{"id":"https://openalex.org/W2081799767","doi":"https://doi.org/10.1016/j.compbiolchem.2003.12.001","title":"The operons, a criterion to compare the reliability of transcriptome analysis tools: ICA is more reliable than ANOVA, PLS and PCA","display_name":"The operons, a criterion to compare the reliability of transcriptome analysis tools: ICA is more reliable than ANOVA, PLS and PCA","publication_year":2004,"publication_date":"2004-02-01","ids":{"openalex":"https://openalex.org/W2081799767","doi":"https://doi.org/10.1016/j.compbiolchem.2003.12.001","mag":"2081799767","pmid":"https://pubmed.ncbi.nlm.nih.gov/15022635"},"language":"en","primary_location":{"id":"doi:10.1016/j.compbiolchem.2003.12.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2003.12.001","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108088138","display_name":"Anne-Sophie Carpentier","orcid":null},"institutions":[{"id":"https://openalex.org/I88467170","display_name":"Universit\u00e9 d'\u00c9vry Val-d'Essonne","ror":"https://ror.org/00e96v939","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954","https://openalex.org/I88467170"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Anne-Sophie Carpentier","raw_affiliation_strings":["Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034,Evry, France. carpentier@genepole.cnrs.fr","Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France#TAB#"],"affiliations":[{"raw_affiliation_string":"Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034,Evry, France. carpentier@genepole.cnrs.fr","institution_ids":["https://openalex.org/I88467170"]},{"raw_affiliation_string":"Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029179605","display_name":"Alessandra Riva","orcid":"https://orcid.org/0000-0003-1732-1292"},"institutions":[{"id":"https://openalex.org/I88467170","display_name":"Universit\u00e9 d'\u00c9vry Val-d'Essonne","ror":"https://ror.org/00e96v939","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954","https://openalex.org/I88467170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alessandra Riva","raw_affiliation_strings":["Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France","Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France#TAB#"],"affiliations":[{"raw_affiliation_string":"Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France","institution_ids":["https://openalex.org/I88467170"]},{"raw_affiliation_string":"Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108487487","display_name":"Pierre Tisseur","orcid":null},"institutions":[{"id":"https://openalex.org/I88467170","display_name":"Universit\u00e9 d'\u00c9vry Val-d'Essonne","ror":"https://ror.org/00e96v939","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954","https://openalex.org/I88467170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Tisseur","raw_affiliation_strings":["Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France","Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France#TAB#"],"affiliations":[{"raw_affiliation_string":"Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France","institution_ids":["https://openalex.org/I88467170"]},{"raw_affiliation_string":"Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027579787","display_name":"Gilles Didier","orcid":"https://orcid.org/0000-0003-0596-9112"},"institutions":[{"id":"https://openalex.org/I88467170","display_name":"Universit\u00e9 d'\u00c9vry Val-d'Essonne","ror":"https://ror.org/00e96v939","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954","https://openalex.org/I88467170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gilles Didier","raw_affiliation_strings":["Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France","Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France#TAB#"],"affiliations":[{"raw_affiliation_string":"Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France","institution_ids":["https://openalex.org/I88467170"]},{"raw_affiliation_string":"Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France#TAB#","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108492815","display_name":"Alain H\u00e9naut","orcid":null},"institutions":[{"id":"https://openalex.org/I88467170","display_name":"Universit\u00e9 d'\u00c9vry Val-d'Essonne","ror":"https://ror.org/00e96v939","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954","https://openalex.org/I88467170"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alain H\u00e9naut","raw_affiliation_strings":["Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France","Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France#TAB#"],"affiliations":[{"raw_affiliation_string":"Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France","institution_ids":["https://openalex.org/I88467170"]},{"raw_affiliation_string":"Laboratoire G\u00e9nome et Informatique, UMR 8116, Tour Evry2, 523 Place des Terrasses, 91034 Evry, France#TAB#","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5108088138"],"corresponding_institution_ids":["https://openalex.org/I88467170"],"apc_list":{"value":2960,"currency":"USD","value_usd":2960},"apc_paid":null,"fwci":1.1975,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.76696184,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"28","issue":"1","first_page":"3","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.9783999919891357,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9769999980926514,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.6065014004707336},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5091156363487244},{"id":"https://openalex.org/keywords/independent-component-analysis","display_name":"Independent