{"id":"https://openalex.org/W2767068709","doi":"https://doi.org/10.1016/j.compbiolchem.2017.10.006","title":"Systematic identification of the druggable interactions between human protein kinases and naturally occurring compounds in endometriosis","display_name":"Systematic identification of the druggable interactions between human protein kinases and naturally occurring compounds in endometriosis","publication_year":2017,"publication_date":"2017-10-17","ids":{"openalex":"https://openalex.org/W2767068709","doi":"https://doi.org/10.1016/j.compbiolchem.2017.10.006","mag":"2767068709","pmid":"https://pubmed.ncbi.nlm.nih.gov/29096379"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiolchem.2017.10.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2017.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101711063","display_name":"Lai Jiang","orcid":"https://orcid.org/0000-0001-7778-2336"},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210129412","display_name":"Anhui Provincial Hospital","ror":"https://ror.org/03n5gdd09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129412"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lai Jiang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China"],"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I4210129412","https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007866518","display_name":"Chaoliang Tang","orcid":"https://orcid.org/0000-0002-1936-028X"},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210129412","display_name":"Anhui Provincial Hospital","ror":"https://ror.org/03n5gdd09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129412"]},{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaoliang Tang","raw_affiliation_strings":["Department of Anesthesiology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, China","Department of Anesthesiology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China","Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, China"],"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, China","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesiology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I4210129412","https://openalex.org/I197869895"]},{"raw_affiliation_string":"Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, China","institution_ids":["https://openalex.org/I37461747","https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060004715","display_name":"Jie Rao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210129412","display_name":"Anhui Provincial Hospital","ror":"https://ror.org/03n5gdd09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129412"]},{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Rao","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China"],"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I4210129412","https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101872724","display_name":"Qing Xue","orcid":"https://orcid.org/0000-0003-4646-4620"},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210129412","display_name":"Anhui Provincial Hospital","ror":"https://ror.org/03n5gdd09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129412"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Xue","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China"],"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I4210129412","https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035962245","display_name":"Hao Wu","orcid":"https://orcid.org/0000-0003-4915-883X"},"institutions":[{"id":"https://openalex.org/I4210129412","display_name":"Anhui Provincial Hospital","ror":"https://ror.org/03n5gdd09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129412"]},{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Wu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China"],"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I4210129412","https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102376707","display_name":"Dabao Wu","orcid":"https://orcid.org/0009-0005-9650-1604"},"institutions":[{"id":"https://openalex.org/I4210129412","display_name":"Anhui Provincial Hospital","ror":"https://ror.org/03n5gdd09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129412"]},{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dabao Wu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China"],"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I4210129412","https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101664062","display_name":"Aijun Zhang","orcid":"https://orcid.org/0000-0003-2879-9961"},"institutions":[{"id":"https://openalex.org/I4210129412","display_name":"Anhui Provincial Hospital","ror":"https://ror.org/03n5gdd09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129412"]},{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aijun Zhang","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China"],"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I4210129412","https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100411133","display_name":"Ling Chen","orcid":"https://orcid.org/0000-0003-0238-1831"},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210129412","display_name":"Anhui Provincial Hospital","ror":"https://ror.org/03n5gdd09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129412"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Chen","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China"],"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I4210129412","https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024671609","display_name":"Zhen Shen","orcid":"https://orcid.org/0000-0002-6109-9775"},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210129412","display_name":"Anhui Provincial Hospital","ror":"https://ror.org/03n5gdd09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129412"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Shen","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China"],"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I4210129412","https://openalex.org/I197869895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100381366","display_name":"Lei Lei","orcid":"https://orcid.org/0000-0003-0987-5092"},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210129412","display_name":"Anhui Provincial Hospital","ror":"https://ror.org/03n5gdd09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129412"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Lei","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China. Electronic