{"id":"https://openalex.org/W4414572691","doi":"https://doi.org/10.1016/j.compbiolchem.2025.108698","title":"Systems analysis of Berberis vulgaris alkaloids unveils their functional synergy and drug-like potential","display_name":"Systems analysis of Berberis vulgaris alkaloids unveils their functional synergy and drug-like potential","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4414572691","doi":"https://doi.org/10.1016/j.compbiolchem.2025.108698","pmid":"https://pubmed.ncbi.nlm.nih.gov/41033163"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiolchem.2025.108698","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2025.108698","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.compbiolchem.2025.108698","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078599630","display_name":"Chinenyenwa Fortune Chukwuneme","orcid":"https://orcid.org/0000-0002-3995-208X"},"institutions":[{"id":"https://openalex.org/I165390105","display_name":"University of South Africa","ror":"https://ror.org/048cwvf49","country_code":"ZA","type":"education","lineage":["https://openalex.org/I165390105"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Chinenyenwa Fortune Chukwuneme","raw_affiliation_strings":["Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Roodepoort, South Africa. Electronic address: chukwf@unisa.ac.za"],"affiliations":[{"raw_affiliation_string":"Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Roodepoort, South Africa. Electronic address: chukwf@unisa.ac.za","institution_ids":["https://openalex.org/I165390105"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014837075","display_name":"Samantha Gildenhuys","orcid":"https://orcid.org/0000-0002-9717-8379"},"institutions":[{"id":"https://openalex.org/I165390105","display_name":"University of South Africa","ror":"https://ror.org/048cwvf49","country_code":"ZA","type":"education","lineage":["https://openalex.org/I165390105"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Samantha Gildenhuys","raw_affiliation_strings":["Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Roodepoort, South Africa. Electronic address: gildes@unisa.ac.za"],"affiliations":[{"raw_affiliation_string":"Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa, Roodepoort, South Africa. Electronic address: gildes@unisa.ac.za","institution_ids":["https://openalex.org/I165390105"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014837075","https://openalex.org/A5078599630"],"corresponding_institution_ids":["https://openalex.org/I165390105"],"apc_list":{"value":2960,"currency":"USD","value_usd":2960},"apc_paid":{"value":2960,"currency":"USD","value_usd":2960},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2919365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"120","issue":"Pt 2","first_page":"108698","last_page":"108698"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12649","display_name":"Alkaloids: synthesis and pharmacology","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.8797000050544739},{"id":"https://openalex.org/keywords/isoquinoline","display_name":"Isoquinoline","score":0.47119998931884766},{"id":"https://openalex.org/keywords/functional-genomics","display_name":"Functional genomics","score":0.4293000102043152},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4142000079154968},{"id":"https://openalex.org/keywords/berberine","display_name":"Berberine","score":0.40299999713897705},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4018999934196472},{"id":"https://openalex.org/keywords/berberis","display_name":"Berberis","score":0.38909998536109924}],"concepts":[{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.8797000050544739},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5913000106811523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5663999915122986},{"id":"https://openalex.org/C2776923262","wikidata":"https://www.wikidata.org/wiki/Q412316","display_name":"Isoquinoline","level":2,"score":0.47119998931884766},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.4293000102043152},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4142000079154968},{"id":"https://openalex.org/C2780116568","wikidata":"https://www.wikidata.org/wiki/Q176525","display_name":"Berberine","level":2,"score":0.40299999713897705},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4018999934196472},{"id":"https://openalex.org/C2777288208","wikidata":"https://www.wikidata.org/wiki/Q158503","display_name":"Berberis","level":2,"score":0.38909998536109924},{"id":"https://openalex.org/C2778848595","wikidata":"https://www.wikidata.org/wiki/Q155949","display_name":"Berberidaceae","level":2,"score":0.3659999966621399},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3424000144004822},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.32350000739097595},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.28839999437332153},{"id":"https://openalex.org/C2779446555","wikidata":"https://www.wikidata.org/wiki/Q7663877","display_name":"Systems