{"id":"https://openalex.org/W7164814313","doi":"https://doi.org/10.1016/j.compbiolchem.2026.109198","title":"Response of MRC-5 human lung fibroblasts to FLASH and conventional radiotherapy: A study on differential DNA damage and transcriptomic response","display_name":"Response of MRC-5 human lung fibroblasts to FLASH and conventional radiotherapy: A study on differential DNA damage and transcriptomic response","publication_year":2026,"publication_date":"2026-06-15","ids":{"openalex":"https://openalex.org/W7164814313","doi":"https://doi.org/10.1016/j.compbiolchem.2026.109198","pmid":"https://pubmed.ncbi.nlm.nih.gov/42314223"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiolchem.2026.109198","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2026.109198","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5137166249","display_name":"Yi Jiang","orcid":null},"institutions":[{"id":"https://openalex.org/I1297991670","display_name":"Southwest University of Science and Technology","ror":"https://ror.org/04d996474","country_code":"CN","type":"education","lineage":["https://openalex.org/I1297991670"]},{"id":"https://openalex.org/I25399270","display_name":"Southwest Forestry University","ror":"https://ror.org/03dfa9f06","country_code":"CN","type":"education","lineage":["https://openalex.org/I25399270"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Jiang","raw_affiliation_strings":["College of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang 621010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang 621010, China","institution_ids":["https://openalex.org/I1297991670","https://openalex.org/I25399270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115592203","display_name":"Xiaofeng Wang","orcid":"https://orcid.org/0000-0001-9670-8916"},"institutions":[{"id":"https://openalex.org/I1297991670","display_name":"Southwest University of Science and Technology","ror":"https://ror.org/04d996474","country_code":"CN","type":"education","lineage":["https://openalex.org/I1297991670"]},{"id":"https://openalex.org/I25399270","display_name":"Southwest Forestry University","ror":"https://ror.org/03dfa9f06","country_code":"CN","type":"education","lineage":["https://openalex.org/I25399270"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaofeng Wang","raw_affiliation_strings":["College of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang 621010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang 621010, China","institution_ids":["https://openalex.org/I1297991670","https://openalex.org/I25399270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103443784","display_name":"Chongkai Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I1297991670","display_name":"Southwest University of Science and Technology","ror":"https://ror.org/04d996474","country_code":"CN","type":"education","lineage":["https://openalex.org/I1297991670"]},{"id":"https://openalex.org/I2801345734","display_name":"China Academy of Engineering Physics","ror":"https://ror.org/039vqpp67","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2801345734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chongkai Yang","raw_affiliation_strings":["College of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang 621010, China; Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang 621010, China; Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621010, China","institution_ids":["https://openalex.org/I1297991670","https://openalex.org/I2801345734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138651480","display_name":"Jiangping Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I1297991670","display_name":"Southwest University of Science and Technology","ror":"https://ror.org/04d996474","country_code":"CN","type":"education","lineage":["https://openalex.org/I1297991670"]},{"id":"https://openalex.org/I2801345734","display_name":"China Academy of Engineering Physics","ror":"https://ror.org/039vqpp67","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2801345734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangping Wu","raw_affiliation_strings":["College of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang 621010, China; Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang 621010, China; Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621010, China","institution_ids":["https://openalex.org/I1297991670","https://openalex.org/I2801345734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138643256","display_name":"Yaotian Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I1297991670","display_name":"Southwest University of Science and Technology","ror":"https://ror.org/04d996474","country_code":"CN","type":"education","lineage":["https://openalex.org/I1297991670"]},{"id":"https://openalex.org/I25399270","display_name":"Southwest Forestry University","ror":"https://ror.org/03dfa9f06","country_code":"CN","type":"education","lineage":["https://openalex.org/I25399270"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaotian Chen","raw_affiliation_strings":["College of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang 621010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang 621010, China","institution_ids":["https://openalex.org/I1297991670","https://openalex.org/I25399270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138632595","display_name":"Jie Li","orcid":null},"institutions":[{"id":"https://openalex.org/I4210095398","display_name":"Mianyang Central Hospital","ror":"https://ror.org/00s528j33","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210095398"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Li","raw_affiliation_strings":["Department of Oncology, Mianyang Central Hospital, Mianyang 621010, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Mianyang Central Hospital, Mianyang 621010, China","institution_ids":["https://openalex.org/I4210095398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100434876","display_name":"Qing Wang","orcid":"https://orcid.org/0000-0002-9855-4348"},"institutions":[{"id":"https://openalex.org/I1297991670","display_name":"Southwest University of Science and Technology","ror":"https://ror.org/04d996474","country_code":"CN","type":"education","lineage":["https://openalex.org/I1297991670"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qing Wang","raw_affiliation_strings":["College of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang 621010, China. Electronic address: superwq@mail.ustc.