address: leilllei@126.com","Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China"],"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China. Electronic address: leilllei@126.com","institution_ids":[]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Anhui Provincial Hospital of Anhui Medical University, Hefei 230001, China","institution_ids":["https://openalex.org/I4210129412","https://openalex.org/I197869895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5100381366"],"corresponding_institution_ids":["https://openalex.org/I197869895","https://openalex.org/I4210129412"],"apc_list":{"value":2960,"currency":"USD","value_usd":2960},"apc_paid":null,"fwci":2.9948,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.90369271,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"71","issue":null,"first_page":"136","last_page":"143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.977400004863739,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/druggability","display_name":"Druggability","score":0.9574604034423828},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.7626055479049683},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.729845404624939},{"id":"https://openalex.org/keywords/endometriosis","display_name":"Endometriosis","score":0.5919345021247864},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5700185894966125},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4100976884365082},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.37567830085754395},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3495754599571228},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3331954777240753},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.32753029465675354},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3032776117324829},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.15972772240638733},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10306766629219055}],"concepts":[{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.9574604034423828},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.7626055479049683},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.729845404624939},{"id":"https://openalex.org/C2779522080","wikidata":"https://www.wikidata.org/wiki/Q205764","display_name":"Endometriosis","level":2,"score":0.5919345021247864},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5700185894966125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4100976884365082},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37567830085754395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3495754599571228},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3331954777240753},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32753029465675354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3032776117324829},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15972772240638733},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10306766629219055},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004715","descriptor_name":"Endometriosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004715","descriptor_name":"Endometriosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004715","descriptor_name":"Endometriosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004715","descriptor_name":"Endometriosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004715","descriptor_name":"Endometriosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004715","descriptor_name":"Endometriosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.compbiolchem.2017.10.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2017.10.006","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},{"id":"pmid:29096379","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29096379","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational biology and chemistry","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5099999904632568}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W83963649","https://openalex.org/W1482806521","https://openalex.org/W1845556393","https://openalex.org/W1867705199","https://openalex.org/W1965916750","https://openalex.org/W1966041739","https://openalex.org/W1969046853","https://openalex.org/W1992159968","https://openalex.org/W2005458011","https://openalex.org/W2006197769","https://openalex.org/W2010952228","https://openalex.org/W2020152184","https://openalex.org/W2025816743","https://openalex.org/W2026207861","https://openalex.org/W2027350423","https://openalex.org/W2034589527","https://openalex.org/W2035744353","https://openalex.org/W2040361853","https://openalex.org/W2044248670","https://openalex.org/W2055120708","https://openalex.org/W2064491099","https://openalex.org/W2065283382","https://openalex.org/W2067174909","https://openalex.org/W2092544415","https://openalex.org/W2095849999","https://openalex.org/W2096916927","https://openalex.org/W2096931514","https://openalex.org/W2105668062","https://openalex.org/W2106140689","https://openalex.org/W2108045411","https://openalex.org/W2118233996","https://openalex.org/W2118424747","https://openalex.org/W2128332459","https://openalex.org/W2133605381","https://openalex.org/W2134399937","https://openalex.org/W2134967712","https://openalex.org/W2142120438","https://openalex.org/W2147993766","https://openalex.org/W2149739984","https://openalex.org/W2156879354","https://openalex.org/W2159203162","https://openalex.org/W2170444099","https://openalex.org/W2181782164","https://openalex.org/W2284803191","https://openalex.org/W2303809014","https://openalex.org/W2537187435","https://openalex.org/W2538114768","https://openalex.org/W2598072789","https://openalex.org/W2598664734","https://openalex.org/W2608846221","https://openalex.org/W2626560501","https://openalex.org/W2735836260","https://openalex.org/W2740239690","https://openalex.org/W2746286638","https://openalex.org/W4231488642","https://openalex.org/W4240689716","https://openalex.org/W6603435860","https://openalex.org/W6628680024","https://openalex.org/W6739832199","https://openalex.org/W6743427744"],"related_works":["https://openalex.org/W2556855892","https://openalex.org/W4214810602","https://openalex.org/W2523769397","https://openalex.org/W2000687555","https://openalex.org/W2259552966","https://openalex.org/W2158546283","https://openalex.org/W2255897055","https://openalex.org/W4306937122","https://openalex.org/W2041690296","https://openalex.org/W2538996250"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}