pharmacology","level":3,"score":0.2879999876022339},{"id":"https://openalex.org/C55112680","wikidata":"https://www.wikidata.org/wiki/Q190549","display_name":"Functional analysis","level":3,"score":0.2838999927043915},{"id":"https://openalex.org/C2777143434","wikidata":"https://www.wikidata.org/wiki/Q53476","display_name":"Lamiaceae","level":2,"score":0.27869999408721924},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.26170000433921814}],"mesh":[{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028142","descriptor_name":"Berberis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D028142","descriptor_name":"Berberis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D028142","descriptor_name":"Berberis","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiolchem.2025.108698","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2025.108698","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},{"id":"pmid:41033163","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41033163","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational biology and chemistry","raw_type":null}],"best_oa_location":{"id":"doi:10.1016/j.compbiolchem.2025.108698","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2025.108698","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1856876921","display_name":null,"funder_award_id":"PSTD230515106428","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":139,"referenced_works":["https://openalex.org/W164848541","https://openalex.org/W560852576","https://openalex.org/W1484061442","https://openalex.org/W1500897968","https://openalex.org/W1591641679","https://openalex.org/W1829776237","https://openalex.org/W1911849142","https://openalex.org/W1969569273","https://openalex.org/W1970518854","https://openalex.org/W1973012451","https://openalex.org/W1976161092","https://openalex.org/W1983762238","https://openalex.org/W1989566757","https://openalex.org/W1993742801","https://openalex.org/W1996913481","https://openalex.org/W2000514960","https://openalex.org/W2008222867","https://openalex.org/W2011301426","https://openalex.org/W2016462887","https://openalex.org/W2022056642","https://openalex.org/W2023018064","https://openalex.org/W2026659768","https://openalex.org/W2028911868","https://openalex.org/W2034851342","https://openalex.org/W2036388286","https://openalex.org/W2038136197","https://openalex.org/W2040387891","https://openalex.org/W2046024621","https://openalex.org/W2047604081","https://openalex.org/W2049374415","https://openalex.org/W2049615786","https://openalex.org/W2055050900","https://openalex.org/W2063592077","https://openalex.org/W2069462832","https://openalex.org/W2069580248","https://openalex.org/W2073471715","https://openalex.org/W2076769226","https://openalex.org/W2076903615","https://openalex.org/W2078549610","https://openalex.org/W2079931904","https://openalex.org/W2084111853","https://openalex.org/W2089747890","https://openalex.org/W2097744565","https://openalex.org/W2107755166","https://openalex.org/W2108871998","https://openalex.org/W2118954175","https://openalex.org/W2120320193","https://openalex.org/W2126838999","https://openalex.org/W2135587451","https://openalex.org/W2137179201","https://openalex.org/W2148232911","https://openalex.org/W2152506438","https://openalex.org/W2158005416","https://openalex.org/W2158217645","https://openalex.org/W2165370634","https://openalex.org/W2168938595","https://openalex.org/W2171397610","https://openalex.org/W2342249984","https://openalex.org/W2409740864","https://openalex.org/W2468941707","https://openalex.org/W2501497123","https://openalex.org/W2512703240","https://openalex.org/W2550888436","https://openalex.org/W2554430865","https://openalex.org/W2620379178","https://openalex.org/W2626427071","https://openalex.org/W2626811882","https://openalex.org/W2698548050","https://openalex.org/W2737759991","https://openalex.org/W2763596939","https://openalex.org/W2791374598","https://openalex.org/W2795421936","https://openalex.org/W2809600798","https://openalex.org/W2886824961","https://openalex.org/W2887021471","https://openalex.org/W2887054120","https://openalex.org/W2895437287","https://openalex.org/W2942578733","https://openalex.org/W2949780892","https://openalex.org/W2950764390","https://openalex.org/W2965769523","https://openalex.org/W2980183483","https://openalex.org/W2980963189","https://openalex.org/W2981294586","https://openalex.org/W2982651636","https://openalex.org/W2984471897","https://openalex.org/W2987045531","https://openalex.org/W3008467453","https://openalex.org/W3016130545","https://openalex.org/W3016979633","https://openalex.org/W3017005730","https://openalex.org