{"id":"https://openalex.org/W7155078783","doi":"https://doi.org/10.1016/j.compbiolchem.2026.109075","title":"Lactate-associated gene PLAU promotes liver metastasis of pancreatic ductal adenocarcinoma","display_name":"Lactate-associated gene PLAU promotes liver metastasis of pancreatic ductal adenocarcinoma","publication_year":2026,"publication_date":"2026-04-21","ids":{"openalex":"https://openalex.org/W7155078783","doi":"https://doi.org/10.1016/j.compbiolchem.2026.109075","pmid":"https://pubmed.ncbi.nlm.nih.gov/42048949"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiolchem.2026.109075","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2026.109075","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031904971","display_name":"Xinghe Liao","orcid":"https://orcid.org/0000-0001-6158-4693"},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinghe Liao","raw_affiliation_strings":["Oncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China","institution_ids":["https://openalex.org/I4210136596","https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134149783","display_name":"Fenglin Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fenglin Zhang","raw_affiliation_strings":["Oncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China","institution_ids":["https://openalex.org/I4210136596","https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134143632","display_name":"Qun Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qun Huang","raw_affiliation_strings":["Department of Clinical Medicine, Gannan Healthcare Vocational College, Ganzhou 341000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Gannan Healthcare Vocational College, Ganzhou 341000, China","institution_ids":["https://openalex.org/I4210113195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023634221","display_name":"Xiaorui Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaorui Wu","raw_affiliation_strings":["Oncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China","institution_ids":["https://openalex.org/I4210136596","https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108581516","display_name":"Jiangang Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangang Zhao","raw_affiliation_strings":["Oncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China","institution_ids":["https://openalex.org/I4210136596","https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134198949","display_name":"zhou zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhou Zhou","raw_affiliation_strings":["Oncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China","institution_ids":["https://openalex.org/I4210136596","https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134173076","display_name":"Hao Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hao Chen","raw_affiliation_strings":["Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China. Electronic address: chengkll@sina.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China. Electronic address: chengkll@sina.com","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5134160261","display_name":"Ping Li","orcid":null},"institutions":[{"id":"https://openalex.org/I253932293","display_name":"Anhui University of Traditional Chinese Medicine","ror":"https://ror.org/0139j4p80","country_code":"CN","type":"education","lineage":["https://openalex.org/I253932293"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ping Li","raw_affiliation_strings":["Oncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; Graduate School of Anhui University of Traditional Chinese Medicine, Hefei 230022, China. Electronic address: 1964liping@sina.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; Graduate School of Anhui University of Traditional Chinese Medicine, Hefei 230022, China. Electronic address: 1964liping@sina.com","institution_ids":["https://openalex.org/I253932293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5134160261","https://openalex.org/A5134173076"],"corresponding_institution_ids":["https://openalex.org/I253932293","https://openalex.org/I4210093194"],"apc_list":{"value":2960,"currency":"USD","value_usd":2960},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.4552928,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"124","issue":"Pt 1","first_page":"109075","last_page":"109075"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.48249998688697815,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.48249998688697815,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14364","display_name":"Clusterin in disease pathology","score":0.19609999656677246,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.08380000293254852,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-silencing","display_name":"Gene silencing","score":0.7060999870300293},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.6798999905586243},{"id":"https://openalex.org/keywords/organoid","display_name":"Organoid","score":0.4787999987602234},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4674000144004822},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.4575999975204468},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.4442000091075897},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"Pancreatic ductal adenocarcinoma","score":0.4090000092983246},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"Liver cancer","score":0.4047999978065491},{"id":"https://openalex.org/keywords/myeloid","display_name":"Myeloid","score":0.3991999924182892}],"concepts":[{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.7060999870300293},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6798999905586243},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6337000131607056},{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.4787999987602234},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4674000144004822},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4575999975204468},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4442000091075897},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.4090000092983246},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.4047999978065491},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.3991999924182892},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38530001044273376},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.38510000705718994},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.36899998784065247},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.36579999327659607},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34529998898506165},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3424000144004822},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3303999900817871},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3009999990463257},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.2842000126838684},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.27639999985694885},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.26899999380111694},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.26420000195503235},{"id":"https://openalex.org/C34981463","wikidata":"https://www.wikidata.org/wiki/Q3311663","display_name":"Suicide gene","level":4,"score":0.2542000114917755}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiolchem.2026.109075","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2026.109075","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},{"id":"pmid:42048949","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42048949","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational biology and chemistry","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/1","display_name":"No poverty","score":0.6155177354812622}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1497915798","https://openalex.org/W1968812902","https://openalex.org/W2043991982","https://openalex.org/W2063632665","https://openalex.org/W2087377825","https://openalex.org/W2121141922","https://openalex.org/W2151253787","https://openalex.org/W2416038770","https://openalex.org/W2531887049","https://openalex.org/W2581973599","https://openalex.org/W2904307134","https://openalex.org/W2982216374","https://openalex.org/W2996335277","https://openalex.org/W2999027176","https://openalex.org/W3023998523","https://openalex.org/W3111244085","https://openalex.org/W4200519100","https://openalex.org/W4211253487","https://openalex.org/W4381742909","https://openalex.org/W4386099719","https://openalex.org/W4388914965","https://openalex.org/W4394875120","https://openalex.org/W4396617365","https://openalex.org/W4400644484","https://openalex.org/W4406969198","https://openalex.org/W4408009893","https://openalex.org/W4409898846","https://openalex.org/W4411196743"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2026-04-22T00:00:00"}
