{"id":"https://openalex.org/W7154741212","doi":"https://doi.org/10.1016/j.compbiolchem.2026.109080","title":"Computational and experimental insights into quinazoline derivatives: Targeting HOTAIR for therapeutic intervention in breast cancer","display_name":"Computational and experimental insights into quinazoline derivatives: Targeting HOTAIR for therapeutic intervention in breast cancer","publication_year":2026,"publication_date":"2026-04-17","ids":{"openalex":"https://openalex.org/W7154741212","doi":"https://doi.org/10.1016/j.compbiolchem.2026.109080","pmid":"https://pubmed.ncbi.nlm.nih.gov/42001825"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiolchem.2026.109080","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2026.109080","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056431914","display_name":"Ali Mohammed Alqahtani","orcid":"https://orcid.org/0000-0001-5464-968X"},"institutions":[{"id":"https://openalex.org/I82952536","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30","country_code":"SA","type":"education","lineage":["https://openalex.org/I82952536"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ali M. Alqahtani","raw_affiliation_strings":["Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia","institution_ids":["https://openalex.org/I82952536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053445061","display_name":"Taha Alqahtani","orcid":"https://orcid.org/0000-0003-4017-8754"},"institutions":[{"id":"https://openalex.org/I82952536","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30","country_code":"SA","type":"education","lineage":["https://openalex.org/I82952536"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Taha Alqahtani","raw_affiliation_strings":["Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia","institution_ids":["https://openalex.org/I82952536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099094748","display_name":"Stalin Arulsamy","orcid":null},"institutions":[{"id":"https://openalex.org/I110360157","display_name":"Lovely Professional University","ror":"https://ror.org/00et6q107","country_code":"IN","type":"education","lineage":["https://openalex.org/I110360157"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Stalin Arulsamy","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, Lovely Professional University, Jalandhar - Delhi, Grand Trunk Rd, Phagwara, Punjab 144411, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, Lovely Professional University, Jalandhar - Delhi, Grand Trunk Rd, Phagwara, Punjab 144411, India","institution_ids":["https://openalex.org/I110360157"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133910271","display_name":"Swati Mayur Keny","orcid":null},"institutions":[{"id":"https://openalex.org/I4210151968","display_name":"Hindu College of Pharmacy","ror":"https://ror.org/04sadrh19","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210151968"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Swati Mayur Keny","raw_affiliation_strings":["Department of Pharmaceutics, PES's Rajaram and Tarabai Bandekar College of Pharmacy, Ponda, Goa 403401, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, PES's Rajaram and Tarabai Bandekar College of Pharmacy, Ponda, Goa 403401, India","institution_ids":["https://openalex.org/I4210151968"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001089262","display_name":"Malarkodi Velraj","orcid":"https://orcid.org/0000-0001-5569-6840"},"institutions":[{"id":"https://openalex.org/I138876546","display_name":"Vels University","ror":"https://ror.org/00tscx035","country_code":"IN","type":"education","lineage":["https://openalex.org/I138876546"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Malarkodi Velraj","raw_affiliation_strings":["Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Pallavaram, Chennai, Tamil Nadu 600117, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Pallavaram, Chennai, Tamil Nadu 600117, India","institution_ids":["https://openalex.org/I138876546"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133837491","display_name":"Kumarappan Chidambaram","orcid":"https://orcid.org/0000-0002-7981-4562"},"institutions":[{"id":"https://openalex.org/I82952536","display_name":"King Khalid University","ror":"https://ror.org/052kwzs30","country_code":"SA","type":"education","lineage":["https://openalex.org/I82952536"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Kumarappan Chidambaram","raw_affiliation_strings":["Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia. Electronic address: kumarappan@kku.edu.sa"],"raw_orcid":"https://orcid.org/0000-0002-7981-4562","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia. Electronic address: kumarappan@kku.edu.sa","institution_ids":["https://openalex.org/I82952536"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040902973","display_name":"Panneerselvam Theivendren","orcid":"https://orcid.org/0000-0002-8197-4688"},"institutions":[{"id":"https://openalex.org/I138876546","display_name":"Vels University","ror":"https://ror.org/00tscx035","country_code":"IN","type":"education","lineage":["https://openalex.org/I138876546"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Panneerselvam