{"id":"https://openalex.org/W7162100331","doi":"https://doi.org/10.1016/j.compbiolchem.2026.109107","title":"Integration of network toxicology, WGCNA, and explainable machine learning to decipher the toxic molecular basis underlying DEGDB plasticizer\u2013induced clear cell renal cell carcinoma (ccRCC) progression","display_name":"Integration of network toxicology, WGCNA, and explainable machine learning to decipher the toxic molecular basis underlying DEGDB plasticizer\u2013induced clear cell renal cell carcinoma (ccRCC) progression","publication_year":2026,"publication_date":"2026-05-22","ids":{"openalex":"https://openalex.org/W7162100331","doi":"https://doi.org/10.1016/j.compbiolchem.2026.109107","pmid":"https://pubmed.ncbi.nlm.nih.gov/42224996"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiolchem.2026.109107","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2026.109107","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119368978","display_name":"Ma Yanpin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ma Yanping","raw_affiliation_strings":["Department of Urology, People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China; Department of Urology, General Hospital of Ningxia Medical University, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China. Electronic address: myp19992023@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China; Department of Urology, General Hospital of Ningxia Medical University, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China. Electronic address: myp19992023@163.com","institution_ids":["https://openalex.org/I4210127460","https://openalex.org/I4210139449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136782813","display_name":"Tian Guolin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]},{"id":"https://openalex.org/I4210164393","display_name":"The Fourth People's Hospital of Ningxia Hui Autonomous Region","ror":"https://ror.org/05kjn8d41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164393"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian Guolin","raw_affiliation_strings":["Department of Urology, People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China. Electronic address: 2834640584@qq.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China. Electronic address: 2834640584@qq.com","institution_ids":["https://openalex.org/I4210127460","https://openalex.org/I4210139449","https://openalex.org/I4210164393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136780122","display_name":"Tao Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Tao","raw_affiliation_strings":["Department of Urology, General Hospital of Ningxia Medical University, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China. Electronic address: angao234@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, General Hospital of Ningxia Medical University, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China. Electronic address: angao234@163.com","institution_ids":["https://openalex.org/I4210127460","https://openalex.org/I4210139449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136764575","display_name":"Du Angyang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Du Angyang","raw_affiliation_strings":["Department of Blood Purification,First Affiliated Hospital of Xi'an Jiaotong University, XiAn 710000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Blood Purification,First Affiliated Hospital of Xi'an Jiaotong University, XiAn 710000, China","institution_ids":["https://openalex.org/I4210121771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136739238","display_name":"Jiaxin Li","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Jiaxin","raw_affiliation_strings":["School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China","institution_ids":["https://openalex.org/I4210127460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083041554","display_name":"Bo Tao","orcid":"https://orcid.org/0000-0002-4058-6128"},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Bo","raw_affiliation_strings":["Department of Urology, General Hospital of Ningxia Medical University, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, General Hospital of Ningxia Medical University, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China","institution_ids":["https://openalex.org/I4210127460","https://openalex.org/I4210139449"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136777159","display_name":"Li Yajie","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]},{"id":"https://openalex.org/I4210164393","display_name":"The Fourth People's Hospital of Ningxia Hui Autonomous Region","ror":"https://ror.org/05kjn8d41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164393"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Yajie","raw_affiliation_strings":["Department of Urology, People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China","institution_ids":["https://openalex.org/I4210127460","https://openalex.org/I4210139449","https://openalex.org/I4210164393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136803210","display_name":"Jia Yaodong","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]},{"id":"https://openalex.org/I4210164393","display_name":"The Fourth People's Hospital of Ningxia Hui Autonomous Region","ror":"https://ror.org/05kjn8d41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164393"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Yaodong","raw_affiliation_strings":["Department of Urology, People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China","institution_ids":["https://openalex.org/I4210127460","https://openalex.org/I4210139449","https://openalex.org/I4210164393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136813073","display_name":"Feng Yuelong","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]},{"id":"https://openalex.org/I4210164393","display_name":"The Fourth People's Hospital of Ningxia Hui Autonomous Region","ror":"https://ror.org/05kjn8d41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164393"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Yuelong","raw_affiliation_strings":["Department of Urology, People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China","institution_ids":["https://openalex.org/I4210127460","https://openalex.org/I4210139449","https://openalex.org/I4210164393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136759484","display_name":"hao yang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]},{"id":"https://openalex.org/I4210164393","display_name":"The Fourth People's Hospital of Ningxia Hui Autonomous