{"id":"https://openalex.org/W7164562064","doi":"https://doi.org/10.1016/j.compbiolchem.2026.109181","title":"Deep learning-guided ligand generation for the strigolactone receptor ShHTL7","display_name":"Deep learning-guided ligand generation for the strigolactone receptor ShHTL7","publication_year":2026,"publication_date":"2026-06-13","ids":{"openalex":"https://openalex.org/W7164562064","doi":"https://doi.org/10.1016/j.compbiolchem.2026.109181","pmid":"https://pubmed.ncbi.nlm.nih.gov/42296721"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiolchem.2026.109181","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2026.109181","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138538205","display_name":"Yu Li","orcid":null},"institutions":[{"id":"https://openalex.org/I1284762954","display_name":"Zhejiang A & F University","ror":"https://ror.org/02vj4rn06","country_code":"CN","type":"education","lineage":["https://openalex.org/I1284762954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Li","raw_affiliation_strings":["State Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou 311300, PR China; College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou 311300, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou 311300, PR China; College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou 311300, PR China","institution_ids":["https://openalex.org/I1284762954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000324476","display_name":"X E Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I1284762954","display_name":"Zhejiang A & F University","ror":"https://ror.org/02vj4rn06","country_code":"CN","type":"education","lineage":["https://openalex.org/I1284762954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing Wang","raw_affiliation_strings":["State Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou 311300, PR China; College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou 311300, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou 311300, PR China; College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou 311300, PR China","institution_ids":["https://openalex.org/I1284762954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138515411","display_name":"Yongxin Shuai","orcid":null},"institutions":[{"id":"https://openalex.org/I4210166194","display_name":"Zhejiang Academy of Forestry","ror":"https://ror.org/05qkx4t42","country_code":"CN","type":"nonprofit","lineage":["https://openalex.org/I4210166194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongxin Shuai","raw_affiliation_strings":["Hangzhou Gengxin Agriculture and Forestry Technology Development Co., Ltd., Hangzhou 311300, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hangzhou Gengxin Agriculture and Forestry Technology Development Co., Ltd., Hangzhou 311300, PR China","institution_ids":["https://openalex.org/I4210166194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101899800","display_name":"Yi Kuang","orcid":"https://orcid.org/0000-0003-1962-4342"},"institutions":[{"id":"https://openalex.org/I1284762954","display_name":"Zhejiang A & F University","ror":"https://ror.org/02vj4rn06","country_code":"CN","type":"education","lineage":["https://openalex.org/I1284762954"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi Kuang","raw_affiliation_strings":["State Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou 311300, PR China; College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou 311300, PR China. Electronic address: kuang_yan_yan@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou 311300, PR China; College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou 311300, PR China. Electronic address: kuang_yan_yan@163.com","institution_ids":["https://openalex.org/I1284762954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138501046","display_name":"Shengxiang Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I1284762954","display_name":"Zhejiang A & F University","ror":"https://ror.org/02vj4rn06","country_code":"CN","type":"education","lineage":["https://openalex.org/I1284762954"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shengxiang Yang","raw_affiliation_strings":["State Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou 311300, PR China; College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou 311300, PR China. Electronic address: shengxiangyang2000@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou 311300, PR China; College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou 311300, PR China. Electronic address: shengxiangyang2000@163.com","institution_ids":["https://openalex.org/I1284762954"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083405314","display_name":"Xu Han","orcid":"https://orcid.org/0000-0002-0238-543X"},"institutions":[{"id":"https://openalex.org/I1284762954","display_name":"Zhejiang A & F University","ror":"https://ror.org/02vj4rn06","country_code":"CN","type":"education","lineage":["https://openalex.org/I1284762954"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xu Han","raw_affiliation_strings":["State Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou 311300, PR China; College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou 311300, PR China. Electronic address: hanxu@zafu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou 311300, PR China; College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou 311300, PR China. Electronic address: hanxu@zafu.edu.cn","institution_ids":["https://openalex.org/I1284762954"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083405314","https://openalex.org/A5101899800","https://openalex.org/A5138501046"],"corresponding_institution_ids":["https://openalex.org/I1284762954"],"apc_list":{"value":2960,"currency":"USD","value_usd":2960},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.73572749,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":"Pt 2","first_page":"109181","last_page":"109181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12475","display_name":"Plant Parasitism and Resistance","score":0.9708999991416931,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12475","display_name":"Plant Parasitism and Resistance","score":0.9708999991416931,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10135","display_name":"Insect-Plant Interactions and Control","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12360","display_name":"Plant-derived Lignans Synthesis and Bioactivity","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/strigolactone","display_name":"Strigolactone","score":0.6819999814033508},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.6621000170707703},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.5468000173568726},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor","display_name":"G protein-coupled receptor","score":0.30559998750686646}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8034999966621399},{"id":"https://openalex.org/C2776822380","wikidata":"https://www.wikidata.org/wiki/Q2157332","display_name":"Strigolactone","level":5,"score":0.6819999814033508},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6621000170707703},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5468000173568726},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38940000534057617},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3804999887943268},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.30559998750686646},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.296999990940094},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2806999981403351},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.26100000739097595}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiolchem.2026.109181","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2026.109181","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},{"id":"pmid:42296721","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42296721","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational biology and chemistry","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1501440660","https://openalex.org/W2009076047","https://openalex.org/W2012227432","https://openalex.org/W2021520922","https://openalex.org/W2023068022","https://openalex.org/W2045683699","https://openalex.org/W2057693322","https://openalex.org/W2061389896","https://openalex.org/W2118566334","https://openalex.org/W2148314253","https://openalex.org/W2152630148","https://openalex.org/W2160592148","https://openalex.org/W2161605421","https://openalex.org/W2257487078","https://openalex.org/W2481364382","https://openalex.org/W2489045970","https://openalex.org/W2499986362","https://openalex.org/W2578240541","https://openalex.org/W2790808809","https://openalex.org/W2810023675","https://openalex.org/W2899190509","https://openalex.org/W2901661105","https://openalex.org/W2945551948","https://openalex.org/W2987934639","https://openalex.org/W2989615256","https://openalex.org/W3094492244","https://openalex.org/W3119872582","https://openalex.org/W3194342664","https://openalex.org/W3217159557","https://openalex.org/W4289815113","https://openalex.org/W4378783128","https://openalex.org/W4389963497","https://openalex.org/W4392015344"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-06-17T06:14:20.161405","created_date":"2026-06-13T00:00:00"}
