084"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaqiao Wu","raw_affiliation_strings":["Department of Anesthesia, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, Sichuan, 610031, China"],"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, Chengdu, Sichuan, 610031, China","institution_ids":["https://openalex.org/I4210093384","https://openalex.org/I4800084"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101607840","display_name":"Meiyan Zhu","orcid":"https://orcid.org/0009-0004-4748-7968"},"institutions":[{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meiyan Zhu","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China"],"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002647988","display_name":"Yuhao Tang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhao Tang","raw_affiliation_strings":["Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, China","Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China"],"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024138063","display_name":"Limin Jin","orcid":"https://orcid.org/0000-0002-8668-8285"},"institutions":[{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]},{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Limin Jin","raw_affiliation_strings":["Department of Anesthesia, The First Hospital of Jilin University, Changchun, Jilin, 130021, China"],"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, The First Hospital of Jilin University, Changchun, Jilin, 130021, China","institution_ids":["https://openalex.org/I4210125137","https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100454399","display_name":"Yong Chen","orcid":"https://orcid.org/0000-0002-3891-2721"},"institutions":[{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Chen","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China"],"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101511211","display_name":"Meng Jin","orcid":"https://orcid.org/0000-0002-6169-8110"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Meng Jin","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China"],"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019319993","display_name":"Zhenwei Peng","orcid":"https://orcid.org/0000-0002-0617-3805"},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenwei Peng","raw_affiliation_strings":["Cancer Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China","Clinical Trials Unit, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China","Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China","Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China"],"affiliations":[{"raw_affiliation_string":"Cancer Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I157773358","https://openalex.org/I4210146711"]},{"raw_affiliation_string":"Clinical Trials Unit, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I157773358"]},{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I157773358"]},{"raw_affiliation_string":"Institute of Precision Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, China","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5019319993","https://openalex.org/A5101511211"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921","https://openalex.org/I4210146711"],"apc_list":{"value":2610,"currency":"USD","value_usd":2610},"apc_paid":{"value":2610,"currency":"USD","value_usd":2610},"fwci":0.452,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.65622268,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"152","issue":null,"first_page":"106437","last_page":"106437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autophagy","display_name":"Autophagy","score":0.8163444995880127},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"Hepatocellular carcinoma","score":0.6979154348373413},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6596828699111938},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.6055915355682373},{"id":"https://openalex.org/keywords/gene-signature","display_name":"Gene signature","score":0.552830159664154},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4988851547241211},{"id":"https://openalex.org/keywords/nomogram","display_name":"Nomogram","score":0.4858078956604004},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.45071208477020264},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.431734174489975},{"id":"https://openalex.org/keywords/survival-analysis","display_name":"Survival analysis","score":0.42992061376571655},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.4247412085533142},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.34899866580963135},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3365124464035034},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3016737699508667},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.26194334030151367},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.23296132683753967},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.06848448514938354}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8163444995880127},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6979154348373413},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6596828699111938},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6055915355682373},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.552830159664154},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4988851547241211},{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.4858078956604004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45071208477020264},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.431734174489975},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.42992061376571655},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4247412085533142},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34899866580963135},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3365124464035034},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3016737699508667},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26194334030151367},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.23296132683753967},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06848448514938354}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.compbiomed.2022.106437","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2022.106437","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.compbiomed.2022.106437","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiomed.2022.106437","pdf_url":null,"source":{"id":"https://openalex.org/S44278595","display_name":"Computers