/W3019727132","https://openalex.org/W3036531528","https://openalex.org/W3037984899","https://openalex.org/W3046037006","https://openalex.org/W3046894249","https://openalex.org/W3095327970","https://openalex.org/W3121845936","https://openalex.org/W3129284602","https://openalex.org/W3132733467","https://openalex.org/W3137483948","https://openalex.org/W3169208133","https://openalex.org/W3198894769","https://openalex.org/W3200353350","https://openalex.org/W4205881120","https://openalex.org/W4206496562","https://openalex.org/W4213007627","https://openalex.org/W4214888288","https://openalex.org/W4220831425","https://openalex.org/W4226073657","https://openalex.org/W4242372416","https://openalex.org/W4291009233","https://openalex.org/W4297458751","https://openalex.org/W4299458434","https://openalex.org/W4308460405","https://openalex.org/W4311815250","https://openalex.org/W4312211437","https://openalex.org/W4313532825","https://openalex.org/W4318757139","https://openalex.org/W4380878202","https://openalex.org/W4382877693","https://openalex.org/W4388489377","https://openalex.org/W4389622595","https://openalex.org/W4390541236","https://openalex.org/W4392468778","https://openalex.org/W4392872362","https://openalex.org/W4393075166","https://openalex.org/W4394918443","https://openalex.org/W4399125270","https://openalex.org/W4399940463","https://openalex.org/W4401931124","https://openalex.org/W4403185190","https://openalex.org/W4404511389","https://openalex.org/W4406289485","https://openalex.org/W4407389778","https://openalex.org/W4407640632","https://openalex.org/W4408377293","https://openalex.org/W4410380504","https://openalex.org/W4410493359"],"related_works":[],"abstract_inverted_index":{"Berberis":[0],"species":[1],"are":[2],"rich":[3],"in":[4,73,81,95,114,241],"isoquinoline":[5],"alkaloids":[6,46,226],"with":[7,138],"promising":[8],"therapeutic":[9,221],"properties":[10],"for":[11,23,204],"various":[12],"diseases,":[13],"including":[14],"SARS-CoV-2.":[15],"Despite":[16],"their":[17,239],"known":[18],"medicinal":[19],"attributes,":[20],"the":[21,34,156,220],"potential":[22,88,222],"combining":[24],"them":[25],"at":[26,132],"suitable":[27],"doses":[28],"remains":[29],"underexplored.":[30],"This":[31],"study":[32],"investigated":[33],"compound-target":[35],"interactions,":[36],"functional":[37,150],"enrichment,":[38],"and":[39,53,75,87,100,105,142,153,166,170,175,179,192,209,212,230,237],"pharmacokinetic":[40],"profiles":[41,117],"of":[42,103,118,126,159,183,223],"seven":[43],"B.":[44,224],"vulgaris":[45,225],"(berberine,":[47],"palmatine,":[48],"berberrubine,":[49],"lambertine,":[50],"obamegine,":[51],"berbidine,":[52],"berbamine)":[54],"using":[55,63,71,97,122],"an":[56,76],"in-silico":[57],"approach.":[58],"Compound-target":[59],"interactions":[60],"were":[61,69,120,129,144],"identified":[62,145,168,203],"SwissTargetPrediction.":[64],"Protein-protein":[65],"interaction":[66],"(PPI)":[67],"networks":[68,181],"constructed":[70],"STRING":[72],"Cytoscape,":[74],"UpSet":[77],"plot":[78],"was":[79,93,202],"generated":[80],"Python":[82],"to":[83,227],"visualize":[84],"overlapping":[85],"targets":[86,160],"synergy.":[89],"Functional":[90,162],"enrichment":[91,163],"analysis":[92],"performed":[94],"DAVID":[96],"Gene":[98],"Ontology":[99],"Kyoto":[101],"Encyclopedia":[102],"Genes":[104,136],"Genomes":[106],"(KEGG)":[107],"pathways,":[108],"followed":[109],"by":[110,131,164],"compound-gene-pathway":[111],"network":[112],"construction":[113],"Cytoscape.":[115],"Pharmacokinetic":[116],"compounds":[119],"assessed":[121],"ADMET-AI.":[123],"A":[124],"total":[125],"42":[127],"genes":[128],"shared":[130,155],"least":[133],"two":[134],"compounds.":[135],"associated":[137],"neurotransmission":[139],"(DRD,":[140],"ADRA,":[141],"ADRB)":[143],"as":[146],"hubs":[147],"mediating":[148],"key":[149],"interactions.":[151],"Berbamine":[152],"obamegine":[154,210],"highest":[157],"number":[158],"(10).":[161],"KEGG":[165],"GO":[167],"16":[169],"20":[171],"significantly":[172],"enriched":[173],"pathways":[174,236],"biological":[176],"processes,":[177],"respectively,":[178],"formed":[180],"consisting":[182],"distinct":[184],"nodes":[185],"(pathway":[186,194],"=":[187,190,195,198],"67,":[188],"GOBP":[189,197],"69)":[191],"edges":[193],"228,":[196],"229).":[199],"Favorable":[200],"drug-likeness":[201],"all":[205],"alkaloids,":[206],"excluding":[207],"berbamine":[208],"(0.3),":[211],"low":[213],"clinical":[214],"toxicity":[215],"(0.0-0.3).":[216],"The":[217],"results":[218],"highlight":[219],"provide":[228],"complementary":[229],"synergistic":[231],"effects":[232],"across":[233],"different":[234],"disease":[235],"support":[238],"development":[240],"botanical":[242],"medicine.":[243]},"counts_by_year":[],"updated_date":"2026-04-09T08:11:56.329763","created_date":"2025-10-10T00:00:00"}