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang 621010, China. Electronic address: superwq@mail.ustc.edu.cn","institution_ids":["https://openalex.org/I1297991670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074906220","display_name":"Wenkun Zhu","orcid":"https://orcid.org/0000-0002-4116-6213"},"institutions":[{"id":"https://openalex.org/I1297991670","display_name":"Southwest University of Science and Technology","ror":"https://ror.org/04d996474","country_code":"CN","type":"education","lineage":["https://openalex.org/I1297991670"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenkun Zhu","raw_affiliation_strings":["College of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang 621010, China; CAEA Innovation Center of Nuclear Environmental Safety Technology, School of National Defense & Nuclear Science and Technology, Southwest University of Science and Technology, Mianyang 621010, China. Electronic address: zhuwenkun@swust.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang 621010, China; CAEA Innovation Center of Nuclear Environmental Safety Technology, School of National Defense & Nuclear Science and Technology, Southwest University of Science and Technology, Mianyang 621010, China. Electronic address: zhuwenkun@swust.edu.cn","institution_ids":["https://openalex.org/I1297991670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5074906220","https://openalex.org/A5100434876","https://openalex.org/A5115592203"],"corresponding_institution_ids":["https://openalex.org/I1297991670","https://openalex.org/I25399270"],"apc_list":{"value":2960,"currency":"USD","value_usd":2960},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.78687666,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":"Pt 2","first_page":"109198","last_page":"109198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.04619999974966049,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.8878999948501587},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.7382000088691711},{"id":"https://openalex.org/keywords/flash","display_name":"Flash (photography)","score":0.6636000275611877},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.5435000061988831},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.4853000044822693},{"id":"https://openalex.org/keywords/downregulation-and-upregulation","display_name":"Downregulation and upregulation","score":0.4271000027656555},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4196999967098236},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.38519999384880066}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.8878999948501587},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7382000088691711},{"id":"https://openalex.org/C2777526259","wikidata":"https://www.wikidata.org/wiki/Q221836","display_name":"Flash (photography)","level":2,"score":0.6636000275611877},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5435000061988831},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5335000157356262},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5062999725341797},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.4853000044822693},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4271000027656555},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42640000581741333},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4196999967098236},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.38519999384880066},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.38510000705718994},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3727000057697296},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3714999854564667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3490000069141388},{"id":"https://openalex.org/C2776657240","wikidata":"https://www.wikidata.org/wiki/Q5275341","display_name":"Differential display","level":4,"score":0.33799999952316284},{"id":"https://openalex.org/C3019921246","wikidata":"https://www.wikidata.org/wiki/Q104853310","display_name":"Differential effects","level":2,"score":0.2842999994754791},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.28060001134872437},{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.26080000400543213},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2558000087738037},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.25360000133514404},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.2506999969482422}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiolchem.2026.109198","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2026.109198","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},{"id":"pmid:42314223","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42314223","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational biology and chemistry","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.748071551322937}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1976391651","https://openalex.org/W1978331091","https://openalex.org/W1986568749","https://openalex.org/W1999796994","https://openalex.org/W2004125597","https://openalex.org/W2041251646","https://openalex.org/W2049048127","https://openalex.org/W2056445557","https://openalex.org/W2064467445","https://openalex.org/W2112348939","https://openalex.org/W2121000910","https://openalex.org/W2128264907","https://openalex.org/W2133853290","https://openalex.org/W2137613124","https://openalex.org/W2148910768","https://openalex.org/W2291148909","https://openalex.org/W2594432738","https://openalex.org/W2809439755","https://openalex.org/W2953590471","https://openalex.org/W2958174590","https://openalex.org/W3000198818","https://openalex.org/W3022824802","https://openalex.org/W3033843978","https://openalex.org/W3034230591","https://openalex.org/W3036006733","https://openalex.org/W3044639600","https://openalex.org/W3089207017","https://openalex.org/W3096261819","https://openalex.org/W3159171143","https://openalex.org/W3185044860","https://openalex.org/W3212060957","https://openalex.org/W4205602022","https://openalex.org/W4220771413","https://openalex.org/W4224080130","https://openalex.org/W4306735593","https://openalex.org/W4307773742","https://openalex.org/W4376121919","https://openalex.org/W4388078145","https://openalex.org/W4403915042","https://openalex.org/W4405012004"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-06-20T20:08:15.867695","created_date":"2026-06-16T00:00:00"}