in Biology and Medicine","issn_l":"0010-4825","issn":["0010-4825","1879-0534"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computers in Biology and Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5199999809265137,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W994533074","https://openalex.org/W1985987855","https://openalex.org/W2016242163","https://openalex.org/W2021630989","https://openalex.org/W2032768377","https://openalex.org/W2050458717","https://openalex.org/W2059036087","https://openalex.org/W2073310925","https://openalex.org/W2078841413","https://openalex.org/W2105114667","https://openalex.org/W2108411283","https://openalex.org/W2141072599","https://openalex.org/W2147784618","https://openalex.org/W2152397453","https://openalex.org/W2164589150","https://openalex.org/W2234453634","https://openalex.org/W2263577129","https://openalex.org/W2296047035","https://openalex.org/W2409027071","https://openalex.org/W2582782032","https://openalex.org/W2614935527","https://openalex.org/W2767499464","https://openalex.org/W2770661082","https://openalex.org/W2791346710","https://openalex.org/W2795334950","https://openalex.org/W2810441000","https://openalex.org/W2910249797","https://openalex.org/W2921982580","https://openalex.org/W2948017644","https://openalex.org/W2967546237","https://openalex.org/W2972479252","https://openalex.org/W2978292571","https://openalex.org/W2986676423","https://openalex.org/W2991044536","https://openalex.org/W2996980891","https://openalex.org/W2999298357","https://openalex.org/W2999491650","https://openalex.org/W3004758826","https://openalex.org/W3018049863","https://openalex.org/W3045949964","https://openalex.org/W3083391098","https://openalex.org/W3085483453","https://openalex.org/W3088113083","https://openalex.org/W3097914258","https://openalex.org/W3109756206","https://openalex.org/W3114013551","https://openalex.org/W3116805545","https://openalex.org/W3119176087","https://openalex.org/W3128646645","https://openalex.org/W3129745135","https://openalex.org/W3154448391","https://openalex.org/W3157965628","https://openalex.org/W3210282726","https://openalex.org/W3212903603","https://openalex.org/W4200399026","https://openalex.org/W4213157778","https://openalex.org/W4213303009","https://openalex.org/W4220876439","https://openalex.org/W4285613359","https://openalex.org/W6655883279","https://openalex.org/W6785728133","https://openalex.org/W6810053893","https://openalex.org/W6840202059"],"related_works":["https://openalex.org/W2911441101","https://openalex.org/W1970018641","https://openalex.org/W4226494765","https://openalex.org/W1993821226","https://openalex.org/W2063908487","https://openalex.org/W3014240535","https://openalex.org/W3150996080","https://openalex.org/W4233588653","https://openalex.org/W4387120015","https://openalex.org/W3132581975"],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"(HCC)":[2],"is":[3,21],"considered":[4],"a":[5,43,78,185],"lethal":[6],"disease":[7],"due":[8],"to":[9,24,120,188],"the":[10,14,25,32,90,137,147,152,178],"poor":[11],"prognosis":[12],"and":[13,31,36,68,74,85,115,136,141,160,170,195],"limited":[15],"therapeutic":[16,197],"efficacy.":[17],"Much":[18],"more":[19],"attention":[20],"being":[22],"attached":[23],"role":[26],"of":[27,99,127,155],"autophagy":[28,35,91,112,148],"in":[29,72,81,105,132,146,164,171],"HCC,":[30],"relationship":[33],"between":[34],"tumor":[37],"immune":[38,128,139,193],"microenvironment.":[39],"Therefore,":[40],"we":[41],"developed":[42],"novel":[44],"prognostic":[45,180],"risk":[46,134,181,190],"signature":[47,66,93,114,182],"based":[48],"on":[49],"autophagy-related":[50],"genes":[51],"(ARGs)":[52],"for":[53,199],"HCC":[54,100,200],"patients":[55],"using":[56],"gene":[57,92,113],"expression":[58,153],"profiles":[59],"collected":[60],"from":[61],"TCGA":[62],"dataset.":[63],"This":[64],"2-ARG-based":[65,179],"(BIRC5":[67],"SNRPB)":[69],"was":[70,118,130],"validated":[71,163],"ICGC":[73],"GSE14520":[75],"datasets,":[76],"achieving":[77],"favorable":[79],"performance":[80],"both":[82],"overall":[83,97],"survival":[84,87,98],"recurrence-free":[86],"outcomes.":[88],"Additionally,":[89],"could":[94,183],"independently":[95],"predict":[96],"after":[101],"adjusting":[102],"clinicopathological":[103],"indicators":[104],"three":[106],"independent":[107],"datasets.":[108],"A":[109],"nomogram":[110],"including":[111],"TNM":[116],"stage":[117],"built":[119],"serve":[121],"clinical":[122],"practice.":[123],"Significantly,":[124],"differential":[125],"abundance":[126],"cells":[129],"shown":[131],"different":[133],"groups":[135],"critical":[138],"checkpoints":[140],"immunosuppressive":[142],"cytokines":[143],"were":[144,162],"upregulated":[145],"high-risk":[149],"group.":[150],"Furthermore,":[151],"levels":[154],"proteins":[156],"encoded":[157],"by":[158,167,174],"BIRC5":[159],"SNRPB":[161],"cell":[165],"lines":[166],"western":[168],"blot":[169],"tissue":[172],"samples":[173],"immunohistochemistry.":[175],"In":[176],"summary,":[177],"be":[184],"useful":[186],"tool":[187],"identify":[189],"subgroups,":[191],"evaluate":[192],"microenvironment":[194],"provide":[196],"targets":[198],"patients.":[201]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
