{"id":"https://openalex.org/W7155417971","doi":"https://doi.org/10.1016/j.compbiolchem.2026.109095","title":"Integrative multi-omics analysis identifies stromal-immune crosstalk as a determinant of immunotherapy efficacy and establishes a prognostic signature in gastric cancer","display_name":"Integrative multi-omics analysis identifies stromal-immune crosstalk as a determinant of immunotherapy efficacy and establishes a prognostic signature in gastric cancer","publication_year":2026,"publication_date":"2026-04-23","ids":{"openalex":"https://openalex.org/W7155417971","doi":"https://doi.org/10.1016/j.compbiolchem.2026.109095","pmid":"https://pubmed.ncbi.nlm.nih.gov/42068630"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiolchem.2026.109095","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2026.109095","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5134419469","display_name":"Fan Zhang","orcid":"https://orcid.org/0009-0003-1770-3407"},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210100868","display_name":"Second Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/012f2cn18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100868"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Zhang","raw_affiliation_strings":["Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Liaoning 116044, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Liaoning 116044, PR China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134417725","display_name":"Qingqing Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingqing Zhang","raw_affiliation_strings":["Department of Pathology and Forensic Medicine, College of Basic Medical Science, Dalian Medical University, Liaoning 116044, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Forensic Medicine, College of Basic Medical Science, Dalian Medical University, Liaoning 116044, PR China","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134428051","display_name":"Shuai Shao","orcid":null},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210100868","display_name":"Second Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/012f2cn18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100868"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Shao","raw_affiliation_strings":["Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Liaoning 116044, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Liaoning 116044, PR China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134402910","display_name":"Xiaobo Li","orcid":null},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaobo Li","raw_affiliation_strings":["Department of Pathology and Forensic Medicine, College of Basic Medical Science, Dalian Medical University, Liaoning 116044, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Forensic Medicine, College of Basic Medical Science, Dalian Medical University, Liaoning 116044, PR China","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134445224","display_name":"Yi Cheng","orcid":null},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210100868","display_name":"Second Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/012f2cn18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100868"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Cheng","raw_affiliation_strings":["Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Liaoning 116044, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Liaoning 116044, PR China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134434604","display_name":"Xu Cao","orcid":null},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Cao","raw_affiliation_strings":["College of Basic Medical Science, Dalian Medical University, Liaoning 116044, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medical Science, Dalian Medical University, Liaoning 116044, PR China","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134410428","display_name":"Xiaotang Yu","orcid":null},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaotang Yu","raw_affiliation_strings":["Department of Pathology and Forensic Medicine, College of Basic Medical Science, Dalian Medical University, Liaoning 116044, PR China. Electronic address: xiaotang_yu@outlook.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Forensic Medicine, College of Basic Medical Science, Dalian Medical University, Liaoning 116044, PR China. Electronic address: xiaotang_yu@outlook.com","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109304882","display_name":"Zhengming Gao","orcid":null},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210100868","display_name":"Second Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/012f2cn18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100868"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhengming Gao","raw_affiliation_strings":["Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Liaoning 116044, PR China. Electronic address: gaozhenmingdl@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Liaoning 116044, PR China. Electronic address: gaozhenmingdl@163.com","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5109304882","https://openalex.org/A5134410428"],"corresponding_institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"],"apc_list":{"value":2960,"currency":"USD","value_usd":2960},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.53522817,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":"Pt 1","first_page":"109095","last_page":"109095"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.37860000133514404,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.37860000133514404,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.21889999508857727,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.05000000074505806,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.7494000196456909},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.6847000122070312},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"Cancer immunotherapy","score":0.4812000095844269},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4713999927043915},{"id":"https://openalex.org/keywords/signature","display_name":"Signature (topology)","score":0.38019999861717224},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.28929999470710754}],"concepts":[{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.7494000196456909},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6847000122070312},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6488999724388123},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.4812000095844269},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48100000619888306},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4713999927043915},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.38019999861717224},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36980000138282776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31380000710487366},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29440000653266907},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.28929999470710754},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.2775000035762787},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.2662999927997589},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2660999894142151},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.26100000739097595},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2556999921798706},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.2517000138759613}],"mesh":[{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiolchem.2026.109095","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2026.109095","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},{"id":"pmid:42068630","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42068630","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational biology and chemistry","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6372296214103699,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320324560","display_name":"Department of Education of Liaoning Province","ror":"https://ror.org/0022v2454"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1985987855","https://openalex.org/W2012034410","https://openalex.org/W2035621887","https://openalex.org/W2049397238","https://openalex.org/W2126547130","https://openalex.org/W2134506748","https://openalex.org/W2301159868","https://openalex.org/W2347070489","https://openalex.org/W2401056916","https://openalex.org/W2419495646","https://openalex.org/W2529308344","https://openalex.org/W2600132724","https://openalex.org/W2773826734","https://openalex.org/W2785803176","https://openalex.org/W2790351808","https://openalex.org/W2884397450","https://openalex.org/W2899204048","https://openalex.org/W2915944698","https://openalex.org/W2954094199","https://openalex.org/W3038022442","https://openalex.org/W3083986479","https://openalex.org/W3132661792","https://openalex.org/W3157208801","https://openalex.org/W3173127935","https://openalex.org/W3206448904","https://openalex.org/W4281263395","https://openalex.org/W4313491581","https://openalex.org/W4366780660","https://openalex.org/W4385983932","https://openalex.org/W4390935792","https://openalex.org/W4391115337","https://openalex.org/W4391241545","https://openalex.org/W4391569637","https://openalex.org/W4391669638","https://openalex.org/W4392168265","https://openalex.org/W4392179288","https://openalex.org/W4392893183","https://openalex.org/W4393071030","https://openalex.org/W4396753800","https://openalex.org/W4396927977","https://openalex.org/W4400146475","https://openalex.org/W4401703744","https://openalex.org/W4402604581","https://openalex.org/W4403299725","https://openalex.org/W4403506731","https://openalex.org/W4405249279","https://openalex.org/W4405781449","https://openalex.org/W4406872528","https://openalex.org/W4408633381","https://openalex.org/W4412774890"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-06-20T22:02:38.213706","created_date":"2026-04-24T00:00:00"}