Region","ror":"https://ror.org/05kjn8d41","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164393"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Hao","raw_affiliation_strings":["Department of Urology, People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China","institution_ids":["https://openalex.org/I4210127460","https://openalex.org/I4210139449","https://openalex.org/I4210164393"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136762911","display_name":"Nie Lihong","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nie Lihong","raw_affiliation_strings":["School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China. Electronic address: nielihong5253@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China. Electronic address: nielihong5253@163.com","institution_ids":["https://openalex.org/I4210127460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5136746370","display_name":"Zhao Ruining","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127460","display_name":"Ningxia Medical University","ror":"https://ror.org/02h8a1848","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210127460"]},{"id":"https://openalex.org/I4210139449","display_name":"Ningxia Medical University General Hospital","ror":"https://ror.org/049dkqr57","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139449"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhao Ruining","raw_affiliation_strings":["Department of Urology, People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China; Department of Urology, General Hospital of Ningxia Medical University, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China. Electronic address: zhaoruining5257@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, People's Hospital of Ningxia Hui Autonomous Region, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China; Department of Urology, General Hospital of Ningxia Medical University, Third Clinical Medical of Ningxia Medical University, Yinchuan 750001, China. Electronic address: zhaoruining5257@163.com","institution_ids":["https://openalex.org/I4210127460","https://openalex.org/I4210139449"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5136746370"],"corresponding_institution_ids":["https://openalex.org/I4210127460","https://openalex.org/I4210139449"],"apc_list":{"value":2960,"currency":"USD","value_usd":2960},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58452324,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":"Pt 1","first_page":"109107","last_page":"109107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.08089999854564667,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.08089999854564667,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.06080000102519989,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14065","display_name":"Biological Research and Disease Studies","score":0.05820000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/decipher","display_name":"DECIPHER","score":0.9688000082969666},{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"Clear cell renal cell carcinoma","score":0.6830000281333923},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"Renal cell carcinoma","score":0.4778999984264374},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.45660001039505005},{"id":"https://openalex.org/keywords/kidney-cancer","display_name":"Kidney cancer","score":0.45350000262260437},{"id":"https://openalex.org/keywords/basis","display_name":"Basis (linear algebra)","score":0.4034000039100647}],"concepts":[{"id":"https://openalex.org/C164614171","wikidata":"https://www.wikidata.org/wiki/Q5204775","display_name":"DECIPHER","level":2,"score":0.9688000082969666},{"id":"https://openalex.org/C2781278892","wikidata":"https://www.wikidata.org/wiki/Q18556340","display_name":"Clear cell renal cell carcinoma","level":3,"score":0.6830000281333923},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49950000643730164},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.4778999984264374},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.475600004196167},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45660001039505005},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.45350000262260437},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.45190000534057617},{"id":"https://openalex.org/C12426560","wikidata":"https://www.wikidata.org/wiki/Q189569","display_name":"Basis (linear algebra)","level":2,"score":0.4034000039100647},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.37950000166893005},{"id":"https://openalex.org/C2778560582","wikidata":"https://www.wikidata.org/wiki/Q18347894","display_name":"Clear cell","level":3,"score":0.3720000088214874},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3709000051021576},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34040001034736633},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33970001339912415},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.322299987077713},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.314300000667572},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.31049999594688416},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3001999855041504},{"id":"https://openalex.org/C136389625","wikidata":"https://www.wikidata.org/wiki/Q334384","display_name":"Supervised learning","level":3,"score":0.2687999904155731}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiolchem.2026.109107","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2026.109107","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},{"id":"pmid:42224996","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42224996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational biology and chemistry","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.47497662901878357}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W2047321776","https://openalex.org/W2049844714","https://openalex.org/W2139252323","https://openalex.org/W2151365262","https://openalex.org/W2432815258","https://openalex.org/W2726542547","https://openalex.org/W2810166643","https://openalex.org/W2950764390","https://openalex.org/W3041611630","https://openalex.org/W3058908590","https://openalex.org/W3186506541","https://openalex.org/W4214828238","https://openalex.org/W4221027531","https://openalex.org/W4298140233","https://openalex.org/W4377092470","https://openalex.org/W4388990582","https://openalex.org/W4391613984","https://openalex.org/W4392746964","https://openalex.org/W4394842797","https://openalex.org/W4403429375","https://openalex.org/W4403587553","https://openalex.org/W4414520304"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2026-05-23T00:00:00"}