component analysis","score":0.46633458137512207},{"id":"https://openalex.org/keywords/operon","display_name":"Operon","score":0.42426592111587524},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.42106005549430847},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3913707435131073},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.32510673999786377},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.29425501823425293},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29002928733825684},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.23712795972824097},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.23417001962661743},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20844680070877075}],"concepts":[{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.6065014004707336},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5091156363487244},{"id":"https://openalex.org/C51432778","wikidata":"https://www.wikidata.org/wiki/Q1259145","display_name":"Independent component analysis","level":2,"score":0.46633458137512207},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.42426592111587524},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.42106005549430847},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3913707435131073},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.32510673999786377},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.29425501823425293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29002928733825684},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.23712795972824097},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23417001962661743},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20844680070877075},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.compbiolchem.2003.12.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.compbiolchem.2003.12.001","pdf_url":null,"source":{"id":"https://openalex.org/S104924063","display_name":"Computational Biology and Chemistry","issn_l":"1476-9271","issn":["1476-9271","1476-928X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biology and Chemistry","raw_type":"journal-article"},{"id":"pmid:15022635","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15022635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational biology and chemistry","raw_type":null},{"id":"pmh:oai:HAL:hal-01614113v1","is_oa":false,"landing_page_url":"https://hal.science/hal-01614113","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational Biology and Chemistry, 2004, 28 (1), pp.3 - 10. ⟨10.1016/j.compbiolchem.2003.12.001⟩","raw_type":"Journal articles"},{"id":"pmh:oai:oskar-bordeaux.fr:20.500.12278/10015","is_oa":false,"landing_page_url":"https://oskar-bordeaux.fr/handle/20.500.12278/10015","pdf_url":null,"source":{"id":"https://openalex.org/S4306402569","display_name":"Oskar-Bordeaux (Universite de Bordeaux)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article de revue"},{"id":"pmh:oai:oskar-bordeaux.fr:20.500.12278/193534","is_oa":false,"landing_page_url":"https://oskar-bordeaux.fr/handle/20.500.12278/193534","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article de revue"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W174064755","https://openalex.org/W1626632972","https://openalex.org/W1816090072","https://openalex.org/W1922999930","https://openalex.org/W1959958506","https://openalex.org/W1965843937","https://openalex.org/W1968828650","https://openalex.org/W1970156673","https://openalex.org/W1976208596","https://openalex.org/W1994154522","https://openalex.org/W1999590490","https://openalex.org/W2010104618","https://openalex.org/W2015255690","https://openalex.org/W2029441111","https://openalex.org/W2037333971","https://openalex.org/W2040711070","https://openalex.org/W2042473127","https://openalex.org/W2057709771","https://openalex.org/W2058738984","https://openalex.org/W2080202391","https://openalex.org/W2089625500","https://openalex.org/W2089762138","https://openalex.org/W2091320570","https://openalex.org/W2093017030","https://openalex.org/W2093290409","https://openalex.org/W2096758922","https://openalex.org/W2099741732","https://openalex.org/W2104695131","https://openalex.org/W2105792118","https://openalex.org/W2108819945","https://openalex.org/W2116811581","https://openalex.org/W2123172482","https://openalex.org/W2125826355","https://openalex.org/W2133199783","https://openalex.org/W2141224535","https://openalex.org/W2151770458","https://openalex.org/W2155120241","https://openalex.org/W2156990747","https://openalex.org/W2159511216","https://openalex.org/W2159557626","https://openalex.org/W2163813213","https://openalex.org/W2168370822","https://openalex.org/W2402058694","https://openalex.org/W2410634280","https://openalex.org/W2415086864","https://openalex.org/W4239901699","https://openalex.org/W4285719527","https://openalex.org/W6682542345","https://openalex.org/W6713244025","https://openalex.org/W6714857287"],"related_works":["https://openalex.org/W1608194938","https://openalex.org/W2121429698","https://openalex.org/W2182042810","https://openalex.org/W4252230435","https://openalex.org/W55679925","https://openalex.org/W3080404860","https://openalex.org/W2572774164","https://openalex.org/W2046761971","https://openalex.org/W3144722888","https://openalex.org/W2089650474"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}