Theivendren","raw_affiliation_strings":["Department of Pharmaceutical Chemistry & Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Pallavaram, Chennai, Tamil Nadu 600117, India. Electronic address: panneerselvam.sps@vistas.ac.in"],"raw_orcid":"https://orcid.org/0000-0002-8197-4688","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry & Analysis, School of Pharmaceutical Sciences, Vels Institute of Science, Technology & Advanced Studies, Pallavaram, Chennai, Tamil Nadu 600117, India. Electronic address: panneerselvam.sps@vistas.ac.in","institution_ids":["https://openalex.org/I138876546"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5040902973","https://openalex.org/A5133837491"],"corresponding_institution_ids":["https://openalex.org/I138876546","https://openalex.org/I82952536"],"apc_list":{"value":2960,"currency":"USD","value_usd":2960},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39765536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":"Pt 1","first_page":"109080","last_page":"109080"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications","score":0.2752000093460083,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications","score":0.2752000093460083,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.05810000002384186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.04490000009536743,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hotair","display_name":"HOTAIR","score":0.8080000281333923},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.707099974155426},{"id":"https://openalex.org/keywords/intervention","display_name":"Intervention (counseling)","score":0.503000020980835},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3815999925136566},{"id":"https://openalex.org/keywords/quinazoline","display_name":"Quinazoline","score":0.33799999952316284}],"concepts":[{"id":"https://openalex.org/C2781128886","wikidata":"https://www.wikidata.org/wiki/Q18062498","display_name":"HOTAIR","level":5,"score":0.8080000281333923},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.707099974155426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6704999804496765},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5267999768257141},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.503000020980835},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.390500009059906},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3815999925136566},{"id":"https://openalex.org/C2778866207","wikidata":"https://www.wikidata.org/wiki/Q426278","display_name":"Quinazoline","level":2,"score":0.33799999952316284},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.33070001006126404},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3264999985694885},{"id":"https://openalex.org/C2993589390","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Breast cancer metastasis","level":5,"score":0.2782999873161316},{"id":"https://openalex.org/C2986637895","wikidata":"https://www.wikidata.org/wiki/Q953865","display_name":"Breast tumor","level":4,"score":0.2766999900341034},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.272599995136261}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiolchem.2026.109080","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2026.109080","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},{"id":"pmid:42001825","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42001825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational biology and chemistry","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4962972104549408}],"awards":[{"id":"https://openalex.org/G8687637640","display_name":null,"funder_award_id":"RGP2/413/46","funder_id":"https://openalex.org/F33954902","funder_display_name":"Deanship of Scientific Research, King Khalid University"}],"funders":[{"id":"https://openalex.org/F33954902","display_name":"Deanship of Scientific Research, King Khalid University","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W2893058406","https://openalex.org/W2907208238","https://openalex.org/W2991228778","https://openalex.org/W3006386970","https://openalex.org/W3014115878","https://openalex.org/W3022501647","https://openalex.org/W3023899890","https://openalex.org/W3095916560","https://openalex.org/W3099592755","https://openalex.org/W3101318777","https://openalex.org/W3164642402","https://openalex.org/W3165011637","https://openalex.org/W3199098970","https://openalex.org/W3213103923","https://openalex.org/W4210277123","https://openalex.org/W4213425068","https://openalex.org/W4282841575","https://openalex.org/W4293102053","https://openalex.org/W4306768310","https://openalex.org/W4387996182","https://openalex.org/W4391323919","https://openalex.org/W4396828390","https://openalex.org/W4398242458","https://openalex.org/W4400781603","https://openalex.org/W4402552520","https://openalex.org/W4403558562","https://openalex.org/W4406749427","https://openalex.org/W4408652954","https://openalex.org/W4412459646","https://openalex.org/W4413996530"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2026-04-18T00:00:00"}
